Publications Print Dumitrascu OM, Li X, Zhu W, Woodruff B, Nikolova S, Youssef A, Sobczak J, Andreev J, Caselli RJ, Chen J, Wang Y. Color fundus photography and deep learning applications in Alzheimer's disease. Mayo Clinic Proceedings: Digital Health. 2024; 2(4):548-558. Guzik AK, Jagolino-Cole AL, Mijalski Sells C, Southerland AM, Dumitrascu OM, Sreekrishnan A, Martini SR, Meyer BC. Telestroke Training: Considerations for Expansion of Vascular Neurology Program Requirements. Stroke. 2024 Oct 2 Epub 2024 Oct 02 View PubMed Harahsheh E, Elshaigi O, Alhayek N, Buckner SA, Quillen JK, O'Carroll CB, Dumitrascu OM. The Impact of Changing Antithrombotic Management in Patients With Atrial Fibrillation and Ischemic Cerebrovascular Events Despite Anticoagulation. Neurohospitalist. 2024 Oct; 14 (4):379-388 Epub 2024 May 15 View PubMed Gaire BP, Koronyo Y, Fuchs DT, Shi H, Rentsendorj A, Danziger R, Vit JP, Mirzaei N, Doustar J, Sheyn J, Hampel H, Vergallo A, Davis MR, Jallow O, Baldacci F, Verdooner SR, Barron E, Mirzaei M, Gupta VK, Graham SL, Tayebi M, Carare RO, Sadun AA, Miller CA, Dumitrascu OM, Lahiri S, Gao L, Black KL, Koronyo-Hamaoui M. Alzheimer's disease pathophysiology in the Retina. Prog Retin Eye Res. 2024 Jul; 101:101273 Epub 2024 May 15 View PubMed Dumitrascu OM, Doustar J, Fuchs DT, Koronyo Y, Sherman DS, Miller MS, Johnson KO, Carare RO, Verdooner SR, Lyden PD, Schneider JA, Black KL, Koronyo-Hamaoui M. Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial. Acta Neuropathol Commun. 2024 Jun 28; 12 (1):109 Epub 2024 June 28 View PubMed Tailor PD, Dalvin LA, Starr MR, Tajfirouz DA, Chodnicki KD, Brodsky MC, Mansukhani SA, Moss HE, Lai KE, Ko MW, Mackay DD, Di Nome MA, Dumitrascu OM, Pless ML, Eggenberger ER, Chen JJ. A Comparative Study of Large Language Models, Human Experts, and Expert-Edited Large Language Models to Neuro-Ophthalmology Questions. J Neuroophthalmol. 2024 Apr 2 Epub 2024 Apr 02 View PubMed Alhayek N, Sobczak JM, Vanood A, O'Carroll CB, Demaerschalk BM, Chen J, Dumitrascu OM. Thrombolytic Therapy for Central Retinal Artery Occlusion in an Academic Multi-Site Stroke Centre. Neuroophthalmology. 2024; 48 (2):111-121 Epub 2024 Jan 04 View PubMed Shahjouei S, Bavarsad Shahripour R, Dumitrascu OM. Thrombolysis for central retinal artery occlusion: An individual participant-level meta-analysis. Int J Stroke. 2024 Jan; 19 (1):29-39 Epub 2023 July 27 View PubMed Beghi E, Ivashynka A, Logroscino G, de Oliveira FF, Fleisher JE, Dumitrascu OM, Patel R, Savica R, Kim YJ. Pitfalls and biases in neuroepidemiological studies of COVID-19 and the nervous system: a critical appraisal of the current evidence and future directions. J Neurol. 2023 Nov; 270 (11):5162-5170 Epub 2023 Sept 08 View PubMed Dumitrascu OM, English S, Alhayek N, Pahl E, Nord C, Vanderhye V, O'Carroll CB, Demaerschalk BM. Telemedicine for Acute Monocular Visual Loss: A Retrospective Large Telestroke Network Experience. Telemed J E Health. 2023 Nov; 29 (11):1738-1743 Epub 2023 Mar 13 View PubMed Alhayek N, Harahsheh E, Dumitrascu O, Green AL. A Case Report of Migraine With Aura Worsened After Starting Apixaban and Literature Review. Neurologist. 2023 Sep 1; 28 (5):335-337 Epub 2023 Sept 01 View PubMed Zhu W, Qiu P, Dumitrascu OM, Sobczak JM, Farazi M, Yang Z, Nandakumar K, Wang Y. OTRE: Where Optimal Transport Guided Unpaired Image-to-Image Translation Meets Regularization by Enhancing. Inf Process Med Imaging. 2023 Jun; 13939:415-427 Epub 2023 June 08 View PubMed Zhu W, Qiu P, Farazi M, Nandakumar K, Dumitrascu OM, Wang Y. OPTIMAL TRANSPORT GUIDED UNSUPERVISED LEARNING FOR ENHANCING LOW-QUALITY RETINAL IMAGES. Proc IEEE Int Symp Biomed Imaging. 2023 Apr; 2023 Epub 2023 Sept 01 View PubMed Parikh PP, Harahsheh EY, Dumitrascu OM. Unilateral Optic Nerve Diffusion Restriction After Sinus Surgery Secondary to Central Retinal Artery Occlusion: Case Report and Literature Review. Neurologist. 2023 Jan 1; 28 (1):46-48 Epub 2023 Jan 01 View PubMed Zhu W, Qiu P, Lepore N, Dumitrascu OM, Wang Y. Self-Supervised Equivariant Regularization Reconciles Multiple Instance Learning: Joint Referable Diabetic Retinopathy Classification and Lesion Segmentation. Proc SPIE Int Soc Opt Eng. 2022 Nov; 12567 Epub 2023 Mar 06 View PubMed Cheung CY, Ran AR, Wang S, Chan VTT, Sham K, Hilal S, Venketasubramanian N, Cheng CY, Sabanayagam C, Tham YC, Schmetterer L, McKay GJ, Williams MA, Wong A, Au LWC, Lu Z, Yam JC, Tham CC, Chen JJ, Dumitrascu OM, Heng PA, Kwok TCY, Mok VCT, Milea D, Chen CL, Wong TY. A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study. Lancet Digit Health. 2022 Nov; 4 (11):e806-e815 Epub 2022 Sept 30 View PubMed Boyko M, Dumitrascu O, Saindane AM, Hoxworth JM, Hu R, Rath T, Chan W, Flowers AM, Harahsheh E, Parikh P, Elshaigi O, Meyer BI, Newman NJ, Biousse V. Retinal and optic nerve magnetic resonance diffusion-weighted imaging in acute non-arteritic central retinal artery occlusion. J Stroke Cerebrovasc Dis. 2022 Sep; 31 (9):106644 Epub 2022 July 15 View PubMed English SW, Barrett KM, Freeman WD, Demaerschalk BM, Dumitrascu OM. Improving the Telemedicine Evaluation of Patients With Acute Vision Loss: A Call to Eyes. Neurology. 2022 Aug 30; 99 (9):381-386 Epub 2022 June 28 View PubMed Dumitrascu OM, Wang Y, Chen JJ. Clinical Machine Learning Modeling Studies: Methodology and Data Reporting. J Neuroophthalmol. 2022 Jun 1; 42 (2):145-148 Epub 2022 Apr 19 View PubMed Chhabra N, Chiang CC, Di Nome MA, Houghton O, Carlin RE, O'Carroll CB, Dodick DW, Dumitrascu OM. Migrainous infarction of the eye: Two cases of monocular ischemic complications associated with retinal migraine. Cephalalgia. 2022 May; 42(6):553-556. Epub 2021 Nov 17. View PubMed Chhabra N, Blech B, Fortuin D, Wilansky S, Demaerschalk BM, Dumitrascu OM. Embolic Stroke in Setting of Iliac Vein Stenosis in an Avid Cyclist. Neurohospitalist. 2022 Apr; 12 (2):413-416 Epub 2022 Feb 20 View PubMed Mbonde AA, O'Carroll CB, Dulamea OA, Anghel D, Chong BW, Dumitrascu OM. Current Guidelines on Management of Amaurosis Fugax and Transient Ischemic Attacks. Asia Pac J Ophthalmol (Phila). 2022 Feb 24 [Epub ahead of print] View PubMed Kayyali MN, Momii A, Xiao J, Fan Z, Dumitrascu OM. The Clinical Utility of High-Resolution Vessel Wall Imaging in Screening for Meningovascular Neurosyphilis. Neurohospitalist. 2022 Jan; 12 (1):63-66 Epub 2021 Mar 15 View PubMed Chiang MC, Dumitrascu OM, Chhabra N, Chiang CC. Migraine with Visual aura and the Risk of Stroke- a Narrative Review. J Stroke Cerebrovasc Dis. 2021 Nov; 30 (11):106067 Epub 2021 Aug 27 View PubMed Dumitrascu OM, Rosenberry R, Sherman DS, Khansari MM, Sheyn J, Torbati T, Sherzai A, Sherzai D, Johnson KO, Czeszynski AD, Verdooner S, Black KL, Frautschy S, Lyden PD, Shi Y, Cheng S, Koronyo Y, Koronyo-Hamaoui M. Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study. Cells. 2021 Oct 28; 10 (11) View PubMed Zaidat OO, Fifi JT, Nanda A, Atchie B, Woodward K, Doerfler A, Tomasello A, Tekle W, Singh IP, Matouk C, Thalwitzer J, Jargiello T, Skrypnik D, Beuing O, Berge J, Katz JM, Biondi A, Bonovich D, Sheth SA, Yoo AJ, Hassan AE, COMPLETE Registry Investigators*. Endovascular Treatment of Acute Ischemic Stroke With the Penumbra System in Routine Practice: COMPLETE Registry Results. Stroke. 2021 Sep 22; STROKEAHA121034268 Epub 2021 Sept 22 View PubMed Chhabra N, Kumar G, Fruin J, Dumitrascu OM. Right-to-left shunt detection using transforaminal insonation of the basilar artery. J Neuroimaging. 2021 Jul; 31 (4):696-700 Epub 2021 Apr 20 View PubMed Xiao J, Song SS, Schlick KH, Xia S, Jiang T, Han T, Jackson RJ, Diniz MA, Dumitrascu OM, Maya MM, Lyden PD, Li D, Yang Q, Fan Z. Disparate trends of atherosclerotic plaque evolution in stroke patients under 18-month follow-up: a 3D whole-brain magnetic resonance vessel wall imaging study. Neuroradiol J. 2021 Jun 23; 19714009211026920 Epub 2021 June 23 View PubMed Willenberg R, Leung B, Song S, Dumitrascu OM, Schlick K, Lyden P. Munchausen Syndrome by Tissue Plasminogen Activator: Patients Seeking Thrombolytic Administration. Neurol Clin Pract. 2021 Feb; 11 (1):64-68 View PubMed Xiao J, Padrick MM, Jiang T, Xia S, Wu F, Guo Y, Gonzalez NR, Li S, Schlick KH, Dumitrascu OM, Maya MM, Diniz MA, Song SS, Lyden PD, Li D, Yang Q, Fan Z. Acute ischemic stroke versus transient ischemic attack: Differential plaque morphological features in symptomatic intracranial atherosclerotic lesions. Atherosclerosis. 2021 Feb; 319:72-78 Epub 2021 Jan 11 View PubMed Padrick MM, Maya MM, Fan Z, Szumski N, Lyden PD, Song SS, Dumitrascu OM. Magnetic Resonance Vessel Wall Imaging in Central Nervous System Vasculitides: A Case Series. Neurologist. 2020 Nov; 25 (6):174-177 View PubMed Gonzalez NR, Jiang H, Lyden P, Song S, Schlick K, Dumitrascu O, Quintero-Consuegra MD, Toscano JF, Liebeskind DS, Restrepo L, Rao N, Hinman J, Alexander MJ, Schievink W, Piantadosi S, Saver JL. Encephaloduroarteriosynangiosis (EDAS) revascularization for symptomatic intracranial atherosclerotic steno-occlusive (ERSIAS) Phase-II objective performance criterion trial. Int J Stroke. 2020 Oct 29; 1747493020967256 [Epub ahead of print] View PubMed Dumitrascu OM, Newman NJ, Biousse V. Thrombolysis for Central Retinal Artery Occlusion in 2020: Time Is Vision! J Neuroophthalmol. 2020 Sep; 40 (3):333-345 View PubMed Dumitrascu OM, Volod O, Bose S, Wang Y, Biousse V, Lyden PD. Acute ophthalmic artery occlusion in a COVID-19 patient on apixaban. J Stroke Cerebrovasc Dis. 2020 Aug; 29 (8):104982 Epub 2020 May 23 View PubMed Shi H, Koronyo Y, Rentsendorj A, Regis GC, Sheyn J, Fuchs DT, Kramerov AA, Ljubimov AV, Dumitrascu OM, Rodriguez AR, Barron E, Hinton DR, Black KL, Miller CA, Mirzaei N, Koronyo-Hamaoui M. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020 May; 139 (5):813-836 Epub 2020 Feb 10 View PubMed Melmed KR, Schlick KH, Rinsky B, Dumitrascu OM, Volod O, Nezhad M, Padrick MM, Runyan C, Arabia FA, Moriguchi JD, Lyden PD, Song SS. Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices. J Neuroimaging. 2020 May; 30 (3):297-302 Epub 2020 Feb 10 View PubMed Dumitrascu OM, Koronyo-Hamaoui M. Retinal vessel changes in cerebrovascular disease. Curr Opin Neurol. 2020 Feb; 33 (1):87-92 View PubMed Dumitrascu OM, Lyden PD, Torbati T, Sheyn J, Sherzai A, Sherzai D, Sherman DS, Rosenberry R, Cheng S, Johnson KO, Czeszynski AD, Verdooner S, Frautschy S, Black KL, Koronyo Y, Koronyo-Hamaoui M. Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline. Alzheimers Dement (Amst). 2020; 12 (1):e12109 Epub 2020 Sept 28 View PubMed Jiang H, Toscano JF, Song SS, Schlick KH, Dumitrascu OM, Pan J, Lyden PD, Saver JL, Gonzalez NR. Differential expression of circulating exosomal microRNAs in refractory intracranial atherosclerosis associated with antiangiogenesis. Sci Rep. 2019 Dec 19; 9 (1):19429 View PubMed Kumar G, Dumitrascu OM, Chiang CC, O'Carroll CB, Alexandrov AV. Prediction of Delayed Cerebral Ischemia with Cerebral Angiography: A Meta-Analysis. Neurocrit Care. 2019 Feb; 30 (1):62-71 View PubMed Jiang H, Toscano JF, Schiraldi M, Song SS, Schlick KH, Dumitrascu OM, Liou R, Lyden PD, Pan J, Zhan R, Saver JL, Gonzalez NR. Differential Expression of Vascular Endothelial Growth Factor-A165 Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease. J Stroke Cerebrovasc Dis. 2019 Feb; 28 (2):360-368 Epub 2018 Nov 02 View PubMed Christiansen ME, O'Carroll CB, Kumar G, Larsen BT, Dumitrascu OM. Transcranial Doppler Evaluation in Takayasu Arteritis With Oculo-Cerebrovascular Complications. Neurologist. 2019 Jan; 24 (1):17-21 View PubMed Nelson T, Leung B, Bannykh S, Shah KS, Patel J, Dumitrascu OM. Cerebral Amyloid Angiopathy-Related Inflammation in the Immunosuppressed: A Case Report. Front Neurol. 2019; 10:1283 Epub 2019 Dec 06 View PubMed Dumitrascu OM, Okazaki EM, Cobb SH, Zarka MA, De Souza SA, Kumar G, O'Carroll CB. Amyloid-Beta-Related Angiitis with Distinctive Neuro-Ophthalmologic Features. Neuroophthalmology. 2018 Aug; 42 (4):237-241 Epub 2017 Sept 19 View PubMed Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY, Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018 Jul 19; 379 (3):215-225 Epub 2018 May 16 View PubMed Dumitrascu OM, Demaerschalk BM, Valencia Sanchez C, Almader-Douglas D, O'Carroll CB, Aguilar MI, Lyden PD, Kumar G. Retinal Microvascular Abnormalities as Surrogate Markers of Cerebrovascular Ischemic Disease: A Meta-Analysis. J Stroke Cerebrovasc Dis. 2018 Jul; 27 (7):1960-1968 Epub 2018 Mar 20 View PubMed Eskenazi J, Nuno M, Graff-Radford S, Dumitrascu OM. Genetic and demographic outcomes in a population of patients with headache and facial pain. J Behavioral and Brain Science. 2018 Jun; 8(6):339-50. Chiang CC, Dumitrascu OM, Wingerchuk DM, O'Carroll CB. Acute Basilar Artery Occlusion: Does Recanalization Improve Clinical Outcome? A Critically Appraised Topic. Neurologist. 2018 Mar; 23(2):71-74. View PubMed Dumitrascu OM, Qureshi TA. Retinal Vascular Imaging in Vascular Cognitive Impairment: Current and Future Perspectives. J Exp Neurosci. 2018; 12:1179069518801291 Epub 2018 Sept 20 View PubMed Dumitrascu OM, O'Carroll CB, Vanderhye V, Demaerschalk BM, Aguilar MI. Improving Blood Pressure Management and Disease Severity Documentation in Patients With Acute Intracerebral Hemorrhage. Mayo Clin Proc Innov Qual Outcomes. 2017 Dec; 1 (3):219-225 Epub 2017 Sept 23 View PubMed Dumitrascu OM, McKeon A, Zuniga L, Grill MF, Goodman BP. Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy. Neurol Neuroimmunol Neuroinflamm. 2017 Sep; 4 (5):e376 Epub 2017 June 26 View PubMed Dumitrascu OM, Demaerschalk BM. Telestroke. Curr Cardiol Rep. 2017 Sep; 19 (9):85 View PubMed Nokes BT, Dumitrascu OM, Shamoun FE, O'Carroll CB. Antiphospholipid Syndrome With a Distinctive Constellation of Neurological Manifestations: Blue Toes, Red Valves, White Retinal Spots. Neurologist. 2017 Jul; 22 (4):147-149 View PubMed Dumitrascu OM, Shen JF, Kurli M, Aguilar MI, Marks LA, Demaerschalk BM, Wingerchuk DM, O'Carroll CB. Is Intravenous Thrombolysis Safe and Effective in Central Retinal Artery Occlusion? A Critically Appraised Topic. Neurologist. 2017 Jul; 22 (4):153-156 View PubMed Dumitrascu OM, Torbati S, Tighiouart M, Newman-Toker DE, Song SS. Pitfalls and Rewards for Implementing Ocular Motor Testing in Acute Vestibular Syndrome: A Pilot Project. Neurologist. 2017 Mar; 22: (2)44-47. View PubMed Dumitrascu OM, Tsimerinov EI, Lewis RA. Gastrointestinal and Urologic Sphincter Dysfunction in Stiff Person Syndrome. J Clin Neuromuscul Dis. 2016 Dec; 18 (2):92-95 View PubMed Dumitrascu OM, Lamb J, Lyden PD. Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke. J Cereb Blood Flow Metab. 2016 Jul; 36 (7):1157-64 Epub 2016 Apr 18 View PubMed Dumitrascu O, Lyden P, Danielpour M, Moser F. Teaching neuroImages: short stature, imperforate anus, and polydactyly: When is a hypothalamic mass an incidentaloma? Neurology. 2015 Apr 14; 84: (15)e117. View PubMed Dumitrascu O, Tsimerinov E. Recurrent ischemic strokes and headaches originating from Lambl's excrescences: A case report. Int J Neurol Neurother. 2015 Jan 31; 2(1):1-3. Dumitrascu O, Mott KR, Ghiasi H. A comparative study of experimental mouse models of central nervous system demyelination. Gene Ther. 2014 Jun; 21: (6)599-608. View PubMed Dumitrascu O, Schenck CH, Applebee G, Attarian H. Parasomnia overlap disorder: a distinct pathophysiologic entity or a variant of rapid eye movement sleep behavior disorder? A case series. Sleep Med. 2013 Nov; 14: (11)1217-20. View PubMed Arnold AC, Costa RM, Dumitrascu OM. The spectrum of optic disc ischemia in patients younger than 50 years (an Amercian Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2013 Sep; 111:93-118 View PubMed Gaster RN, Dumitrascu O, Rabinowitz YS. Penetrating keratoplasty using femtosecond laser-enabled keratoplasty with zig-zag incisions versus a mechanical trephine in patients with keratoconus. Br J Ophthalmol. 2012 Sep; 96: (9)1195-9. View PubMed Dumitrascu O, Chacko J, Nazarian S. Cryptococcal meningitis in a young obese female with Takayasu arteritis and idiopathic intracranial hypertension. Neuro-Ophthalmology. 2012 Jun 1; 36(3):108-10. Zandian M, Mott KR, Allen SJ, Dumitrascu O, Kuo JZ, Ghiasi H. Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2. Gene Ther. 2011 Jul; 18: (7)734-42. View PubMed Dumitrascu O, Costa R, Kirsch C, Arnold A, Gordon L. Cavernous sinus syndrome resulting from contiguous spread of adenoid cystic carcinoma: A systematic analysis of reported cases. Neuro-Ophthalmology. 2009 Oct; 33(7):300-7. Costa RM, Dumitrascu OM, Gordon LK. Orbital myositis: diagnosis and management. Curr Allergy Asthma Rep. 2009 Jul; 9 (4):316-23 View PubMed Mihalcea O, Arnold AC. Side effect of head and neck radiotherapy: optic neuropathy. Oftalmologia. 2008; 52(1):36-40. View PubMed Armegioiu M, Staicu C, Mihalcea O, Pulbere L, Beraru V, Craiu A. [The role of total vitrectomy in severe acute postoperative endophthalmitis]. Oftalmologia. 2006; 50(3):65-8. View PubMed Armegioiu M, Jitianu B, Mihalcea O. [Posterior lens luxation--method of therapeutic approach]. Oftalmologia. 2006; 50(2):36-9. View PubMed Cârstocea B, Armegioiu M, Buliga S, Georgieva V, Mihalcea O, Caruntu F. [Fungal endogenous endophthalmitis--case report]. Oftalmologia. 2005; 49(3):25-9. View PubMed Mihalcea O. [Epiretinal macular membranes]. 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