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Gang Zheng, M.D., Ph.D.

  1. Hematopathologist
  2. Pathologist
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Publications

  1. Li P, Alnoor FNU, Xie W, Williams M, Feusier J, Ding Y, Zhao X, Zheng G, Zhao C, Zieske AW, Zu Y, Raess PW, Tantravahi S, Osman A, Patel AB, Tashi T, Patel JL, Matynia AP, Menon MP, Miles RR, Jacobsen JR, George TI, Sborov DW, Szankasi P, Rindler P, Close D, Ohgami RS. Rapid growth of acquired UBA1 mutations predisposes male patients to low-risk MDS. Leukemia. 2024 Nov 8 Epub 2024 Nov 08
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  2. Shimshak SJ, Jasmine S, Davis MDP, Johnson EF, Peters MS, Zheng G, Sokumbi O, Comfere NI. Myelodysplasia cutis and VEXAS syndrome initially diagnosed as histiocytoid Sweet syndrome: A diagnostic pitfall. J Cutan Pathol. 2024 Nov; 51 (11):834-839 Epub 2024 July 12
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  3. Zhang X, Ding Y, Li P, Bourgeois K, Rangan A, Herrick JL, Pardanani A, Chen D, Viswanatha D, He R, Zheng G. Null-type SH2B3 mutations are potential drivers in a subset of Ph-negative myeloproliferative neoplasms. Am J Hematol 2024 Sep; 99 (9):1841-1844 Epub 2024 June 25
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  4. Koleilat A, Kumar V, Al Hmada Y, Milosevic D, Zheng G, Lopes MB, Ida CM. Concurrent TERT promoter C228T and C250T mutations in diffuse gliomas: Rare occurrence of intratumoral heterogeneity. J Neuropathol Exp Neurol. 2023 Nov 20; 82 (12):1044-1047
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  5. Wilton KM, Zheng G. Lineage switch of B-acute lymphoblastic leukemia with t(11;19)(q23;p13.3) into acute myeloid leukemia with monocytic differentiation after induction chemotherapy. EJHaem. 2023 Aug; 4 (3):863-864 Epub 2023 May 01
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  6. Buglioni A, Guo R, Rumilla KM, Edgar MA, Markovic SN, Zheng G. An Unexpected Diagnosis Uncovered by Quantitative Molecular Findings: A Case Report. J Natl Compr Canc Netw. 2023 Aug; 21 (8):787-791
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  7. Choudhuri J, Pan Z, Yuan J, Chen M, Wu X, Zheng G, Zhao C, Yuan Y, Agarwal B, Liu J, Ma MY, Wang Y, Shi Y. CD138- Plasmablastic Lymphoma: A Multi-institutional Study and Review of the Literature. Arch Pathol Lab Med. 2023 Jun 1; 147 (6):643-654
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  8. Zheng G, Li P, Zhang X, Pan Z. The fifth edition of the World Health Organization Classification and the International Consensus Classification of myeloid neoplasms: evolving guidelines in the molecular era with practical implications. Curr Opin Hematol. 2023 Mar 1; 30 (2):53-63 Epub 2022 Dec 23
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  9. Zong N, Wen A, Moon S, Fu S, Wang L, Zhao Y, Yu Y, Huang M, Wang Y, Zheng G, Mielke MM, Cerhan JR, Liu H. Computational drug repurposing based on electronic health records: a scoping review. NPJ Digit Med. 2022 Jun 14; 5 (1):77 Epub 2022 June 14
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  10. Zimmerman Zuckerman E, Thompson JA, Schneider AR, Campion MB, Johns JJ, Stier TJ, Peterson LM, Ward AM, Blommel JH, Gnanaolivu RD, Lauer KP, Sivasankaran G, Balan J, Dasari S, Sakai Y, Marcou CA, Zheng G, Halling KC, Shen W, Viswanatha DS, Niu Z. Automation of hybridization and capture based next generation sequencing library preparation requires reduction of on-deck bead binding and heated wash temperatures. SLAS Technol. 2022 Jun; 27 (3):214-218 Epub 2021 Nov 26
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  11. Li P, White T, Xie W, Cui W, Peker D, Zeng G, Wang HY, Vagher J, Brown S, Williams M, Kovacsovics T, Patel JL. AML with germline DDX41 variants is a clinicopathologically distinct entity with an indolent clinical course and favorable outcome. Leukemia. 2022 Mar; 36 (3):664-674 Epub 2021 Oct 20
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  12. Lin MT, Zheng G, Rodriguez E, Tseng LH, Parini V, Xian R, Zou Y, Gocke CD, Eshleman JR. Double PIK3CA Alterations and Parallel Evolution in Colorectal Cancers. Am J Clin Pathol. 2022 Feb 3; 157 (2):244-251
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  13. Jawad M, Afkhami M, Ding Y, Zhang X, Li P, Young K, Xu ML, Cui W, Zhao Y, Halene S, Al-Kali A, Viswanatha D, Chen D, He R, Zheng G. DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation. Front Oncol. 2022; 12:849376 Epub 2022 Feb 28
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  14. Zheng G, He R, Reichard KK, Peterson JF, Olteanu H, Oliveira JL, Rangan A, Chen D, Shi M. Genetic and Clinical Studies of Patients With Increased Multinucleated Megakaryocytes in Bone Marrow as an Isolated Finding: A Diagnostic Pitfall for Myelodysplastic Syndrome. Am J Surg Pathol. 2021 Nov 1; 45 (11):1534-1540
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  15. Horton RK, Zheng G. A case of VEXAS syndrome with subtle morphologic findings. Blood. 2021 Oct 14; 138 (15):1378
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  16. Pryzbylski AL, Kollmeyer TM, Praska CE, Raghunathan A, Jentoft ME, Giannini C, Vaubel RA, Halling KC, Zheng G, DiGuardo MA, Kipp BR, Jenkins RB, Ida CM. Non-canonical IDH Mutation Frequency in IDH1-R132H-Negative Glioblastoma Patients Older Than 54 Years. J Neuropathol Exp Neurol 2021 Sep 10; 80 (8):804-806
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  17. Fang H, Yabe M, Zhang X, Kim Y, Wu X, Wei P, Chi S, Zheng L, Garcia-Manero G, Shao L, Yuan J, Shen Y, Zheng G, Tang G, Wang W, Loghavi S, Shen Q, Yuan Y, He R, Chen D, Medeiros LJ, Hu S. Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases. Mod Pathol. 2021 Jun; 34 (6):1143-1152 Epub 2021 Feb 08
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  18. Vogt SL, Patel M, Lakha A, Philip V, Omar T, Ashmore P, Pather S, Haley LM, Zheng G, Stone J, Mayne E, Stevens W, Wagner-Johnston N, Gocke CD, Martinson NA, Ambinder RF, Xian RR. Feasibility of Cell-Free DNA Collection and Clonal Immunoglobulin Sequencing in South African Patients With HIV-Associated Lymphoma. JCO Glob Oncol. 2021 Apr; 7:611-621
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  19. Zhao Y, Yu H, Ida CM, Halling KC, Kipp BR, Geiersbach K, Rumilla KM, Gupta S, Lin MT, Zheng G. Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases. JAMA Netw Open. 2021 Jan 04; 4(1):e2035479.
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  20. Huang Z, Siddhanta S, Zheng G, Kickler T, Barman I. Rapid, Label-free Optical Spectroscopy Platform for Diagnosis of Heparin-Induced Thrombocytopenia. Angew Chem Int Ed Engl. 2020 Apr 6; 59 (15):5972-5978 Epub 2020 Feb 19
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  21. Lin MT, Zheng G, Tseng LH, Zhang P, Ling H, Azad N, Gocke CD, Montgomery E, Eshleman JR. Multiclonal colorectal cancers with divergent histomorphological features and RAS mutations: one cancer or separate cancers? Hum Pathol. 2020 Apr; 98:120-128 Epub 2020 Mar 12
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  22. Bynum J, Batista D, Xian R, Xing D, Eshleman JR, Ronnett BM, Zheng G. Tetraploid Partial Hydatidiform Moles: Molecular Genotyping and Determination of Parental Contributions. J Mol Diagn. 2020 Jan; 22 (1):90-100 Epub 2019 Oct 24
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  23. Zheng G, Chen P, Pallavajjalla A, Haley L, Gondek L, Dezern A, Ling H, De Marchi F, Lin MT, Gocke C. The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia. Am J Hematol. 2019 Oct; 94 (10):1141-1148 Epub 2019 Aug 07
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  24. De Marchi F, Haley L, Fryer H, Ibrahim J, Beierl K, Zheng G, Gocke CD, Eshleman JR, Belchis D, Illei P, Lin MT. Clinical Validation of Coexisting Activating Mutations Within EGFR, Mitogen-Activated Protein Kinase, and Phosphatidylinositol 3-Kinase Pathways in Lung Cancers Arch Pathol Lab Med. 2019.
  25. Wobker SE, Matoso A, Pratilas CA, Mangray S, Zheng G, Lin MT, Debeljak M, Epstein JI, Argani P. Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status. Am J Surg Pathol. 2019 Sep; 43 (9):1157-1169
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  26. Aggarwal MV, Jarrell AS, Gilmore VT, Aboagye JK, Haut ER, Hobson DB, Lau BD, Kickler T, Kraus PS, Shaffer DL, Shermock KM, Streiff MB, Zheng G, Kruer RM. Anti-Xa activity by weight in critically ill patients receiving unfractionated heparin for venous thromboembolism prophylaxis. J Crit Care. 2019 Aug; 52:180-185 Epub 2019 Apr 29
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  27. Xing D, Zheng G, Pallavajjala A, Schoolmeester JK, Liu Y, Haley L, Hu Y, Liu L, Logan L, Lin Y, Pearce KE, Sattler CA, Tsai YC, Vang R, Hung CF, Wu TC, Ronnett BM. Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics. Clin Cancer Res. 2019 Jul 15; 25 (14):4516-4529 Epub 2019 Apr 22
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  28. Yuan J, Li S, Liu X, Su RJ, Chen M, Wu X, Zheng G, Smith LM, Wang L, Li Y, Liu C, Zhou J, Shen Q, Zhang L, Wang E, Xu ML, Pan Z. Mantle Cell Lymphoma With Mantle Zone Growth Pattern. Am J Clin Pathol. 2019 Jul 05; 152(2):132-145.
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  29. PM Lokhandwala, LH Tseng, E Rodriguez, G Zheng, A Pallavajjalla, CD Gocke, JR Eshleman, MT Lin. Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing. BMC Cancer. 2019.
  30. Haddaway K, Bloch EM, Tobian AAR, Frank SM, Sikorski R, Cho BC, Zheng G, Jani J, Lokhandwala PM, Lawrence CE, Blagg L, Ness PM, Kickler TS, Gehrie EA. Hemostatic properties of cold-stored whole blood leukoreduced using a platelet-sparing versus a non-platelet-sparing filter. Transfusion. 2019 Feb 11 [Epub ahead of print]
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  31. Chen P, jani J, Streiff MB, Zheng G*, Kickler T. Evaluation of global hemostatic assays in response to factor VIII inhibitors. Clinical and Applied thrombosis/Hemostasis. 2019; Corresponding Author.
  32. Zheng G, Tseng LH, Haley L, Ibrahim J, Bynem J, Xian R, Gocke CD, Eshleman JR, Lin MT. Clinical validation of coexisting driver mutations in colorectal cancers Hum Pathol. 2018.
  33. De Marchi F, Haley L, Fryer H, Ibrahim J, Beierl K, Zheng G, Gocke CD, Eshleman JR, Belchis D, Illei P, Lin MT. Detection of RAS and RAS-associated alterations in primary lung adenocarcinomas. A correlation between molecular findings and tumor characteristics Hum Pathol. 2018.
  34. Xing D, Zheng G, Schoolmeester JK, Li Z, Pallavajjala A, Haley L, Conner MG, Vang R, Hung CF, Wu TC, Ronnett BM. Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix. Am J Surg Pathol. 2018 Jun; 42 (6):750-760
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  35. Pan Z, Chen M, Zhang Q, Wang E, Yin L, Xu Y, Huang Q, Yuan Y, Zhang X, Zheng G, Yuan J. CD3-positive plasmablastic B-cell neoplasms: a diagnostic pitfall. Mod Pathol. 2018 May; 31 (5):718-731 Epub 2018 Jan 12
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  36. Zheng G, Richmond A, Liu C, Berrebi A, Pallavajjala A, Haley L, Stone RL, McCarthy E, Vang R, Xing D. Clinicopathologic Features and Genetic Alterations of a Primary Osteosarcoma of the Uterine Corpus Int J Gynecol Pathol. 2018.
  37. Zheng G, MB Streiff, D Allison, C M Takemoto, K Salimian, P Morris, J Jani, R McCord and TS Kickler. A novel diagnostic algorithm for heparin-induced thrombocytopenia. International Journal of Laboratory Hematology. 2018.
  38. KJ Salimian, R Fazeli, G Zheng, D Ettinger, Z Maleki. V600E BRAF versus Non-V600E BRAF Mutated Lung Adenocarcinomas: Cytomorphology, Histology, Coexistence of Other Driver Mutations and Patient Characteris Acta Cytologica. 2018; 62(2): 79-84.
  39. PM Lokhandwala, A O’Neal, EU Patel, PA Brunker, EA Gehrie, G Zheng, TS Kickler, PM Ness, AA Tobian. Hemostatic Profile and Safety of Pooled Cryoprecipitate up to 120 Hours After Thawing Transfusion. 2018.
  40. Sandfort V, Bluemke DA, Vargas J, Brinker JA, Gerstenblith G, Kickler T, Zheng G, Li J, Chen S, Lai H, Fishman EK, Lai S. Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses: A Preliminary Study J Addict Med. 2017.
  41. ZF Huang, S Siddhanta, C Zhang, T Kickler, G Zheng, I Barman. Painting and heating: A nonconventional, scalable route to sensitive biomolecular analysis with plasmon-enhanced spectroscopy Journal of Raman Spectroscopy. 2017.
  42. PB Illei, D Belchis, LH Tseng, D Nguyen, F De Marchi, L Haley, S Riel, K Beierl, G Zheng, JR Brahmer, FB Askin, CD Gocke, JR Eshleman, PM Forde, MT Lin. Clinical mutational profiling of 1006 lung cancers by next generation sequencing Oncotarget. 2017.
  43. Zheng G, Streiff MB, Takemoto CM, Bynum J, Gelwan E, Jani J, Judge D, Kickler TS. The Clinical Utility of the Heparin Neutralization Assay in the Diagnosis of Heparin-Induced Thrombocytopenia Clin Appl Thromb Hemost. 2017.
  44. Lokhandwala PM, Riel SL, Haley L, Lu C, Chen Y, Silberstein J, Zhu Y, Zheng G, Lin MT, Gocke CD, Partin AW, Antonarakis ES, Luo J, Eshleman JR. Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting J Mol Diagn. 2017.
  45. Zheng G, Lin MT, Lokhandwala PM, Beierl K, Netto GJ, Gocke CD, Eshleman JR, McCarthy E, Illei PB. Clinical mutational profiling of bone metastases of lung and colon carcinoma and malignant melanoma using next-generation sequencing. Cancer Cytopathol. 2016 Oct; 124 (10):744-753 Epub 2016 June 10
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  46. Gondek LP*, Zheng G*, Ghiaur G, DeZern AE, Matsui W, Yegnasubramanian S, Lin MT, Levis M, Eshleman JR, Varadhan R, Tucker N, Jones R*, Gocke CD. Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation. Leukemia. 2016; (Equal Contribution).
  47. Allison DB, Lilo MT, Geddes S, Pallavajjalla A, Askin F, Gabrielson E, Zheng G, Li QK. Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases Cancer Cytopathol. 2016.
  48. Zheng G, Tsai H, Tseng LH, Illei P, Gocke CD, Eshleman JR, Netto G, Lin MT. Test feasibility of next generation sequencing assays in clinical mutation detection of small biopsy and fine needle aspiration specimens Am J Clin Pathol. 2016.
  49. Argani P, Lee J, Netto GJ, Zheng G, Tseh-Lin M, Park BH. Frequent BRAF V600E Mutations in Metanephric Stromal Tumor The American journal of surgical pathology. 2016.
  50. Stolnicu S, Szekely E, Molnar C, Molnar CV, Barsan I, D'Alfonso V, Moldovan C, Zheng G, Ronnett BM, Soslow RA. Mature and Immature Solid Teratomas Involving Uterine Corpus, Cervix, and Ovary. Int J Gynecol Pathol. 2016.
  51. Zheng G, Tseng LH, Chen G, Haley L, Illei P, Gocke CD, Eshleman JR, Lin MT. Clinical detection and categorization of uncommon and concomitant mutations involving BRAF BMC cancer. 2015.
  52. Lin MT, Tseng LH, Dudley JC, Riel S, Tsai H, Zheng G, Pratz KW, Levis MJ, Gocke CD. A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML Molecular diagnosis & therapy. 2015.
  53. Haley L, Tseng LH, Zheng G, Dudley J, Anderson DA, Azad NS, Gocke CD, Eshleman JR, Lin MT. Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers Modern pathology. 2015.
  54. Carter J, Tseng LH, Zheng G, Dudley J, Illei P, Gocke CD, Eshleman JR, Lin MT. Non-p.V600E BRAF Mutations Are Common Using a More Sensitive and Broad Detection Tool American journal of clinical pathology. 2015.
  55. Zheng G, Martignoni G, Antonescu C, Montgomery E, Eberhart C, Netto G, Taube J, Westra W, Epstein JI, Lotan T, Maitra A, Gabrielson E, Torbenson M, Iacobuzio-Donahue C, Demarzo A, Shih IeM, Illei P, Wu TC, Argani P. A broad survey of cathepsin K immunoreactivity in human neoplasms. Am J Clin Pathol. 2013 Feb; 139(2):151-9.
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  56. Zheng G, Ettinger DS, Maleki Z. Utility of the quantitative Ki-67 proliferation index and CD56 together in the cytologic diagnosis of small cell lung carcinoma and other lung neuroendocrine tumors Acta cytologica. 2013.
  57. Zheng G, Chaux A, Sharma R, Netto G, Caturegli P. LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma Experimental and molecular pathology. 2013.
  58. Zheng G, Schmieg J, Guan H, Ali SZ. Blastic plasmacytoid dendritic cell neoplasm: cytopathologic findings Acta cytologica. 2012.
  59. Guaraldi F, Zang G, Dackiw AP, Caturegli P. Oncocytic mania: a review of oncocytic lesions throughout the body. J Endocrinol Invest. 2011 May; 34 (5):383-94 Epub 2011 Feb 07
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  60. Park JK, Gelber AC, Zheng G, McDevitt MA, Gocke CD, Baer AN. Large-vessel vasculitis as an early manifestation of chronic myelomonocytic leukemia Journal of clinical oncology. 2011.
  61. Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM. Brd4 regulation of papillomavirus protein E2 stability Journal of virology. 2009.
  62. Ning J, Zheng G, Yang YC. Tip60 modulates PLAGL2-mediated transactivation by acetylation Journal of cellular biochemistry. 2008.
  63. Zheng G, Ning J, Yang YC. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53 Biochemical and biophysical research communications. 2007.
  64. Zhang K, Zheng G, Yang YC. Stability of Nmi protein is controlled by its association with Tip60 Molecular and cellular biochemistry. 2007.
  65. Zheng G, Yang YC. Acetylation and alternative splicing regulate ZNF76-mediated transcription Biochemical and biophysical research communications. 2006.
  66. Zheng G, Yang YC. Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2 The Journal of biological chemistry. 2005.
  67. Zheng G, Yang YC. ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation The Journal of biological chemistry. 2004.
  68. Han M, Zheng G, Shou CC. Construction of expression vector of cDNA encoding p185 extracellular domains Ningxia Medical Journal. 2001.
  69. Zhang T, Zheng G. Effects of Lycium Barbarum extracts on prevention of micronuclear formation in bone marrow Journal of eugenics. 1997.
PST-20514959