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Isa J. Houwink, M.D., Ph.D.

  1. Family Physician
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Publications

  1. Wolthuis DFGJ, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw DJ, van Westrhenen R, Deneer VHM, Houwink EJF. Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between SLCO1B1 and statins and CYP2C9 and sulfonylureas. Eur J Hum Genet. 2024 Dec 15 [Epub ahead of print]
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  2. Beunk L, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw D, Deneer VHM, van Westrhenen R. Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants. Eur J Hum Genet. 2024 Nov; 32 (11):1371-1377 Epub 2024 July 02
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  3. Manson LEN, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw DJ, van Westrhenen R, Deneer VHM, Guchelaar HJ. Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of CYP2C9, HLA-A and HLA-B with anti-epileptic drugs. Eur J Hum Genet. 2024 Aug; 32 (8):903-911 Epub 2024 Apr 03
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  4. Baynam G, Hartman AL, Letinturier MCV, Bolz-Johnson M, Carrion P, Grady AC, Dong X, Dooms M, Dreyer L, Graessner H, Granados A, Groza T, Houwink E, Jamuar SS, Vasquez-Loarte T, Tumiene B, Wiafe SA, Bjornson-Pennell H, Groft S. Global health for rare diseases through primary care. Lancet Glob Health. 2024 Jul; 12 (7):e1192-e1199
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  5. Harteveld K, Houwink E. Hemoglobinopathieën: het identificeren van dragers Nasholing. 2024; 67(1):28-30.
  6. Ferwerda ME, Wright JA, El Melik RM, Swen JJ, Houwink EJ. Pharmacogenetic educational needs and the role of pharmacogenetics in primary care: a focus group study with multiple perspectives. Front Pharmacol. 2024; 15:1404370 Epub 2024 July 23
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  7. Nijenhuis M, Soree B, Jama WOM, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Rongen GA, van Schaik RHN, Swen JJ, Touw D, van der Weide J, van Westrhenen R, Deneer VHM, Risselada A. Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate. Eur J Hum Genet. 2023 Dec; 31 (12):1364-1370 Epub 2022 Dec 12
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  8. Severijns Y, de Vries H, Tan Sindhunata G, Stuurman K, Ottenheim C, Lichtenbelt K, van Kuijk S. Joosten S, Houwink E, Crutzen R, Corsten-Janssen N, Bijlsma E, de Die-ulders C, van Osch L. The Effectiveness of an Online Decision Aid on Reproductive Options for Couples at Risk of Transmitting a Genetic Disease to their Offspring: Protocol for a Randomized Controlled Trial Health Psychology Bulletin. 2023; 7(1):17-26.
  9. Beunk L, Nijenhuis M, Sorre B, de Boer-Veger NJ, Buunk AM, Gushelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, van Schalk RHN, Swen JJ, Touw D, van Wetrhene R, Deneer VHM, van der Weide J. Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics European Society of Human Genetics. 2023.
  10. Tommel J, Kenis D, Lambrechts N, Brohet RM, Swysen J, Mollen L, Hoefmans MF, Pusparum M, Evers AWM, Ertaylan G, Roos M, Hens K, Houwink EJF. Personal Genomes in Practice: Exploring Citizen and Healthcare Professionals' Perspectives on Personalized Genomic Medicine and Personal Health Data Spaces Using a Mixed-Methods Design. Genes (Basel). 2023 Mar 24; 14 (4)
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  11. Hulshof EC, Deenen MJ, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Touw DJ, van der Weide J, van Westrhenen R, Deneer VHM, Guchelaar HJ, Swen JJ. Correction: Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan. Eur J Hum Genet. 2023 Feb 16 [Epub ahead of print]
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  12. Suerink M, Bleiker EMA, Nielsen M, Houwink EJF, Baas JM, Ausems MGEM. Oncogenetics Article for Education and Training Nederlands Tijdschrift voor Geneeskunde (NTVG). 2023.
  13. Middleton HT, Boswell CL, Houwink EJ, Allen-Rhoades WA, Kuhn AK, Wright JA. Vincristine-Induced Acrocyanosis and Erythema Pernio. J Prim Care Community Health. 2023 Jan-Dec; 14:21501319231181879
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  14. Suerink M, Bleiker EMA, Nielsen M, Houwink EJF, Baas JM, Ausems MGEM. [Oncogenetics]. Ned Tijdschr Geneeskd. 2022 Dec 22; 167
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  15. van der Pol KH, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Risselada A, van Schaik RHN, Swen JJ, Touw D, van der Weide J, van Westrhenen R, Deneer VHM, Houwink EJF, Rongen GA. Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate. Eur J Hum Genet. 2022 Sep 2 Epub 2022 Sept 02
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  16. van Vliet ME, Kerkhoffs JH, Harteveld CL, Houwink EJF. Hemoglobinopathy screening in primary care in the Netherlands: exploring the problems and needs of patients and general practitioners. Eur J Hum Genet. 2022 Aug 9 Epub 2022 Aug 09
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  17. Wood GM, van Boom S, Recourt K, Houwink EJF. FHH Quick App Review: How Can a Quality Review Process Assist Primary Care Providers in Choosing a Family Health History App for Patient Care? Genes (Basel). 2022 Aug 8; 13 (8) Epub 2022 Aug 08
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  18. van Vliet ME, Kerkhoffs JH, Harteveld CL, Houwink EJF. Hemoglobinopathy prevention in primary care: a reflection of underdetection and difficulties with accessibility of medical care, a quantitative study. Eur J Hum Genet. 2022 Jul; 30 (7):790-794 Epub 2022 Feb 25
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  19. Houwink EJF. Comment on Future trends in clinical genetic and genomic services by Borle et al. Eur J Hum Genet. 2022 May; 30 (5):505-506 Epub 2022 Feb 08
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  20. Brouwer JMIL, Nijenhuis M, Soree B, Guchelaar HJ, Swen JJ, Van Schaik RHN, Weide JV, Rongen CAPJM, Buunk AM, de Boer-Veger NJ, Houwink EJF, et. al. Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs Eur J Hum Genet. 2021.
  21. Houwink E, Chavennes N, Kramer A. Beschouwing eHealth onderwijs een nieuwe uitdaging voor de huisartsopleiding. Huisarts en Wetenschap Huisarts en wetenschap. 2021; 64:19-22.
  22. Wilden RS, Messersmith DJ, Houwink E. Modernizing Family Health History: Achievable Strategies to Reduce Implementation Gaps Journal of Community Genetics. 2021.
  23. van Westrhenen R, van Schaik RHN, van Gelder T, Birkenhager TK, Bakker PR, Houwink EJF, Bet PM, Hoogendijk WJG, van Weelden-Hulshof MJM. Policy and Practice Review: A First Guideline on the Use of Pharmacogenetics in Clinical Psychiatric Practice. Front Pharmacol. 2021; 12:640032 Epub 2021 Apr 12
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  24. Verhoeven W, Houwink E, de Leeuw N, Egger J. Huisarts Wet. 2021; 64 (11):68-70 Epub 2021 Oct 07
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  25. Boers SN, Jongsma KR, Lucivero F, Aardoom J, Buchner FL, de Vries M, Honkoop P, Houwink E, et. al. SERIES: eHealth in primary care. Part 2: Exploring the ethical implications of its application in primary care practice Eur J Gen Pract.. 2020; 26(1):26-32.
  26. Overkleeft R, Tommel J, Evers AWM, den Dunnen JT, Roos M, Hoefmans MJ, Schrader WE, Swen JJ, Numans ME, Houwink E. Using Personal Genomic Data within Primary Care: A Bioinformatics Approach to Pharmacogenomics . Genes (Basel). 2020; 11(12):e1143.
  27. Houwink E. Leidraad farmacogenetica voor de dagelijkse psychiatrische praktijk Initiatief Nederlandse Vereniging voor Psychiatrie. 2020.
  28. van der Kleij RMII, Kasteleyn MI, Meijer E, Bonten TN, Houwink E. SERIES: eHealth in primary care. Part 1: Concepts, conditions and challenges The European Journal of General Practice. 2019; 25(4):179-189.
  29. Houwink, Hortensius OR, van K, Sollie A, Numans ME. Genetics in primary care: validating a tool to pre-symptomatically assess common disease risk using an Australian questionnaire on family history Clin Transl Med. 2019; 8(1):17.
  30. Houwink E. NHG-Standpunt Farmacogenetisch onderzoek in de huisartsenpraktijk de huisartsenpraktijk. 2019.
  31. Swen JJ, Nijenhuis M, van Rhenen M, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GA, van Schaik RHN, van der Weide J, Wilffert B, Deneer VHM, Guchelaar HJ, Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Pharmacists Association (KNMP). Pharmacogenetic Information in Clinical Guidelines: The European Perspective. Clin Pharmacol Ther. 2018 May; 103 (5):795-801 Epub 2018 Mar 30
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  32. Jansen ME, Rigter R, Rodenburg W, Fleur, Houwink E, et al. Review of the reported measures of clinical validity and clinical utility as arguments for the implementation of pharmacogenetic testing: A case study of statin-induced muscle toxicity Frontiers in Pharmacology, section Pharmacogenetics and Pharmacogenomics. 2017.
  33. Houwink E. Book - Clinical Genetics in Oncology Huisarts en Genetica. 2017.
  34. Paneque M, Turchetti D, Jakcson L, Lunt P, Houwink E, Skirton H. A systematic review of interventions to provide genetics education for primary care BMC Family Practice. 2016; 22(17):89.
  35. van Schaik RHN, Houwink E, van Gelder T. Farmacogenetische testen op CYP450-enzymen Clinical Genetics. 2016; 160:A9404Q.
  36. Houwink E, Rigter T, Swen JJ, Cornel MC, Kienhuis A, Rodenburg W, Weda M. Farmacogenetica in de eerstelijnszorg, toepassing en toekomstverwachtingen Farmacogenetica in de eerstelijnszorg, toepassing en toekomstverwachtingen. 2015; 159:A9204.
  37. Swen JJ, Houwink E. Pharmacogenetics in primary care: Application and future expectations NTVG. 2015.
  38. Houwink E. Effect of a comprehensive oncogenetics training intervention for primary care physicians on multiple performance levels PlosOne. 2015; 10(4):e0122648.
  39. Houwink E, Van Teeffelen SR, Muijtjens AMM, Henneman L, Jacobi F, van Luijk SJ, Dinant GI, van der Vleuten C, Cornel MC. Sustained educational effect after online training in oncogenetics: A Randomized Controlled Trial European Journal of Human Genetics. 2014; 22(3):310-316.
  40. Cornel MC, Houwink E, Houwink PEF. Geef voorlichting over bloedverwantschap als risicofactor voor aangeboren afwijkingen. Ned Tijdschr Geneeskd Nederlands Tijdschrift Voor Geneeskunde. 2014; 158:A6766.
  41. HOuwink E, et al. Effectiviteit van nascholing over (onco)genetica voor eerstelijns zorgverlener Huisarts en Wetenschap, jaargang. 2014; 6:294-297.
  42. Houwink E, van der Vleuten C, Cornel MC. Effectiveness of oncogenetics training on general practitioners' consultation skills: a randomized controlled trial Genet Med. 2013.
  43. HOuwink E. Training in genetics and genomics for primary health care workers Vrije Universitteit Amsterdam. 2013.
  44. Houwink EJ, Sollie AW, Numans ME, Cornel MC. Proposed roadmap to stepwise integration of genetics in family medicine and clinical research. Clin Transl Med. 2013 Feb 16; 2 (1):5
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  45. Houwink E, van der Vleuten C. Prioritization of future genetics education for general practitioners: a Delphi study Genetics in Medicine. 2012; 14(3):323-329.
  46. Houwink E, van Luijk SJ, Henneman L, et al. Genetic educational needs and role of genetics in primary care:a focus group study with multiple perspectives BMC Family Practice. 2011; 17(12):5.
  47. Kuijper EA, Houwink EJ, van Weissenbruch MM, Heij HA, Blankenstein MA, Huijser J, Martens F, Lambalk CB. Urinary gonadotropin measurements in neonates: a valuable non-invasive method. Ann Clin Biochem. 2006 Jul; 43 (Pt 4):320-2
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  48. Schanen C, Houwink EJ, Dorrani N, Lane J, Everett R, Feng A, Cantor RM, Percy A. Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome. Am J Med Genet A. 2004 Apr 15; 126A (2):129-40
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  49. Leonard H, Silberstein J, Falk R, Houwink-Manville I, Ellaway C, Raffaele LS, Engerstrom IW, Schanen C. Occurrence of Rett syndrome in boys. J Child Neurol. 2001 May; 16 (5):333-8
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  50. Dragich J, Houwink-Manville I, Schanen C. Rett syndrome: a surprising result of mutation in MECP2. Hum Mol Genet. 2000 Oct; 9 (16):2365-75
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  51. Wan M, Lee SS, Zhang X, Houwink-Manville I, Song HR, Amir RE, Budden S, Naidu S, Pereira JL, Lo IF, Zoghbi HY, Schanen NC, Francke U. Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots. Am J Hum Genet. 1999 Dec; 65 (6):1520-9
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