Gastroenterology and Hepatology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Evaluate Evacuation Mechanisms Using Advanced Brain Imaging

   Rochester, Minn.

   The objective of this study is to compare the central neural circuitry with fMRI (7T) in 30 asymptomatic healthy controls, 30 constipated patients without DD, and 30 constipated patients with DD at rest (functional connectivity analysis), during rectal distention to desire to defecate and urgency, and during evacuation. 

    

    

    

2. A Study to Develop a Registry for Outcomes and Predictors in Pouch-Related Disorders

   Rochester, Minn.

   The primary purpose of this study is to create a prospective registry of patients with pouch-related conditions to allow for longitudinal assessment of outcomes at 3, 6 and 12 months after a enrollment with a specific diagnosis (acute pouchitis, CADP, CARP, or CD of the pouch).

3. A Study To Examine Quality of Life Assessment in Patients Receiving Cryotherapy for Palliation of Dysphagia in Unresectable Esophageal or Gastroesophageal Junctional Cancer

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to determine the effect of endoscopic cryoablation for lessening the effects of dysphagia on the quality of life (QOL) of patients with unresectable esophageal or gastroesophageal junctional cancer.

4. A Safety to Evaluate the Safety and Effectiveness of Pressurized Intraperitoneal Aerosolized Chemotherapy in Ovarian, Uterine, Colorectal, and Gastric Cancer Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the safety of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in 2 groups of patients with peritoneal carcinomatosis (PC), either due to primary ovarian, uterine, or gastric carcinoma (Arm 1) or to primary colorectal carcinoma (Arm 2), based on treatment-related adverse events reported by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.  

5. Effect of Cholecystokinin (CCK) on Gastroduodenal Activity in Humans

   Rochester, Minn.

   The purpose of this research study to compare the effects a hormone cholecystokinin (CCK) in the bloodstream in healthy people and in patients with rapid gastric emptying. CCK regulates (controls) the rate at which food empties from the stomach into the small intestine. We want to learn how CCK affects the activity of the stomach and small intestines in patients with rapid gastric emptying. We are also trying to learn if genes regulate the effects of CCK.

6. A Study to Evaluate the Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers

   Rochester, Minn.

   The purpose of this study is to evaluate the effects of tradipitant relative to placebo in healthy volunteers:

   • Difference in fasting GV;
   • Difference in postprandial GV and in accommodation volume (that is, postprandial minus fasting gastric volumes);
   • Difference in gastric emptying (T1/2, emptying at 2h and emptying at 4h);
   • Volume to fullness (sensation of usual postprandial fullness) and maximum feeling of fullness (MTV).

7. A Study to Assess Intestinal Barrier Function and Permeability in Patients with Functional Dyspepsia

   Jacksonville, Fla.

   The purpose of this study is to investigate, using several novel techniques, potential pathophysiologic abnormalities that could lead to the development of symptoms of functional dyspepsia.

8. A Study to Evaluate the Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients

   Jacksonville, Fla.

   The purpose of this study is to establish if abdominal breathing exercises can reduce symptoms associated with reflux.

9. Mayo Clinic Inflammatory Bowel Disease Repository

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this research study is to collect clinical information and human samples from patients with IBD. The data collected will be used to create an organized, accessible resource of human samples for biological research in IBD.

10. A Study of Intratumoral Injection of Dendritic Cells after High-Dose Conformal External Beam Radiotherapy in Patients with Unresectable Liver Cancer

    Rochester, Minn.

    Group 1: The primary purpose of this study is to evaluate the safety and tolerability of an autologous dendritic cells (DC) vaccine delivered by intra-tumoral injection in patients with primary liver cancer treated with high-dose conformal external beam radiotherapy (EBRT).

    Group 2: The primary purpose of this study is to estimate the progression-free survival rate at 2 years post-registration to see if treatment is efficacious compared to historical data