Cardiovascular Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Analysis of Outcomes of Left Cardiac Sympathetic Denervation in Arrhythmia Syndromes and Cardiomyopathies

   Rochester, Minn.

   The purpose of this study is to collect and review the Mayo Clinic experience with left cardiac sympathetic denervation (LCSD) in patients with heritable arrhythmias syndromes or refractory ventricular arrhythmias beginning in 2000.

2. Hypoplastic Left Heart Syndrome: Validating Functional Parameters and Novel Echocardiographic Imaging Strategies for Evaluation of Functionally Single Right Ventricular Performance using Previously Recorded Studies

   Rochester, Minn.

   The purpose of this study is to validate novel echocardiographic parameters and algorithms to quantitatively evaluate right ventricular function in patients with Hypoplastic Left Heart Syndrome (HLHS) by applying these methods to previously acquired echocardiographic examinations. 

3. COVID-19 (Coronavirus) Pandemic on Health and Healthcare

   Rochester, Minn.

   The purpose of this study is to identify correlates of healthcare-seeking behavior in patients with ACS and CHF and its association with psychosocial and health outcomes.

4. Acoustic Spectrograms and Detection of Early LVAD Thrombosis

   Rochester, Minn.

   The purpose of this study is to characterize the acoustic features of normal left ventricular assist device (LVAD) pump function using spectrography and fast Fourier transformation. The study will also identify abnormalities seen in the acoustic spectrograms of those patients presenting with LVAD thrombosis. Furthermore, the study aims to follow patients where abnormalities are seen in order to ascertain which features are predictive of the development of pump thrombosis and may be considered early markers thereof.

    

5. A Study to Assess Virtual Reality As Anesthesia Adjunct During Electrophysiology Lab Procedures

   Jacksonville, Fla.

   The purpose of this study is to evaluate the use of virtual reality (VR) technology as adjunct to routine anesthesia care for patients undergoing electrophysiology (EP) procedures.

6. A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

   Rochester, Minn.

   We are currently enrolling both healthy volunteers and people who have been diagnosed with heart failure to participate in our research study.  The purpose of this study is to better understand the relationship between exercise, breathing, blood flow and blood pressure.  This study includes two study visits if you are a healthy or heart failure volunteer.    All testing will be performed at our testing center at St. Mary’s Hospital located in Rochester, MN. 

   On the first study visit, the research activities will be discussed and all questions will be answered. Once written consent is provided and the participant is enrolled, lung function and exercise capacity will be measured.

   The second study visit includes two separate breathing muscle workouts (a light and moderate workload) each followed by 10 min of light to moderate cycling exercise. In addition, two breathing tests will also be performed. During this visit, blood is drawn during exercise.

   If you are a patient at Mayo Clinic, who is currently enrolled or will be enrolling in a cardiac rehabilitation exercise program, you will have the option to complete four study visits.  Your first two study visits as described above will be completed at the beginning of cardiac rehabilitation and then we will ask you to return to complete those same two study visits following the completion of your cardiac rehabilitation program.

   Remuneration and parking reimbursement are provided.

7. A Study of In Vitro Mapping of Cardiac Tissue Obtained from Patients with Refractory Arrhythmias who Underwent Heart Transplant or Replacement with Mechanical Heart

   Rochester, Minn.

   The purpose of this study is to obtain electro-anatomic maps of human myocardium in sinus rhythm and ventricular arrhythmias to identify activation patterns, identify and perform tissue ablation at targeted sites of interest that could play an important trigger for development of arrhythmias, and to perform histologic analysis of the myocardial tissue to identify triggers and/or targets for therapies to terminate ventricular arrhythmias.

8. Spontaneous Coronary Artery Dissection: Case Review

   Rochester, Minn.

   Spontaneous coronary artery dissection (SCAD) is uncommon but important cause of acute coronary syndrome and sudden cardiac death. There is very little data exists in regards to patient clinical characteristics, risk factors, treatment and outcomes. Our objective is to prospectively assess long term outcomes. 

9. A Study of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction

   Jacksonville, Fla.

   The purpose of this study is to establish a registry that will address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction) between ED (Emergency Department) arrival and diagnostic angiography in detail, by characterizing and following the ED and peri-ED use of advanced OAP (Oral Anti-Platelet) agents. In addition to exploring ED treatment patterns and success of both ischemic and bleeding risk stratification prior to definition of the coronary anatomy, data generated via the UPSTREAM registry will allow plausible attribution of ischemic and bleeding outcomes to pre-catheterization antiplatelet therapy in the management of NSTEMI. This registry further seeks to demonstrate that contemporary use of upstream ticagrelor is associated with an economically-sound utilization of hospital resources, and smooth transition of care into the outpatient, secondary prevention setting for the first 30 days after hospitalization. Finally, it will allow characterization of patient selection factors and processes for ticagrelor vs alternative OAP agents, carrying out that descriptive comparison through discharge. Patients transferred in to an UPSTREAM hospital are eligible for inclusion, but the timing for OAP agent administration and diagnostic catheterization begin with ED care at the first hospital.

10. Treating Breast Cancer Patients Undergoing Trastuzumab Treatment with Carvedilol to Reduce Incidence of Heart Failure

    Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

    The purpose of this study is to evaluate different strategies of cardiovascular therapy with Carvedilol, aiming to reduce the incidence of left ventricular ejection fraction (LVEF) decline and heart failure (HF) in patients undergoing curative intent Trastuzumab for breast cancer.

     

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