Neurology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Resting State Connectivity in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Pain

   Rochester, Minn.

   The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

2. A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

   Rochester, Minn.

   The purpose of this study is to monitor outcome to ensure that children and young adults with localized central nervous system (CNS) non-germinomatous germ cell tumors (NGGCT) treated with Induction chemotherapy followed by response evaluation and whole ventricular + spinal canal irradiation (WVSCI) will maintain the excellent 2-year progression free survival (PFS) rate as compared to ACNS0122. Also, to improve disease control by decreasing the number of spinal relapses for patients who achieve a complete response (CR) or partial response (PR) and receive WVSCI as compared to whole ventricular radiation on ACNS1123.

3. Long-Term Observational Extension of Participants in CREST-2Trial

   Scottsdale/Phoenix, Ariz.

   The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial study is to assess post-procedural efficiency of carotid endarterectomy and carotid stenting.

4. A Study to Review Magnetic Resonance Imaging in Patients with Epilepsy

   Rochester, Minn.

   The primary purpose of this study is to compare the diagnostic utility of 7T MRI versus 3T MRI in the detection of subtle epileptogenic lesions in the brain.

5. A study to create and analyze a comprehensive longitudinal resource using testing results from those with genetic risk of Alzheimer's disease

   Scottsdale/Phoenix, Ariz.

   This study aims to establish, use, and extensively share a comprehensive longitudinal resource of genetic, non-genetic, and cognitive data, brain imaging and fluid biomarker measurements of amyloid-β (Aβ), tau pathophysiology, neurodegeneration, and inflammation (“A,T,N,I”), and biological samples to advance the study of cognitively unimpaired older adults at six levels of genetic risk for Alzheimer’s disease (AD) due to their apolipoprotein E (APOE) genotype, including understudied APOE2 and APOE4 homozygotes (HMs) at the lowest and highest risk and those APOE4 HMs and heterozygotes (HTs) who remain unimpaired at older ages due to unknown protective factors and spared pathophysiological effects despite their genetic risk.

6. Cerebrospinal Fluid (CSF) Biomarkers for Prediction of Dementia

   Rochester, Minn., Jacksonville, Fla.

   To further investigate biomarkers in CSF as possible predictors for mild cognitive impairment and dementia

7. A Multimodal Monitoring (MMM) Computer to Detect Physiologic Trends in Data in Neurointensive Care Unit Patients

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to identify important physiologic trends in bedside ICU data such as cerebral perfusion pressure (CPP), intracranial pressure (ICP) using a bedside “Multimodal monitoring” (MMM) computer which utilizes ICM+ Cambridge software.

8. A Study of Immune-Mediated Activation of Astrocytes in Healthy Volunteers

   Rochester, Minn.

   The purpose of this study is to characterize the astrocyte response to various inflammatory drivers in the presence of innate immune cells collected from healthy subjects. We will identify innate immune cell populations that contribute to astrocyte reactivity and elucidate the mechanisms responsible for altering the transcriptional and translational profile of astrocytes.

9. Creation of PLACENTA/Serum Repository Database: Autoimmunity from Mother To Baby Study

   Rochester, Minn.

   The purpose of the study is to learn more about autoimmunity and potential mother to baby transmission of pathogenic antibodies. The collected research samples from children will be frozen and stored at the Mayo Clinic and will be used for future studies of autoimmune diseases.

10. A Prospective Registry for Patients with REM Sleep Behavior Disorder and Polysomnographic REM Sleep without Atonia and Controls

    Rochester, Minn.

    The purpose of this study is to follow patients with REM sleep behavior disorder (RBD) over time and learn which types of RBD patients may be at risk of developing other diseases.