Liver Transplant Program

Each year Mayo's doctors and surgeons diagnose and treat thousands of people who have liver disease. Mayo Clinic's three-site Liver Transplant Program is one of the largest and most experienced in the country. And the liver transplant teams in Arizona, Florida and Minnesota are leaders and innovators, improving techniques and conducting groundbreaking research, such as:

• Preclinical work on bioartificial livers and biliary stem cells
• Active trials on the optimal use of anti-rejection drugs that help ensure positive outcomes

Obesity and liver disease

Talk with your doctor about liver transplant options that improve outcomes.

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People with challenging health situations come to Mayo Clinic for help because our doctors and surgeons are experts in specialized liver transplant options, such as those listed below. The experience, expertise and unique multidisciplinary approach at Mayo Clinic ensure that all options are considered to deliver the most individualized care for every patient. And Mayo has one of the largest living-donor programs in the United States. Living-donor transplant is an option that, for many people, reduces time on the waiting list for a donor liver and improves outcomes.

• Multiorgan transplants, such as heart-liver and liver-kidney
• Liver transplant for children
• Living-donor liver transplant
• Transplantation in people who are hepatitis C positive
• Specialized treatment for patients with immune-mediated liver disease, such as primary biliary cirrhosis, autoimmune hepatitis and primary sclerosing cholangitis
• Specialized treatment for obese people with nonalcoholic steatohepatitis (NASH) who need a liver transplant
• Specialized treatment for people with a type of bile duct cancer called hilar cholangiocarcinoma
• Domino liver transplant
• Novel strategies to prevent the immune system from rejecting donated tissue
• Optimized use of extended criteria organ donors, which helps people on a waiting list get transplanted sooner

Nationally ranked

Mayo Clinic's Liver Transplant Program was established in 1985. Since then Mayo Clinic has completed more than 10,200 liver transplants in children and adults. In 2016, Mayo Clinic's Florida campus completed its 3,000th liver transplant, a milestone that very few centers nationwide have achieved. And Mayo Clinic's Arizona campus completed its 1,000th liver transplant.

Liver transplant outcomes compare favorably with the national average.

Mayo Clinic in Rochester, Minnesota, ranks No. 1 for digestive disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for digestive disorders by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings.

Learn more about Mayo Clinic's quality rankings.