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Meera Sridharan, M.D., Ph.D.

  1. Hematologist
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Publications

  1. Chohan KL, Pruthi RK, Zanwar S, Paludo J, Go R, Pardanani A, Ashrani A, Cook JM, Thompson CA, Chanan-Khan A, Ailawadhi S, Habermann TM, Witzig TE, Gertz MA, Dingli D, Buadi FK, Dispenzieri A, Leung N, Kumar SK, Rajkumar V, Nichols WL, Kyle RA, Ansell SM, Kapoor P, Sridharan M, Abeykoon JP. The clinical impact of acquired von Willebrand syndrome secondary to Waldenstrom macroglobulinemia: an underrecognized source of major bleeding events. Leukemia. 2024 Nov; 38 (11):2497-2500 Epub 2024 Aug 28
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  2. Abou-Ismail MY, Zhang C, Presson AP, Chaturvedi S, Antun AG, Farland AM, Woods R, Metjian A, Park YA, de Ridder G, Gibson B, Kasthuri RS, Liles DK, Akwaa F, Clover T, Kreuziger LB, Sridharan M, Go RS, McCrae KR, Upreti HV, Gangaraju R, Kocher NK, Zheng XL, Raval JS, Masias C, Cataland SR, Johnson AD, Davis E, Evans MD, Mazepa M, Lim MY. A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura. Res Pract Thromb Haemost. 2024 Mar; 8 (3):102388 Epub 2024 Mar 19
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  3. Nelson Strande BJ, Sridharan M, Leger RR, Stuart MS, Tange JI, Navitska SD, Heikal N, Ashrani AA, Chen D, Seheult JN, Pruthi RK. Effect of residual platelets in frozen-thawed plasma on results of dilute Russell's viper venom time assay for lupus anticoagulant testing. Am J Clin Pathol. 2024 Mar 1; 161 (3):212-215
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  4. Houghton DE, Casanegra AI, Wysokinski WE, Padrnos LJ, Wysokinska E, Pruthi R, Heaton H, Sridharan M, McBane RD, Shah S. COVID-19 infection and risk stratification for pulmonary embolism: Identifying optimal D-dimer thresholds. Thromb Res 2024 Mar; 235:8-10 Epub 2024 Jan 12
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  5. Abou-Ismail MY, Zhang C, Presson AP, Chaturvedi S, Antun AG, Farland AM, Woods R, Metjian A, Park YA, de Ridder G, Gibson B, Kasthuri RS, Liles DK, Akwaa F, Clover T, Baumann Kreuziger L, Sridharan M, Go RS, McCrae KR, Upreti HV, Gangaraju R, Kocher NK, Zheng XL, Raval JS, Masias C, Cataland SR, Johnson AD, Davis E, Evans MD, Mazepa M, Lim MY. A descriptive analysis of fatal outcomes in immune thrombotic thrombocytopenic purpura in the USTMA TTP Registry. Blood Adv. 2024 Feb 13; 8 (3):620-623
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  6. Kanack AJ, Schaefer JK, Sridharan M, Splinter NP, Kohlhagen MC, Singh B, De Lorenzo SB, Mauch EE, Hussein MA, Shaikh M, Kumar S, Wen R, Wang D, Murray DL, Padmanabhan A. Monoclonal gammopathy of thrombotic/thrombocytopenic significance. Blood. 2023 Apr 6; 141 (14):1772-1776
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  7. Houghton DE, Wysokinski WE, Padrnos LJ, Shah S, Wysokinska E, Pruthi R, Ghorbanzadeh A, Ashrani A, Sridharan M, McBane RD, Padmanabhan A, Casanegra AI. Venous thromboembolism after COVID-19 vaccination in patients with thrombophilia. Am J Hematol. 2023 Apr; 98 (4):566-570 Epub 2023 Jan 28
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  8. Acosta-Medina AA, Moyer AM, Go RS, Willrich MAV, Fervenza FC, Leung N, Bourlon C, Winters JL, Spears GM, Bryant SC, Sridharan M. Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation. Blood Adv. 2023 Feb 14; 7 (3):340-350
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  9. Sridharan M, Go RS, Willrich MAV. Clinical Utility and Potential Cost Savings of Pharmacologic Monitoring of Eculizumab for Complement-Mediated Thrombotic Microangiopathy. Mayo Clin Proc Innov Qual Outcomes. 2022 Oct; 6 (5):458-464 Epub 2022 Sept 17
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  10. Chaturvedi S, Antun AG, Farland AM, Woods R, Metjian A, Park YA, de Ridder G, Gibson B, Kasthuri RS, Liles DK, Akwaa F, Clover T, Baumann Kreuziger L, Sadler JE, Sridharan M, Go RS, McCrae KR, Upreti HV, Liu A, Lim MY, Gangaraju R, Zheng XL, Raval JS, Masias C, Cataland SR, Johnson A, Davis E, Evans MD, Mazepa MA, United States Thrombotic Microangiopathies Consortium. Race, rituximab, and relapse in TTP. Blood. 2022 Sep 22; 140 (12):1335-1344
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  11. Palma LMP, Vaisbich-Guimaraes MH, Sridharan M, Tran CL, Sethi S. Thrombotic microangiopathy in children. Pediatr Nephrol. 2022 Sep; 37 (9):1967-1980 Epub 2022 Jan 18
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  12. Houghton DE, Wysokinski W, Casanegra AI, Padrnos LJ, Shah S, Wysokinska E, Pruthi R, Ashrani A, Sridharan M, Baumann-Kreuziger L, McBane R, Padmanabhan A. Risk of venous thromboembolism after COVID-19 vaccination. J Thromb Haemost. 2022 Jul; 20 (7):1638-1644 Epub 2022 Apr 20
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  13. Sridharan M, D Navitskas S, M Kock E, E Houghton D, Houghton D, Heikal NM, M Heikal N, Chen D, Pruthi R, K Pruthi R. Evaluation of soluble fibrin monomer complex in patients in SARS-CoV-2 COVID-19 infection-associated coagulopathy. Eur J Haematol. 2022 Apr; 108 (4):319-326 Epub 2022 Jan 10
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  14. Sridharan M, Pruthi R. Autoimmune (acquired) Hemophilia: Updates in Diagnosis and Management The Hematologist. 2022; 19(2).
  15. Goswami J, MacArthur TA, Sridharan M, Tange J, Kirmse AJ, Lundell KA, Chen D, Auton MT, Chon TY, Hurt RT, Salonen BR, Ganesh R, Erben YM, Marquez CP, Dong JF, Kozar RA, Heller SF, Loomis EA, Johnstone AL, Bailey KR, Spears GM, Park MS. Biomarkers of thromboinflammation correlate to COVID-19 infection and admission status in emergency department patients. Thromb Update. 2021 Dec; 5:100090 Epub 2021 Nov 19
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  16. Pasha AK, McBane RD, Chaudhary R, Padrnos LJ, Wysokinska E, Pruthi R, Ashrani A, Daniels P, Sridharan M, Wysokinski WE, Houghton DE. Timing of venous thromboembolism diagnosis in hospitalized and non-hospitalized patients with COVID-19. Thromb Res. 2021 Nov; 207:150-157 Epub 2021 Oct 07
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  17. Seheult JN, Dalenberg D, Sridharan MR, Stuart M, Moericke K, Cardel L, Heikal N, Chen D, Pruthi RK. Revisiting the effects of spectral interfering substances in optical end-point coagulation assays. Int J Lab Hematol. 2021 Oct; 43(5):1181-1190. Epub 2021 Jan 17.
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  18. Chaudhary R, Padrnos L, Wysokinska E, Pruthi R, Misra S, Sridharan M, Wysokinski W, McBane RD 2nd, Houghton DE. Macrovascular Thrombotic Events in a Mayo Clinic Enterprise-Wide Sample of Hospitalized COVID-19-Positive Compared With COVID-19-Negative Patients. Mayo Clin Proc. 2021 Jul; 96 (7):1718-1726 Epub 2021 May 04
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  19. Goswami J, MacArthur TA, Sridharan M, Pruthi RK, McBane RD 2nd, Witzig TE, Park MS. A Review of Pathophysiology, Clinical Features, and Management Options of COVID-19 Associated Coagulopathy. Shock. 2021 Jun 1; 55 (6):700-716
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  20. Willrich MAV, Ladwig PM, Martinez MA, Sridharan MR, Go RS, Murray DL, Complement Alternative Pathway Thrombotic Microangiopathy (CAP-TMA) Disease Oriented Group at the Mayo Clinic. Monitoring Ravulizumab effect on complement assays. J Immunol Methods. 2021 Mar; 490:112944 Epub 2020 Dec 13
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  21. Smith CJ, Kluck LA, Ruan GJ, Ashrani AA, Marshall AL, Pruthi RK, Shah MV, Wolanskyj-Spinner A, Gangat N, Litzow MR, Hogan WJ, Sridharan M, Go RS. Leukocytosis and Tobacco Use: An Observational Study of Asymptomatic Leukocytosis. Am J Med. 2021 Jan; 134 (1):e31-e35 Epub 2020 July 16
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  22. Palma LMP, Sridharan M, Sethi S. Complement in Secondary Thrombotic Microangiopathy. Kidney Int Rep. 2021 Jan; 6 (1):11-23 Epub 2020 Oct 21
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  23. Sridharan M, Kluge ML, Go RS, Abraham RS, Moyer AM. Challenges in classification of novel CFH variants in patients with atypical hemolytic uremic syndrome Thrombosis Update. 2020.
  24. Heybeli C, Sridharan M, Alkhateeb HB, Villasboas Bisneto JC, Buadi FK, Chen D, Dingli D, Dispenzieri A, Gertz MA, Go RS, Hashmi SK, Hayman SR, Hogan WJ, Inwards DJ, Kenderian SS, Kumar SK, Litzow MR, Porrata LF, Lacy MQ, Micallef IN, Patnaik MM, Shah MV, Leung N. Characteristics of late transplant-associated thrombotic microangiopathy in patients who underwent allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2020 Oct; 95 (10):1170-1179 Epub 2020 Aug 08
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  25. Brown CS, Scott RA, Sridharan M, Rabinstein AA. Real-world utilization of andexanet alfa. Am J Emerg Med. 2020 Apr; 38 (4):810-814 Epub 2019 Dec 10
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  26. Sridharan M, Hook CC, Leung N, Winters JL, Go RS, Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy Disease-Oriented Group. Postsurgical thrombotic microangiopathy: Case series and review of the literature. Eur J Haematol. 2019 Oct; 103 (4):307-318 Epub 2019 July 23
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  27. Sridharan M, Ali U, Hook CC, Nichols WL, Pruthi RK. The Mayo Clinic Experience With Psychogenic Purpura (Gardner-Diamond Syndrome). Am J Med Sci. 2019 May; 357 (5):411-420 Epub 2019 Feb 07
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  28. Sridharan M, Coon LM, Chen D, Pruthi RK. Factor V Deficiency with a Thrombotic Clinical Phenotype. Semin Thromb Hemost 2019 Feb; 45 (1):108-112 Epub 2019 Jan 10
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  29. Sridharan M, Fylling KA, Ashrani AA, Chen D, Marshall AL, Hook CC, Cardel LK, Nichols WL, Pruthi RK. Clinical and laboratory diagnosis of autoimmune factor V inhibitors: A single institutional experience. Thromb Res. 2018 Nov; 171:14-21 Epub 2018 Sept 05
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  30. Nalluru SS, Sridharan M, Go RS, Said S, Marshall AL. Shiga Toxin as a Potential Trigger of CFHR1 Deletion-Associated Thrombotic Microangiopathy. Am J Med Sci. 2018 Nov; 356 (5):492-498 Epub 2018 June 05
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  31. Sridharan M, Highsmith WE, Kurtin PJ, Zimmermann MT, Theis JD, Dasari S, Dingli D. A Patient With Hereditary ATTR and a Novel AGel p.Ala578Pro Amyloidosis. Mayo Clin Proc. 2018 Nov; 93 (11):1678-1682 Epub 2018 Aug 07
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  32. Sridharan M, Go RS, Abraham RS, Fervenza FC, Sethi S, Bryant SC, Spears GM, Murray DL, Willrich MAV. Diagnostic Utility of Complement Serology for Atypical Hemolytic Uremic Syndrome. Mayo Clin Proc. 2018 Oct; 93 (10):1351-1362
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  33. Sridharan M, Go RS, Willrich MAV. Atypical hemolytic uremic syndrome: Review of clinical presentation, diagnosis and management. J Immunol Methods. 2018 Oct; 461:15-22 Epub 2018 July 19
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  34. Willrich MAV, Andreguetto BD, Sridharan M, Fervenza FC, Tostrud LJ, Ladwig PM, Rivard AM, Hetrick MD, Olson RN, Bryant SC, Snyder MR, Murray DL. The impact of eculizumab on routine complement assays. J Immunol Methods. 2018 Sep; 460:63-71 Epub 2018 June 20
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  35. Tan NY, Majumder S, Sridharan M, Kerr SE, Graham RP, Ravi K. Metastatic Epstein-Barr Virus-Positive Lymphoepithelioma-Like Cholangiocarcinoma in a Young Man With Ulcerative Colitis. Am J Gastroenterol 2017 Mar; 112 (3):518-520
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  36. Sridharan M, Wysokinski WE, Pruthi R, Oyen L, Freeman WD, Rabinstein AA, McBane RD. Periprocedural warfarin reversal with prothrombin complex concentrate. Thromb Res. 2016 Mar; 139:160-5 Epub 2015 Nov 18
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  37. Robinson S, Sridharan M, Okuno S. Current Treatment of Soft Tissue Sarcomas: A Focus on Medical Management. The Journal of Targeted Therapies in Cancer. 2014 Jun; 3(3):42-9.
  38. Sridharan M, Hubbard JM, Grothey A. Colorectal cancer: how emerging molecular understanding affects treatment decisions. Oncology (Williston Park). 2014 Feb; 28 (2):110-8
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  39. Sridharan M, Bowles EA, Richards JP, Krantic M, Davis KL, Dietrich KA, Stephenson AH, Ellsworth ML, Sprague RS. Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel. Am J Physiol Heart Circ Physiol. 2012 Feb 1; 302 (3):H553-9 Epub 2011 Dec 09
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  40. Adderley SP, Thuet KM, Sridharan M, Bowles EA, Stephenson AH, Ellsworth ML, Sprague RS. Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5. Med Sci Monit. 2011 May; 17 (5):CR241-7
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  41. Adderley SP, Sridharan M, Bowles EA, Stephenson AH, Sprague RS, Ellsworth ML. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation. 2011 Feb; 18 (2):128-35
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  42. Sridharan M, Adderley SP, Bowles EA, Egan TM, Stephenson AH, Ellsworth ML, Sprague RS. Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. Am J Physiol Heart Circ Physiol. 2010 Oct; 299 (4):H1146-52 Epub 2010 July 09
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  43. Sridharan M, Sprague RS, Adderley SP, Bowles EA, Ellsworth ML, Stephenson AH. Diamide decreases deformability of rabbit erythrocytes and attenuates low oxygen tension-induced ATP release. Exp Biol Med (Maywood). 2010 Sep; 235 (9):1142-8 Epub 2010 Aug 03
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  44. Adderley SP, Sridharan M, Bowles EA, Stephenson AH, Ellsworth ML, Sprague RS. Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes. Am J Physiol Heart Circ Physiol. 2010 Feb; 298 (2):H587-93 Epub 2009 Dec 11
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  45. Hanson MS, Ellsworth ML, Achilleus D, Stephenson AH, Bowles EA, Sridharan M, Adderley S, Sprague RS. Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular control. Microcirculation. 2009 Jul; 16 (5):424-33 Epub 2009 Apr 29
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  46. Adderley SP, Dufaux EA, Sridharan M, Bowles EA, Hanson MS, Stephenson AH, Ellsworth ML, Sprague RS. Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans. Am J Physiol Heart Circ Physiol. 2009 May; 296 (5):H1617-24 Epub 2009 Feb 27
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  47. Sprague RS, Hanson MS, Achilleus D, Bowles EA, Stephenson AH, Sridharan M, Adderley S, Procknow J, Ellsworth ML. Rabbit erythrocytes release ATP and dilate skeletal muscle arterioles in the presence of reduced oxygen tension. Pharmacol Rep. 2009 Jan-Feb; 61 (1):183-90
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  48. Hanson MS, Stephenson AH, Bowles EA, Sridharan M, Adderley S, Sprague RS. Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. Am J Physiol Heart Circ Physiol. 2008 Aug; 295 (2):H786-93 Epub 2008 June 27
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  49. Sprague RS, Bowles EA, Hanson MS, DuFaux EA, Sridharan M, Adderley S, Ellsworth ML, Stephenson AH. Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes. Microcirculation. 2008 Jul; 15 (5):461-71
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PST-20506066