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Jonathan A. Leighton, M.D.

  1. Gastroenterologist
  2. Internist
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Publications

  1. Leighton JA, Oxentenko AS, Maida M, Ramai D, Mori Y, Dinis-Ribeiro M, Facciorusso A, Hassan C, and the AI-CORE (Artificial Intelligence COlorectal cancer Research) Working Group. The role of generative language systems in increasing patient awareness of colon cancer screening. Endoscopy. 2024 Oct 23 [Epub ahead of print]
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  2. Tuck J, Lizaola-Mayo BC, Leighton JA. Deep enteroscopy - what's new and what works best? Curr Opin Gastroenterol. 2024 Sep 1; 40 (5):338-341 Epub 2024 Apr 22
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  3. Bhat S, Lyu R, Agarwal M, Becker M, Bloomfeld R, Bruining DH, Cohen BL, Ivanov M, Leighton JA, Stewart AP, Trocke L, Tse SS, Ungaro RC, Vaughn BP, Regueiro M, Sokn E, Rieder F. Defining the Roles of Inflammatory Bowel Disease Clinical Pharmacists in the United States: A Systematic Review and National RAND/UCLA Consensus. Inflamm Bowel Dis. 2024 Jun 3; 30 (6):950-959
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  4. Sengupta N, Kastenberg DM, Bruining DH, Latorre M, Leighton JA, Brook OR, Wells ML, Guglielmo FF, Naringrekar HV, Gee MS, Soto JA, Park SH, Yoo DC, Ramalingam V, Huete A, Khandelwal A, Gupta A, Allen BC, Anderson MA, Dane BR, Sokhandon F, Grand DJ, Tse JR, Fidler JL. The Role of Imaging for GI Bleeding: ACG and SAR Consensus Recommendations. Radiology. 2024 Mar; 310 (3):e232298
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  5. Sengupta N, Kastenberg DM, Bruining DH, Latorre M, Leighton JA, Brook OR, Wells ML, Guglielmo FF, Naringrekar HV, Gee MS, Soto JA, Park SH, Yoo DC, Ramalingam V, Huete A, Khandelwal A, Gupta A, Allen BC, Anderson MA, Dane BR, Sokhandon F, Grand DJ, Tse JR, Fidler JL. The Role of Imaging for Gastrointestinal Bleeding: Consensus Recommendations From the American College of Gastroenterology and Society of Abdominal Radiology. Am J Gastroenterol. 2024 Mar 1; 119 (3):438-449 Epub 2023 Oct 04
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  6. Pemmasani G, Ashwath A, Aronow WS, Yandrapalli S, Leighton J, John S. Six-month cardiovascular prognostic impact of type 1 And type 2 myocardial infarction in patients hospitalized for gastrointestinal bleeding. Eur J Intern Med. 2023 Oct; 116:51-57 Epub 2023 July 26
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  7. Wang MH, Friton JJ, Raffals LE, Leighton JA, Pasha SF, Picco MF, Monroe K, Nix BD, Newberry RD, Faubion WA. Polygenic risk score predicts risk of primary sclerosing cholangitis in inflammatory bowel disease. BMJ Open Gastroenterol. 2023 Oct; 10 (1)
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  8. Ebner DW, Burger KN, Mahoney DW, Broderick BT, Eckmann JD, Devens ME, Lowrie KL, League JB, Bering J, Kahn A, Rodriguez EA, Prichard DO, Wallace MB, Kane SV, Leighton JA, Buttar NS, Rutten LJF, Gurudu SR, Kisiel JB. Neoplasia Diagnosis After Multi-target Stool DNA Is Enhanced Among Lowest Baseline Detectors. Dig Dis Sci. 2023 Sep; 68 (9):3721-3731 Epub 2023 July 24
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  9. Wang MH, Friton JJ, Rebert N, Monroe K, Nix BD, Fiocchi C, Raffals LE, Leighton JA, Pasha SF, Picco MF, Newberry RD, Achkar JP, Faubion WA. Novel Genetic Risk Variants and Clinical Predictors Associated With Primary Sclerosing Cholangitis in Patients With Ulcerative Colitis. Clin Transl Gastroenterol. 2023 Sep 1; 14 (9):e00615 Epub 2023 Sept 01
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  10. Guerrero Vinsard D, Bruining DH, East JE, Ebner D, Kane SV, Kisiel JB, Leighton JA, Lennon RJ, Loftus EV Jr, Malik T, Picco M, Raffals L, Ramos GP, Santiago P, Coelho-Prabhu N. Interobserver agreement of the modified Paris classification and histology prediction of colorectal lesions in patients with inflammatory bowel disease. Gastrointest Endosc. 2023 Apr; 97 (4):790-798.e2 Epub 2022 Nov 17
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  11. Hunt TL 2nd, West CP, Leighton JA, Mueller PS. Is it Time to Intentionally Improve the Satisfaction of Health Care Employees? Mayo Clin Proc Innov Qual Outcomes. 2023 Apr; 7 (2):140-142 Epub 2023 Mar 17
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  12. Stonnington CM, Jones K, Leighton JA. How to Infuse Joy in Your Practice: Our Journey to Sustainable Well-Being. Am J Gastroenterol. 2022 Nov 1; 117 (11):1723-1727 Epub 2022 June 21
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  13. Leighton JA, Brock AS, Semrad CE, Hass DJ, Guda NM, Barkin JA, Eisen GM. Quality Indicators for Capsule Endoscopy and Deep Enteroscopy. Am J Gastroenterol. 2022 Nov 1; 117 (11):1780-1796 Epub 2022 Sept 26
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  14. Leighton JA, Brock AS, Semrad CE, Hass DJ, Guda NM, Barkin JA, Eisen GM. Quality indicators for capsule endoscopy and deep enteroscopy. Gastrointest Endosc. 2022 Nov; 96 (5):693-711 Epub 2022 Sept 26
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  15. Shome M, Song L, Williams S, Chung Y, Murugan V, Park JG, Faubion W, Pasha SF, Leighton JA, LaBaer J, Qiu J. Serological profiling of Crohn's disease and ulcerative colitis patients reveals anti-microbial antibody signatures. World J Gastroenterol. 2022 Aug 14; 28 (30):4089-4101
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  16. Cohen BL, Fleshner P, Kane SV, Herfarth HH, Palekar N, Farraye FA, Leighton JA, Katz JA, Cohen RD, Gerich ME, Cross RK, Higgins PDR, Tinsley A, Glover S, Siegel CA, Bohl JL, Iskandar H, Ji J, Hu L, Sands BE. Prospective Cohort Study to Investigate the Safety of Preoperative Tumor Necrosis Factor Inhibitor Exposure in Patients With Inflammatory Bowel Disease Undergoing Intra-abdominal Surgery. Gastroenterology. 2022 Jul; 163 (1):204-221 Epub 2022 Apr 10
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  17. Vande Casteele N, Leighton JA, Pasha SF, Cusimano F, Mookhoek A, Hagen CE, Rosty C, Pai RK, Pai RK. Utilizing Deep Learning to Analyze Whole Slide Images of Colonic Biopsies for Associations Between Eosinophil Density and Clinicopathologic Features in Active Ulcerative Colitis. Inflamm Bowel Dis. 2022 Mar 30; 28 (4):539-546
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  18. Uson PLS Jr, Riegert-Johnson D, Boardman L, Kisiel J, Mountjoy L, Patel N, Lizaola-Mayo B, Borad MJ, Ahn D, Sonbol MB, Jones J, Leighton JA, Gurudu S, Singh H, Klint M, Kunze KL, Golafshar MA, Esplin ED, Nussbaum RL, Stewart AK, Bekaii-Saab TS, Jewel Samadder N. Germline Cancer Susceptibility Gene Testing in Unselected Patients With Colorectal Adenocarcinoma: A Multicenter Prospective Study. Clin Gastroenterol Hepatol. 2022 Mar; 20 (3):e508-e528 Epub 2021 Apr 20
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  19. Wang MH, Friton JJ, Raffals LE, Leighton JA, Pasha SF, Picco MF, Monroe K, Nix BD, Newberry RD, Faubion WA. Novel Genetic Variant Predicts Surgical Recurrence Risk in Crohn's Disease Patients. Inflamm Bowel Dis. 2021 Nov 15; 27 (12):1968-1974
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  20. Pai RK, Hartman DJ, Leighton JA, Pasha SF, Rivers CR, Regueiro M, Binion DG, Pai RK. Validated Indices for Histopathologic Activity Predict Development of Colorectal Neoplasia in Ulcerative Colitis. J Crohns Colitis. 2021 Sep 25; 15 (9):1481-1490
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  21. Pemmasani G, Elgendy I, Mamas MA, Leighton JA, Aronow WS, Tremaine WJ. Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome. Inflamm Bowel Dis. 2021 Jun 15; 27 (7):1017-1025
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  22. McCain JD, Pasha SF, Leighton JA. Role of Capsule Endoscopy in Inflammatory Bowel Disease. Gastrointest Endosc Clin N Am. 2021 Apr; 31 (2):345-361 Epub 2021 Feb 16
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  23. Sandborn WJ, Nguyen DD, Beattie DT, Brassil P, Krey W, Woo J, Situ E, Sana R, Sandvik E, Pulido-Rios MT, Bhandari R, Leighton JA, Ganeshappa R, Boyle DL, Abhyankar B, Kleinschek MA, Graham RA, Panes J. Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme. J Crohns Colitis. 2020 Sep 16; 14 (9):1202-1213
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  24. Rajan E, Martinez M, Gorospe E, Al Bawardy B, Dobashi A, Mara KC, Hansel SL, Bruining DH, Murray JA, Leggett CL, Nehra V, Iyer PG, Pasha SF, Leighton JA, Shiff AD, Gurudu SR, Raffals LE, Lavey C, Katzka DA, Chen CH. Prospective multicenter study to evaluate capsule endoscopy competency using a validated assessment tool. Gastrointest Endosc. 2020 May; 91 (5):1140-1145 Epub 2019 Dec 26
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  25. Wang MH, Mousa OY, Friton JJ, Raffals LE, Leighton JA, Pasha SF, Picco MF, Cushing KC, Monroe K, Nix BD, Newberry RD, Faubion WA. Unique Phenotypic Characteristics and Clinical Course in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis: A Multicenter US Experience. Inflamm Bowel Dis. 2020 Apr 11; 26 (5):774-779
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  26. Pasha SF, Pennazio M, Rondonotti E, Wolf D, Buras MR, Albert JG, Cohen SA, Cotter J, D'Haens G, Eliakim R, Rubin DT, Leighton JA. Capsule Retention in Crohn's Disease: A Meta-analysis. Inflamm Bowel Dis. 2020 Jan 1; 26 (1):33-42
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  27. Wang , Mousa OY, Friton JJ, Raffals LE, Leighton JA, Pasha SF, Picco MF, Cushing KC, Monroe K, Nix BD, Newberry RD, Faubion WA. Unique Phenotypic Characteristics and Clinical Course in Patients With Ulcerative Colitis and Primary Inflamm Bowel Dis. 2019.
  28. Wang MH, Friton JJ, Raffals LE, Leighton JA, Pasha SF, Picco MF, Cushing KC, Monroe K, Nix BD, Newberry RD, Faubion WA. Novel Genetic Risk Variants Can Predict Anti-TNF Agent Response in Patients With Inflammatory Bowel Disease. J Crohns Colitis. 2019 Aug 14; 13 (8):1036-1043
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  29. Samadder NJ, Valentine JF, Guthery S, Singh H, Bernstein CN, Leighton JA, Wan Y, Wong J, Boucher K, Pappas L, Rowe K, Burt RW, Curtin K, Smith KR. Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 Aug; 17 (9):1807-1813.e1 Epub 2018 Sept 26
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  30. Kuo JR, Pasha SF, Leighton JA. The Clinician's Guide to Suspected Small Bowel Bleeding. Am J Gastroenterol. 2019 Apr; 114 (4):591-598
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  31. Yi S, Meng F, Xiong F, Bharati S, Leighton JA, Shabana P. Capsule endoscopy with 720-degree imaging and VR Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2019 Feb; 10868:108681K
  32. Yi S, Meng F, Mui P, Xiong F, Leighton JA, Ramirez FC. Augmenting endoscopic instruments with 3D surface imaging Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2019 Feb; 10868:108681J
  33. Melmed GY, Dubinsky MC, Rubin DT, Fleisher M, Pasha SF, Sakuraba A, Tiongco F, Shafran I, Fernandez-Urien I, Rosa B, Papageorgiou NP, Leighton JA. Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel: a prospective study. Gastrointest Endosc. 2018 Dec; 88 (6):947-955.e2 Epub 2018 Aug 04
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  34. Adike A, Buras MR, Gurudu SR, Leighton JA, Faigel DO, Ruff KC, Umar SB, Ramirez FC. Is the level of cleanliness using segmental Boston bowel preparation scale associated with a higher adenoma detection rate? Ann Gastroenterol. 2018 Mar-Apr; 31 (2):217-223 Epub 2018 Jan 31
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  35. Gurudu SR, Boroff ES, Crowell MD, Atia M, Umar SB, Leighton JA, Faigel DO, Ramirez FC. Impact of feedback on adenoma detection rates: Outcomes of quality improvement program. J Gastroenterol Hepatol. 2018 Mar; 33 (3):645-649
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  36. Yang M, Leighton JA, Faigel DO, Katariya NN. Duodenal gangliocytic paraganglioma: Endoscopy, sonography and F-18 FDG PET/CT imaging. Dig Liver Dis. 2017 Oct; 49 (10):1162 Epub 2017 May 18
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  37. Franco DL, Leighton JA, Gurudu SR. Approach to Incomplete Colonoscopy: New Techniques and Technologies. Gastroenterol Hepatol (N Y). 2017 Aug; 13 (8):476-483
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  38. Wang H, Demirkan G, Bian X, Wallstrom G, Barker K, Karthikeyan K, Tang Y, Pasha SF, Leighton JA, Qiu J, LaBaer J. Identification of Antibody Against SNRPB, Small Nuclear Ribonucleoprotein-Associated Proteins B and B', as an Autoantibody Marker in Crohn's Disease using an Immunoproteomics Approach. J Crohns Colitis. 2017 Jul 1; 11 (7):848-856
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  39. Pasha SF, Leighton JA. Evidence-Based Guide on Capsule Endoscopy for Small Bowel Bleeding. Gastroenterol Hepatol (N Y). 2017 Feb; 13 (2):88-93
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  40. Leighton JA, Helper DJ, Gralnek IM, Dotan I, Fernandez-Urien I, Lahat A, Malik P, Mullin GE, Rosa B. Comparing diagnostic yield of a novel pan-enteric video capsule endoscope with ileocolonoscopy in patients with active Crohn's disease: a feasibility study. Gastrointest Endosc. 2017 Jan; 85 (1):196-205.e1 Epub 2016 Sept 19
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  41. Leighton JA, Pasha SF. Inflammatory Disorders of the Small Bowel. Gastrointest Endosc Clin N Am. 2017 Jan; 27: (1)63-77.
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  42. Uribe DJ, Mandell EK, Watson A, Martinez JD, Leighton JA, Ghosh S, Rothlin CV. The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. PLoS One. 2017; 12 (7):e0179979 Epub 2017 July 20
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  43. Pasha SF, Leighton JA. Detection of suspected small bowel bleeding: challenges and controversies. Expert Rev Gastroenterol Hepatol. 2016 Nov; 10 (11):1235-1244 Epub 2016 July 07
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  44. Spada C, Pasha SF, Gross SA, Leighton JA, Schnoll-Sussman F, Correale L, Gonzalez Suarez B, Costamagna G, Hassan C. Accuracy of First- and Second-Generation Colon Capsules in Endoscopic Detection of Colorectal Polyps: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2016 Nov; 14 (11):1533-1543.e8 Epub 2016 May 07
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  45. Pasha SF, Leighton JA. The Elusive Bleeder: Tips for Avoiding a Wild Goose Chase. Am J Gastroenterol. 2016 Mar; 111 (3):301-4 Epub 2016 Feb 09
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  46. Villa NA, Pannala R, Pasha SF, Leighton JA. Alternatives to Incomplete Colonoscopy. Curr Gastroenterol Rep. 2015 Nov; 17 (11):43
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  47. Miranda R, Glenn SW, Leighton JA, Pasha SE, Gurudu SR, Teaford HG, Mertz LE, Lee HR, Mamby SA, Johnson MF, Raghu TS. Using Hybrid Change Strategies to Improve the Patient Experience in Outpatient Specialty Care. J Healthc Manag. 2015 Sep-Oct; 60: (5)363-76.
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  48. Gerson LB, Fidler JL, Cave DR, Leighton JA. ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding. Am J Gastroenterol. 2015 Sep; 110 (9):1265-87; quiz 1288 Epub 2015 Aug 25
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  49. Atia MA, Patel NC, Ratuapli SK, Boroff ES, Crowell MD, Gurudu SR, Faigel DO, Leighton JA, Ramirez FC. Nonneoplastic polypectomy during screening colonoscopy: the impact on polyp detection rate, adenoma detection rate, and overall cost. Gastrointest Endosc. 2015 Aug; 82: (2)370-375.e1.
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  50. Rahman A, Ross A, Leighton JA, Schembre D, Gerson L, Lo SK, Waxman I, Dye C, Semrad C. Double-balloon enteroscopy in Crohn's disease: findings and impact on management in a multicenter retrospective study. Gastrointest Endosc. 2015 Jul; 82 (1):102-7 Epub 2015 Apr 01
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  51. Boroff ES, Leighton JA. The role of capsule endoscopy in evaluating both suspected and known Crohn's disease. (Review). Techniques in Gastrointestinal Endoscopy. 2015 Jan; 17(1):5-11.
  52. Rothlin CV, Leighton JA, Ghosh S. Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. Inflamm Bowel Dis. 2014 Aug; 20 (8):1472-80
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  53. Islam RS, Leighton JA, Pasha SF. Evaluation and management of small-bowel tumors in the era of deep enteroscopy. Gastrointest Endosc. 2014 May; 79 (5):732-40 Epub 2013 Dec 21
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  54. Leighton JA, Gralnek IM, Cohen SA, Toth E, Cave DR, Wolf DC, Mullin GE, Ketover SR, Legnani PE, Seidman EG, Crowell MD, Bergwerk AJ, Peled R, Eliakim R. Capsule endoscopy is superior to small-bowel follow-through and equivalent to ileocolonoscopy in suspected Crohn's disease. Clin Gastroenterol Hepatol. 2014 Apr; 12 (4):609-15 Epub 2013 Sept 27
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  55. Ratuapli SK, Gurudu SR, Atia MA, Crowell MD, Umar SB, Harrison ME, Leighton JA, Ramirez FC. Postcolonoscopy Followup Recommendations: Comparison with and without Use of Polyp Pathology. Diagn Ther Endosc. 2014; 2014:683491 Epub 2014 Aug 27
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  56. Leighton JA. Advances in capsule endoscopy in the diagnosis of Crohn's disease. Gastroenterol. Hepatol. 2014; 10(5):319-21.
  57. Yi S, Jiao H, Meng F, Leighton JA, Shabana P, Rentz L. GISentinel: A software platform for automatic ulcer detection on capsule endoscopy videos. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2014; 9035:90352Y.
  58. Poh TW, Madsen CS, Gorman JE, Marler RJ, Leighton JA, Cohen PA, Gendler SJ. Downregulation of hematopoietic MUC1 during experimental colitis increases tumor-promoting myeloid-derived suppressor cells. Clin Cancer Res. 2013 Sep 15; 19 (18):5039-52 Epub 2013 July 19
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  59. Picco MF, Pasha S, Leighton JA, Bruining D, Loftus EV Jr, Thomas CS, Crook JE, Krishna M, Wallace M. Procedure time and the determination of polypoid abnormalities with experience: implementation of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis. Inflamm Bowel Dis. 2013 Aug; 19 (9):1913-20
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  60. Choi EH, Mergener K, Semrad C, Fisher L, Cave DR, Dodig M, Burke C, Leighton JA, Kastenberg D, Simpson P, Sul J, Bhattacharya K, Charles R, Gerson L, Weber L, Eisen G, Reidel W, Vargo JJ, Wakim-Fleming J, Lo SK. A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope. Gastrointest Endosc. 2013 Aug; 78(2):325-32. Epub 2013 May 07.
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  61. Boroff ES, Gurudu SR, Hentz JG, Leighton JA, Ramirez FC. Polyp and adenoma detection rates in the proximal and distal colon. Am J Gastroenterol. 2013 Jun; 108 (6):993-9 Epub 2013 Apr 09
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  62. Dzeletovic I, Harrison ME, Crowell MD, Ramirez FC, Yows CR, Harris LA, Pasha SF, Gurudu SR, Leighton JA, Heigh RI. Impact of fentanyl in lieu of meperidine on endoscopy unit efficiency: a prospective comparative study in patients undergoing EGD. Gastrointest Endosc. 2013 Jun; 77(6):883-7. Epub 2013 Mar 06.
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  63. CarreraSilva E, Chan P, Joannas L, Errasti A, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton J, Lemke G, Ghosh S, Rothlin C. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013; 39(1):160-70.
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  64. Yi S, Xie J, Mui P, Leighton JA. Achieving real-time capsule endoscopy (CE) video visualization through panoramic imaging. Proceedings of SPIE - The International Society for Optical Engineering. 2013; 8656:86560I.
  65. Harris LA, Hansel SL, Rajan E, Srivathsan K, Rea R, Crowell MD, Fleischer DE, Pasha SF, Gurudu SR, Heigh RI, Shiff AD, Post JK, Leighton JA. Capsule Endoscopy in Patients with Implantable Electromedical Devices is Safe. Gastroenterol Res Pract. 2013; 2013:959234 Epub 2013 Apr 03
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  66. Yi S, Jiao H, Xie J, Mui P, Leighton JA, Pasha S, Rentz L, Abedi M. A clinically viable Capsule Endoscopy video analysis platform for automatic bleeding detection. Proceedings of SPIE - The International Society for Optical Engineering. 2013; 8670:867028.
  67. Pasha SF, Leighton JA. Endoscopic techniques for small bowel imaging. Radiol Clin North Am. 2013 Jan; 51 (1):177-87
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  68. Kane S, Leighton J, Kefalas C, Cohen L, Katz P, Rizk M, Pike I, Lashner B, Ho I, Pochapin M, Seabrook M, Greenwald D, Demarco D, Johnson D. Quality commitment: the newly established American College of Gastroenterology Quality Council to meet the needs of clinical gastroenterology. Am J Gastroenterol. 2013 Jan; 108(1):7-9.
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  69. Dzeletovic I, Harrison ME, Pasha SF, Crowell MD, Decker GA, Gurudu SR, Leighton JA. Comparison of single- versus double-balloon assisted-colonoscopy for colon examination after previous incomplete standard colonoscopy. Dig Dis Sci. 2012 Oct; 57 (10):2680-6 Epub 2012 May 22
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  70. Gurudu SR, Ramirez FC, Harrison ME, Leighton JA, Crowell MD. Increased adenoma detection rate with system-wide implementation of a split-dose preparation for colonoscopy. Gastrointest Endosc. 2012 Sep; 76 (3):603-8.e1 Epub 2012 June 23
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  71. Vikram HR, Smilack JD, Leighton JA, Crowell MD, De Petris G. Emergence of gastrointestinal basidiobolomycosis in the United States, with a review of worldwide cases. Clin Infect Dis. 2012 Jun; 54 (12):1685-91 Epub 2012 Mar 22
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  72. Pasha SF, Leighton JA, Das A, Harrison ME, Gurudu SR, Ramirez FC, Fleischer DE, Sharma VK. Comparison of the yield and miss rate of narrow band imaging and white light endoscopy in patients undergoing screening or surveillance colonoscopy: a meta-analysis. Am J Gastroenterol. 2012 Mar; 107 (3):363-70; quiz 371 Epub 2011 Dec 20
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  73. Islam RS, Patel NC, Leighton JA. Current place of capsule endoscopy in Crohn's disease. Inflammatory Bowel Disease Monitor. 2012; 12(4):143-8.
  74. Yadav A, Heigh RI, Hara AK, Decker GA, Crowell MD, Gurudu SR, Pasha SF, Fleischer DE, Harris LA, Post J, Leighton JA. Performance of the patency capsule compared with nonenteroclysis radiologic examinations in patients with known or suspected intestinal strictures. Gastrointest Endosc. 2011 Oct; 74 (4):834-9 Epub 2011 Aug 15
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  75. Gurudu SR, Ratuapli SK, Leighton JA, Heigh RI, Crowell MD. Adenoma detection rate is not influenced by the timing of colonoscopy when performed in half-day blocks. Am J Gastroenterol. 2011 Aug; 106(8):1466-71. Epub 2011 Apr 19.
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  76. Leighton JA, Rex DK. A grading scale to evaluate colon cleansing for the PillCam COLON capsule: a reliability study. Endoscopy. 2011 Feb; 43 (2):123-7 Epub 2010 Oct 29
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  77. Leighton JA. The role of endoscopic imaging of the small bowel in clinical practice. Am J Gastroenterol. 2011 Jan; 106(1):27-36; quiz 37. Epub 2010 Oct 26.
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  78. Gurudu SR, Ratuapli S, Heigh R, DiBaise J, Leighton J, Crowell M. Quality of bowel cleansing for afternoon colonoscopy is influenced by time of administration. Am J Gastroenterol. 2010 Nov; 105 (11):2318-22
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  79. Gurudu SR, Heigh RI, De Petris G, Heigh EG, Leighton JA, Pasha SF, Malagon IB, Das A. Sessile serrated adenomas: demographic, endoscopic and pathological characteristics. World J Gastroenterol. 2010 Jul 21; 16 (27):3402-5
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  80. Dionisio PM, Gurudu SR, Leighton JA, Leontiadis GI, Fleischer DE, Hara AK, Heigh RI, Shiff AD, Sharma VK. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn's disease: a meta-analysis. Am J Gastroenterol. 2010 Jun; 105 (6):1240-8; quiz 1249 Epub 2009 Dec 22
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  81. Batheja MJ, Leighton J, Azueta A, Heigh R. The Face of Tropical Sprue in 2010. Case Rep Gastroenterol. 2010 May 19; 4 (2):168-172
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  82. Dzeletovic I, Pasha S, Leighton JA. Human papillomavirus-related rectal squamous cell carcinoma in a patient with ulcerative colitis diagnosed on narrow-band imaging. Clin Gastroenterol Hepatol. 2010 May; 8(5):e47-8. Epub 2009 Oct 29.
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  83. Sandborn WJ, Korzenik J, Lashner B, Leighton JA, Mahadevan U, Marion JF, Safdi M, Sninsky CA, Patel RM, Friedenberg KA, Dunnmon P, Ramsey D, Kane S. Once-daily dosing of delayed-release oral mesalamine (400-mg tablet) is as effective as twice-daily dosing for maintenance of remission of ulcerative colitis. Gastroenterology. 2010 Apr; 138(4):1286-96, 1296.e1-3. Epub 2010 Jan 11.
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  84. Waye JD, Heigh RI, Fleischer DE, Leighton JA, Gurudu S, Aldrich LB, Li J, Ramrakhiani S, Edmundowicz SA, Early DS, Jonnalagadda S, Bresalier RS, Kessler WR, Rex DK. A retrograde-viewing device improves detection of adenomas in the colon: a prospective efficacy evaluation (with videos). Gastrointest Endosc. 2010 Mar; 71(3):551-6. Epub 2009 Dec 16.
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  85. Nguyen VX, Nguyen CC, Leighton JA, Pasha SF, Silva AC, Heppell JP, De Petris G. The Association of Menetrier Disease with Ulcerative Colitis: A Case Report with Implications on the Pathogenesis of Menetrier Disease. Case Rep Gastroenterol. 2010 Feb 19; 4 (1):66-70
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  86. Decker GA, Miller ED, Pasha SF, Harrison ME, Leighton JA. Deep enteroscopy in patients with left ventricular assist devices: practical and technical considerations. Endoscopy. 2010; 42 Suppl 2:E194 Epub 2010 Sept 15
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  87. Gurudu SR, Leighton JA, Dionisio PM, Leontiadis GI, Fleischer DE, Hara AK, Heigh RI, Shiff AD, Sharma VK. Response to Doherty, Moss, and Cheifetz. (PMID: 20818355). Am J Gastroenterol. 2010; 105(9):2111-2.
  88. Leighton JA, Gralnek IM, Richner RE, Lacey MJ, Papatheofanis FJ. Capsule endoscopy in suspected small bowel Crohn's disease: economic impact of disease diagnosis and treatment. World J Gastroenterol. 2009 Dec 7; 15(45):5685-92.
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  89. Pasha SF, Hara AK, Leighton JA. Diagnostic evaluation and management of obscure gastrointestinal bleeding: a changing paradigm. Gastroenterol Hepatol (N Y). 2009 Dec; 5(12):839-50.
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  90. Hara AK, Walker FB, Silva AC, Leighton JA. Preliminary estimate of triphasic CT enterography performance in hemodynamically stable patients with suspected gastrointestinal bleeding. AJR Am J Roentgenol. 2009 Nov; 193: (5)1252-60.
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  91. Gerson LB, Tokar J, Chiorean M, Lo S, Decker GA, Cave D, Bouhaidar D, Mishkin D, Dye C, Haluszka O, Leighton JA, Zfass A, Semrad C. Complications associated with double balloon enteroscopy at nine US centers. Clin Gastroenterol Hepatol. 2009 Nov; 7(11):1177-82, 1182.e1-3. Epub 2009 Sep 16.
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  190. Anderson ML, Pasha TM, Leighton JA. Endoscopic perforation of the colon: lessons from a 10-year study. Am J Gastroenterol. 2000 Dec; 95 (12):3418-22
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  191. Pardi DS, Leighton JA. Pneumatosis intestinalis complicating C. difficile pseudomembranous colitis. Am J Gastroenterol. 2000; 95(4):110-1.
  192. Egan LJ, Sandborn WJ, Tremaine WJ, Leighton JA, Mays DC, Pike MG, Zinsmeister AR, Lipsky JJ. A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis. Aliment Pharmacol Ther. 1999 Dec; 13 (12):1597-604
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  193. Ritland SR, Leighton JA, Hirsch RE, Morrow JD, Weaver AL, Gendler SJ. Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. Clin Cancer Res. 1999 Apr; 5(4):855-63.
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  194. Sandborn WJ, Tremaine WJ, Leighton JA, Lawson GM, Zins BJ, Compton RF, Mays DC, Lipsky JJ, Batts KP, Offord KP, Hurt RD, Green J, Green J. Nicotine tartrate liquid enemas for mildly to moderately active left-sided ulcerative colitis unresponsive to first-line therapy: a pilot study. Aliment Pharmacol Ther. 1997 Aug; 11 (4):663-71
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  195. Abdelmalek MF, Pockaj BA, Leighton JA. Rectal bleeding from a mucous fistula secondary to a Dieulafoy's lesion. J Clin Gastroenterol. 1997 Jun; 24 (4):259-61
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  196. Pasha TM, Leighton JA, Smilack JD, Heppell J, Heppell J, Colby TV, Kaufman L. Basidiobolomycosis: an unusual fungal infection mimicking inflammatory bowel disease. Gastroenterology. 1997 Jan; 112 (1):250-4
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  197. McReynolds SD, Gharagozloo CF, Leighton JA, Dausmann MA, Wesche DE, Pluth JR. Radical resection of malignant thymoma with reconstruction of the mediastinal venous confluence. J Cardiovasc Surg (Torino). 1996 Feb; 37: (1)83-6.
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  198. Leighton JA, Valdovinos MA, Pemberton JH, Rath DM, Camilleri M. Anorectal dysfunction and rectal prolapse in progressive systemic sclerosis. Dis Colon Rectum. 1993 Feb; 36 (2):182-5
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  199. Leighton JA, Bay MK, Maldonado AL, Schenker S, Speeg KV. Colchicine clearance is impaired in alcoholic cirrhosis. Hepatology. 1991; 14:1013-1015.
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  200. Leighton JA, Bay ME, Maldonado AL, Johnson RF, Schenker S, Speeg KV. The effect of liver dysfunction on colchicine pharmacokinetics in the rat. Hepatology. 1990; 11:210-5.
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  201. Watson WA, Leighton JA, Guy J, Bergman R, Garriott JC. Recovery of cyclic antidepressants with gastric lavage. J Emergency Med. 1989; 7:373-377.
  202. Speeg KV, Leighton JA, Maldonado AL. Case report: toxic delirium in a patient taking amantadine and trimethoprim-sulfamethoxazole. Amer J Med Sci. 1989; 296:410-2.
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