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Paul C. Tang, M.D., Ph.D.

  1. Cardiovascular Surgeon
  2. Transplant Surgeon

Publications

  1. Tang PC, Millar J, Noly PE, Sicim H, Likosky DS, Zhang M, Pagani FD, Michigan Congestive Heart Failure Investigators. Preoperative passive venous pressure-driven cardiac function determines left ventricular assist device outcomes. J Thorac Cardiovasc Surg. 2024 Jul; 168 (1):133-144.e5 Epub 2023 July 24
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  2. Sicim H, Tam WSV, Tang PC. Primary graft dysfunction in heart transplantation: the challenge to survival. J Cardiothorac Surg. 2024 Jun 1; 19 (1):313 Epub 2024 June 01
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  3. Liu L, Lei I, Tian S, Gao W, Guo Y, Li Z, Sabry Z, Tang P, Chen YE, Wang Z. 14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming. Cell Rep. 2024 Apr 23; 43 (4):114054 Epub 2024 Apr 04
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  4. Sicim H, Noly PE, Naik S, Sood V, Ohye RG, Haft JW, Aaronson KD, Pagani FD, Si MS, Tang PC. Determinants of survival following heart transplantation in adults with congenital heart disease. J Cardiothorac Surg. 2024 Feb 10; 19 (1):83
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  5. Lander MM, Brener MI, Goel K, Tang PC, Verlinden NJ, Zalawadiya S, Lindenfeld J, Kanwar MK. Mitral Interventions in Heart Failure. JACC Heart Fail. 2023 Aug; 11 (8 Pt 2):1055-1069
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  6. Ferrel MN, Raza SS, Tang P, Haft J, Ala AAE. Cannulation strategies for extracorporeal membrane oxygenation. Indian J Thorac Cardiovasc Surg. 2023 Jul; 39 (Suppl 1):91-100 Epub 2023 June 02
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  7. Duggal NM, Lei I, Wu X, Aaronson KD, Pagani FD, Lam HY, Tang PC, Michigan Congestive Heart Failure Investigators. Mitral regurgitation severity at left ventricular assist device implantation is associated with distinct myocardial transcriptomic signatures. J Thorac Cardiovasc Surg. 2023 Jul; 166 (1):141-152.e1 Epub 2021 Sept 14
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  8. Pienta MJ, Cascino TM, Likosky DS, Ghaferi AA, Aaronson KD, Pagani FD, Thompson MP, Michigan Congestive Heart Failure Investigators. Failure to rescue: A candidate quality metric for durable left ventricular assist device implantation. J Thorac Cardiovasc Surg. 2023 Jun; 165 (6):2114-2123.e5 Epub 2021 Nov 09
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  9. Chapman EA, Aballo TJ, Melby JA, Zhou T, Price SJ, Rossler KJ, Lei I, Tang PC, Ge Y. Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-Down Proteomics. J Proteome Res. 2023 Mar 3; 22 (3):931-941 Epub 2023 Feb 17
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  10. Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC. Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function. Sci Transl Med. 2023 Feb 8; 15 (682):eade3782 Epub 2023 Feb 08
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  11. Jones-Ungerleider KC, Raza SS, Tang PC. Case report: Facilitating right heart recovery after durable LVAD implantation through repair of atrioventricular valves and RVAD implantation using tunneled Dacron grafts. Front Cardiovasc Med. 2023; 10:1251837 Epub 2023 Sept 07
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  12. Noly PE, Naik S, Tang P, Lei I. Assessment of Ex Vivo Murine Biventricular Function in a Langendorff Model. J Vis Exp. 2022 Dec 23; (190)
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  13. Likosky DS, Yang G, Zhang M, Malani PN, Fetters MD, Strobel RJ, Chenoweth CE, Hou H, Pagani FD, Michigan Congestive Heart Failure Investigators. Interhospital variability in health care-associated infections and payments after durable ventricular assist device implant among Medicare beneficiaries. J Thorac Cardiovasc Surg. 2022 Nov; 164 (5):1561-1568 Epub 2021 May 04
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  14. Tang PC, Haft JW, Lei I, Wang Z, Chen YE, Abou El Ela A, Wu X, Pitt B, Aaronson KD, Pagani FD. Impact of donor blood type on outcomes after prolonged allograft ischemic times. J Thorac Cardiovasc Surg. 2022 Sep; 164 (3):981-993.e8 Epub 2021 Jan 12
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  15. Tang PC, Wu X, Zhang M, Likosky D, Haft JW, Lei I, Abou El Ela A, Si MS, Aaronson KD, Pagani FD. Determining optimal donor heart ischemic times in adult cardiac transplantation. J Card Surg. 2022 Jul; 37 (7):2042-2050 Epub 2022 Apr 30
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  16. Noly PE, Pagani FD, Obadia JF, Bouchard D, Bolling SF, Ailawadi G, Tang PC. The role of surgery for secondary mitral regurgitation and heart failure in the era of transcatheter mitral valve therapies. Rev Cardiovasc Med. 2022 Mar 4; 23 (3):87
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  17. Noly PE, Duggal N, Jiang M, Nordsletten D, Bonini M, Lei I, Ela AAE, Haft JW, Pagani FD, Cascino TM, Tang PC. Role of the mitral valve in left ventricular assist device pathophysiology. Front Cardiovasc Med. 2022; 9:1018295 Epub 2022 Oct 28
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  18. Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z. Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation. Elife. 2021 Dec 23; 10
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  19. Cui H, Chen Y, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, Lei I, Zhang J, Li C, Sun Y, Zhang X, Horng T, Lu HS, Chen YE, Daugherty A, Wang D, Zheng L. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. Eur Heart J. 2021 Nov 7; 42 (42):4373-4385
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  20. Tang PC, Duggal NM, Haft JW, Romano MA, Bolling SF, Abou El Ela A, Wu X, Colvin MM, Aaronson KD, Pagani FD. Left Ventricular Assist Device Implantation in Patients with Preoperative Severe Mitral Regurgitation. ASAIO J. 2021 Oct 1; 67 (10):1139-1147
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  21. Lei I, Huang W, Ward PA, Pober JS, Tellides G, Ailawadi G, Pagani FD, Landstrom AP, Wang Z, Mortensen RM, Cascalho M, Platt J, Eugene Chen Y, Lam HYK, Tang PC. Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation. Physiol Rep. 2021 Sep; 9 (17):e15004
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  22. Tang PC, Lei I, Chen YE, Wang Z, Ailawadi G, Romano MA, Salvi S, Aaronson KD, Si MS, Pagani FD, Haft JW. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021 Aug; 36 (8):2677-2684 Epub 2021 May 20
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  23. Habertheuer A, Geirsson A, Gleason T, Woo J, Whitson B, Arnaoutakis GJ, Atluri P, Jassar A, Kaneko T, Kilic A, Tang PC, Schranz AJ, Bin Mahmood SU, Mori M, Sultan I. STratification risk analysis in OPerative management (STOP score) for drug-induced endocarditis. J Card Surg. 2021 Jul; 36 (7):2442-2451 Epub 2021 Apr 24
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  24. Tang PC, Duggal NM, Haft JW, Aaronson KD, Pagani FD. Fate of preoperative moderate mitral regurgitation following left ventricular assist device implantation. J Card Surg. 2021 Jun; 36 (6):1843-1849 Epub 2021 Feb 18
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  25. Guo M, St Pierre E, Clemence J Jr, Wu X, Tang P, Romano M, Kim KM, Yang B. Impact of Chronic Renal Failure on Surgical Outcomes in Patients With Infective Endocarditis. Ann Thorac Surg. 2021 Mar; 111 (3):828-835 Epub 2020 Aug 18
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  26. Tang PC, Sarsour N, Haft JW, Romano MA, Konerman M, Colvin M, Koelling T, Aaronson KD, Pagani FD. Aortic Valve Repair Versus Replacement Associated With Durable Left Ventricular Assist Devices. Ann Thorac Surg. 2020 Oct; 110 (4):1259-1264 Epub 2020 Feb 24
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  27. Mori M, Bin Mahmood SU, Schranz AJ, Sultan I, Axtell AL, Sarsour N, Hiesinger W, Boskovski MT, Hirji S, Kaneko T, Woo J, Tang P, Jassar AS, Atluri P, Whitson BA, Gleason T, Geirsson A. Risk of reoperative valve surgery for endocarditis associated with drug use. J Thorac Cardiovasc Surg. 2020 Apr; 159 (4):1262-1268.e2 Epub 2019 July 10
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  28. Lei I, Wang Z, Chen YE, Ma PX, Huang W, Kim E, Lam HYK, Goldstein DR, Aaronson KD, Pagani FD, Tang PC. "The Secret Life of Human Donor Hearts": An Examination of Transcriptomic Events During Cold Storage. Circ Heart Fail. 2020 Apr; 13 (4):e006409 Epub 2020 Apr 08
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  29. Fukuhara S, Shiomi S, Yang B, Kim K, Bolling SF, Haft J, Tang P, Pagani F, Prager RL, Chetcuti S, Grossman PM, Patel HJ, Deeb GM. Early Structural Valve Degeneration of Trifecta Bioprosthesis. Ann Thorac Surg. 2020 Mar; 109 (3):720-727 Epub 2019 Aug 06
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  30. Tang PC, Haft JW, Romano MA, Bitar A, Hasan R, Palardy M, Wu X, Aaronson KD, Pagani FD. Right ventricular function and residual mitral regurgitation after left ventricular assist device implantation determines the incidence of right heart failure. J Thorac Cardiovasc Surg. 2020 Mar; 159 (3):897-905.e4 Epub 2019 Apr 05
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  31. Mokbel M, Zamani H, Lei I, Chen YE, Romano MA, Aaronson KD, Haft JW, Pagani FD, Tang PC. Histidine-Tryptophan-Ketoglutarate Solution for Donor Heart Preservation Is Safe for Transplantation. Ann Thorac Surg. 2020 Mar; 109 (3):763-770 Epub 2019 Aug 27
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  32. Hobbs RD, Assi A, Bolling SF, Patel HJ, Deeb GM, Romano MA, Haft JW, Prager RL, Pagani FD, Tang PC. Long-Term Survival and Echocardiographic Findings After Surgical Ventricular Restoration. Ann Thorac Surg. 2019 Jun; 107 (6):1754-1760 Epub 2018 Dec 23
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  33. Tang PC, Haft JW, Romano MA, Bitar A, Hasan R, Palardy M, Wu X, Aaronson K, Pagani FD. Cluster analysis of preoperative echocardiographic findings and outcomes following left ventricular device implantation. J Thorac Cardiovasc Surg. 2019 May; 157 (5):1851-1860.e1 Epub 2018 Dec 11
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  34. Tang PC, Haft JW, Romano MA, Bitar A, Hasan R, Palardy M, Aaronson KD, Pagani FD. Right ventricular failure following left ventricular assist device implantation is associated with a preoperative pro-inflammatory response. J Cardiothorac Surg. 2019 Apr 25; 14 (1):80
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  35. Tang PC, Pagani FD. Continuous-Flow Device Engineering and Pump Technology. Cardiol Clin. 2018 Nov; 36 (4):451-463
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  36. Philip JL, Zens T, Lozonschi L, De Oliveira NC, Osaki S, Kohmoto T, Akhter SA, Tang PC. Outcomes of surgical aortic valve replacement for mixed aortic valve disease. J Thorac Dis. 2018 Jul; 10 (7):4042-4051
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  37. Tang PC, DiMusto PD, De Oliveira NC, Rademacher BL, Philip JL, Akhter SA, Acher CW. Natural history of the proximal aorta in patients with descending thoracic aortic disease. J Vasc Surg. 2018 Jun; 67 (6):1659-1663 Epub 2017 Dec 21
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  38. Stojanovska J, Lumeng CN, Griffin C, Hernando D, Hoffmann U, Haft JW, Kim KM, Burant CF, Singer K, Tsodikov A, Long BD, Romano MA, Tang PC, Yang B, Chenevert TL. Water-fat magnetic resonance imaging quantifies relative proportions of brown and white adipose tissues: ex-vivo experiments. J Med Imaging (Bellingham). 2018 Apr; 5 (2):024007 Epub 2018 June 29
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  39. Lozonschi L, Kohmoto T, Osaki S, De Oliveira NC, Dhingra R, Akhter SA, Tang PC. Coronary bypass in left ventricular dysfunction and differential cardiac recovery. Asian Cardiovasc Thorac Ann. 2017 Nov; 25 (9):586-593 Epub 2017 Nov 20
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  40. Philip JL, De Oliveira NC, Akhter SA, Rademacher BL, Goodavish CB, DiMusto PD, Tang PC. Cluster analysis of acute ascending aortic dissection provides novel insight into mechanisms of distal progression. J Thorac Dis. 2017 Sep; 9 (9):2966-2973
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  41. DiMusto PD, Rademacher BL, Philip JL, Akhter SA, Goodavish CB, De Oliveira NC, Tang PC. Acute retrograde type A aortic dissection: morphologic analysis and clinical implications. J Surg Res. 2017 Jun 1; 213:39-45 Epub 2017 Feb 27
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  42. Tang PC, Akhter SA, Osaki S, Lozonschi L, Kohmoto T, De Oliveira NC. Coronary Events in Patients Presenting for Repair of Acute Type A Aortic Dissection. Aorta (Stamford). 2017 Jun; 5 (3):71-79 Epub 2017 June 01
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  43. Tang PC, Badami A, Akhter SA, Osaki S, Lozonschi L, Kohmoto T, De Oliveira N. Efficacy of Aortic Valve Resuspension in Establishing Valve Competence in Acute Type A Dissections. Ann Thorac Surg. 2017 May; 103 (5):1460-1466 Epub 2016 Nov 15
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  44. Tang P, Onaitis M, Gaca JG, Milano CA, Stafford-Smith M, Glower D. Right Minithoracotomy Versus Median Sternotomy for Mitral Valve Surgery: A Propensity Matched Study. Ann Thorac Surg. 2015 Aug; 100 (2):575-81 Epub 2015 July 02
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  45. Tang P, Onaitis M, Desai B, Gaca JG, Milano CA, Stafford-Smith M, Glower DD Jr. Minithoracotomy versus sternotomy for mitral surgery in patients with chronic renal impairment: a propensity-matched study. Innovations (Phila). 2013 Sep-Oct; 8 (5):325-31
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  46. Zhou J, Tang PC, Qin L, Gayed PM, Li W, Skokos EA, Kyriakides TR, Pober JS, Tellides G. CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. J Exp Med. 2010 Aug 30; 207 (9):1951-66 Epub 2010 Aug 23
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  47. Bhaskarla A, Tang PC, Mashtare T, Nwogu CE, Demmy TL, Adjei AA, Reid ME, Yendamuri S. Analysis of second primary lung cancers in the SEER database. J Surg Res. 2010 Jul; 162 (1):1-6 Epub 2010 Jan 25
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  48. Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G. MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. J Exp Med. 2008 Dec 22; 205 (13):3159-71 Epub 2008 Dec 08
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  49. Yi T, Rao DA, Tang PC, Wang Y, Cuchara LA, Bothwell AL, Colangelo CM, Tellides G, Pober JS, Lorber MI. Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells. Transplantation. 2008 Sep 15; 86 (5):719-27
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  50. Elefteriades J, Singh M, Tang P, Siegel MD, Kenney B, Pandey A, Kopf GS. Unilateral diaphragm paralysis: etiology, impact, and natural history. J Cardiovasc Surg (Torino). 2008 Apr; 49 (2):289-95
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  51. Tang PC, Ravji K, Key JJ, Mahler DB, Blume PA, Sumpio B. Let them walk! Current prosthesis options for leg and foot amputees. J Am Coll Surg. 2008 Mar; 206 (3):548-60 Epub 2007 Dec 19
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  52. Pimiento JM, Maloney SP, Tang PC, Muto A, Westvik TS, Fitzgerald TN, Fancher TT, Tellides G, Dardik A. Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice. J Vasc Res. 2008; 45 (3):251-8 Epub 2008 Jan 10
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  53. Tang PC, Yakimov AO, Teesdale MA, Coady MA, Dardik A, Elefteriades JA, Tellides G. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. FASEB J. 2005 Sep; 19 (11):1528-30 Epub 2005 July 12
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  54. Tang PC, Coady MA, Lovoulos C, Dardik A, Aslan M, Elefteriades JA, Tellides G. Hyperplastic cellular remodeling of the media in ascending thoracic aortic aneurysms. Circulation. 2005 Aug 23; 112 (8):1098-105
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  55. Burns WR, Wang Y, Tang PC, Ranjbaran H, Iakimov A, Kim J, Cuffy M, Bai Y, Pober JS, Tellides G. Recruitment of CXCR3+ and CCR5+ T cells and production of interferon-gamma-inducible chemokines in rejecting human arteries. Am J Transplant. 2005 Jun; 5 (6):1226-36
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  56. Wang Y, Burns WR, Tang PC, Yi T, Schechner JS, Zerwes HG, Sessa WC, Lorber MI, Pober JS, Tellides G. Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries. FASEB J. 2004 Mar; 18 (3):606-8 Epub 2004 Jan 20
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  57. Lovoulos C, Tittle S, Goldstein L, Austin DJ, Singh S, Rocco E, Keane J, Tang P, Kopf GS, Elefteriades JA. Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension. J Heart Lung Transplant. 2004 Feb; 23 (2):236-41
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  58. Elefteriades J, Lovoulos C, Edwards R, Tittle S, Riley T, Tang P, Rocco E, Kopf G. Novel technique for isolated accessory right heart transplantation for congenital heart disease. J Thorac Cardiovasc Surg. 2003 Jun; 125 (6):1283-90
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PST-20552060