Publications Print Clark SC, Pareek A, Hevesi M, Okoroha KR, Saris DBF, Camp CL, Krych AJ. High incidence of medial meniscus root/radial tears and extrusion in 253 patients with subchondral insufficiency fractures of the knee. Knee Surg Sports Traumatol Arthrosc. 2024 Nov; 32 (11):2755-2761 Epub 2024 May 20 View PubMed Holliday CL, Pan X, Tagliero AJ, Saris DBF, Milbrandt TA, Krych AJ, Hevesi M. Arthroscopic Debridement and Fixation of Osteochondritis Dissecans Lesions of the Medial Femoral Condyle. Arthrosc Tech. 2024 Oct; 13 (10):103111 Epub 2024 July 20 View PubMed Struijk C, Korpershoek J, Lydon KL, Verdonk P, Michielsen J, Krych AJ, Vonk LA, Saris DBF. Identification and culture of meniscons, meniscus cells with their pericellular matrix. Cytotherapy. 2024 Sep 11 Epub 2024 Sept 11 View PubMed Feroe AG, Clark SC, Hevesi M, Okoroha KR, Saris DBF, Krych AJ, Tagliero AJ. Management of Meniscus Pathology with Concomitant Anterior Cruciate Ligament Injury. Curr Rev Musculoskelet Med. 2024 Aug; 17 (8):321-334 Epub 2024 June 01 View PubMed Wang AS, Nagelli CV, Lamba A, Saris DBF, Krych AJ, Hevesi M. Minimum 10-Year Outcomes of Matrix-Induced Autologous Chondrocyte Implantation in the Knee: A Systematic Review. Am J Sports Med. 2024 Jul; 52 (9):2407-2414 Epub 2024 Feb 05 View PubMed Lydon KL, Struijk C, Michielsen J, Prokop L, Krych AJ, Saris D, Verdonk P. Fresh Versus Frozen Meniscal Allograft Transplant: Revisit or Redundant? A Systematic Review. Am J Sports Med. 2024 Jul; 52 (8):2159-2167 Epub 2024 Jan 29 View PubMed Meta F, Clark SC, Tagliero AJ, Hevesi M, Saris DBF, Krych AJ. Athlete-Specific Considerations of Cartilage Injuries. Sports Med Arthrosc Rev. 2024 Jun 1; 32 (2):60-67 Epub 2024 June 03 View PubMed Husen M, Wang AS, Levy BA, Saris DBF, Stuart MJ, Krych AJ. Influence of Concomitant Meniscal Allograft Transplantation on Midterm Outcomes After Osteochondral Allograft Transplantation: A Comparative Matched-Pair Analysis. Am J Sports Med. 2024 Apr; 52 (5):1238-1249 Epub 2024 Mar 25 View PubMed Lee DR, Lu Y, Reinholz AK, Till SE, Lamba A, Saris DBF, Camp CL, Krych AJ. Root Repair Has Superior Radiological and Clinical Outcomes Than Partial Meniscectomy and Nonoperative Treatment in the Management of Meniscus Root Tears: A Systematic Review. Arthroscopy. 2024 Feb 22. [Epub ahead of print] View PubMed Struijk C, Lydon KL, Husen M, Verdonk P, Michielsen J, van Wijnen AJ, Krych AJ, Saris DBF. Cellular Enhancement of Frozen Meniscus Allograft Combining Native Meniscus and Mesenchymal Stromal Cell Injections. Cartilage. 2024 Feb 7; 19476035231224802 Epub 2024 Feb 07 View PubMed Hendriks J, Zoetebier B, Larrea CS, Le NXT, Saris DBF, Karperien M. Gelatin-tyramine addition and low hydrogel density improves cell attachment, migration, and metabolic activity in vitro and tissue response in vivo in enzymatically crosslinkable dextran-hyaluronic acid hydrogels. Int J Biol Macromol. 2024 Feb; 259 (Pt 2):128843 Epub 2023 Dec 16 View PubMed Kruckeberg BM, Wilbur RR, Song BM, Lamba A, Camp CL, Saris DBF, Krych AJ, Stuart MJ. Comparison of Failure Rates at Long-term Follow-up Between MPFL Repair and Reconstruction for Recurrent Lateral Patellar Instability. Orthop J Sports Med. 2024 Jan; 12 (1):23259671231221239 Epub 2024 Jan 08 View PubMed van der Weiden GS, van Cruchten S, van Egmond N, Mastbergen SC, Husen M, Saris DBF, Custers RJH. Osteochondritis Dissecans of the Knee Associated With Mechanical Overload. Am J Sports Med. 2024 Jan; 52 (1):155-163 View PubMed Husen M, Poudel K, Wang A, Saul D, Stuart MJ, Levy BA, Saris DBF, Krych AJ. Survivorship of 157 Arthroscopic Meniscal Allograft Transplants Using Bone Fixation at a Mean of 7 Years and Prognostic Factors Analysis. Am J Sports Med. 2024 Jan; 52 (1):96-108 View PubMed Dancy ME, Tagliero AJ, Till SE, Saris DB, Levy BA, Camp CL, Krych AJ. Surgical Repair of Hypermobile Lateral Meniscus Secondary to Popliteomeniscal Fascicle Tears Improves Pain and Mechanical Symptoms. Arthrosc Sports Med Rehabil. 2023 Dec; 5 (6):100802 Epub 2023 Sept 22 View PubMed Husen M, Engrav SK, Saul D, Stuart MJ, Milbrandt TA, Levy BA, Krych AJ, Saris DBF. Differences in Trampoline-Related Knee Injuries Between Children and Adults: A Cross-Sectional Study. Orthop J Sports Med. 2023 Nov; 11 (11):23259671231209666 Epub 2023 Nov 09 View PubMed Hevesi M, Saris D. Innovations that Keep You Moving MN Monthly article - OSM Innovations https://www.minnesotamonthly.com/sponsored/innovations-that-keep-you-moving/. 2023. Korpershoek JV, Vonk LA, Filardo G, Kester EC, van Egmond N, Saris DBF, Custers RJH. Effect of Autologous Conditioned Plasma Injections in Patients With Knee Osteoarthritis. Orthop J Sports Med. 2023 Jul; 11 (7):23259671231184848 Epub 2023 July 28 View PubMed Langhans MT, Lamba A, Saris DBF, Smith P, Krych AJ. Meniscal Extrusion: Diagnosis, Etiology, and Treatment Options. Curr Rev Musculoskelet Med. 2023 Jul; 16 (7):316-327 Epub 2023 May 16 View PubMed Lu Y, Reinholz AK, Till SE, Kalina SV, Saris DBF, Camp CL, Stuart MJ. Predicting the Risk of Posttraumatic Osteoarthritis After Primary Anterior Cruciate Ligament Reconstruction: A Machine Learning Time-to-Event Analysis. Am J Sports Med. 2023 Jun; 51 (7):1673-1685 Epub 2023 May 12 View PubMed Husen M, Van der Weiden GS, Custers RJH, Poudel K, Stuart MJ, Krych AJ, Saris DBF. Internal Fixation of Unstable Osteochondritis Dissecans of the Knee: Long-term Outcomes in Skeletally Immature and Mature Patients. Am J Sports Med. 2023 May; 51 (6):1403-1413 Epub 2023 Apr 07 View PubMed Husen M, Milbrandt TA, Shah V, Krych AJ, Stuart MJ, Saris DBF. Medial Patellofemoral Ligament Reconstruction Using Allografts in Skeletally Immature Patients. Am J Sports Med. 2023 May; 51 (6):1513-1524 Epub 2023 Apr 11 View PubMed Jurgensmeier K, Till SE, Lu Y, Arguello AM, Stuart MJ, Saris DBF, Camp CL, Krych AJ. Risk factors for secondary meniscus tears can be accurately predicted through machine learning, creating a resource for patient education and intervention. Knee Surg Sports Traumatol Arthrosc. 2023 Feb; 31 (2):518-529 Epub 2022 Aug 16 View PubMed Reinholz AK, Till SE, Crowe MM, Hevesi M, Saris DBF, Stuart MJ, Krych AJ. Grooveplasty Compared With Trochleoplasty for the Treatment of Trochlear Dysplasia in the Setting of Patellar Instability. Arthrosc Sports Med Rehabil. 2023 Feb; 5 (1):e239-e247 Epub 2022 Dec 26 View PubMed Ow ZGW, Cheong CK, Hai HH, Ng CH, Wang D, Krych AJ, Saris DBF, Wong KL, Lin HA. Securing Transplanted Meniscal Allografts Using Bone Plugs Results in Lower Risks of Graft Failure and Reoperations: A Meta-analysis. Am J Sports Med. 2022 Dec; 50 (14):4008-4018 Epub 2021 Oct 11 View PubMed Korpershoek JV, Rikkers M, Wallis FSA, Dijkstra K, Te Raa M, de Knijff P, Saris DBF, Vonk LA. Mitochondrial Transport from Mesenchymal Stromal Cells to Chondrocytes Increases DNA Content and Proteoglycan Deposition In Vitro in 3D Cultures. Cartilage. 2022 Dec; 13 (4):133-147 Epub 2022 Oct 19 View PubMed Lu Y, Jurgensmeier K, Till SE, Reinholz A, Saris DBF, Camp CL, Krych AJ. Early ACLR and Risk and Timing of Secondary Meniscal Injury Compared With Delayed ACLR or Nonoperative Treatment: A Time-to-Event Analysis Using Machine Learning. Am J Sports Med. 2022 Nov; 50 (13):3544-3556 Epub 2022 Sept 30 View PubMed Murray IR, Chahla J, Wordie SJ, Shapiro SA, Piuzzi NS, Frank RM, Halbrecht J, Okada K, Nakamura N, Mandelbaum B, Dragoo JL, Borg-Stein J, Anz A, Gobbi A, Gomoll AH, Cole BJ, Lattermann C, Chu C, Grande DA, Saris DBF, Flanigan D, Kon E, Muschler GF, Malanga GA, Dummer G, Farr J, Tokish JM, Spindler KP, Horsch K, Zaslav K, McIntyre LF, Sgaglione NA, Sherman SL, Rodeo S, Awan TM, Vangsness CT, Biologics Association. Regulatory and Ethical Aspects of Orthobiologic Therapies. Orthop J Sports Med. 2022 Nov; 10 (11):23259671221101626 Epub 2022 Nov 30 View PubMed Husen M, Krych AJ, Stuart MJ, Milbrandt TA, Saris DBF. Successful Fixation of Traumatic Articular Cartilage-Only Fragments in the Juvenile and Adolescent Knee: A Case Series. Orthop J Sports Med. 2022 Nov; 10 (11):23259671221138074 Epub 2022 Nov 21 View PubMed Husen M, Kennedy NI, Till S, Reinholz A, Stuart MJ, Krych AJ, Saris DBF. Benefits of Meniscal Repair in Selected Patients Aged 60 Years and Older. Orthop J Sports Med. 2022 Sep; 10 (9):23259671221117491 Epub 2022 Sept 01 View PubMed Kluyskens L, Debieux P, Wong KL, Krych AJ, Saris DBF. Biomaterials for meniscus and cartilage in knee surgery: state of the art. J ISAKOS. 2022 Apr; 7 (2):67-77 Epub 2022 Jan 20 View PubMed Hevesi M, Wilbur RR, Keyt LK, Abdel MP, Levy BA, Saris DBF, Stuart MJ, Krych AJ. Total Knee Arthroplasty Function at 25 Years Following Proximal Tibial Osteotomy: Paired Outcomes of Bilateral TKAs Following Unilateral Osteotomy. J Bone Joint Surg Am. 2022 Mar 16; 104 (6):552-558 View PubMed Struijk C, Van Genechten W, Verdonk P, Krych AJ, Dietz AB, van Wijnen AJ, Saris DBF. Human meniscus allograft augmentation by allogeneic mesenchymal stromal/stem cell injections. J Orthop Res. 2022 Mar; 40 (3):712-726 Epub 2021 May 24 View PubMed Hendriks J, Schasfoort RBM, Huskens J, Saris DBF, Karperien M. Kinetic characterization of SPR-based biomarker assays enables quality control, calibration free measurements and robust optimization for clinical application. Analytical Biochemistry. 2022; 658:114918 Saris TFF , de Windt TS , Custers RJH , Saris DBF . Use of allogeneic mesenchymal signaling cells (MSCs) to augment cartilage repair. Operative Techniques in Sports Medicine. 2022; 30 (4):150962 Husen M, Custers RJH, Hevesi M, Krych AJ, Saris DBF. Size of cartilage defects and the need for repair: a systematic review. Journal of Cartilage and Joint Preservation. 2022; 2 (3):100049 Husen M, Custers RJH, Krych AJ, Saris DBF. Autologous chondrocyte implantation for treatment of articular cartilage defects in the knee and ankle of football (soccer) players. Journal of Cartilage and Joint Preservation. 2022; 2 (2):100059 Melugin HP, Bernard CD, Camp CL, Saris DBF, Krych AJ. Bipolar Cartilage Lesions of the Knee: A Systematic Review of Techniques, Outcomes, and Complications. Cartilage. 2021 Dec; 13 (1_suppl):17S-30S Epub 2019 June 16 View PubMed Melugin HP, Bernard CD, Camp CL, Stuart MJ, Saris DBF, Nakamura N, Krych AJ. Tibial Plateau Cartilage Lesions: A Systematic Review of Techniques, Outcomes, and Complications. Cartilage. 2021 Dec; 13 (1_suppl):31S-41S Epub 2019 June 16 View PubMed Denbeigh JM, Hevesi M, Paggi CA, Resch ZT, Bagheri L, Mara K, Arani A, Zhang C, Larson AN, Saris DBF, Krych AJ, van Wijnen AJ. Modernizing Storage Conditions for Fresh Osteochondral Allografts by Optimizing Viability at Physiologic Temperatures and Conditions. Cartilage. 2021 Dec; 13 (1_suppl):280S-292S Epub 2019 Nov 28 View PubMed Ow ZGW, Law MSN, Ng CH, Krych AJ, Saris DBF, Debieux P, Wong KL, Lin HA. All-Cause Failure Rates Increase With Time Following Meniscal Repair Despite Favorable Outcomes: A Systematic Review and Meta-analysis. Arthroscopy. 2021 Dec; 37 (12):3518-3528 Epub 2021 May 29 View PubMed Hevesi M, Denbeigh JM, Paggi CA, Galeano-Garces C, Bagheri L, Larson AN, Stuart MJ, Saris DBF, van Wijnen AJ, Krych AJ. Fresh Osteochondral Allograft Transplantation in the Knee: A Viability and Histologic Analysis for Optimizing Graft Viability and Expanding Existing Standard Processed Graft Resources Using a Living Donor Cartilage Program. Cartilage. 2021 Dec; 13 (1_suppl):948S-956S Epub 2019 Oct 16 View PubMed Zarringam D, Saris DBF, Bekkers JEJ. The Value of SPECT/CT for Knee Osteoarthritis: A Systematic Review. Cartilage. 2021 Oct; 12 (4):431-437 Epub 2019 June 16 View PubMed Hevesi M, van Genechten W, Krych AJ, Saris DBF. The Sound of Cartilage Repair: The Importance of Using Pitch and Volume Cues in Cartilage Restoration Surgery. Arthrosc Tech. 2021 Sep; 10 (9):e2049-e2052 Epub 2021 Aug 02 View PubMed Korpershoek JV, Rikkers M, de Windt TS, Tryfonidou MA, Saris DBF, Vonk LA. Selection of Highly Proliferative and Multipotent Meniscus Progenitors through Differential Adhesion to Fibronectin: A Novel Approach in Meniscus Tissue Engineering. Int J Mol Sci. 2021 Aug 10; 22 (16) View PubMed Barras LA, Pareek A, Parkes CW, Song BM, Camp CL, Saris DBF, Stuart MJ, Krych AJ. Post-arthroscopic Subchondral Insufficiency Fractures of the Knee Yield High Rate of Conversion to Arthroplasty. Arthroscopy. 2021 Aug; 37 (8):2545-2553 Epub 2021 Mar 25 View PubMed Hagmeijer MH, Korpershoek JV, Crispim JF, Chen LT, Jonkheijm P, Krych AJ, Saris DBF, Vonk LA. The regenerative effect of different growth factors and platelet lysate on meniscus cells and mesenchymal stromal cells and proof of concept with a functionalized meniscus implant. J Tissue Eng Regen Med. 2021 Jul; 15 (7):648-659 Epub 2021 May 21 View PubMed Kluyskens L, Debieux P, Wong KL, Krych AJ, Saris DBF. Biomaterials for meniscus and cartilage in knee surgery: state of the art. J ISAKOS. 2021 Jun 28 Epub 2021 June 28 View PubMed Tagliero AJ, Kurian EB, LaPrade MD, Song BM, Saris DBF, Stuart MJ, Camp CL, Krych AJ. Arthritic progression secondary to meniscus root tear treated with knee arthroplasty demonstrates similar outcomes to primary osteoarthritis: a matched case-control comparison. Knee Surg Sports Traumatol Arthrosc. 2021 Jun; 29 (6):1977-1982 Epub 2020 Sept 25 View PubMed Brinkhof S, Nizak R, Sim S, Khlebnikov V, Quenneville E, Garon M, Klomp DWJ, Saris D. In vivo biochemical assessment of cartilage with gagCEST MRI: Correlation with cartilage properties. NMR Biomed. 2021 Mar; 34 (3):e4463 Epub 2020 Dec 22 View PubMed Saris TFF, de Windt TS, Kester EC, Vonk LA, Custers RJH, Saris DBF. Five-Year Outcome of 1-Stage Cell-Based Cartilage Repair Using Recycled Autologous Chondrons and Allogenic Mesenchymal Stromal Cells: A First-in-Human Clinical Trial. Am J Sports Med. 2021 Mar; 49 (4):941-947 Epub 2021 Feb 16 View PubMed Parkes CW, Leland DP, Levy BA, Stuart MJ, Camp CL, Saris DBF, Krych AJ. Hamstring Autograft Anterior Cruciate Ligament Reconstruction Using an All-Inside Technique With and Without Independent Suture Tape Reinforcement. Arthroscopy. 2021 Feb; 37 (2):609-616 Epub 2020 Nov 02 View PubMed Van Genechten W, Hevesi M, Olson N, Carstens M, Krych AJ, Verdonk P, van Wijnen AJ, Saris DBF. Anterior cruciate ligament graft healing by peptide-based vascular endothelial growth factor and bone morphogenetic protein recruitment. Journal of Cartilage and Joint Preservation. 2021; 1 (4):100030 Hacken BA, LaPrade MD, Stuart MJ, Saris DBF, Camp CL, Krych AJ. Small Cartilage Defect Management. J Knee Surg. 2020 Dec; 33 (12):1180-1186 Epub 2020 Sept 08 View PubMed Korpershoek JV, Vonk LA, De Windt TS, Admiraal J, Kester EC, Van Egmond N, Saris DBF, Custers RJH. Intra-articular injection with Autologous Conditioned Plasma does not lead to a clinically relevant improvement of knee osteoarthritis: a prospective case series of 140 patients with 1-year follow-up. Acta Orthop. 2020 Dec; 91 (6):743-749 Epub 2020 July 23 View PubMed Krych AJ, Saris DBF, Stuart MJ, Hacken B. Cartilage Injury in the Knee: Assessment and Treatment Options. J Am Acad Orthop Surg. 2020 Nov 15; 28 (22):914-922 View PubMed Korpershoek JV, Vonk LA, Kester EC, Creemers LB, de Windt TS, Kip MMA, Saris DBF, Custers RJH. Efficacy of one-stage cartilage repair using allogeneic mesenchymal stromal cells and autologous chondron transplantation (IMPACT) compared to nonsurgical treatment for focal articular cartilage lesions of the knee: study protocol for a crossover randomized controlled trial. Trials. 2020 Oct 9; 21 (1):842 Epub 2020 Oct 09 View PubMed Pareek A, Parkes CW, Bernard CD, Abdel MP, Saris DBF, Krych AJ. The SIFK score: a validated predictive model for arthroplasty progression after subchondral insufficiency fractures of the knee. Knee Surg Sports Traumatol Arthrosc. 2020 Oct; 28 (10):3149-3155 Epub 2019 Nov 20 View PubMed Van W, Verdonk P, Krych AJ, Saris DB. Biologic adjuvants in meniscus repair: A review of current translational and clinical evidence Oper Tech Sports Med. 2020; 28:150758. Carlson Strother CR, Saris DB, Verdonk P, Nakamura N, Krych AJ. Biological augmentation to promote meniscus repair: from basic science to clinic application—state of the art Journal of ISAKOS: Joint Disorders & Orthopaedic Sports Medicine. 2020; 5:150-157. Krych AJ, Wu IT, Desai VS, Kennedy NI, Littrell LA, Collins MS, Saris DBF, Stuart MJ. Osteomeniscal Impact Edema (OMIE): Description of a Distinct MRI Finding in Displaced Flap Tears of the Medial Meniscus, with Comparison to Posterior Root Tears. J Knee Surg. 2020 Jul; 33 (7):659-665 Epub 2019 Mar 28 View PubMed Hevesi M, Sanders TL, Pareek A, Milbrandt TA, Levy BA, Stuart MJ, Saris DBF, Krych AJ. Osteochondritis Dissecans in the Knee of Skeletally Immature Patients: Rates of Persistent Pain, Osteoarthritis, and Arthroplasty at Mean 14-Years' Follow-Up. Cartilage. 2020 Jul; 11 (3):291-299 Epub 2018 July 12 View PubMed Korpershoek JV, de Windt TS, Vonk LA, Krych AJ, Saris DBF. Does Anterior Cruciate Ligament Reconstruction Protect the Meniscus and Its Repair? A Systematic Review. Orthop J Sports Med. 2020 Jul; 8 (7):2325967120933895 Epub 2020 July 28 View PubMed Pareek A, Parkes CW, Bernard C, Camp CL, Saris DBF, Stuart MJ, Krych AJ. Spontaneous Osteonecrosis/Subchondral Insufficiency Fractures of the Knee: High Rates of Conversion to Surgical Treatment and Arthroplasty. J Bone Joint Surg Am. 2020 May 6; 102 (9):821-829 View PubMed van de Graaf VA, van Dongen JM, Willigenburg NW, Noorduyn JCA, Butter IK, de Gast A, Saris DBF, van Tulder MW, Poolman RW, ESCAPE Research Group. How do the costs of physical therapy and arthroscopic partial meniscectomy compare? A trial-based economic evaluation of two treatments in patients with meniscal tears alongside the ESCAPE study. Br J Sports Med. 2020 May; 54 (9):538-545 Epub 2019 June 21 View PubMed Zarringam D, Saris DBF, Bekkers JEJ. Identification of early prognostic factors for knee and hip arthroplasty; a long-term follow-up of the CHECK cohort. J Orthop. 2020 May-Jun; 19:41-45 Epub 2019 Nov 06 View PubMed Bloembergen CH, van de Graaf VA, Virgile A, Willigenburg NW, Noorduyn JCA, Saris DB, Harris I, Poolman RW. Infographic. Can even experienced orthopaedic surgeons predict who will benefit from surgery when patients present with degenerative meniscal tears? A survey of 194 orthopaedic surgeons who made 3880 predictions. Br J Sports Med. 2020 May; 54 (9):556-557 Epub 2019 Oct 25 View PubMed Pareek A, Parkes CW, Bernard C, Camp CL, Saris DBF, Stuart MJ, Krych AJ. Spontaneous Osteonecrosis/Subchondral Insufficiency Fractures of the Knee: High Rates of Conversion to Surgical Treatment and Arthroplasty. J Bone Joint Surg Am. 2020 Apr 2 Epub 2020 Apr 02 View PubMed Merkely G, Farr J, Saris D, Lattermann C. Cartilage surface treatment: factors affecting success and failure mechanisms Operative Techniques In Sports Medicine. 2020 Mar; 28 (1):150711 van de Graaf VA, Bloembergen MD, Willigenburg NW, Noorduyn MSc, Saris DB, Harris IA, Poolman RW, ESCAPE Research Group. Can even experienced orthopaedic surgeons predict who will benefit from surgery when patients present with degenerative meniscal tears? A survey of 194 orthopaedic surgeons who made 3880 predictions. Br J Sports Med. 2020 Mar; 54 (6):354-359 Epub 2019 Aug 01 View PubMed Bernard CD, Kennedy NI, Tagliero AJ, Camp CL, Saris DBF, Levy BA, Stuart MJ, Krych AJ. Medial Meniscus Posterior Root Tear Treatment: A Matched Cohort Comparison of Nonoperative Management, Partial Meniscectomy, and Repair. Am J Sports Med. 2020 Jan; 48 (1):128-132 Epub 2019 Nov 25 View PubMed Hevesi M, LaPrade M, Saris DBF, Krych AJ. Stem Cell Treatment for Ligament Repair and Reconstruction. Curr Rev Musculoskelet Med. 2019 Dec; 12 (4):446-450 View PubMed Leland DP, Bernard CD, Camp CL, Nakamura N, Saris DBF, Krych AJ. Does Internal Fixation for Unstable Osteochondritis Dissecans of the Skeletally Mature Knee Work? A Systematic Review. Arthroscopy. 2019 Aug; 35 (8):2512-2522 View PubMed Dijkstra K, Huitsing RPJ, Custers RJH, Kouwenhoven JWM, Bleys RLAW, Vonk LA, Saris DBF. Preclinical Feasibility of the Bio-Airbrush for Arthroscopic Cell-Based Cartilage Repair. Tissue Eng Part C Methods. 2019 Jul; 25 (7):379-388 View PubMed Hagmeijer MH, Hevesi M, Desai VS, Sanders TL, Camp CL, Hewett TE, Stuart MJ, Saris DBF, Krych AJ. Secondary Meniscal Tears in Patients With Anterior Cruciate Ligament Injury: Relationship Among Operative Management, Osteoarthritis, and Arthroplasty at 18-Year Mean Follow-up. Am J Sports Med. 2019 Jun; 47 (7):1583-1590 View PubMed Hevesi M, Krych AJ, Saris DBF. Treatment of Cartilage Defects With the Matrix-Induced Autologous Chondrocyte Implantation Cookie Cutter Technique. Arthrosc Tech. 2019 Jun; 8 (6):e591-e596 Epub 2019 May 16 View PubMed Murray IR, Chahla J, Safran MR, Krych AJ, Saris DBF, Caplan AI, LaPrade RF, Cell Therapies Communication Expert Group. International Expert Consensus on a Cell Therapy Communication Tool: DOSES. J Bone Joint Surg Am 2019 May 15; 101 (10):904-911 View PubMed Hevesi M, Crispim JF, Paggi CA, Dudakovic A, van Genechten W, Hewett T, Kakar S, Krych AJ, van Wijnen AJ, Saris DBF. A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. Tissue Eng Part C Methods. 2019 Apr; 25 (4):191-196 View PubMed Hagmeijer MH, Kennedy NI, Tagliero AJ, Levy BA, Stuart MJ, Saris DBF, Dahm DL, Krych AJ. Long-term Results After Repair of Isolated Meniscal Tears Among Patients Aged 18 Years and Younger: An 18-Year Follow-up Study. Am J Sports Med. 2019 Mar; 47 (4):799-806 Epub 2019 Feb 25 View PubMed Hevesi M, Paradise CR, Paggi CA, Galeano-Garces C, Dudakovic A, Karperien M, Kakar S, Hewett T, Krych A, van Wijnen AJ, Saris DBF. Defining the baseline transcriptional fingerprint of rabbit hamstring autograft Gene Reports. 1/18/2019. de Windt TS, Niemansburg SL, Vonk LA, van Delden JM, Roes KCB, Dhert WJA, Saris DBF, Bredenoord AL. Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials. Osteoarthritis Cartilage. 2019 Jan; 27 (1):34-40 Epub 2018 Sept 20 View PubMed Hagmeijer MH, Vonk LA, Kouwenhoven JW, Custers RJH, Bleys RL, Krych AJ, Saris DBF. Surgical Feasibility of a One-Stage Cell-Based Arthroscopic Procedure for Meniscus Regeneration: A Cadaveric Study. Tissue Eng Part C Methods. 2018 Dec; 24 (12):688-696 View PubMed van de Graaf VA, Noorduyn JCA, Willigenburg NW, Butter IK, de Gast A, Mol BW, Saris DBF, Twisk JWR, Poolman RW, ESCAPE Research Group. Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial. JAMA. 2018 Oct 2; 320 (13):1328-1337 View PubMed Hevesi M, Hartigan DE, Wu IT, Wyles CC, Desai VS, van Wijnen AJ, Saris DBF, Levy BA, Krych AJ. The Rapidly Assessed Predictor of Intraoperative Damage (RAPID) Score: An In-Clinic Predictive Model for High-Grade Acetabular Chondrolabral Disruption. Orthop J Sports Med. 2018 Oct; 6 (10):2325967118799068 Epub 2018 Oct 03 View PubMed Paradise CR, Galeano-Garces C, Galeano-Garces D, Dudakovic A, Milbrandt TA, Saris DBF, Krych AJ, Karperien M, Ferguson GB, Evseenko D, Riester SM, van Wijnen AJ, Larson AN. Molecular characterization of physis tissue by RNA sequencing. Gene. 2018 Aug 20; 668:87-96 Epub 2018 May 25 View PubMed Wu IT, Custers RJH, Desai VS, Pareek A, Stuart MJ, Saris DBF, Krych AJ. Internal Fixation of Unstable Osteochondritis Dissecans: Do Open Growth Plates Improve Healing Rate? Am J Sports Med. 2018 Aug; 46 (10):2394-2401 Epub 2018 July 11 View PubMed Brinkhof S, Nizak R, Khlebnikov V, Prompers JJ, Klomp DWJ, Saris DBF. Detection of early cartilage damage: feasibility and potential of gagCEST imaging at 7T. Eur Radiol. 2018 Jul; 28 (7):2874-2881 Epub 2018 Jan 30 View PubMed Krych AJ, Hevesi M, Desai VS, Camp CL, Stuart MJ, Saris DBF. Learning From Failure in Cartilage Repair Surgery: An Analysis of the Mode of Failure of Primary Procedures in Consecutive Cases at a Tertiary Referral Center. Orthop J Sports Med. 2018 May; 6 (5):2325967118773041 Epub 2018 May 17 View PubMed Brittberg M, Recker D, Ilgenfritz J, Saris DBF, SUMMIT Extension Study Group. Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Five-Year Follow-up of a Prospective Randomized Trial. Am J Sports Med. 2018 May; 46 (6):1343-1351 Epub 2018 Mar 22 View PubMed Krych AJ, Wu IT, Desai VS, Murthy NS, Collins MS, Saris DBF, Levy BA, Stuart MJ. High Rate of Missed Lateral Meniscus Posterior Root Tears on Preoperative Magnetic Resonance Imaging. Orthop J Sports Med. 2018 Apr; 6 (4):2325967118765722 Epub 2018 Apr 09 View PubMed Ghebes CA, Groen N, Cheuk YC, Fu SC, Fernandes HM, Saris DBF. Muscle-Secreted Factors Improve Anterior Cruciate Ligament Graft Healing: An In Vitro and In Vivo Analysis. Tissue Eng Part A. 2018 Feb; 24 (3-4):322-334 Epub 2017 July 05 View PubMed Saris DBF, de Windt TS, Vonk LA, Krych AJ, Terzic A. Regenerative Musculoskeletal Care: Ensuring Practice Implementation. Clin Pharmacol Ther. 2018 Jan; 103 (1):50-53 Epub 2017 Oct 16 View PubMed Vonk LA, van Dooremalen SFJ, Liv N, Klumperman J, Coffer PJ, Saris DBF, Lorenowicz MJ. Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro. Theranostics. 2018; 8 (4):906-920 Epub 2018 Jan 01 View PubMed Hendriks J, Stojanovic I, Schasfoort RBM, Saris D, Karperien M. Nanoparticle enhancement cascade for sensitive multiplex measurements of biomarkers in complex fluids with surface pasmon resonance imaging Anal Chem. 2018; 90:6563-6571. Zhao X, Hwang NS, Bichara DA, Saris DB, Malda J, Vacanti JP, Pomerantseva I, Sundback CA, Langer R, Anderson DG, Randolph MA. Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction. J Tissue Eng Regen Med. 2017 Oct; 11 (10):2763-2773 Epub 2016 June 03 View PubMed de Windt TS, Sorel JC, Vonk LA, Kip MMA, Ijzerman MJ, Saris DBF. Early health economic modelling of single-stage cartilage repair. Guiding implementation of technologies in regenerative medicine. J Tissue Eng Regen Med. 2017 Oct; 11 (10):2950-2959 Epub 2016 July 12 View PubMed Mouser VHM, Levato R, Bonassar LJ, D'Lima DD, Grande DA, Klein TJ, Saris DBF, Zenobi-Wong M, Gawlitta D, Malda J. Three-Dimensional Bioprinting and Its Potential in the Field of Articular Cartilage Regeneration. Cartilage. 2017 Oct; 8 (4):327-340 Epub 2016 Sept 01 View PubMed Woodmass JM, Melugin HP, Wu IT, Saris DBF, Stuart MJ, Krych AJ. Viable Osteochondral Allograft for the Treatment of a Full-Thickness Cartilage Defect of the Patella. Arthrosc Tech. 2017 Oct; 6 (5):e1661-e1665 Epub 2017 Sept 25 View PubMed Pareek A, Sanders TL, Wu IT, Larson DR, Saris DBF, Krych AJ. Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County. Osteoarthritis Cartilage. 2017 Oct; 25 (10):1663-1671 Epub 2017 July 12 View PubMed Dijkstra K, Hendriks J, Karperien M, Vonk LA, Saris DBF. Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles. Tissue Eng Part C Methods. 2017 Sep; 23 (9):505-515 Epub 2017 Aug 08 View PubMed de Windt TS, Vonk LA, Slaper-Cortenbach ICM, Nizak R, van Rijen MHP, Saris DBF. Allogeneic MSCs and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion: A First-in-Man Trial in 35 Patients. Stem Cells. 2017 Aug; 35 (8):1984-1993 Epub 2017 June 23 View PubMed Woodmass JM, Johnson JD, Wu IT, Saris DBF, Stuart MJ, Krych AJ. Horizontal Cleavage Meniscus Tear Treated With All-inside Circumferential Compression Stitches. Arthrosc Tech. 2017 Aug; 6 (4):e1329-e1333 Epub 2017 Aug 14 View PubMed van Gorp JS, Nizak R, Bouwman JG, Saris DBF, Seevinck PR. Multispectral 3D phase-encoded turbo spin-echo for imaging near metal: Limitations and possibilities demonstrated by simulations and phantom experiments. Magn Reson Imaging. 2017 Jun; 39:31-43 Epub 2017 Jan 25 View PubMed van der Linde JA, van Kampen DA, van Beers LWAH, van Deurzen DFP, Saris DBF, Terwee CB. The Responsiveness and Minimal Important Change of the Western Ontario Shoulder Instability Index and Oxford Shoulder Instability Score. J Orthop Sports Phys Ther. 2017 Jun; 47 (6):402-410 Epub 2017 May 12 View PubMed Nizak R, Bekkers J, de Jong PA, Witkamp T, Luijkx T, Saris D. Osteochondral lesion depth on MRI can help predict the need for a sandwich procedure. Eur J Radiol. 2017 May; 90:245-249 Epub 2017 Mar 18 View PubMed Crispim J, Fernandes HAM, Fu SC, Lee YW, Jonkheijm P, Saris DBF. TGF-beta1 activation in human hamstring cells through growth factor binding peptides on polycaprolactone surfaces. Acta Biomater. 2017 Apr 15; 53:165-178 Epub 2017 Jan 26 View PubMed Vazao H, Rosa S, Barata T, Costa R, Pitrez PR, Honorio I, de Vries MR, Papatsenko D, Benedito R, Saris D, Khademhosseini A, Quax PH, Pereira CF, Mercader N, Fernandes H, Ferreira L. High-throughput identification of small molecules that affect human embryonic vascular development. Proc Natl Acad Sci U S A. 2017 Apr 11; 114 (15):E3022-E3031 Epub 2017 Mar 27 View PubMed Korpershoek JV, de Windt TS, Hagmeijer MH, Vonk LA, Saris DB. Cell-Based Meniscus Repair and Regeneration: At the Brink of Clinical Translation?: A Systematic Review of Preclinical Studies. Orthop J Sports Med. 2017 Feb; 5 (2):2325967117690131 Epub 2017 Feb 21 View PubMed de Windt TS, Vonk LA, Slaper-Cortenbach IC, van den Broek MP, Nizak R, van Rijen MH, de Weger RA, Dhert WJ, Saris DB. Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons. Stem Cells. 2017 Jan; 35 (1):256-264 Epub 2016 Aug 29 View PubMed Ghebes CA, van Lente J, Post JN, Saris DB, Fernandes H. High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-beta1 Signaling Pathway. SLAS Discov. 2017 Jan; 22 (1):40-50 Epub 2016 Sept 27 View PubMed van de Graaf VA, Scholtes VA, Wolterbeek N, Noorduyn JC, Neeter C, van Tulder MW, Saris DB, de Gast A, Poolman RW, Escape Research Group. Cost-effectiveness of Early Surgery versus Conservative Treatment with Optional Delayed Meniscectomy for Patients over 45 years with non-obstructive meniscal tears (ESCAPE study): protocol of a randomised controlled trial. BMJ Open. 2016 Dec 21; 6 (12):e014381 View PubMed Ghebes CA, Braham MV, Zeegers AV, Renard AJ, Fernandes H, Saris DB. Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation. BMC Biotechnol. 2016 Dec 12; 16 (1):89 View PubMed van de Graaf VA, Wolterbeek N, Mutsaerts EL, Scholtes VA, Saris DB, de Gast A, Poolman RW. Arthroscopic Partial Meniscectomy or Conservative Treatment for Nonobstructive Meniscal Tears: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arthroscopy. 2016 Sep; 32 (9):1855-1865.e4 Epub 2016 July 27 View PubMed Mok SW, Nizak R, Fu SC, Ho, Qin L, Saris, Chan KM, Malda J. From the printer: Potential of three-dimensional printing for orthopaedic applications J Orthop Trans. 2016; 6:42-49. Zhao X, Papadopoulos A, Ibusuki S, Bichara DA, Saris DB, Malda J, Anseth KS, Gill TJ, Randolph MA. Articular cartilage generation applying PEG-LA-DM/PEGDM copolymer hydrogels. BMC Musculoskelet Disord. 2016 Jun 3; 17:245 Epub 2016 June 03 View PubMed Wiegant K, Beekhuizen M, Mastbergen SC, Kuchuk NO, Barten-van Rijbroek AD, Custers RJ, Saris DB, Creemers LB, Lafeber FP. Early evolving joint degeneration by cartilage trauma is primarily mechanically controlled. Knee. 2016 Jun; 23 (3):487-94 Epub 2016 Feb 11 View PubMed Ekwueme EC, Shah JV, Mohiuddin M, Ghebes CA, Crispim JF, Saris DB, Fernandes HA, Freeman JW. Cross-Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro. J Cell Biochem. 2016 Mar; 117 (3):684-93 Epub 2015 Sept 29 View PubMed Martin I, Ireland H, Baldomero H, Dominici M, Saris DB, Passweg J. The Survey on Cellular and Engineered Tissue Therapies in Europe in 2013. Tissue Eng Part A. 2016 Jan; 22 (1-2):5-16 View PubMed de Windt TS, Saris DB, Slaper-Cortenbach IC, van Rijen MH, Gawlitta D, Creemers LB, de Weger RA, Dhert WJ, Vonk LA. Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis. Tissue Eng Part A. 2015 Oct; 21 (19-20):2536-47 Epub 2015 Aug 12 View PubMed Hendriks J, Willem Visser C, Henke S, Leijten J, Saris DB, Sun C, Lohse D, Karperien M. Optimizing cell viability in droplet-based cell deposition. Sci Rep. 2015 Jun 11; 5:11304 Epub 2015 June 11 View PubMed Vonk LA, de Windt TS, Slaper-Cortenbach IC, Saris DB. Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review. Stem Cell Res Ther. 2015 May 15; 6:94 View PubMed Rutgers M, Creemers LB, Auw Yang KG, Raijmakers NJ, Dhert WJ, Saris DB. Osteoarthritis treatment using autologous conditioned serum after placebo. Acta Orthop. 2015 Feb; 86 (1):114-8 Epub 2014 Aug 20 View PubMed de Windt TS, Vonk LA, Buskermolen JK, Visser J, Karperien M, Bleys RL, Dhert WJ, Saris DB. Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study. Osteoarthritis Cartilage. 2015 Jan; 23 (1):143-50 Epub 2014 Sept 18 View PubMed van Geene AR, Saris DB, Custers RJ. [Pain following primary total knee replacement: causes, diagnosis and treatment]. Ned Tijdschr Geneeskd. 2015; 159:A8445 View PubMed Vonk LA, de Windt TS, Kragten AH, Beekhuizen M, Mastbergen SC, Dhert WJ, Lafeber FP, Creemers LB, Saris DB. Enhanced cell-induced articular cartilage regeneration by chondrons; the influence of joint damage and harvest site. Osteoarthritis Cartilage. 2014 Nov; 22 (11):1910-7 Epub 2014 Aug 20 View PubMed Benders KE, Boot W, Cokelaere SM, Van Weeren PR, Gawlitta D, Bergman HJ, Saris DB, Dhert WJ, Malda J. Multipotent Stromal Cells Outperform Chondrocytes on Cartilage-Derived Matrix Scaffolds. Cartilage. 2014 Oct; 5 (4):221-30 View PubMed Tsuchida AI, Beekhuizen M, 't Hart MC, Radstake TR, Dhert WJ, Saris DB, van Osch GJ, Creemers LB. Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes. Arthritis Res Ther. 2014 Sep 26; 16 (5):441 Epub 2014 Sept 26 View PubMed Stenberg J, de Windt TS, Synnergren J, Hynsjo L, van der Lee J, Saris DB, Brittberg M, Peterson L, Lindahl A. Clinical Outcome 3 Years After Autologous Chondrocyte Implantation Does Not Correlate With the Expression of a Predefined Gene Marker Set in Chondrocytes Prior to Implantation but Is Associated With Critical Signaling Pathways. Orthop J Sports Med. 2014 Sep; 2 (9):2325967114550781 Epub 2014 Sept 24 View PubMed Saris D, Price A, Widuchowski W, Bertrand-Marchand M, Caron J, Drogset JO, Emans P, Podskubka A, Tsuchida A, Kili S, Levine D, Brittberg M, SUMMIT study group. Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial. Am J Sports Med. 2014 Jun; 42 (6):1384-94 Epub 2014 Apr 08 View PubMed de Windt TS, Hendriks JA, Zhao X, Vonk LA, Creemers LB, Dhert WJ, Randolph MA, Saris DB. Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how? Stem Cells Transl Med. 2014 Jun; 3 (6):723-33 Epub 2014 Apr 24 View PubMed Cucchiarini M, Madry H, Guilak F, Saris DB, Stoddart MJ, Koon Wong M, Roughley P. A vision on the future of articular cartilage repair. Eur Cell Mater. 2014 May 6; 27:12-6 Epub 2014 May 06 View PubMed Bekkers JE, Saris DB, Tsuchida AI, van Rijen MH, Dhert WJ, Creemers LB. Chondrogenic potential of articular chondrocytes depends on their original location. Tissue Eng Part A. 2014 Feb; 20 (3-4):663-71 Epub 2013 Nov 14 View PubMed Vonk LA, Kragten AH, Dhert WJ, Saris DB, Creemers LB. Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2014 Jan; 22 (1):145-53 Epub 2013 Nov 21 View PubMed Saris D. SP0121 Joint Homeostasis: Limitations and Advantages for Cartilage Repair in Oa. Annals of the Rheumatic Diseases. 2014; 73:32-33. Beekhuizen M, van Osch GJ, Bot AG, Hoekstra MC, Saris DB, Dhert WJ, Creemers LB. Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair. Eur Cell Mater. 2013 Sep 11; 26:80-90; discussion 90 Epub 2013 Sept 11 View PubMed Bekkers JE, Tsuchida AI, van Rijen MH, Vonk LA, Dhert WJ, Creemers LB, Saris DB. Single-stage cell-based cartilage regeneration using a combination of chondrons and mesenchymal stromal cells: comparison with microfracture. Am J Sports Med. 2013 Sep; 41 (9):2158-66 Epub 2013 July 05 View PubMed Tsuchida AI, Bekkers JE, Beekhuizen M, Vonk LA, Dhert WJ, Saris DB, Creemers LB. Pronounced biomaterial dependency in cartilage regeneration using nonexpanded compared with expanded chondrocytes. Regen Med. 2013 Sep; 8 (5):583-95 View PubMed de Windt TS, Welsch GH, Brittberg M, Vonk LA, Marlovits S, Trattnig S, Saris DB. Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage repair of the knee? A systematic review and meta-analysis. Am J Sports Med. 2013 Jul; 41 (7):1695-702 Epub 2013 Jan 30 View PubMed Bekkers JE, Creemers LB, Tsuchida AI, van Rijen MH, Custers RJ, Dhert WJ, Saris DB. One-stage focal cartilage defect treatment with bone marrow mononuclear cells and chondrocytes leads to better macroscopic cartilage regeneration compared to microfracture in goats. Osteoarthritis Cartilage. 2013 Jul; 21 (7):950-6 Epub 2013 Apr 09 View PubMed Bekkers JE, Bartels LW, Benink RJ, Tsuchida AI, Vincken KL, Dhert WJ, Creemers LB, Saris DB. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) can be effectively applied for longitudinal cohort evaluation of articular cartilage regeneration. Osteoarthritis Cartilage. 2013 Jul; 21 (7):943-9 Epub 2013 Apr 09 View PubMed Beekhuizen M, Gierman LM, van Spil WE, Van Osch GJ, Huizinga TW, Saris DB, Creemers LB, Zuurmond AM. An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid. Osteoarthritis Cartilage. 2013 Jul; 21 (7):918-22 Epub 2013 Apr 15 View PubMed de Windt TS, Vonk LA, Brittberg M, Saris DB. Treatment and Prevention of (Early) Osteoarthritis Using Articular Cartilage Repair-Fact or Fiction? A Systematic Review. Cartilage. 2013 Jul; 4 (3 Suppl):5S-12S View PubMed Thakkar S, Ghebes CA, Ahmed M, Kelder C, van Blitterswijk CA, Saris D, Fernandes HA, Moroni L. Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes. Biofabrication. 2013 Jun; 5 (2):025003 Epub 2013 Feb 27 View PubMed Bekkers JE, Bartels LW, Vincken KL, Dhert WJ, Creemers LB, Saris DB. Articular cartilage evaluation after TruFit plug implantation analyzed by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Am J Sports Med. 2013 Jun; 41 (6):1290-5 Epub 2013 Apr 12 View PubMed Mastbergen SC, Saris DB, Lafeber FP. Functional articular cartilage repair: here, near, or is the best approach not yet clear? Nat Rev Rheumatol. 2013 May; 9 (5):277-90 Epub 2013 Mar 19 View PubMed Doorn J, Fernandes HA, Le BQ, van de Peppel J, van Leeuwen JP, De Vries MR, Aref Z, Quax PH, Myklebost O, Saris DB, van Blitterswijk CA, de Boer J. A small molecule approach to engineering vascularized tissue. Biomaterials. 2013 Apr; 34 (12):3053-63 Epub 2013 Jan 29 View PubMed Benders KE, van Weeren PR, Badylak SF, Saris DB, Dhert WJ, Malda J. Extracellular matrix scaffolds for cartilage and bone regeneration. Trends Biotechnol. 2013 Mar; 31 (3):169-76 Epub 2013 Jan 05 View PubMed Saris DBF. Cell therapy, biomaterials and other options may enhance cartilage repair. Orthopaedics Today Europe. 2013. Rutgers M, Saris DB, Vonk LA, van Rijen MH, Akrum V, Langeveld D, van Boxtel A, Dhert WJ, Creemers LB. Effect of collagen type I or type II on chondrogenesis by cultured human articular chondrocytes. Tissue Eng Part A. 2013 Jan; 19 (1-2):59-65 Epub 2012 Sept 13 View PubMed Tsuchida AI, Beekhuizen M, Rutgers M, van Osch GJ, Bekkers JE, Bot AG, Geurts B, Dhert WJ, Saris DB, Creemers LB. Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther. 2012 Dec 3; 14 (6):R262 Epub 2012 Dec 03 View PubMed de Windt TS, Concaro S, Lindahl A, Saris DB, Brittberg M. Strategies for patient profiling in articular cartilage repair of the knee: a prospective cohort of patients treated by one experienced cartilage surgeon. Knee Surg Sports Traumatol Arthrosc. 2012 Nov; 20 (11):2225-32 Epub 2012 Jan 14 View PubMed Martin I, Baldomero H, Bocelli-Tyndall C, Passweg J, Saris D, Tyndall A. The survey on cellular and engineered tissue therapies in Europe in 2010. Tissue Eng Part A. 2012 Nov; 18 (21-22):2268-79 Epub 2012 July 19 View PubMed Longo UG, Saris D, Poolman RW, Berton A, Denaro V. Instruments to assess patients with rotator cuff pathology: a systematic review of measurement properties. Knee Surg Sports Traumatol Arthrosc. 2012 Oct; 20 (10):1961-70 Epub 2011 Dec 20 View PubMed Malda J, Benders KE, Klein TJ, de Grauw JC, Kik MJ, Hutmacher DW, Saris DB, van Weeren PR, Dhert WJ. Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthritis Cartilage. 2012 Oct; 20 (10):1147-51 Epub 2012 July 07 View PubMed Rutgers M, Bartels LW, Tsuchida AI, Castelein RM, Dhert WJ, Vincken KL, van Heerwaarden RJ, Saris DB. dGEMRIC as a tool for measuring changes in cartilage quality following high tibial osteotomy: a feasibility study. Osteoarthritis Cartilage. 2012 Oct; 20 (10):1134-41 Epub 2012 July 10 View PubMed Meuffels DE, Poldervaart MT, Diercks RL, Fievez AW, Patt TW, Hart CP, Hammacher ER, Meer Fv, Goedhart EA, Lenssen AF, Muller-Ploeger SB, Pols MA, Saris DB. Guideline on anterior cruciate ligament injury. Acta Orthop. 2012 Aug; 83 (4):379-86 Epub 2012 Aug 20 View PubMed Vanlauwe J, Huylebroek J, Van Der Bauwhede J, Saris D, Veeckman G, Bobic V, Victor J, Almqvist KF, Verdonk P, Fortems Y, Van Lommel N, Haazen L. Clinical Outcomes of Characterized Chondrocyte Implantation. Cartilage. 2012 Apr; 3 (2):173-80 View PubMed Kroon DJ, Kowalski P, Tekieli W, Reeuwijk E, Saris DBF, Slump CH. MRI based knee cartilage assessment. Proceedings Medical Imaging 2012: Computer-Aided Diagnosis (Event: SPIE Medical Imaging, 2012, San Diego, California, United States). 2012; 8315. Mithoefer K, Peterson L, Saris DB, Mandelbaum BR. Evolution and Current Role of Autologous Chondrocyte Implantation for Treatment of Articular Cartilage Defects in the Football (Soccer) Player. Cartilage. 2012 Jan; 3 (1 Suppl):31S-6S View PubMed Mithoefer K, Peterson L, Saris D, Mandelbaum B, Dvorak J. Special Issue on Articular Cartilage Injury in the Football (Soccer) Player. Cartilage. 2012 Jan; 3 (1 Suppl):4S-5S View PubMed Mandelbaum B, Mithoefer K, Peterson L, Saris D, Dvorak J. Cartilage Issues in Football (Soccer): An Executive Summary of the Federation Internationale de Football Association (FIFA)/ International Cartilage Repair Society (ICRS) Initiative. Cartilage. 2012 Jan; 3 (1 Suppl):6S-10S View PubMed Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP, TIG/ACT/01/2000&EXT Study Group. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med. 2011 Dec; 39 (12):2566-74 Epub 2011 Sept 09 View PubMed Beekhuizen M, Bastiaansen-Jenniskens YM, Koevoet W, Saris DB, Dhert WJ, Creemers LB, van Osch GJ. Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture. Arthritis Rheum. 2011 Jul; 63 (7):1918-27 View PubMed Mithoefer K, Saris DB, Farr J, Kon E, Zaslav K, Cole BJ, Ranstam J, Yao J, Shive M, Levine D, Dalemans W, Brittberg M. Guidelines for the Design and Conduct of Clinical Studies in Knee Articular Cartilage Repair: International Cartilage Repair Society Recommendations Based on Current Scientific Evidence and Standards of Clinical Care. Cartilage. 2011 Apr; 2 (2):100-21 View PubMed Hoemann C, Kandel R, Roberts S, Saris DB, Creemers L, Mainil-Varlet P, Methot S, Hollander AP, Buschmann MD. International Cartilage Repair Society (ICRS) Recommended Guidelines for Histological Endpoints for Cartilage Repair Studies in Animal Models and Clinical Trials. Cartilage. 2011 Apr; 2 (2):153-72 View PubMed Assche DV, Caspel DV, Staes F, Saris DB, Bellemans J, Vanlauwe J, Luyten FP. Implementing one standardized rehabilitation protocol following autologous chondrocyte implantation or microfracture in the knee results in comparable physical therapy management. Physiother Theory Pract. 2011 Feb; 27 (2):125-36 Epub 2010 Aug 08 View PubMed Benders KE, Malda J, Saris DB, Dhert WJ, Steck R, Hutmacher DW, Klein TJ. Formalin fixation affects equilibrium partitioning of an ionic contrast agent-microcomputed tomography (EPIC-muCT) imaging of osteochondral samples. Osteoarthritis Cartilage. 2010 Dec; 18 (12):1586-91 Epub 2010 Oct 13 View PubMed Dijkstra AJ, Anbeek P, Yang KG, Vincken KL, Viergever MA, Castelein RM, Saris DB. Validation of a Novel Semiautomated Segmentation Method for MRI Detection of Cartilage-Related Bone Marrow Lesions. Cartilage. 2010 Oct; 1 (4):328-34 View PubMed Bekkers JE, Creemers LB, Dhert WJ, Saris DB. Diagnostic Modalities for Diseased Articular Cartilage-From Defect to Degeneration: A Review. Cartilage. 2010 Jul; 1 (3):157-64 View PubMed Van Assche D, Staes F, Van Caspel D, Vanlauwe J, Bellemans J, Saris DB, Luyten FP. Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up. Knee Surg Sports Traumatol Arthrosc. 2010 Apr; 18 (4):486-95 Epub 2009 Oct 10 View PubMed Custers RJ, Saris DB, Creemers LB, Verbout AJ, van Rijen MH, Mastbergen SC, Lafeber FP, Dhert WJ. Replacement of the medial tibial plateau by a metallic implant in a goat model. J Orthop Res. 2010 Apr; 28 (4):429-35 View PubMed Custers RJ, Dhert WJ, Saris DB, Verbout AJ, van Rijen MH, Mastbergen SC, Lafeber FP, Creemers LB. Cartilage degeneration in the goat knee caused by treating localized cartilage defects with metal implants. Osteoarthritis Cartilage. 2010 Mar; 18 (3):377-88 Epub 2009 Oct 23 View PubMed Bekkers JE, Tsuchida AI, Malda J, Creemers LB, Castelein RJ, Saris DB, Dhert WJ. Quality of scaffold fixation in a human cadaver knee model. Osteoarthritis Cartilage. 2010 Feb; 18 (2):266-72 Epub 2009 Sept 22 View PubMed Rutgers M, van Pelt MJ, Dhert WJ, Creemers LB, Saris DB. Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage. Osteoarthritis Cartilage. 2010 Jan; 18 (1):12-23 Epub 2009 Sept 02 View PubMed Buckens CF, Saris DB. Reconstruction of the medial patellofemoral ligament for treatment of patellofemoral instability: a systematic review. Am J Sports Med. 2010 Jan; 38 (1):181-8 Epub 2009 Dec 04 View PubMed Rutgers M, Saris DB, Dhert WJ, Creemers LB. Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection. Arthritis Res Ther. 2010; 12 (3):R114 Epub 2010 June 10 View PubMed Bekkers JE, de Windt TS, Raijmakers NJ, Dhert WJ, Saris DB. Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions. Osteoarthritis Cartilage. 2009 Nov; 17 (11):1434-9 Epub 2009 May 07 View PubMed Saris DB, Vanlauwe J, Victor J, Almqvist KF, Verdonk R, Bellemans J, Luyten FP, TIG/ACT/01/2000&EXT Study Group. Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009 Nov; 37 Suppl 1:10S-19S Epub 2009 Oct 21 View PubMed Van Assche D, Van Caspel D, Vanlauwe J, Bellemans J, Saris DB, Luyten FP, Staes F. Physical activity levels after characterized chondrocyte implantation versus microfracture in the knee and the relationship to objective functional outcome with 2-year follow-up. Am J Sports Med. 2009 Nov; 37 Suppl 1:42S-49S Epub 2009 Oct 27 View PubMed de Windt TS, Bekkers JE, Creemers LB, Dhert WJ, Saris DB. Patient profiling in cartilage regeneration: prognostic factors determining success of treatment for cartilage defects. Am J Sports Med. 2009 Nov; 37 Suppl 1:58S-62S View PubMed Bekkers JE, Inklaar M, Saris DB. Treatment selection in articular cartilage lesions of the knee: a systematic review. Am J Sports Med. 2009 Nov; 37 Suppl 1:148S-55S View PubMed van Eijk F, Saris DB, Fedorovich NE, Kruyt MC, Willems WJ, Verbout AJ, Martens AC, Dhert WJ, Creemers L. In vivo matrix production by bone marrow stromal cells seeded on PLGA scaffolds for ligament tissue engineering. Tissue Eng Part A. 2009 Oct; 15 (10):3109-17 View PubMed Rutgers M, Saris DB, Yang KG, Dhert WJ, Creemers LB. Joint injury and osteoarthritis: soluble mediators in the course and treatment of cartilage pathology. Immunotherapy. 2009 May; 1 (3):435-45 View PubMed de Boer TN, Huisman AM, Polak AA, Niehoff AG, van Rinsum AC, Saris D, Bijlsma JW, Lafeber FJ, Mastbergen SC. The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment. Osteoarthritis Cartilage. 2009 Apr; 17 (4):482-8 Epub 2008 Oct 15 View PubMed Custers RJ, Saris DB, Dhert WJ, Verbout AJ, van Rijen MH, Mastbergen SC, Lafeber FP, Creemers LB. Articular cartilage degeneration following the treatment of focal cartilage defects with ceramic metal implants and compared with microfracture. J Bone Joint Surg Am. 2009 Apr; 91 (4):900-10 View PubMed Custers RJ, Creemers LB, van Rijen MH, Verbout AJ, Saris DB, Dhert WJ. Cartilage damage caused by metal implants applied for the treatment of established localized cartilage defects in a rabbit model. J Orthop Res. 2009 Jan; 27 (1):84-90 View PubMed van Eijk F, Saris DB, Creemers LB, Riesle J, Willems WJ, van Blitterswijk CA, Verbout AJ, Dhert WJ. The effect of timing of mechanical stimulation on proliferation and differentiation of goat bone marrow stem cells cultured on braided PLGA scaffolds. Tissue Eng Part A. 2008 Aug; 14 (8):1425-33 View PubMed Auw Yang KG, Raijmakers NJ, van Arkel ER, Caron JJ, Rijk PC, Willems WJ, Zijl JA, Verbout AJ, Dhert WJ, Saris DB. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis Cartilage. 2008 Apr; 16 (4):498-505 Epub 2007 Sept 06 View PubMed Marijnissen AC, Vincken KL, Vos PA, Saris DB, Viergever MA, Bijlsma JW, Bartels LW, Lafeber FP. Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail. Osteoarthritis Cartilage. 2008 Feb; 16 (2):234-43 Epub 2007 Aug 10 View PubMed Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F, Lagae K, van der Bauwhede J, Vandenneucker H, Yang KG, Jelic M, Verdonk R, Veulemans N, Bellemans J, Luyten FP. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008 Feb; 36 (2):235-46 View PubMed van Dijck RA, Saris DB, Willems JW, Fievez AW. Additional surgery after anterior cruciate ligament reconstruction: can we improve technical aspects of the initial procedure? Arthroscopy. 2008 Jan; 24 (1):88-95 Epub 2007 Nov 05 View PubMed van den Borne MP, Raijmakers NJ, Vanlauwe J, Victor J, de Jong SN, Bellemans J, Saris DB, International Cartilage Repair Society. International Cartilage Repair Society (ICRS) and Oswestry macroscopic cartilage evaluation scores validated for use in Autologous Chondrocyte Implantation (ACI) and microfracture. Osteoarthritis Cartilage. 2007 Dec; 15 (12):1397-402 Epub 2007 July 02 View PubMed Custers RJ, Creemers LB, Verbout AJ, van Rijen MH, Dhert WJ, Saris DB. Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System. Osteoarthritis Cartilage. 2007 Nov; 15 (11):1241-8 Epub 2007 June 18 View PubMed Custers RJ, Dhert WJ, van Rijen MH, Verbout AJ, Creemers LB, Saris DB. Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects. Osteoarthritis Cartilage. 2007 Aug; 15 (8):937-45 Epub 2007 Mar 21 View PubMed Jenner JM, van Eijk F, Saris DB, Willems WJ, Dhert WJ, Creemers LB. Effect of transforming growth factor-beta and growth differentiation factor-5 on proliferation and matrix production by human bone marrow stromal cells cultured on braided poly lactic-co-glycolic acid scaffolds for ligament tissue engineering. Tissue Eng. 2007 Jul; 13 (7):1573-82 View PubMed de Jong SN, van Caspel DR, van Haeff MJ, Saris DB. Functional assessment and muscle strength before and after reconstruction of chronic anterior cruciate ligament lesions. Arthroscopy. 2007 Jan; 23 (1):21-8, 28.e1-3 View PubMed Yang KG, Raijmakers NJ, Verbout AJ, Dhert WJ, Saris DB. Validation of the short-form WOMAC function scale for the evaluation of osteoarthritis of the knee. J Bone Joint Surg Br. 2007 Jan; 89 (1):50-6 View PubMed van Oostveen DP, Schild FJ, van Haeff MJ, Saris DB. Suture anchors are superior to transglenoid sutures in arthroscopic shoulder stabilization. Arthroscopy. 2006 Dec; 22 (12):1290-7 View PubMed Yang KG, Saris DB, Verbout AJ, Creemers LB, Dhert WJ. The effect of synovial fluid from injured knee joints on in vitro chondrogenesis. Tissue Eng. 2006 Oct; 12 (10):2957-64 View PubMed Yang KG, Saris DB, Geuze RE, Helm YJ, Rijen MH, Verbout AJ, Dhert WJ, Creemers LB. Impact of expansion and redifferentiation conditions on chondrogenic capacity of cultured chondrocytes. Tissue Eng. 2006 Sep; 12 (9):2435-47 View PubMed Yang KG, Saris DB, Geuze RE, van Rijen MH, van der Helm YJ, Verbout AJ, Creemers LB, Dhert WJ. Altered in vitro chondrogenic properties of chondrocytes harvested from unaffected cartilage in osteoarthritic joints. Osteoarthritis Cartilage. 2006 Jun; 14 (6):561-70 View PubMed Schep NW, Stavenuiter MH, Diekerhof CH, Martens EP, van Haeff CM, Broeders IA, Saris DB. Intersurgeon variance in computer-assisted planning of anterior cruciate ligament reconstruction. Arthroscopy. 2005 Aug; 21 (8):942-7 View PubMed Van Eijk F, Saris DB, Riesle J, Willems WJ, Van Blitterswijk CA, Verbout AJ, Dhert WJ. Tissue engineering of ligaments: a comparison of bone marrow stromal cells, anterior cruciate ligament, and skin fibroblasts as cell source. Tissue Eng. 2004 May-Jun; 10 (5-6):893-903 View PubMed Reinholz GG, Lu L, Saris DB, Yaszemski MJ, O'Driscoll SW. Animal models for cartilage reconstruction. Biomaterials. 2004 Apr; 25 (9):1511-21 View PubMed Auw Yang KG, Saris, Dhert, Verbout AJ. Osteoarthritis of the Knee: Current treatment options and future directions. Current Orthopaedics. 2004; 18:311-320. Saris DB, Dhert WJ, Verbout AJ. Joint homeostasis. The discrepancy between old and fresh defects in cartilage repair. J Bone Joint Surg Br. 2003 Sep; 85 (7):1067-76 View PubMed Moojen DJ, Saris DB, Auw Yang KG, Dhert WJ, Verbout AJ. The correlation and reproducibility of histological scoring systems in cartilage repair. Tissue Eng. 2002 Aug; 8 (4):627-34 View PubMed Mukherjee N, Saris DB, Schultz FM, Berglund LJ, An KN, O' Driscoll SW. The enhancement of periosteal chondrogenesis in organ culture by dynamic fluid pressure. J Orthop Res. 2001 Jul; 19 (4):524-30 View PubMed O'Driscoll SW, Saris DB, Ito Y, Fitzimmons JS. The chondrogenic potential of periosteum decreases with age. J Orthop Res. 2001 Jan; 19 (1):95-103 View PubMed Saris DB, Mukherjee N, Berglund LJ, Schultz FM, An KN, O'Driscoll SW. Dynamic pressure transmission through agarose gels. Tissue Eng. 2000 Oct; 6(5):531-7. View PubMed Sanyal A, Sarkar G, Saris DB, Fitzsimmons JS, Bolander ME, O'Driscoll SW. Initial evidence for the involvement of bone morphogenetic protein-2 early during periosteal chondrogenesis. J Orthop Res. 1999 Nov; 17(6):926-34. View PubMed Saris DB, Sanyal A, An KN, Fitzsimmons JS, O'Driscoll SW. Periosteum responds to dynamic fluid pressure by proliferating in vitro. J Orthop Res. 1999 Sep; 17(5):668-77. View PubMed Schroder J, Saris D, Besselaar PP, Marti RK. Comparison of the results of the Girdlestone pseudarthrosis with reimplantation of a total hip replacement. Int Orthop. 1998; 22 (4):215-8 View PubMed Saris DB, van Rinsum AC, Dhert WJ, Roosendaal G, Mali WP. Periarticular aneurysm formation in haemophilia. Lancet. 1997 Mar 15; 349 (9054):766-8 View PubMed PST-20421024 Home Publications