What causes PSA levels to increase after partial prostate removal due to prostate gland enlargement (benign prostatic hyperplasia)?

Answer From Patricio C. Gargollo, M.D.

Increased levels of prostate-specific antigen (PSA) in your blood can be a sign of prostate cancer. But cancer is just one of several possible causes of increased PSA.

Prostate tissue typically releases small amounts of PSA into your blood. When the prostate grows, PSA levels increase. When the entire prostate is removed, PSA levels fall close to zero. Most procedures used to treat an enlarged prostate remove only part of the prostate, which partially decreases PSA levels.

After any enlarged prostate procedure, a number of factors can cause PSA levels to go up again, including:

  • Prostate cancer. Prostate cancer cells in remaining prostate tissue or in other parts of your body can release PSA.
  • Recurrent benign prostate growth. Remaining prostate tissue might continue to grow, leading to increased PSA levels.
  • Inflammation of prostate tissue (prostatitis). Infection or inflammation of the prostate gland or remaining prostate tissue can cause your PSA levels to increase.

If you have increasing PSA levels after surgery for an enlarged prostate, your health care provider might recommend:

  • A wait-and-see approach. You might need to retake the PSA test.
  • Medication. If your provider suspects prostatitis, you might take certain medications to cure the infection.
  • Additional tests. If a second test shows high PSA levels, your provider might recommend an imaging exam of the prostate with ultrasound, a computerized tomography (CT) scan or magnetic resonance imaging (MRI). If cancer is suspected, you might need a biopsy to check remaining prostate tissue.

With

Patricio C. Gargollo, M.D.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

Dec. 20, 2022 See more Expert Answers

See also

  1. Ablation therapy
  2. Benign prostatic hyperplasia (BPH)
  3. Bladder outlet obstruction
  4. Bladder stones
  5. Computerized tomography (CT) urogram
  6. Cystoscopy
  7. Digital rectal exam
  8. Enlarged prostate: Does diet play a role?
  9. Frequent urination
  10. Holmium laser prostate surgery
  11. Intravenous pyelogram
  12. Laser PVP surgery
  13. Minimally invasive surgery
  14. Prostate biopsy
  15. Prostate cancer screening
  16. Prostate laser surgery
  17. PSA test
  18. PSA: To Test or Not To Test
  19. Mayo Clinic Minute: Steam treatment for enlarged prostate
  20. Symptom Checker
  21. TUIP
  22. TUMT
  23. TURP
  24. Urinalysis
  25. Urinary tract infection (UTI)