General Internal Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Evaluate Wellness Coaching for Caregivers of Thoracic Transplant Candidates

   Rochester, Minn.

   The purpose of this study is to examine the effects of a health coaching intervention on the stress and burden of caregivers of patients awaiting heart or lung transplant.

   Hypotheses:  Caregivers will have traits and behaviors pre-transplant that will predict caregiver readiness, quality of life, and transplant recipient outcomes. Specifically, thoracic pre-transplant caregivers report stress, symptoms of anxiety or depression, and perceive high caregiver burden. These factors may be amenable to pre-transplant intervention to improve overall patient and caregiver outcomes.

   Aims, purpose, or objectives:  We will conduct a pilot trial to test whether caregivers of heart and lung transplant candidates who receive wellness coaching will experience improvement in caregiver-related distress. We will also explore the relationship between caregiving and factors such as uncertainty, resilience, stress level, and affect.

2. Undiagnosed Tumor/Undifferentiated Mass Registry

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to create a research registry to prospectively collect research biospecimens and corresponding clinical data from subjects with an undiagnosed tumor or undifferentiated mass.

3. A Study to Evaluate the Impact of Menopause on Blood Pressure Regulation During Exercise

   Rochester, Minn.

   The purpose of this study is to determine how menopause influences blood pressure responses during exercise in women.

4. GENetic Risk Estimation of Breast Cancer Prior to Decisions on Preventive Therapy Uptake, Risk Reducing Surgery or Intensive Imaging Surveillance

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The primary aim of this study is to determine if the addition of an individual polygenic risk score (PRS) in addition to the Breast Cancer Risk Assessment Tool (BCRAT) or Tyrer-Cuzick (IBIS) score will aid women at risk of breast cancer in making a decision to take (or not take) medications to prevent breast cancer.

5. Using Authentic Stories to Build Resilience Among Medical Professionals

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   The purpose of this study is to adapt a collection of authentic stories to a performance designed to improve vulnerability awareness and empathy, as well as encourage supportive behavior among Mayo Clinic students, residents, and faculty.

6. Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS

   Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The primary objective of the trial is to evaluate the long-term safety of glepaglutide treatment in patients with short bowel syndrome (SBS). Glepaglutide is the International Nonproprietary Name and USAN for ZP1848.

7. Cellular Senescence and COVID-19 Long-Hauler Syndrome

   Rochester, Minn.

   The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated. 

8. Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women

   Rochester, Minn.

   This is a pilot study to evaluate whether targeting inflammation will help reduce markers of insulin resistance inflammation, bone resorption and physical dysfunction in elderly women with gait disturbance. Positive results of this study would lead to the development of a larger clinical trial examining the effects of this intervention on age-related dysfunction.