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Robert L. Frye, M.D.

  1. Cardiologist
  2. Internist
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Publications

  1. Karadzha A, Schaff HV, Frye RL, Bois MC, Crestanello JA, Bagameri G, Greason KL, Shrestha ML. Post-mortem examination of fatal acute type A aortic dissection: what does it teach us? Eur J Cardiothorac Surg. 2024 Jan 2; 65 (1)
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  2. Zhao TV, Hu Z, Ohtsuki S, Jin K, Wu B, Berry GJ, Frye RL, Goronzy JJ, Weyand CM. Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease. Nat Cardiovasc Res. 2022 Jul; 1 (7):634-648 Epub 2022 July 13
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  3. Patlolla SH, Schaff HV, Greason KL, Pochettino A, Daly RC, Frye RL, Nishimura RA, Dearani JA. Early Right Ventricular Reverse Remodeling Predicts Survival After Isolated Tricuspid Valve Surgery. Ann Thorac Surg. 2021 Nov; 112 (5):1402-1409 Epub 2021 Mar 09
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  4. Anand V, Bradley D, Frye RL, Borlaug BA. Things Are Not Always as They Seem: Multimodality Exercise Assessment in the Evaluation of Dyspnea. Circulation. 2021 Jun 22; 143 (25):2502-2507 Epub 2021 June 21
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  5. Farkouh ME, Godoy LC, Brooks MM, Mancini GBJ, Vlachos H, Bittner VA, Chaitman BR, Siami FS, Hartigan PM, Frye RL, Boden WE, Fuster V. Influence of LDL-Cholesterol Lowering on Cardiovascular Outcomes in Patients With Diabetes Mellitus Undergoing Coronary Revascularization. J Am Coll Cardiol. 2020 Nov 10; 76 (19):2197-2207
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  6. Gerber Y, Gibbons RJ, Weston SA, Fabbri M, Herrmann J, Manemann SM, Frye RL, Asleh R, Greason K, Killian JM, Roger VL. Coronary Disease Surveillance in the Community: Angiography and Revascularization. J Am Heart Assoc. 2020 Apr 7; 9 (7):e015231 Epub 2020 Apr 02
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  7. Cui H, Schaff HV, Abel MD, Helder MRK, Frye RL, Ommen SR, Nishimura RA. Left ventricular ejection hemodynamics before and after relief of outflow tract obstruction in patients with hypertrophic obstructive cardiomyopathy and valvular aortic stenosis. J Thorac Cardiovasc Surg. 2020 Mar; 159 (3):844-852.e1 Epub 2019 Apr 04
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  8. Genuth SM, Vlachos H, Brooks MM, Bantle JP, Chaitman BR, Green J, Kelsey SF, King SB 3rd, McBane R, Sako EY, Schneider DJ, Steffes M, Frye RL, BARI 2D Study Group. BARI 2D: A Reanalysis Focusing on Cardiovascular Events. Mayo Clin Proc. 2019 Nov; 94 (11):2249-2262 Epub 2019 Oct 04
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  9. Locker C, Greiten LE, Bell MR, Frye RL, Lerman A, Daly RC, Greason KL, Said SM, Lahr BD, Stulak JM, Dearani JA, Schaff HV. Repeat Coronary Bypass Surgery or Percutaneous Coronary Intervention After Previous Surgical Revascularization. Mayo Clin Proc. 2019 Sep; 94 (9):1743-1752
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  10. Ward RC, Prasad M, Frye RL. 71-Year-Old Man Presenting With Postoperative Chest Tightness. Mayo Clin Proc. 2019 May; 94 (5):887-891 Epub 2019 Apr 04
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  11. Frye RL. Dr Shahbudin H. Rahimtoola. Eur Heart J. 2019 Mar 14; 40 (11):865
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  12. Farkouh ME, Sidhu MS, Brooks MM, Vlachos H, Boden WE, Frye RL, Hartigan P, Siami FS, Bittner VA, Chaitman BR, Mancini GBJ, Fuster V. Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes. J Am Coll Cardiol. 2019 Feb 5; 73 (4):400-411
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  13. Conover CA, Bale LK, Frye RL, Schaff HV. Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes. Physiol Rep. 2019 Feb; 7 (4):e14006
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  14. Rezende PC, Everett BM, Brooks MM, Vlachos H, Orchard TJ, Frye RL, Bhatt DL, Hlatky MA. Hypoglycemia and Elevated Troponin in Patients With Diabetes and Coronary Artery Disease. J Am Coll Cardiol. 2018 Oct 9; 72 (15):1778-1786
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  15. Mancini GBJ, Boden WE, Brooks MM, Vlachos H, Chaitman BR, Frye R, Bittner V, Hartigan PM, Dagenais GR. Impact of treatment strategies on outcomes in patients with stable coronary artery disease and type 2 diabetes mellitus according to presenting angina severity: A pooled analysis of three federally-funded randomized trials. Atherosclerosis. 2018 Oct; 277:186-194 Epub 2018 June 01
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  16. Locker C, Schaff HV, Daly RC, Bell MR, Frye RL, Stulak JM, Said SM, Dearani JA, Joyce LD, Greason KL, Pochettino A, Li Z, Lennon RJ, Lerman A. Multiarterial grafts improve the rate of early major adverse cardiac and cerebrovascular events in patients undergoing coronary revascularization: analysis of 12 615 patients with multivessel disease. Eur J Cardiothorac Surg. 2017 Oct 1; 52 (4):746-752
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  17. Jouni H, Aubry MC, Lacy MQ, Vincent Rajkumar S, Kumar SK, Frye RL, Herrmann J. Ixazomib cardiotoxicity: A possible class effect of proteasome inhibitors. Am J Hematol. 2017 Feb; 92 (2):220-221
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  18. Ikeno F, Brooks MM, Nakagawa K, Kim MK, Kaneda H, Mitsutake Y, Vlachos HA, Schwartz L, Frye RL, Kelsey SF, Waseda K, Hlatky MA, BARI-2D Study Group. SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial. J Am Coll Cardiol. 2017 Jan 31; 69 (4):395-403
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  19. Mancini GB, Farkouh ME, Brooks MM, Chaitman BR, Boden WE, Vlachos H, Hartigan PM, Siami FS, Sidhu MS, Bittner V, Frye R, Fuster V. Medical Treatment and Revascularization Options in Patients With Type 2 Diabetes and Coronary Disease. J Am Coll Cardiol. 2016 Sep 6; 68 (10):985-95
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  20. Locker C, Schaff HV, Daly RC, Dearani JA, Bell MR, Frye RL, Greason KL, Stulak JM, Joyce LD, Pochettino A, Li Z, Lennon RJ, Lerman A. Multiple arterial grafts improve survival with coronary artery bypass graft surgery versus conventional coronary artery bypass grafting compared with percutaneous coronary interventions. J Thorac Cardiovasc Surg. 2016 Aug; 152 (2):369-379.e4 Epub 2016 Apr 13
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  21. Wolk R, Bertolet M, Singh P, Brooks MM, Pratley RE, Frye RL, Mooradian AD, Rutter MK, Calvin AD, Chaitman BR, Somers VK, BARI 2D Study Group. Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox. Mayo Clin Proc. 2016 Jul; 91 (7):858-66 Epub 2016 June 09
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  22. Mahmoud KD, Sanon S, Habermann EB, Lennon RJ, Thomsen KM, Wood DL, Zijlstra F, Frye RL, Holmes DR Jr. Perioperative Cardiovascular Risk of Prior Coronary Stent Implantation Among Patients Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Mar 8; 67 (9):1038-1049
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  23. Singh A, Schaff HV, Mori Brooks M, Hlatky MA, Wisniewski SR, Frye RL, Sako EY, BARI 2D Study Group. On-pump versus off-pump coronary artery bypass graft surgery among patients with type 2 diabetes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. Eur J Cardiothorac Surg. 2016 Feb; 49 (2):406-16 Epub 2015 May 11
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  24. Wolk R, Bertolet M, Brooks MM, Pratley RE, Sobel BE, Frye RL, Singh P, Calvin AD, Rutter MK, Mooradian AD, Somers VK, BARI 2D study group. Differential effects of insulin sensitization and insulin provision treatment strategies on concentrations of circulating adipokines in patients with diabetes and coronary artery disease in the BARI 2D trial. Eur J Prev Cardiol. 2016 Jan; 23 (1):50-8 Epub 2014 July 29
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  25. Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL, BARI 2D Study Group. Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. N Engl J Med. 2015 Aug 13; 373 (7):610-20
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  26. Thalji NM, Suri RM, Daly RC, Greason KL, Dearani JA, Stulak JM, Joyce LD, Burkhart HM, Pochettino A, Li Z, Frye RL, Schaff HV. The prognostic impact of concomitant coronary artery bypass grafting during aortic valve surgery: implications for revascularization in the transcatheter era. J Thorac Cardiovasc Surg. 2015 Feb; 149(2):451-60. Epub 2014 Sep 17
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  27. Frye RL. Response: A lifelong challenge: Conflict resolution. J Am Coll Cardiol. 2015; 65(1):100.
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  28. Sako EY, Brooks MM, Hardison RM, Schaff H, Frye RL. Coronary artery bypass in patients with type 2 diabetes: experience from the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. J Thorac Cardiovasc Surg. 2014 Oct; 148 (4):1268-72 Epub 2014 Jan 02
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  29. Eleid MF, Bjarnason H, Frye RL, Nishimura RA. Exercise right heart catheterization for inferior vena cava obstruction: confirming the hemodynamic significance of an anatomic lesion. Catheter Cardiovasc Interv. 2014 Jan 01; 83: (1)E105-8.
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  30. Thalji NM, Suri RM, Daly RC, Dearani JA, Burkhart HM, Park SJ, Greason KL, Joyce LD, Stulak JM, Huebner M, Li Z, Frye RL, Schaff HV. Assessment of coronary artery disease risk in 5463 patients undergoing cardiac surgery: when is preoperative coronary angiography necessary? J Thorac Cardiovasc Surg. 2013 Nov; 146 (5):1055-1063, 1064.e1; discussion 1 Epub 2013 Sept 04
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  31. Schneider DJ, Avera ES, Bergmann SR, Braunwald E, Collen D, Frye R, Jaffe A, Kirk RJ, Ludbrook PA, Roberts R, Spector P, Vlasuk GP, Willerson JT. In memoriam: Burton E. Sobel a tribute from family, friends and colleagues October 21, 1937 - May 3, 2013. Exp Biol Med (Maywood). 2013 Oct; 238(10):1101-15.
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  32. Bach RG, Brooks MM, Lombardero M, Genuth S, Donner TW, Garber A, Kennedy L, Monrad ES, Pop-Busui R, Kelsey SF, Frye RL, BARI 2D Investigators. Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2013 Aug 20; 128(8):785-94. Epub 2013 Jul 15.
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  33. Farkouh ME, Boden WE, Bittner V, Muratov V, Hartigan P, Ogdie M, Bertolet M, Mathewkutty S, Teo K, Maron DJ, Sethi SS, Domanski M, Frye RL, Fuster V. Risk factor control for coronary artery disease secondary prevention in large randomized trials. J Am Coll Cardiol. 2013 Apr 16; 61(15):1607-15.
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  34. Dagenais GR, Lu J, Faxon DP, Bogaty P, Adler D, Fuentes F, Escobedo J, Krishnaswami A, Slater J, Frye RL, BARI 2D Study Group. Prognostic impact of the presence and absence of angina on mortality and cardiovascular outcomes in patients with type 2 diabetes and stable coronary artery disease: results from the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. J Am Coll Cardiol. 2013 Feb 19; 61(7):702-11.
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  35. Singh M, Holmes DR Jr, Gersh BJ, Frye RL, Lennon RJ, Rihal CS. Thirty-year trends in outcomes of percutaneous coronary interventions in diabetic patients. Mayo Clin Proc. 2013 Jan; 88(1):22-30.
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  36. Brooks MM, Chaitman BR, Nesto RW, Hardison RM, Feit F, Gersh BJ, Krone RJ, Sako EY, Rogers WJ, Garber AJ, King SB 3rd, Davidson CJ, Ikeno F, Frye RL, BARI 2D Study Group. Clinical and angiographic risk stratification and differential impact on treatment outcomes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2012 Oct 23; 126(17):2115-24. Epub 2012 Sep 24.
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  37. Probstfield JL, Frye RL. Strategies for recruitment and retention of participants in clinical trials. JAMA. 2011 Oct 26; 306(16):1798-9.
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  38. Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG, BARI 2D Study Group. Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial. Circulation. 2011 Sep 27; 124(13):1426-34. Epub 2011 Sep 12.
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  39. Sobel BE, Hardison RM, Genuth S, Brooks MM, McBane RD 3rd, Schneider DJ, Pratley RE, Huber K, Wolk R, Krishnaswami A, Frye RL, BARI 2D Investigators. Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2011 Aug 9; 124(6):695-703. Epub 2011 Jul 18.
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  40. Dagenais GR, Lu J, Faxon DP, Kent K, Lago RM, Lezama C, Hueb W, Weiss M, Slater J, Frye RL, Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group. Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease. Circulation. 2011 Apr 12; 123(14):1492-500. Epub 2011 Mar 28.
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  41. Gard JJ, Bader W, Enriquez-Sarano M, Frye RL, Michelena HI. Uncommon cause of ST elevation. Circulation. 2011 Mar 8; 123(9):e259-61.
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  42. Brooks MM, Boden WE, Frye RL. Clinical implications of the BARI 2D and COURAGE trials: overview. Coron Artery Dis. 2010 Nov; 21(7):383-5.
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  43. Srinivasan M, Irving BA, Frye RL, O'Brien P, Hartman SJ, McConnell JP, Nair KS. Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men. J Clin Endocrinol Metab. 2010 Apr; 95 (4):1617-25 Epub 2010 Feb 05
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  44. Chaitman BR, Hardison RM, Adler D, Gebhart S, Grogan M, Ocampo S, Sopko G, Ramires JA, Schneider D, Frye RL, Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group. The Bypass Angioplasty Revascularization Investigation 2 Diabetes randomized trial of different treatment strategies in type 2 diabetes mellitus with stable ischemic heart disease: impact of treatment strategy on cardiac mortality and myocardial infarction. Circulation. 2009 Dec 22; 120(25):2529-40. Epub 2009 Nov 17.
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  45. Frye RL, Simari RD, Gersh BJ, Burnett JC, Brumm S, Myerle K, Jaffe AS, Holmes DR, Lerman A, Terzic A. Ethical issues in cardiovascular research involving humans. Circulation. 2009 Nov 24; 120 (21):2113-21
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  46. Piekarz RL, Frye R, Turner M, Wright JJ, Allen SL, Kirschbaum MH, Zain J, Prince HM, Leonard JP, Geskin LJ, Reeder C, Joske D, Figg WD, Gardner ER, Steinberg SM, Jaffe ES, Stetler-Stevenson M, Lade S, Fojo AT, Bates SE. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2009 Nov 10; 27(32):5410-7. Epub 2009 Oct 13.
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  47. Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM, Orchard TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TL, Molitch ME, Nesto RW, Sako EY, Sobel BE. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009 Jun 11; 360(24):2503-15. Epub 2009 Jun 07.
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  48. Pop-Busui R, Lu J, Lopes N, Jones TL, BARI 2D Investigators. Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort. J Peripher Nerv Syst. 2009 Mar; 14 (1):1-13
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  49. Arruda-Olson AM, Patch RK 3rd, Leibson CL, Vella A, Frye RL, Weston SA, Killian JM, Roger VL. Effect of second-generation sulfonylureas on survival in patients with diabetes mellitus after myocardial infarction. Mayo Clin Proc. 2009; 84 (1):28-33
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  50. McKellar SH, Brown ML, Frye RL, Schaff HV, Sundt TM 3rd. Comparison of coronary revascularization procedures in octogenarians: a systematic review and meta-analysis. Nat Clin Pract Cardiovasc Med. 2008 Nov; 5 (11):738-46 Epub 2008 Sept 30
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  51. Bax JJ, Young LH, Frye RL, Bonow RO, Steinberg HO, Barrett EJ, Ada. Screening for coronary artery disease in patients with diabetes. Diabetes Care. 2007 Oct; 30(10):2729-36.
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  52. Chareonthaitawee P, Sorajja P, Rajagopalan N, Miller TD, Hodge DO, Frye RL, Gibbons RJ. Prevalence and prognosis of left ventricular systolic dysfunction in asymptomatic diabetic patients without known coronary artery disease referred for stress single-photon emission computed tomography and assessment of left ventricular function. Am Heart J. 2007 Sep; 154(3):567-74.
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  53. Frye RL. Update in cardiology. Ann Intern Med. 2007 Aug 7; 147 (3):180-6
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  54. Holmes DR Jr, Kim LJ, Brooks MM, Kip KE, Schaff HV, Detre KM, Frye RL, Bypass Angioplasty Revascularization Investigation (BARI) Investigators. The effect of coronary artery bypass grafting on specific causes of long-term mortality in the Bypass Angioplasty Revascularization Investigation. J Thorac Cardiovasc Surg. 2007 Jul; 134(1):38-46, 46.e1.
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  55. Erbel C, Sato K, Meyer FB, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. Functional profile of activated dendritic cells in unstable atherosclerotic plaque. Basic Res Cardiol. 2007 Mar; 102(2):123-32. Epub 2006 Dec 01.
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  56. Brooks MM, Frye RL, Genuth S, Detre KM, Nesto R, Sobel BE, Kelsey SF, Orchard TJ, Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial Investigators. Hypotheses, design, and methods for the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. Am J Cardiol. 2006 Jun 19; 97(12A):9G-19G. Epub 2006 Apr 17.
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  57. Barsness GW, Gersh BJ, Brooks MM, Frye RL, BARI 2D Trial Investigators. Rationale for the revascularization arm of the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. Am J Cardiol. 2006 Jun 19; 97(12A):31G-40G. Epub 2006 Apr 17.
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  58. Gerber Y, Jacobsen SJ, Frye RL, Weston SA, Killian JM, Roger VL. Secular trends in deaths from cardiovascular diseases: a 25-year community study. Circulation. 2006 May 16; 113 (19):2285-92 Epub 2006 May 08
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  59. Zhang X, Niessner A, Nakajima T, Ma-Krupa W, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque. Circ Res. 2006 Mar 3; 98(4):524-31. Epub 2006 Jan 19.
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  60. Sato K, Niessner A, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. J Exp Med. 2006 Jan 23; 203(1):239-50. Epub 2006 Jan 17.
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  61. Sorajja P, Chareonthaitawee P, Rajagopalan N, Miller TD, Frye RL, Hodge DO, Gibbons RJ. Improved survival in asymptomatic diabetic patients with high-risk SPECT imaging treated with coronary artery bypass grafting. Circulation. 2005 Aug 30; 112 (9 Suppl):I311-6
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  62. Rajagopalan N, Miller TD, Hodge DO, Frye RL, Gibbons RJ. Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging. J Am Coll Cardiol. 2005 Jan 4; 45(1):43-9.
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  63. Warrington KJ, Kent PD, Frye RL, Lymp JF, Kopecky SL, Goronzy JJ, Weyand CM. Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study. Arthritis Res Ther. 2005; 7 (5):R984-91 Epub 2005 June 29
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  64. Shen WK, Decker WW, Smars PA, Goyal DG, Walker AE, Hodge DO, Trusty JM, Brekke KM, Jahangir A, Brady PA, Munger TM, Gersh BJ, Hammill SC, Frye RL. Syncope Evaluation in the Emergency Department Study (SEEDS): a multidisciplinary approach to syncope management. Circulation 2004 Dec 14; 110 (24):3636-45 Epub 2004 Nov 09
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  65. Arciero TJ, Jacobsen SJ, Reeder GS, Frye RL, Weston SA, Killian JM, Roger Vr Ve, Roger VL. Temporal trends in the incidence of coronary disease. Am J Med. 2004 Aug 15; 117: (4)228-33.
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  66. Miller TD, Rajagopalan N, Hodge DO, Frye RL, Gibbons RJ. Yield of stress single-photon emission computed tomography in asymptomatic patients with diabetes. Am Heart J. 2004 May; 147(5):890-6.
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  67. Mathew V, Frye RL, Lennon R, Barsness GW, Holmes DR Jr. Comparison of survival after successful percutaneous coronary intervention of patients with diabetes mellitus receiving insulin versus those receiving only diet and/or oral hypoglycemic agents. Am J Cardiol. 2004 Feb 15; 93(4):399-403.
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  68. Frye RL. Optimal care of patients with type 2 diabetes mellitus and coronary artery disease. Am J Med. 2003 Dec 8; 115 Suppl 8A:93S-98S
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  69. Nakajima T, Goek O, Zhang X, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. Circ Res. 2003 Jul 25; 93 (2):106-13 Epub 2003 June 19
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  70. Goraya TY, Jacobsen SJ, Kottke TE, Frye RL, Weston SA, Roger VL. Coronary heart disease death and sudden cardiac death: a 20-year population-based study. Am J Epidemiol. 2003 May 1; 157 (9):763-70
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  71. Schwartz L, Kip KE, Frye RL, Alderman EL, Schaff HV, Detre KM. Coronary bypass graft patency in patients with diabetes in the bypass angioplasty revascularization investigation (BARI). Circulation. 2002 Nov 19; 106(21):2652-8.
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  72. Goraya TY, Leibson CL, Palumbo PJ, Weston SA, Killian JM, Pfeifer EA, Jacobsen SJ, Frye RL, Roger VL. Coronary atherosclerosis in diabetes mellitus: a population-based autopsy study. J Am Coll Cardiol. 2002 Sep 4; 40 (5):946-53
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  73. Mathew V, Wilson SH, Barsness GW, Frye RL, Lennon R, Holmes DR, Lennon R, Holmes DR. Comparative outcomes of percutaneous coronary interventions in diabetics vs non-diabetics with prior coronary artery bypass grafting. Eur Heart J. 2002 Sep; 23 (18):1456-64
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  74. Grigioni F, Avierinos JF, Ling LH, Scott CG, Bailey KR, Tajik AJ, Frye RL, Enriquez-Sarano M. Atrial fibrillation complicating the course of degenerative mitral regurgitation: determinants and long-term outcome. J Am Coll Cardiol. 2002 Jul 3; 40 (1):84-92
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  75. Roger VL, Killian J, Henkel M, Weston SA, Goraya TY, Yawn BP, Kottke TE, Frye RL, Jacobsen SJ. Coronary disease surveillance in Olmsted County objectives and methodology. J Clin Epidemiol. 2002 Jun; 55 (6):593-601
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  76. Reeder GS, Holmes DR, Holmes DR, Lennon RJ, Larson TS, Frye RL. Proteinuria, serum creatinine, and outcome of percutaneous coronary intervention in patients with diabetes mellitus. Am J Cardiol. 2002 Mar 15; 89 (6):760-4
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  77. Whisnant JP, Wiebers DO, O'Fallon WM, Sicks JD, Frye RL. Effect of time since onset of risk factors on the occurrence of ischemic stroke. Neurology. 2002 Mar 12; 58 (5):787-94
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  78. Roger VL, Jacobsen SJ, Weston SA, Goraya TY, Killian J, Reeder GS, Kottke TE, Yawn BP, Frye RL. Trends in the incidence and survival of patients with hospitalized myocardial infarction, Olmsted County, Minnesota, 1979 to 1994. Ann Intern Med. 2002 Mar 5; 136 (5):341-8
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  79. Nakajima T, Schulte S, Warrington KJ, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation. 2002 Feb 5; 105 (5):570-5
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  80. Frye RL, Bell MR, Schaff HV, Holubkov R, Detre KM. The role of PCI and CABG in the management of coronary artery disease in patients with diabetes. Curr Diab Rep. 2002 Feb; 2 (1):16-20
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  81. Weyand CM, Goronzy JJ, Liuzzo G, Kopecky SL, Holmes DR Jr, Frye RL. T-cell immunity in acute coronary syndromes. Mayo Clin Proc. 2001 Oct; 76 (10):1011-20
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  82. Liuzzo G, Vallejo AN, Kopecky SL, Frye RL, Holmes DR, Holmes DR, Goronzy JJ, Weyand CM. Molecular fingerprint of interferon-gamma signaling in unstable angina. Circulation. 2001 Mar 20; 103 (11):1509-14
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  83. Roger VL, Weston SA, Killian JM, Pfeifer EA, Belau PG, Kottke TE, Frye RL, Bailey KR, Jacobsen SJ. Time trends in the prevalence of atherosclerosis: a population-based autopsy study. Am J Med. 2001 Mar; 110 (4):267-73
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  84. Rahimtoola SH, Frye RL. Valvular heart disease. Circulation. 2000 Nov 14; 102(20 Special Issue SI):24-33.
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  85. Liuzzo G, Goronzy JJ, Yang H, Kopecky SL, Holmes DR, Holmes DR, Frye RL, Weyand CM. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation. 2000 Jun 27; 101 (25):2883-8
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  86. Feit F, Brooks MM, Sopko G, Keller NM, Rosen A, Krone R, Berger PB, Shemin R, Attubato MJ, Williams DO, Frye R, Detre KM. Long-term clinical outcome in the bypass angioplasty revascularization investigation registry comparison with the randomized trial. Circulation. 2000 Jun 20; 101(24):2795-802.
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  87. Detre KM, Lombardero MS, Brooks MM, Hardison RM, Holubkov R, Sopko G, Frye RL, Chaitman BR. The effect of previous coronary-artery bypass surgery on the prognosis of patients with diabetes who have acute myocardial infarction. N Engl J Med. 2000 Apr 6; 342(14):989-997.
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  88. Grigioni F, Enriquez-Sarano M, Ling LH, Bailey KR, Seward JB, Tajik AJ, Frye RL. Sudden death in mitral regurgitation due to flail leaflet. J Am Coll Cardiol. 1999 Dec; 34 (7):2078-85
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  89. Liuzzo G, Kopecky SL, Frye RL, O'Fallon WM, Maseri A, Goronzy JJ, Weyand CM. Perturbation of the T-cell repertoire in patients with unstable angina. Circulation. 1999 Nov 23; 100 (21):2135-9
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  90. Holubkov R, Detre KM, Sopko G, Sutton-Tyrrell K, Kelsey SF, Frye RL. Trends in coronary revascularization 1989 to 1997: the Bypass Angioplasty Revascularization Investigation (BARI) survey of procedures. Am J Cardiol. 1999 Jul 15; 84(2):157-61.
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  91. Roger VL, Jacobsen SJ, Weston SA, Bailey KR, Kottke TE, Frye RL. Trends in heart disease deaths in Olmsted County, Minnesota, 1979-1994. Mayo Clin Proc. 1999 Jul; 74 (7):651-7
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  92. Bourassa MG, Kip KE, Jacobs AK, Jones RH, Sopko G, Rosen AD, Sharaf BL, Schwartz L, Chaitman BR, Alderman EL, Holmes DR, Roubin GS, Detre KM, Frye RL. Is a strategy of intended incomplete percutaneous transluminal coronary angioplasty revascularization acceptable in nondiabetic patients who are candidates for coronary artery bypass graft surgery? The Bypass Angioplasty Revascularization Investigation (BARI). J Am Coll Cardiol. 1999 May; 33(6):1627-36.
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  93. Detre KM, Guo P, Holubkov R, Califf RM, Sopko G, Bach R, Brooks MM, Bourassa MG, Shemin RJ, Rosen AD, Krone RJ, Frye RL, Feit F. Coronary revascularization in diabetic patients - a comparison of the randomized and observational components of the bypass angioplasty revascularization investigation (Bari). Circulation. 1999 Feb 9; 99(5):633-640.
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  97. Tribouilloy CM, Enriquez-Sarano M, Schaff HV, Orszulak TA, Fett SL, Bailey KR, Tajik AJ, Frye RL. Excess mortality due to coronary artery disease after valve surgery. Secular trends in valvular regurgitation and effect of internal mammary artery bypass. Circulation. 1998 Nov 10; 98 (19 Suppl):II108-15
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  99. Chaitman BR, Rosen AD, Williams DO, Bourassa MG, Aguirre FV, Pitt B, Rautaharju PM, Rogers WJ, Sharaf B, Attubato M, Hardison RM, Srivatsa S, Kouchoukos NT, Stocke K, Sopko G, Detre K, Frye R. Myocardial infarction and cardiac mortality in the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial. Circulation. 1997 Oct 7; 96 (7):2162-70
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  100. Ling LH, Enriquez-Sarano M, Seward JB, Orszulak TA, Schaff HV, Bailey KR, Tajik AJ, Frye RL. Early surgery in patients with mitral regurgitation due to flail leaflets: a long-term outcome study. Circulation. 1997 Sep 16; 96 (6):1819-25
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  101. Alderman EL, Andrews K, Brooks MM, Detre K, Kelsey SF, Rosen AD, Suttontyrrell K, Bourassa M, Chaitman BR, Faxon DP, Follmann D, Sopko G, Frye RL, Schaff H, Hlatky M, Jones RH, Sellers MA, Rogers WJ, Williams DO. Five-year clinical and functional outcome comparing bypass surgery and angioplasty in patients with multivessel coronary disease - a multicenter randomized trial. JAMA. 1997 Mar 5; 277(9):715-21.
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  102. Hlatky MA, Rogers WJ, Johnstone I, Boothroyd D, Brooks MM, Pitt B, Reeder G, Ryan T, Smith H, Whitlow P, Wiens R, Mark DB, Frye RL. Medical care costs and quality of life after randomization to coronary angioplasty or coronary bypass surgery. N Engl J Med. 1997 Jan 9; 336(2):92-99.
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  103. Whisnant JP, Wiebers DO, O'Fallon WM, Sicks JD, Frye RL. A population-based model of risk factors for ischemic stroke: Rochester, Minnesota. Neurology. 1996 Dec; 47 (6):1420-8
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  104. Ling LH, Enriquez-Sarano M, Seward JB, Tajik AJ, Schaff HV, Bailey KR, Frye RL. Clinical outcome of mitral regurgitation due to flail leaflet. N Engl J Med. 1996 Nov 7; 335 (19):1417-23
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  105. Detre KM, Rosen AD, Bost JE, Cooper ME, Sutton-Tyrrell K, Holubkov R, Shemin RJ, Frye RL. Contemporary practice of coronary revascularization in U.S. hospitals and hospitals participating in the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol. 1996 Sep; 28(3):609-15.
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  106. Enriquez-Sarano M, Enriquez-Sarano M, Schaff HV, Orszulak TA, Bailey KR, Tajik AJ, Frye RL. Congestive heart failure after surgical correction of mitral regurgitation. A long-term study. Circulation. 1995 Nov 1; 92 (9):2496-503
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  107. Bourassa MG, Roubin GS, Detre KM, Sopko G, Krone RJ, Attabuto MJ, Bjerregaad P, Bolling S, Herman MV, Frye RL. Bypass angioplasty revascularization investigation - patient screening, selection, and recruitment. Am J Cardiol. 1995 Mar 23; 75:C3-C8.
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  108. Enriquez-Sarano M, Enriquez-Sarano M, Schaff HV, Orszulak TA, Tajik AJ, Bailey KR, Frye RL. Valve repair improves the outcome of surgery for mitral regurgitation. A multivariate analysis. Circulation. 1995 Feb 15; 91 (4):1022-8
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  109. Enriquez-Sarano M, Tajik AJ, Schaff HV, Orszulak TA, McGoon MD, Bailey KR, Frye RL. Echocardiographic prediction of left ventricular function after correction of mitral regurgitation: results and clinical implications. J Am Coll Cardiol. 1994 Nov 15; 24 (6):1536-43
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  110. Morris JJ, Schaff HV, Mullany CJ, Morris PB, Frye RL, Orszulak TA. Gender differences in left ventricular functional response to aortic valve replacement. Circulation. 1994 Nov; 90(5 part 2):II-183-9.
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  111. King SB 3rd, Frye RL, Fuster V, Garson A Jr, Gay WA Jr, Popp RL. Task Force 2: Academic health centers. J Am Coll Cardiol. 1994 Aug; 24(2):290-5.
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  112. Enriquez-Sarano M, Tajik AJ, Schaff HV, Orszulak TA, Bailey KR, Frye RL. Echocardiographic prediction of survival after surgical correction of organic mitral regurgitation. Circulation. 1994 Aug; 90 (2):830-7
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  113. Morris JJ, Schaff HV, Mullany CJ, Rastogi A, McGregor CG, Daly RC, Frye RL, Orszulak TA. Determinants of survival and recovery of left ventricular function after aortic valve replacement. Ann Thorac Surg. 1993 Jul; 56 (1):22-9; discussion 29-30
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  114. Maruta T, Hamburgen ME, Jennings CA, Offord KP, Colligan RC, Frye RL, Malinchoc M. Keeping hostility in perspective: coronary heart disease and the Hostility Scale on the Minnesota Multiphasic Personality Inventory. Mayo Clin Proc. 1993 Feb; 68 (2):109-14
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  115. Frye RL, Sopko G, Detre KM. The BARI trial: baseline observations. The BARI Investigators. Trans Am Clin Climatol Assoc. 1993; 104:26-30.
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  116. Rihal CS, Schaff HV, Frye RL, Bailey KR, Hammes LN, Holmes DR Jr, Holmes DR Jr. Long-term follow-up of patients undergoing closed transventricular mitral commissurotomy: a useful surrogate for percutaneous balloon mitral valvuloplasty? J Am Coll Cardiol. 1992 Oct; 20 (4):781-6
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  117. Broderick JP, Phillips SJ, O'Fallon WM, Frye RL, Whisnant JP. Relationship of cardiac disease to stroke occurrence, recurrence, and mortality. Stroke. 1992 Sep; 23 (9):1250-6
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  118. Frye RL, Kronmal R, Schaff HV, Myers WO, Gersh BJ. Stroke in coronary artery bypass graft surgery: an analysis of the CASS experience. The participants in the Coronary Artery Surgery Study. Int J Cardiol. 1992 Aug; 36 (2):213-21
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  119. Frye RL. Thrombolytic treatment in acute MI. The Practice of Internal Medicine-1992. 1992 May 11-15; 17-9.
  120. Frye RL. Presidents Page: JACC: Entering its 10th year of scientific excellence. JACC 1992 Jan; 19(No. 1):232-3.
  121. Frye RL. Presidents Page: Does it really make a difference? JACC 1992 Feb; 19(No. 2):468-70.
  122. Frye RL. Presidents Page: A change in ACC leadership JACC 1992 Mar; 19(No. 4):880.
  123. Frye RL. Presidents Page: A visit to the Physician Payment Commission JACC 1992 Apr; 19(No. 5):1114-5.
  124. Frye RL, Friesinger GC, Winters WL. Task Force 3: The role of the cardiovascular specialist. JACC 1992 Jun; 19(No. 7):1464-69.
  125. Frye RL, Sopko G, Detre KM. The BARI trial: baseline observations. The BARI Investigators. Transactions of the American Clinical & Climatological Association. 1992; 104:26-30.
  126. Frye RL. The Medicare fee schedule. J Am Coll Cardiol. 1991 Nov 15; 18 (6):1583-4
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  127. Frye RL. President's page: role of the cardiologist in peripheral vascular disease. J Am Coll Cardiol. 1991 Aug; 18 (2):641-2
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  128. Frye RL. Access to cardiovascular care: defining the role of the ACC. J Am Coll Cardiol. 1991 Apr; 17:1239-1241.
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  129. Kirklin JW, Frye RL, Blackstone EH, Naftel DC. Some comments on the indications for the coronary artery bypass graft operation. Int J Cardiol. 1991 Apr; 31(1):23-30; discussion 31-2.
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  130. Frye RL. Presidents Page: The national ACC database JACC 1991 May; 17(No. 6):1448-9.
  131. Frye RL. Presidents Page: Controlled growth: the need to set priorities. JACC 1991 Jul; 18(No. 1):308-9.
  132. Frye RL. Presidents Page: ACC leadership: challenges and opportunities for participation. JACC 1991 Sep; 18(No. 3):886-7.
  133. Frye RL. Presidents Page: The health policy retreat. JACC 1991 Nov 1; 18(No. 5):1426-7.
  134. Frye RL. Presidents Page: The Medicare Fee Schedule JACC 1991 Nov 15; 18(No. 6):1583-4.
  135. Anonymous, Frye RL. Protocol for the bypass angioplasty revascularization investigation. Circulation. 1991; 84(6 Suppl V):V1-V27.
  136. Kottke TE, Pesch DG, Frye RL, McGoon DC, Warnes CA, Kurland LT. The potential contribution of cardiac replacement to the control of cardiovascular diseases. A population-based estimate. Arch Surg. 1990 Sep; 125 (9):1148-51
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  137. Phillips SJ, Whisnant JP, O'Fallon WM, Frye RL. Prevalence of cardiovascular disease and diabetes mellitus in residents of Rochester, Minnesota. Mayo Clin Proc. 1990 Mar; 65 (3):344-59
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  138. Vlietstra RE, Frye RL. Topical issues--a U.S. viewpoint. Int J Cardiol. 1989 May; 23 (2):153-7
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  139. Frye RL, Gibbons RJ, Schaff HV, Vlietstra RE, Gersh BJ, Mock MB. Treatment of coronary artery disease. J Am Coll Cardiol. 1989 Apr; 13 (5):957-68
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  140. Huber KC, Gersh BJ, Sugrue DD, Frye RL, Bailey KR, Ritts RE Jr. T-lymphocyte subsets in patients with idiopathic dilated cardiomyopathy. Int J Cardiol. 1989 Jan; 22 (1):59-66
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  141. Proano M, Oh JK, Frye RL, Johnson CM, Tajik AJ, Taliercio CP. Successful treatment of pulmonary embolism and associated mobile right atrial thrombus with use of a central thrombolytic infusion. Mayo Clin Proc. 1988 Dec; 63 (12):1181-5
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  142. Fisher LD, Frye RL, Smith HC, Gersh BJ, Vlietstra RE, Fulton RE, Mock MB, et al. Risk of developing an acute myocardial infarction or sudden coronary death in patients with exercise-induced silent myocardial ischemia. A report from the coronary artery surgery study (CASS) registry. Am J Cardiol. 1988 Dec 1; 62:1155-1158.
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  143. Schlant RC, Abelmann WH, O'Rourke RA, Rahimtoola SH, Ronan JA Jr, Moore FI, Frye RL, Russell ROJ, Demaria AN, Leonard JJ. Task force vii: summary: a look at the future. J Am Coll Cardiol. 1988 Sep; 12:862-868.
  144. Weiner DA, Fisher LD, Frye RL, Smith HC, Gersh BJ, Vlietstra RE, Fulton RE, Mock MB, et al. Comparison of coronary artery bypass surgery and medical therapy in patients with exercised-induced silent myocardial ischemia: a report from the coronary artery surgery study (CASS) registry. J Am Coll Cardiol. 1988 Sep; 12:595-599.
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  145. Frye RL, Gersh BJ, et al. Task force III: major demographic and epidemiologic trends affecting adult cardiology. J Am Coll Cardiol. 1988 Sep; 12:840-846.
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  146. Frye RL. Cardiologists and molecular biology. Int J Cardiol. 1988 Mar; 18 (3):289-91
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  147. Frye RL, Vlietstra RE, Anderson RH, Kawai C, Tynan M. The problem of deception within medical science. Int J Cardiol. 1988 Feb; 18 (2):123-4
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  148. Kopecky SL, Gersh BJ, McGoon MD, Whisnant JP, Holmes DR, Ilstrup DM, Frye RL. The natural history of lone atrial fibrillation. A population-based study over three decades. N Engl J Med. 1987 Sep 10; 317(11):669-74.
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  149. Frye RL, Fisher L, Schaff HV, Gersh BJ, Vlietstra RE, Mock MB. Randomized trials in coronary artery bypass surgery. Prog Cardiovasc Dis. 1987 Jul-Aug; 30(1):1-22.
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  150. Mullany CJ, Elveback LR, Frye RL, Pluth JR, Edwards WD, Orszulak TA, Nassef LA Jr, Riner RE, Danielson GK. Coronary artery disease and its management: influence on survival in patients undergoing aortic valve replacement. J Am Coll Cardiol. 1987 Jul; 10(1):66-72.
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  151. Fisher LD, Frye RL, Smith HC, Mock MB, Vlietstra RE, Fulton RE, et al. Bundle branch block in patients with chronic coronary artery disease: angiographic correlates and prognostic significance. J Am Coll Cardiol. 1987 Jul; 10:73-80.
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  152. Rubanyl GM, Frye RL, Holmes DR Jr, Vanhoutte PM. Vasoconstrictor activity of coronary sinus plasma from patients with coronary artery disease. J Am Coll Cardiol. 1987 Jun; 9(6):1243-9.
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  153. Frye RL, Smith HC, Vlietstra RE, Mock MB, Holmes DR Jr, Fulton RE, et al. The role of coronary bypass surgery for 'left main equivalent' coronary disease: The Coronary Artery Surgery Study Registry. Circulation. 1986 Nov; 74(Suppl. 3):III-17--III-25.
  154. Frye RL, Fuster V, Joyce JW, et al. Task force I: training in clinical cardiology. J Am Coll Cardiol. 1986 Jun; 7:1196-2000.
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  155. Kemp HG, Kronmal RA, Vlietstra RE, Frye RL, Gersh B, Holmes DR, Mock MB, Schaff H, et al. Seven year survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol. 1986 Mar; 7(3):479-83.
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  156. Vlietstra RE, Kronmal RA, Oberman A, Frye RL, Killip T 3rd. Effect of cigarette smoking on survival of patients with angiographically documented coronary artery disease. Report from the CASS registry. JAMA. 1986 Feb 28; 255(8):1023-7.
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  157. Van Citters RL, Bauer CB, Christopherson LK, Eberhart RC, Eddy DM, Frye RL, Jonsen AR, Keller KH, Levine RJ, McGoon DC. Artificial heart and assist devices: directions, needs, costs, societal and ethical issues. Artif Organs. 1985 Nov; 9(4):375-415.
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  158. Gersh BJ, Kronmal RA, Schaff HV, Frye RL, Ryan TJ, Mock MB, Myers WO, Athearn MW, Gosselin AJ, Kaiser GC. Comparison of coronary artery bypass surgery and medical therapy in patients 65 years of age or older. A nonrandomized study from the Coronary Artery Surgery Study (CASS) registry. N Engl J Med. 1985 Jul 25; 313(4):217-24.
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  159. Passamani E, Davis KB, Gillespie MJ, Killip T, Frye RL, Smith HC, Vlietstra RE, Mock MB, Holmes DR Jr, Fulton RE, et al. A randomized trial of coronary artery bypass surgery: survival of patients with a low ejection fraction. N Engl J Med. 1985 Jun 27; 312:1665-71.
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  160. Orszulak TA, Schaff HV, Danielson GK, Piehler JM, Pluth JR, Frye RL, McGoon DC, Elveback LR. Mitral regurgitation due to ruptured chordae tendineae. Early and late results of valve repair. J Thorac Cardiovasc Surg. 1985 Apr; 89(4):491-8.
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  161. Sutton-St. John MG, Lie JT, Tajik AJ, Giuliani ER, Danielson GK, Frye RL. Hypertrophic obstructive cardiomyopathy. Heart Fail. 1985; 1:152-178.
  162. Schaff HV, Gersh BJ, Fisher LD, Frye RL, Mock MB, Ryan TJ, Ells RB, Chaitman BR, Alderman EL, Kaiser GC. Detrimental effect of perioperative myocardial infarction on late survival after coronary artery bypass. Report from the Coronary Artery Surgery Study--CASS. J Thorac Cardiovasc Surg. 1984 Dec; 88(6):972-81.
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  163. Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation. 1984 Oct; 70(4):580-7.
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  164. Frye RL, Orszulak TA. Mitral stenosis: case report. Card Impulse. 1984 Sep; 5:1-6.
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  166. Patton JN, Vlietstra RE, Frye RL. Randomized, placebo-controlled study of the effect of verapamil on exercise hemodynamics in coronary artery disease. Am J Cardiol. 1984 Mar 1; 53(6):674-8.
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  167. Chesebro JH, Fuster V, Elveback LR, Clements IP, Smith HC, Holmes DR Jr, Bardsley WT, Pluth JR, Wallace RB, Puga FJ, Orszulak TA, Piehler JM, Danielson GK, Schaff HV, Frye RL. Effect of dipyridamole and aspirin on late vein-graft patency after coronary bypass operations. N Engl J Med. 1984 Jan 26; 310(4):209-14.
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  168. Frye RL, Fisch C, Collins J. Guidelines for permanent cardiac pacemaker implantation, May 1984: A report of the Joint American College of Cardiology/American Heart Association Task Force on assessment of cardiovascular procedures (Subcommittee on Pacemaker Implantation). JACC. 1984; 4(No. 2):434-42.
  169. Frye RL, Mock MB, Vlietstra RE, Gersh BJ, Schaff HV, Smith HC, Holmes DR Jr, et al. Coronary Artery Surgery Study (CASS): a randomized trial of coronary artery bypass surgery: quality of life in patients randomly assigned to treatment groups. Circulation. 1983 Nov; 68:951-60.
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  170. Gersh BJ, Kronmal RA, Schaff HV, Frye RL, Ryan TJ, Myers WO, Athearn MW, Gosselin AJ, Kaiser GC, Killip T 3rd. Long-term (5 year) results of coronary bypass surgery in patients 65 years old or older: a report from the Coronary Artery Surgery Study. Circulation. 1983 Sep; 68 (3 Pt 2):II190-9
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  171. Schaff HV, Gersh BJ, Pluth JR, Danielson GK, Orszulak TA, Puga FJ, Piehler JM, Frye RL. Survival and functional status after coronary artery bypass grafting: results 10 to 12 years after surgery in 500 patients. Circulation. 1983 Sep; 68 (3 Pt 2):II200-4
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  172. Vlietstra RE, Farias MA, Frye RL, Smith HC, Ritman EL. Effect of verapamil on left ventricular function: a randomized, placebo-controlled study. Am J Cardiol. 1983 Apr; 51(7):1213-7.
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  173. Patton JN, Vlietstra RE, Frye RL. Randomized, placebo-controlled study of effect of verapamil on exercise hemodynamics in patients with coronary artery disease. Clin Res. 1983 Apr; 31:212A.
  174. Gersh BJ, Kronmal RA, Frye RL, Schaff HV, Ryan TJ, Gosselin AJ, Kaiser GC, Killip T III. Coronary arteriography and coronary artery bypass surgery: morbidity and mortality in patients ages 65 years or older. A report from the Coronary Artery Surgery Study. Circulation. 1983 Mar; 67(3):483-91.
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  175. Kennedy RH, Kennedy MA, Frye RL, Giuliani ER, McGoon DC, Pluth JR, Smith HC, Ritter DG, Nobrega FT, Kurland LT. Cardiac-catheterization and cardiac-surgical facilities: use, trends, and future requirements. N Engl J Med. 1982 Oct 14; 307(16):986-93.
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  176. Chesebro JH, Clements IP, Fuster V, Elveback LR, Smith HC, Bardsley WT, Frye RL, Holmes DR Jr, Vlietstra RE, Pluth JR, Wallace RB, Puga FJ, Orszulak TA, Piehler JM, Schaff HV, Danielson GK. A platelet-inhibitor-drug trial in coronary-artery bypass operations: benefit of perioperative dipyridamole and aspirin therapy on early postoperative vein-graft patency. N Engl J Med. 1982 Jul 8; 307(2):73-8.
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  177. Frye RL. National Institutes of Health consensus development conference statement on coronary bypass surgery: scientific and clinical aspects. Circulation. 1982 Jun; 65(Suppl II):II-126--II-129.
  178. Chesebro JH, Ritman EL, Frye RL, Smith HC, Vlietstra RE, Pluth JR. Left ventricular performance before and after aortocoronary artery bypass surgery. Circulation. 1982 Jun; 65(7 Pt 2):98-105.
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  179. Vlietstra RE, Kronmal RA, Frye RL, Seth AK, Tristani FE, Killip T 3rd. Factors affecting the extent and severity of coronary artery disease in patients enrolled in the coronary artery surgery study. Arteriosclerosis. 1982 May-Jun; 2(3):208-15.
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  180. Chesebro JH, Fuster V, Elveback LR, Frye RL. Strong family history and cigarette smoking as risk factors of coronary artery disease in young adults. Br Heart J. 1982 Jan; 47(1):78-83.
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  181. Fuster V, Gersh BJ, Giuliani ER, Tajik AJ, Brandenburg RO, Frye RL. Miocardiopatia dilatada o congestiva. Conceptos clinicos y etipopatogenicos e historia natura. Rev Lat Cardiol. 1982; 3:67-77.
  182. Tinker JH, Noback CR, Vlietstra RE, Frye RL. Management of patients with heart disease for noncardiac surgery. JAMA. 1981 Sep 18; 246(12):1348-50.
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  183. Fuster V, Chesebro JH, Frye RL, Elveback LR. Platelet survival and the development of coronary artery disease in the young adult: effects of cigarette smoking, strong family history and medical therapy. Circulation. 1981 Mar; 63(3):546-51.
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  184. Fuster V, Gersh BJ, Giuliani ER, Tajik AJ, Brandenburg RO, Frye RL. The natural history of idiopathic dilated cardiomyopathy. Am J Cardiol. 1981 Mar; 47(3):525-31.
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  185. Frye RL. Chronic congestive heart failure. Eight steps in management. Postgrad Med. 1981 Mar; 69(3):165-69-74.
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  186. Holmes DR Jr, Elveback LR, Frye RL, Kottke BA, Ellefson RD. Association of risk factor variables and coronary artery disease documented with angiography. Circulation. 1981 Feb; 63(2):293-9.
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  187. Vlietstra RE, Chesebro JH, Frye RL, Wallace RB. Improvement of left ventricular exercise hemodynamic function after aorta-coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1981 Jan; 81(1):85-91.
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  188. Kennedy RH, Kennedy MA, Frye RL, Giuliani ER, Pluth JR, Smith HC, Ritter DG, Nobrega FT. Use of the cardiac-catheterization laboratory in a defined population. N Engl J Med. 1980 Nov; 303:1273-1277.
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  189. St John Sutton MG, Lie JT, Anderson KR, O'Brien PC, Frye RL. Histopathological specificity of hypertrophic obstructive cardiomyopathy. Myocardial fibre disarray and myocardial fibrosis. Br Heart J. 1980 Oct; 44(4):433-43.
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  190. Vlietstra RE, Frye RL, Kronmal RA, Sim DA, Tristani FE, Killip T 3rd. Risk factors and angiographic coronary artery disease: a report from the coronary artery surgery study (CASS). Circulation. 1980 Aug; 62(2):254-61.
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  191. Fuster V, Frye RL, Kennedy MA, Connolly DC, Mankin HT. The role of collateral circulation in the various coronary syndromes. Circulation. 1979 Jun; 59(6):1137-44.
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  192. Chesebro JH, Fuster V, Frye RL. Smoking family history and shortened platelet survival in coronary disease patients age 50 and under. Circulation. 1978 Oct; 58:II-221.
  193. St John Sutton MG, Frye RL, Smith HC, Chesebro JH, Ritman EL. Relation between left coronary artery stenosis and regional left ventricular function. Circulation. 1978 Sep; 58(3):491-7.
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  194. Chesebro JH, Ritman EL, Frye RL, Smith HC, Rutherford BD, Fulton RE, Pluth JR, Barnhorst DA. Regional myocardial wall thickening response to nitroglycerin. A predictor of myocardial response to aortocoronary bypass surgery. Circulation. 1978 May; 57(5):952-7.
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  195. Frye RL, Gura GM, Chesebro JH, Ritman EL. Complete occlusion of the left main coronary artery and the importance of coronary collateral circulation. Mayo Clin Proc. 1977 Nov; 52(11):742-5.
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  196. Vlietstra RE, Assad-Morell JL, Frye RL, Elveback LR, Connolly DC, Ritman EL, Pluth JR, Barnhorst DA, Danielson GK, Wallace RB. Survival predictors in coronary artery disease. Medical and surgical comparisons. Mayo Clin Proc. 1977 Feb; 52(2):85-90.
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  197. Chesebro JH, Ritman EL, Frye RL, Smith HC, Connolly DC, Rutherford BD, Davis GD, Danielson GK, Pluth JR, Barnhorst DA, Wallace RB. Videometric analysis of regional left ventricular function before and after aortocoronary artery bypass surgery: correlation of peak rate of myocardial wall thickening with late postoperative graft flows. J Clin Invest. 1976 Dec; 58(6):1339-47.
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  198. Madigan NP, Rutherford BD, Frye RL. The clinical course, early prognosis and coronary anatomy of subendocardial infarction. Am J Med. 1976 May 10; 60(5):634-41.
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  199. Kennedy CC, Spiekerman RE, Lindsay MI Jr, Mankin HT, Frye RL, McCallister BD. One-year graduated exercise program for men with angina pectoris. Evaluation by physiologic studies and coronary arteriography. Mayo Clin Proc. 1976 Apr; 51(4):231-6.
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  200. Roy P, Tajik AJ, Giuliani ER, Schattenberg TT, Gau GT, Frye RL. Spectrum of echocardiographic findings in bacterial endocarditis. Circulation. 1976 Mar; 53(3):474-82.
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  201. Fuster V, Frye RL, Connolly DC, Danielson MA, Elveback LR, Kurland LT. Arteriographic patterns early in the onset of the coronary syndromes. Br Heart J. 1975 Dec; 37(12):1250-5.
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  202. Dumesnil JG, Ritman EL, Davis GD, Gau GT, Rutherford BD, Frye RL. Regional left ventricular wall dynamics before and after sublingual administration of nitroglycerin. Am J Cardiol. 1975 Oct 6; 36(4):419-25.
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  203. Assad-Morell JL, Frye RL, Connolly DC, Davis GD, Pluth JR, Wallace RB, Barnhorst DA, Elveback LR, Danielson GK. Aorta-coronary artery saphenous vein bypass surgery: clinical and angiographic results. Mayo Clin Proc. 1975 Jul; 50(7):379-86.
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  204. Assad-Morell JL, Frye RL, Connolly DC, Gau GT, Pluth JR, Barnhorst DA, Wallace RB, Davis GD, Elveback LR, Danielson GK. Relation of intraoperative or early postoperative transmural myocardial infarction to patency of aortocoronary bypass grafts and to diseased ungrafted coronary arteries. Am J Cardiol. 1975 Jun; 35(6):767-73.
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  205. Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LSC, McGoon DC, Murphy ML, Roe BB. AHA committee report: a reporting system on patients evaluated for coronary artery disease. Circulation. 1975 Apr; 51:7-40.
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  206. Unni KK, Kottke BA, Titus JL, Frye RL, Wallace RB, Brown AL. Pathologic changes in aortocoronary saphenous vein grafts. Am J Cardiol. 1974 Oct 3; 34(5):526-32.
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  207. Dumesnil JG, Ritman EL, Frye RL, Gau GT, Rutherford BD, Davis GD. Quantitative determination of regional left ventricular wall dynamics by roentgen videometry. Circulation. 1974 Oct; 50(4):700-8.
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  208. Hynes KM, Frye RL, Brandenburg RO, McGoon DC, Titus JL, Giuliani ER. Atrial septal defect (secundum) associated with mitral regurgitation. Am J Cardiol. 1974 Sep; 34(3):333-8.
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  209. Hawe A, Frye RL, Ellis FH Jr. Late hemodynamic studies after mitral valve surgery. J Thorac Cardiovasc Surg. 1973 Mar; 65(3):351-8.
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  210. Hynes KM, Gau GT, Rutherford BD, Kazmier FJ, Frye RL. Effect of aspirin on brachial artery occlusion following brachial arteriotomy for coronary arteriography. Circulation. 1973 Mar; 47(3):554-7.
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  211. Greenleaf JF, Ritman EL, Wood EH, Frye RL, Robb RA, Johnson SA. Dynamic computer generated displays for study of human left ventricle. Proc Soc Photo Opt Instrum Eng. 1973; 32:111-2.
  212. Tajik AJ, Giuliani ER, Frye RL, McGoon DC, Nunn SL. Muscular subaortic stenosis associated with complete heart block. Am J Cardiol. 1973 Jan; 31(1):101-4.
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  213. Rutherford BD, Gau GT, Danielson GK, Pluth JR, Davis GD, Wallace RB, Frye RL. Left ventricular haemodynamics before and soon after saphenous vein bypass graft operation for angina pectoris. Br Heart J. 1972 Nov; 34(11):1156-62.
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  214. Greenberg BH, McCallister BD, Frye RL. Effects of glucagon on resting and exercise hemodynamics in patients with coronary heart disease. Br Heart J. 1972; 34:924-929.
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  215. Smith HC, Frye RL, Donald DE, Davis GD, Pluth JR, Sturm RE, Wood EH. Roentgen videodensitometric measure of coronary blood flow. Determination from simultaneous indicator-dilution curves at selected sites in the coronary circulation and in coronary artery-saphenous vein grafts. Mayo Clin Proc. 1971 Dec; 46(12):800-6.
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  216. Campion BC, Frye RL, Pluth JR, Fairbairn JF 2nd, Davis GD. Arterial complications of retrograde brachial arterial catheterization: a prospective study. Mayo Clin Proc. 1971 Sep; 46(9):589-92.
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  217. Tarhan S, Moffitt EA, Lundborg RO, Frye RL. Hemodynamic and blood-gas effects of Innovar in patients with acquired heart disease. Anesthesiology. 1971 Mar; 34(3):250-5.
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  218. Von Bernuth G, Ritter DG, Frye RL, Weidman WH, Davis GD, McGoon DC. Evaluation of patients with tetralogy of Fallot and Potts anastomosis. Am J Cardiol. 1971 Mar; 27(3):259-63.
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  219. Wychulis AR, Frye RL, Kincaid OW, Ongley PA, Ellis FH Jr. Postventriculotomy aneurysm in patients with idiopathic hypertrophic subaortic stenosis. Am J Cardiol. 1971 Mar; 27(3):322-6.
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  220. Spangler RD, Yipintsoi T, Knopp TJ, Frye RL, Bassingthwaighte JB. Pulmonary mean-transit-time blood volumes in anesthetized dogs. J Appl Physiol. 1971 Jan; 30(1):56-63.
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  221. Saltups A, McCallister BD, Hallermann FJ, Wallace RB, Smith RE, Frye RL. Left ventricular hemodynamics in patients with coronary artery disease and in normal subjects. Correlations with the extent of coronary artery lesions and the electrocardiogram. Am J Med. 1971 Jan; 50(1):8-19.
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  222. Moffitt EA, Rosevear JW, Lundborg RO, Frye RL. Myocardial metabolism in adults with heart disease. Anesth Analg. 1970 Nov-Dec; 49(6):942-7.
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  223. McCallister BD, Richmond DR, Saltups A, Hallermann FJ, Wallace RB, Frye FL. Left ventricular hemodynamics before and 1 year after internal mammary artery implantation in patients with coronary artery disease and angina pectoris. Circulation. 1970 Sep; 42(3):471-7.
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  224. Mercer EN, Frye RL, Giuliani ER. Late systolic click in non-obstructive cardiomyopathy. Br Heart J. 1970 Sep; 32(5):691-5.
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  225. Campion BC, Frye RL, Zitnik RS. Effects of nitroglycerin on capacitance vessels: a mechanism for reduction of left ventricular end-diastolic pressure. Mayo Clin Proc. 1970 Aug; 45(8):573-8.
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  226. Greenberg RH, McCallister BD, Frye RL, Wallace RB. Serum glutamic oxaloacetic transaminase and electrocardiographic changes after myocardial revascularization procedures in patients with coronary artery disease. Am J Cardiol. 1970 Aug; 26(2):135-42.
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  227. Frye RL, Brandenburg RO. Indications for cardiac catheterization. Med Clin North Am. 1970 Jul; 54(4):973-8.
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  228. Greenberg BH, Tsakiris AG, Moffitt EA, Frye RL. The hemodynamic and metabolic effects of glucagon in patients with chronic valvular heart disease. Mayo Clin Proc. 1970 Feb; 45(2):132-9.
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  229. Dunlap RW, Frye RL, Ellis FH Jr. Mitral valve replacement with stented aortic homograft. A hemodynamic evaluation. Arch Surg. 1969 Dec; 99(6):821-4.
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  230. Rouleau CA, Frye RL, Ellis FH Jr. Hemodynamic state after open mitral valve replacement and reconstruction. J Thorac Cardiovasc Surg. 1969 Dec; 58:870-878.
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  231. Frye RL, Krebs M, Rahimtoola SH, Ongley PA, Hallermann FJ, Wallace RB. Partial anomalous pulmonary venous connection without atrial septal defect. Am J Cardiol. 1968 Aug; 22(2):242-50.
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  232. Clarkson PM, Frye RL, DuShane JW, Burchell HB, Wood EH, Weidman WH. Prognosis for patients with ventricular septal defect and severe pulmonary vascular obstructive disease. Circulation. 1968 Jul; 38 (1):129-35
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  233. McCallister BD, Yipintsoi T, Hallermann FJ, Wallace RB, Frye RL. Left ventricular performance during mild supine leg exercise in coronary artery disease. Circulation. 1968 Jun; 37(6):922-31.
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  234. Burchell HB, Frye RL, Anderson MW, McGoon DC. Atrioventricular and ventriculoatrial excitation in Wolff-Parkinson-White syndrome (type B). Temporary ablation at surgery. Circulation. 1967 Nov; 36(5):663-72.
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  235. Rastelli GC, Tsakiris AG, Frye RL, Kirklin JW. Exercise tolerance and hemodynamic studies after replacement of canine mitral valve with and without preservation of chordae tendineae. Circulation. 1967 Apr; 35(Suppl I):34-41.
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  236. Ellis FH Jr, Frye RL, McGoon DC. Results of reconstructive operations for mitral insufficiency due to ruptured chordae tendineae. Surgery. 1966 Jan; 59(1):165-72.
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  237. Frye RL, Kincaid OW, Swan HJC, Kirklin JW. Results of surgical treatment of patients with diffuse subvalvular aortic stenosis. Circulation. 1965 Jul; 32:52-57.
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  238. Coder DM, Frye RL, Bernatz PE, Sheps SG. Symptomatic bilateral subclavian steal. Mayo Clin Proc. 1965 Jun; 40:473-476.
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  239. Kahler RL, Thompson RH, Buskirk ER, Frye RL, Braunwald E. Studies on digitalis. VI. Reduction of the oxygen debt after exercise with digoxin in cardiac patients without heart failure. Circulation. 1963 Mar; 27:397-405.
  240. Frye RL, Marshall HW, Kincaid OW, Burchell HB. Anomalous pulmonary venous drainage of the right lung into the inferior vena cava. Br Heart J. 1962 Nov; 24:696-702.
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  241. Braunwald E, Brockenbrough EC, Frye RL. Studies on digitalis. V. Comparison of the effects of ouabain on left ventricular dynamics in valvular aortic stenosis and hypertrophic subaortic stenosis. Circulation. 1962 Aug; 26:166-173.
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  242. Mason DT, Frye RL, Wagner HN Jr. Radioisotope scanning of the precordial distribution of iodide in patients with myocardial infarction. Circulation. 1961 Dec; 24:1338-1341.
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  243. Frye RL, Kahler RL, Braunwald E. The ineffectiveness of an inotropic agent, mephentermine (Wyamine), in the treatment of congestive heart failure. Am Heart J. 1961 Sep; 62:301-303.
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  244. Chidsey CA, Frye RL, Kahler RL, Braunwald E. Influence of syrosingopine on the cardiovascular response to acute hypoxemia and exercise. Circ Res. 1961 Sep; 9:989-995.
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  245. Frye RL, Braunwald E. Studies on digitalis. III. The influence of triiodothyronine on digitalis requirements. Circulation. 1961 Mar; 23:376-382.
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  246. Braunwald E, Frye RL, Aygen MM, Gilbert JW Jr. Studies on Starling's law of the heart. III. Observations in patients with mitral stenosis and atrial fibrillation on the relationships between left ventricular end-diastolic segment length, filling pressure, and the characteristics of ventricular contraction. J Clin Invest. 1960 Dec; 39:1874-1884.
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  247. Braunwald E, Frye RL, Ross J Jr, Lewis R. Studies on Starling's law of the heart, determinants of the relationship between left ventricular end-diastolic pressure and circumference. Circ Res. 1960 Nov; 8:1254-1263.
  248. Frye RL, Braunwald E. Bilateral diaphragmatic contraction synchronous with cardiac systole. N Engl J Med. 1960 Oct 20; 263:775-778.
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  249. Frye RL, Braunwald E, Cohen ER. Studies on Starling's law of the heart. I. The circulatory response to acute hypervolemia and its modification by ganglionic blockade. J Clin Invest. 1960 Jul; 39:1043-1050.
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