Publications Print Sandooja R, Saini J, Kittithaworn A, Gregg-Garcia R, Dogra P, Atkinson E, Yu K, Fell V, Simha V, Connelly MA, Dullaart RPF, Bancos I. High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas. J Clin Endocrinol Metab. 2024 Dec 18; 110 (1):195-207 View PubMed Vaishnav MS, Kumari N, Srikanta S, Simha V, Krishnaswamy PR, Bhat N. Truncated Albumins as Novel Surrogate Biomarkers in Diabetes Therapy: Epiphenomena and Potential Clinical Applications. Metab Syndr Relat Disord. 2024 Dec; 22 (10):743-752 Epub 2024 Nov 12 View PubMed Akinci G, Alyaarubi S, Patni N, Alhashmi N, Al-Shidhani A, Prodam F, Gagne N, Babalola F, Al Senani A, Muniraj K, Elsayed SM, Beghini M, Saydam BO, Allawati M, Vaishnav MS, Can E, Simsir IY, Sorkina E, Dursun F, Kamrath C, Cavdar U, Chakraborty PP, Dogan OA, Al Hosin A, Al Maimani A, Comunoglu N, Hamed A, Huseinbegovic T, Scherer T, Curtis J, Brown RJ, Topaloglu H, Simha V, Wabitsch M, Tuysuz B, Oral EA, Akinci B, Garg A. Metabolic and other morbid complications in congenital generalized lipodystrophy type 4. Am J Med Genet A. 2024 Jun; 194 (6):e63533 Epub 2024 Jan 17 View PubMed Vaishnav MS, Kumari N, Srikanta S, Simha V, Krishnaswamy PR, Balaram P, Bhat N, Bhat N. Albumin Oxidation and Albumin Glycation Discordance During Type 2 Diabetes Therapy: Biological and Clinical Implications. Metab Syndr Relat Disord. 2024 Jun; 22 (5):372-384 Epub 2024 May 02 View PubMed Fourman LT, Lima JG, Simha V, Cappa M, Alyaarubi S, Montenegro R Jr, Akinci B, Santini F. A rapid action plan to improve diagnosis and management of lipodystrophy syndromes. Front Endocrinol (Lausanne). 2024; 15:1383318 Epub 2024 June 04 View PubMed Schmidt T, Harmon DM, Kludtke E, Mickow A, Simha V, Kopecky S. Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series. Am J Prev Cardiol. 2023 Jun; 14:100495. Epub 2023 Apr 06. View PubMed Dhanasekaran M, Sandooja R, Higgins AS, Simha V. Marked Hypoleptinemia Precedes Overt Fat Loss in Immune Checkpoint Inhibitor-induced Acquired Generalized Lipodystrophy. JCEM Case Rep. 2023 Mar; 1(2):luad025. Epub 2023 Mar 09. View PubMed Lange S, Simha V, Desjardins D, Garg SK, Grunberger G, Weinstock R, Lawson ML, Hirsch IB, DiMeglio LA, Pop-Busui R, Philis-Tsimikas A, Kipnes M, Liljenquist DR, Brazg RL, Kudva YC, Buckingham BA, McGill JB, Carlson AL, Criego AB, Christiansen MP, Kaiserman KB, Griffin KJ, Forlenza GP, Bode BW, Slover RH, Keiter A, Ling C, Marinos B, Cordero TL, Shin J, Lee SW, Rhinehart AS, Vigersky RA, Adult and Pediatric MiniMed HCL Outcomes 6-month RCT: HCL versus CSII Control Study Group. Improved Glycemia with Hybrid Closed-Loop Versus Continuous Subcutaneous Insulin Infusion Therapy: Results from a Randomized Controlled Trial. Diabetes Technol Ther. 2023 Jan; 25 (1):1-12 Epub 2022 Dec 20 View PubMed Egan AM, Galior KD, Maus AD, Fatica E, Simha V, Shah P, Singh RJ, Vella A. Pitfalls in Diagnosing Hypoglycemia Due to Exogenous Insulin: Validation and Utility of an Insulin Analog Assay. Mayo Clin Proc. 2022 Nov; 97(11):1994-2004. Epub 2022 Oct 07. View PubMed Simha V, Lanza IR, Dasari S, Klaus KA, Le Brasseur N, Vuckovic I, Laurenti MC, Cobelli C, Port JD, Nair KS. Impaired Muscle Mitochondrial Function in Familial Partial Lipodystrophy. J Clin Endocrinol Metab. 2022 Jan 18; 107 (2):346-362 View PubMed Buryska S, Ahn JC, Allen AM, Simha V, Simonetto DA. Familial Hypobetalipoproteinemia: An Underrecognized Cause of Lean NASH. Hepatology. 2021 Nov; 74(5):2897-2898. Epub 2021 Jul 08. View PubMed Gonzales KM, Donato LJ, Shah P, Simha V. Measurement of apolipoprotein B levels helps in the identification of patients at risk for hypertriglyceridemic pancreatitis. J Clin Lipidol. 2021 Jan-Feb; 15 (1):97-103 Epub 2020 Dec 04 View PubMed Himes CP, Ganesh R, Wight EC, Simha V, Liebow M. Perioperative Evaluation and Management of Endocrine Disorders. Mayo Clin Proc. 2020 Dec; 95 (12):2760-2774 Epub 2020 Nov 06 View PubMed Simha V. Management of hypertriglyceridemia. BMJ. 2020 Oct 12; 371:m3109 View PubMed Brown SA, Beck RW, Raghinaru D, Buckingham BA, Laffel LM, Wadwa RP, Kudva YC, Levy CJ, Pinsker JE, Dassau E, Doyle FJ 3rd, Ambler-Osborn L, Anderson SM, Church MM, Ekhlaspour L, Forlenza GP, Levister C, Simha V, Breton MD, Kollman C, Lum JW, Kovatchev BP, iDCL Trial Research Group. Glycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial. Diabetes Care. 2020 Aug; 43 (8):1822-1828 Epub 2020 May 29 View PubMed Simha V, Shah P. Perioperative Glucose Control in Patients With Diabetes Undergoing Elective Surgery. JAMA. 2019 Jan 29; 321 (4):399-400 View PubMed Simha V, Qin S, Shah P, Smith BH, Kremers WK, Kushwaha S, Wang L, Pereira NL. Sirolimus Therapy Is Associated with Elevation in Circulating PCSK9 Levels in Cardiac Transplant Patients. J Cardiovasc Transl Res. 2017 Feb; 10 (1):9-15 Epub 2016 Dec 27 View PubMed Moriarty PM, Parhofer KG, Babirak SP, Cornier MA, Duell PB, Hohenstein B, Leebmann J, Ramlow W, Schettler V, Simha V, Steinhagen-Thiessen E, Thompson PD, Vogt A, von Stritzky B, Du Y, Manvelian G. Alirocumab in patients with heterozygous familial hypercholesterolaemia undergoing lipoprotein apheresis: the ODYSSEY ESCAPE trial. Eur Heart J. 2016 Dec 21; 37 (48):3588-3595 Epub 2016 Aug 29 View PubMed Simha V, Kudva YC. HDL Cholesterol Story Is Dead: Long Live HDL! Diabetes 2016 Oct; 65 (10):2826-8 View PubMed Moriarty PM, Parhofer KG, Babirak SP, deGoma E, Duell PB, Hohenstein B, Ramlow W, Simha V, Steinhagen-Thiessen E, Thompson PD, Vogt A, von Stritzky B, Du Y, Manvelian G. Alirocumab in patients with heterozygous familial hypercholesterolemia undergoing lipoprotein apheresis: Rationale and design of the ODYSSEY ESCAPE trial. J Clin Lipidol. 2016 May-Jun; 10 (3):627-34 Epub 2016 Feb 18 View PubMed Musso C, Major ML, Andres E, Simha V. Metreleptin Treatment in Three Patients with Generalized Lipodystrophy. Clin Med Insights Case Rep. 2016; 9:123-127 Epub 2017 Jan 05 View PubMed Simha V. Drug-induced dyslipidemia Contemporary Endocrinology. 2015; 1:267-86. Lopez-Jimenez F, Simha V, Thomas RJ, Allison TG, Basu A, Fernandes R, Hurst RT, Kopecky SL, Kullo IJ, Mulvagh SL, Thompson WG, Trejo-Gutierrez JF, Wright RS. A summary and critical assessment of the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: filling the gaps. Mayo Clin Proc. 2014 Sep; 89 (9):1257-78 Epub 2014 Aug 12 View PubMed Simha V. Metreleptin for metabolic disorders associated with generalized or partial lipodystrophy. Expert Rev. Endocrinol. Metab. 2014; 9(3):205-12. Nelson MD, Victor RG, Szczepaniak EW, Simha V, Garg A, Szczepaniak LS. Cardiac steatosis and left ventricular hypertrophy in patients with generalized lipodystrophy as determined by magnetic resonance spectroscopy and imaging. Am J Cardiol. 2013 Oct 1; 112(7):1019-24. Epub 2013 Jun 22. View PubMed Ahmad Z, Subramanyam L, Szczepaniak L, Simha V, Adams-Huet B, Garg A. Cholic acid for hepatic steatosis in patients with lipodystrophy: a randomized, controlled trial. Eur J Endocrinol. 2013 May; 168(5):771-8. Epub 2013 Apr 15. View PubMed Simha V, Mahmood M, Ansari M, Spellman CW, Shah P. Effect of vitamin D replacement on insulin sensitivity in subjects with vitamin D deficiency. J Investig Med. 2012 Dec; 60: (8)1214-8. View PubMed Simha V, Subramanyam L, Szczepaniak L, Quittner C, Adams-Huet B, Snell P, Garg A. Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety. J Clin Endocrinol Metab. 2012 Mar; 97(3):785-92. Epub 2011 Dec 14. View PubMed Shrikanth V, Vanderheiden A, Simha V. Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication. Clin Neurol Neurosurg. 2011 Feb; 113(2):167-9. Epub 2010 Nov 13. View PubMed Shastry S, Simha V, Godbole K, Sbraccia P, Melancon S, Yajnik CS, Novelli G, Kroiss M, Garg A. A novel syndrome of mandibular hypoplasia, deafness, and progeroid features associated with lipodystrophy, undescended testes, and male hypogonadism. J Clin Endocrinol Metab. 2010 Oct; 95(10):E192-7. Epub 2010 Jul 14. View PubMed Subramanyam L, Simha V, Garg A. Overlapping syndrome with familial partial lipodystrophy, Dunnigan variety and cardiomyopathy due to amino-terminal heterozygous missense lamin A/C mutations. Clin Genet. 2010 Jul; 78(1):66-73. Epub 2009 Dec 22. View PubMed Ahmed K, Rao S, Simha V. Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazole. Endocr Pract. 2010 May-Jun; 16(3):449-51. View PubMed Garg A, Subramanyam L, Agarwal AK, Simha V, Levine B, D'Apice MR, Novelli G, Crow Y. Atypical progeroid syndrome due to heterozygous missense LMNA mutations. J Clin Endocrinol Metab. 2009 Dec; 94(12):4971-83. Epub 2009 Oct 29. View PubMed Simha V, Garg A. Inherited lipodystrophies and hypertriglyceridemia. Curr Opin Lipidol. 2009 Aug; 20(4):300-8. View PubMed Keller J, Subramanyam L, Simha V, Gustofson R, Minjarez D, Garg A. Lipodystrophy: an unusual diagnosis in a case of oligomenorrhea and hirsutism. Obstet Gynecol. 2009 Aug; 114(2 Pt 2):427-31. View PubMed Simha V, Agarwal AK, Aronin PA, Iannaccone ST, Garg A. Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability. Am J Med Genet A. 2008 Sep 15; 146A(18):2318-26. View PubMed Simha V. Dietary carbohydrates and risk of type 2 diabetes: are rice eaters doomed? Natl Med J India. 2008 Mar-Apr; 21(2):80-1. View PubMed O'Neill B, Simha V, Kotha V, Garg A. Body fat distribution and metabolic variables in patients with neonatal progeroid syndrome. Am J Med Genet A. 2007 Jul 1; 143A(13):1421-30. View PubMed Garg A, Simha V. Update on dyslipidemia. J Clin Endocrinol Metab. 2007 May; 92(5):1581-9. View PubMed Shah M, Simha V, Garg A. Review: long-term impact of bariatric surgery on body weight, comorbidities, and nutritional status. J Clin Endocrinol Metab. 2006 Nov; 91(11):4223-31. Epub 2006 Sep 5 View PubMed Simha V, Garg A. Lipodystrophy: lessons in lipid and energy metabolism. Curr Opin Lipidol. 2006 Apr; 17(2):162-9. View PubMed Simha V, Garg A. Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes. J Clin Endocrinol Metab. 2003 Nov; 88(11):5433-7. View PubMed Agarwal AK, Simha V, Oral EA, Moran SA, Gorden P, O'Rahilly S, Zaidi Z, Gurakan F, Arslanian SA, Klar A, Ricker A, White NH, Bindl L, Herbst K, Kennel K, Patel SB, Al-Gazali L, Garg A. Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy. J Clin Endocrinol Metab. 2003 Oct; 88(10):4840-7. View PubMed Simha V, Agarwal AK, Oral EA, Fryns JP, Garg A. Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy. J Clin Endocrinol Metab. 2003 Jun; 88(6):2821-4. View PubMed Simha V, Szczepaniak LS, Wagner AJ, DePaoli AM, Garg A. Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Diabetes Care. 2003 Jan; 26(1):30-5. View PubMed Simha V, Zerwekh JE, Sakhaee K, Garg A. Effect of subcutaneous leptin replacement therapy on bone metabolism in patients with generalized lipodystrophy. J Clin Endocrinol Metab. 2002 Nov; 87(11):4942-5. View PubMed Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A. Leptin-replacement therapy for lipodystrophy. N Engl J Med. 2002 Feb 21; 346(8):570-8. View PubMed Simha V, Garg A. Body fat distribution and metabolic derangements in patients with familial partial lipodystrophy associated with mandibuloacral dysplasia. J Clin Endocrinol Metab. 2002 Feb; 87(2):776-85. View PubMed PST-20226972 Home Publications