Publications Print Virk A, Strasburg AP, Kies KD, Donadio AD, Mandrekar J, Harmsen WS, Stevens RW, Estes LL, Tande AJ, Challener DW, Osmon DR, Fida M, Vergidis P, Suh GA, Wilson JW, Rajapakse NS, Borah BJ, Dholakia R, Reed KA, Hines LM, Schuetz AN, Patel R. Rapid multiplex PCR panel for pneumonia in hospitalised patients with suspected pneumonia in the USA: a single-centre, open-label, pragmatic, randomised controlled trial. Lancet Microbe. 2024 Oct 16; 100928 [Epub ahead of print] View PubMed O'Horo JC, Challener DW, Kudrna C, Buckmeier JR, Peters SG, Kor DJ, Matson MW, Badley AD, Burger CD, Chaudhry R. Leveraging real-time patient data during the COVID-19 pandemic. Infect Control Hosp Epidemiol. 2024 Oct 8; 1-2 Epub 2024 Oct 08 View PubMed Challener DW, Fida M, Martin P, Rivera CG, Virk A, Walker LW. Machine learning for adverse event prediction in outpatient parenteral antimicrobial therapy: a scoping review. J Antimicrob Chemother. 2024 Oct 1 Epub 2024 Oct 01 View PubMed Crowley PD, Whalen FX, Siegel LR, Challener DW. Antibiotics at End of Life: Where Are We Now and Where Are We Going? A Narrative Review. Am J Hosp Palliat Care. 2024 Sep 09; 10499091241282627. [Epub ahead of print] View PubMed Challener DW, Tande AJ, Koutras C, Wade RL, McIntee MA, Strauss DM, Yao X, Chang YH, Berbari E. Evaluation of germicidal ultraviolet-C disinfection in a real-world outpatient health care environment. Am J Infect Control. 2024 Sep; 52 (9):1030-1034 Epub 2024 May 23 View PubMed Chesdachai S, Baddour LM, Sohail MR, Palraj BR, Madhavan M, Tabaja H, McGinnis MT, Fida M, Challener DW, DeSimone DC. Outcome of Corynebacterial Bloodstream Infection in Patients With Cardiac Implantable Electronic Devices: A Brief Report and Systematic Review. Open Forum Infect Dis. 2024 Aug; 11 (8):ofae441 Epub 2024 July 29 View PubMed Yetmar ZA, Khodadadi RB, Chesdachai S, McHugh JW, Clement J, Challener DW, Wengenack NL, Bosch W, Seville MT, Beam E. Trimethoprim-sulfamethoxazole dosing and outcomes of pulmonary nocardiosis. Infection. 2024 Jun 26 Epub 2024 June 26 View PubMed El Zein S, Challener DW, Ranganath N, Khodadadi RB, Theel ES, Abu Saleh OM. Acute Coxiella burnetii Infection: A 10-Year Clinical Experience at a Tertiary Care Center in the United States. Open Forum Infect Dis. 2024 Jun; 11 (6):ofae277 Epub 2024 May 10 View PubMed Yetmar ZA, Khodadadi RB, Chesdachai S, McHugh JW, Challener DW, Wengenack NL, Bosch W, Seville MT, Beam E. Epidemiology, Timing, and Secondary Prophylaxis of Recurrent Nocardiosis. Open Forum Infect Dis. 2024 Apr; 11 (4):ofae122 Epub 2024 Mar 01 View PubMed Yetmar ZA, Chesdachai S, Khodadadi RB, McHugh JW, Challener DW, Wengenack NL, Bosch W, Seville MT, Beam E. Outcomes of transplant recipients with pretransplant Nocardia colonization or infection. Transpl Infect Dis. 2023 Oct; 25 (5):e14097 Epub 2023 June 28 View PubMed Yetmar ZA, Chesdachai S, Duffy D, Smith BH, Challener DW, Seville MT, Bosch W, Beam E. Risk factors and prophylaxis for nocardiosis in solid organ transplant recipients: A nested case-control study. Clin Transplant. 2023 Sep; 37 (9):e15016 Epub 2023 May 11 View PubMed Yetmar ZA, Khodadadi RB, Chesdachai S, McHugh JW, Challener DW, Wengenack NL, Bosch W, Seville MT, Beam E. Mortality After Nocardiosis: Risk Factors and Evaluation of Disseminated Infection. Open Forum Infect Dis. 2023 Aug; 10 (8):ofad409 Epub 2023 Aug 01 View PubMed Chesdachai S, Baddour LM, Sohail MR, Palraj BR, Madhavan M, Tabaja H, Fida M, Challener DW, DeSimone DC. Candidemia in Patients With Cardiovascular Implantable Electronic Devices: Uncertainty in Management Based on Current International Guidelines. Open Forum Infect Dis. 2023 Jul; 10 (7):ofad318 Epub 2023 June 13 View PubMed Yetmar ZA, Chesdachai S, Lahr BD, Challener DW, Arensman Hannan KN, Epps K, Stevens RW, Seville MT, Tande AJ, Virk A. Comparison of Oral and Intravenous Definitive Antibiotic Therapy for Beta-Hemolytic Streptococcus Species Bloodstream Infections from Soft Tissue Sources: a Propensity Score-Matched Analysis. Antimicrob Agents Chemother. 2023 Jun 15; 67 (6):e0012023 Epub 2023 May 16 View PubMed Challener DW, Gao X, Tehranian S, Kashani KB, O'Horo JC. Body temperature and infection in critically ill patients on continuous kidney replacement therapy. BMC Nephrol. 2023 Jun 7; 24 (1):161 Epub 2023 June 07 View PubMed Yetmar ZA, Challener DW, Seville MT, Bosch W, Beam E. Outcomes of Nocardiosis and Treatment of Disseminated Infection in Solid Organ Transplant Recipients. Transplantation. 2023 Mar 1; 107 (3):782-791 Epub 2022 Oct 28 View PubMed Ranganath N, Shirley JD, Challener DW, Stevens RW, Kind DR, Comba IY, Patel R, Schuetz AN, Shah AS. Leptotrichia Bacteremia: 10-Year Retrospective Clinical Analysis and Antimicrobial Susceptibility Profiles. J Clin Microbiol. 2023 Feb 22; 61 (2):e0173322 Epub 2023 Jan 30 View PubMed Ranganath N, O'Horo JC, Challener DW, Tulledge-Scheitel SM, Pike ML, O'Brien M, Razonable RR, Shah A. Rebound Phenomenon After Nirmatrelvir/Ritonavir Treatment of Coronavirus Disease 2019 (COVID-19) in High-Risk Persons. Clin Infect Dis. 2023 Feb 8; 76 (3):e537-e539 View PubMed Challener D, O'Horo J, Tande AJ. Infectious disease physician characteristics and prescription of meropenem in the hospital. Antimicrob Steward Healthc Epidemiol. 2023; 3 (1):e126 Epub 2023 July 17 View PubMed Challener D, Frank R, Kashani K, O'Horo J. Body temperature trends of critically Ill patients on continuous renal replacement therapy: A single-center retrospective study. Am J Med Sci. 2022 Oct; 364 (4):404-408 Epub 2022 Apr 20 View PubMed Razonable RR, O'Horo JC, Challener DW, Arndt L, Arndt RF, Clune CG, Culbertson TL, Hall ST, Heyliger A, Jackson TA, Kennedy BD, Larsen J, Hanson SN, Sweeten PW, Tulledge-Scheitel SM, Ganesh R. Curbing the Delta Surge: Clinical Outcomes After Treatment With Bamlanivimab-Etesevimab, Casirivimab-Imdevimab, or Sotrovimab for Mild to Moderate Coronavirus Disease 2019. Mayo Clin Proc. 2022 Sep; 97 (9):1641-1648 Epub 2022 June 23 View PubMed Tande AJ, Swift MD, Challener DW, Berbari EF, Tommaso CP, Christopherson DR, Binnicker MJ, Breeher LE. Utility of Follow-up Coronavirus Disease 2019 (COVID-19) Antigen Tests After Acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Healthcare Personnel. Clin Infect Dis. 2022 Aug 24; 75 (1):e347-e349 View PubMed Comba IY, Riestra Guiance I, Corsini Campioli C, Challener D, Sampathkumar P, Orenstein R, Gordon J, Bosch W, O'Horo JC. Clinical Characteristics and Outcomes of Patients With SARS-CoV-2 Reinfection. Mayo Clin Proc Innov Qual Outcomes. 2022 Aug; 6 (4):361-372 Epub 2022 May 30 View PubMed Pawlowski C, Silvert E, O'Horo JC, Lenehan PJ, Challener D, Gnass E, Murugadoss K, Ross J, Speicher L, Geyer H, Venkatakrishnan AJ, Badley AD, Soundararajan V. SARS-CoV-2 and influenza coinfection throughout the COVID-19 pandemic: an assessment of coinfection rates, cohort characteristics, and clinical outcomes. PNAS Nexus. 2022 Jul; 1 (3):pgac071 Epub 2022 July 04 View PubMed O'Horo J, Challener DW, Anderson RJ, Arndt RF, Ausman SE, Hall ST, Heyliger A, Kennedy BD, Sweeten PW, Ganesh R, Razonable RR. Rates of Severe Outcomes After Bamlanivimab-Etesevimab and Casirivimab-Imdevimab Treatment of High-Risk Patients With Mild to Moderate Coronavirus Disease 2019. Mayo Clin Proc. 2022 May; 97 (5):943-950 Epub 2022 Feb 23 View PubMed Puranik A, Lenehan PJ, O'Horo JC, Pawlowski C, Virk A, Swift MD, Kremers W, Venkatakrishnan AJ, Challener DW, Breeher L, Gordon JE, Geyer HL, Speicher LL, Soundararajan V, Badley AD. Durability analysis of the highly effective mRNA-1273 vaccine against COVID-19. PNAS Nexus. 2022 May; 1 (2):pgac058 Epub 2022 May 20 View PubMed Niesen MJM, Matson R, Puranik A, O'Horo JC, Pawlowski C, Vachon C, Challener D, Virk A, Swift M, Speicher L, Gordon J, Geyer H, Lenehan PJ, Venkatakrishnan AJ, Soundararajan V, Badley A. Third dose vaccination with mRNA-1273 or BNT162b2 vaccines improves protection against SARS-CoV-2 infection. PNAS Nexus. 2022 May; 1 (2):pgac042 Epub 2022 Apr 28 View PubMed Niesen MJM, Pawlowski C, O'Horo J, Challener DW, Silvert E, Donadio G, Lenehan PJ, Virk A, Swift MD, Speicher L, Gordon JE, Geyer H, Halamka J, Venkatakrishnan AJ, Soundararajan V, Badley AD. Three doses of COVID-19 mRNA vaccination are safe based on adverse events reported in electronic health records Journal of the American Medical Association (JAMA) Network Open. 2022. Niesen MJM, Pawlowski C, O'Horo JC, Challener DW, Silvert E, Donadio G, Lenehan PJ, Virk A, Swift MD, Speicher LL, Gordon JE, Geyer HL, Halamka JD, Venkatakrishnan AJ, Soundararajan V, Badley AD. Surveillance of Safety of 3 Doses of COVID-19 mRNA Vaccination Using Electronic Health Records. JAMA Netw Open. 2022 Apr 1; 5 (4):e227038 Epub 2022 Apr 01 View PubMed Chesdachai S, Yetmar ZA, Tabaja H, Comba IY, Go JR, Challener DW, Misra A, Abu Saleh OM. Contemporary experience of Abiotrophia, Granulicatella and Gemella bacteremia. J Infect. 2022 Apr; 84 (4):511-517 Epub 2022 Feb 01 View PubMed O'Horo JC, Challener DW, Speicher L, Bosch W, Seville MT, Bierle DM, Ganesh R, Wilker CG, Arndt RF, Arndt LL, Tulledge-Scheitel SM, Hanson SN, Razonable RR. Effectiveness of Monoclonal Antibodies in Preventing Severe COVID-19 With Emergence of the Delta Variant. Mayo Clin Proc. 2022 Feb; 97 (2):327-332 Epub 2021 Dec 16 View PubMed Go JR, Challener D, Corsini Campioli C, Sohail MR, Palraj R, Baddour LM, Abu Saleh O. Clinical Significance of Staphylococcus aureus in a Single Positive Blood Culture Bottle. Open Forum Infect Dis. 2022 Feb; 9 (2):ofab642 Epub 2021 Dec 18 View PubMed Corsini Campioli C, Challener D, Comba IY, Shah A, Wilson WR, Sohail MR, Van Gompel JJ, O'Horo JC. Overview and risk factors for postcraniotomy surgical site infection: A four-year experience. Antimicrob Steward Healthc Epidemiol. 2022; 2 (1):e14 Epub 2022 Jan 31 View PubMed Tande AJ, Swift MD, Challener DW, Berbari EF, Tommaso CP, Christopherson DR, Binnicker MJ, Breeher LE. Utility of follow-up coronavirus disease 2019 (COVID-19) antigen tests after acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among healthcare personnel. Clinical Infectious Diseases. 2022; 75 (1):e347-9 Fida M, Khalil S, Abu Saleh O, Challener DW, Sohail MR, Yang JN, Pritt BS, Schuetz AN, Patel R. Diagnostic Value of 16S Ribosomal RNA Gene Polymerase Chain Reaction/Sanger Sequencing in Clinical Practice. Clin Infect Dis. 2021 Sep 15; 73 (6):961-968 View PubMed Pennington KM, Vu A, Challener D, Rivera CG, Shweta FNU, Zeuli JD, Temesgen Z. Approach to the diagnosis and treatment of non-tuberculous mycobacterial disease. J Clin Tuberc Other Mycobact Dis. 2021 Aug; 24:100244 Epub 2021 May 08 View PubMed Shah A, Challener DW, O'Horo JC, Badley AD. Vaccination Safety: Don't Toss the Champagne With the Cork. Mayo Clin Proc. 2021 Jul; 96 (7):1712-1713 View PubMed Corsini Campioli C, Castillo Almeida NE, O'Horo JC, Challener D, Go JR, DeSimone DC, Sohail MR. Clinical Presentation, Management, and Outcomes of Patients With Brain Abscess due to Nocardia Species. Open Forum Infect Dis. 2021 Apr; 8 (4):ofab067 Epub 2021 Apr 07 View PubMed Yetmar ZA, Challener DW, Tleyjeh IM, Sohail MR, Cerhan JR, Badley AD, O'Horo JC. Association Between Chronic Statin Use and 30-Day Mortality in Hospitalized Patients With COVID-19. Mayo Clin Proc Innov Qual Outcomes. 2021 Apr; 5 (2):442-446 Epub 2021 Mar 14 View PubMed Challener DW, Breeher LE, Frain J, Swift MD, Tosh PK, O'Horo J. Healthcare personnel absenteeism, presenteeism, and staffing challenges during epidemics. Infect Control Hosp Epidemiol. 2021 Apr; 42 (4):388-391 Epub 2020 Oct 26 View PubMed Corsini Campioli C, Go JR, Abu Saleh O, Challener D, Yetmar Z, Osmon DR. Antistaphylococcal Penicillin vs Cefazolin for the Treatment of Methicillin-Susceptible Staphylococcus aureus Spinal Epidural Abscesses. Open Forum Infect Dis. 2021 Mar; 8 (3):ofab071 Epub 2021 Feb 16 View PubMed O'Horo JC, Cerhan JR, Cahn EJ, Bauer PR, Temesgen Z, Ebbert J, Abril A, Abu Saleh OM, Assi M, Berbari EF, Bierle DM, Bosch W, Burger CD, Cano Cevallos EJ, Clements CM, Carmona Porquera EM, Castillo Almeida NE, Challener DW, Chesdachai S, Comba IY, Corsini Campioli CG, Crane SJ, Dababneh AS, Enzler MJ, Fadel HJ, Ganesh R, De Moraes AG, Go JR, Gordon JE, Gurram PR, Guru PK, Halverson EL, Harrison MF, Heaton HA, Hurt R, Kasten MJ, Lee AS, Levy ER, Libertin CR, Mallea JM, Marshall WF 3rd, Matcha G, Meehan AM, Franco PM, Morice WG 2nd, O'Brien JJ, Oeckler R, Ommen S, Oravec CP, Orenstein R, Ough NJ, Palraj R, Patel BM, Pureza VS, Pickering B, Phelan DM, Razonable RR, Rizza S, Sampathkumar P, Sanghavi DK, Sen A, Siegel JL, Singbartl K, Shah AS, Shweta F, Speicher LL, Suh G, Tabaja H Jr, Tande A, Ting HH, Tontz RC 3rd, Vaillant JJ, Vergidis P, Warsame MY, Yetmar ZA, Zomok CCD, Williams AW, Badley AD. Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research. Mayo Clin Proc. 2021 Mar; 96 (3):601-618 Epub 2020 Dec 26 View PubMed Eberly AR, Challener DW, Shweta FNU, Fida M, Boerger AC, Assi M, O'Horo JC, Binnicker MJ. Initial SARS-CoV-2 PCR crossing point does not predict hospitalization and duration of PCR positivity. J Microbiol Immunol Infect. 2021 Feb; 54 (1):77-80 Epub 2020 Oct 10 View PubMed Agarwal V, Venkatakrishnan AJ, Puranik A, Kirkup C, Lopez-Marquez A, Challener DW, Theel ES, O'Horo JC, Binnicker MJ, Kremers WK, Faubion WA Jr, Badley AD, Williams AW, Gores GJ, Halamka JD, Morice WG 2nd, Soundararajan V. Long-term SARS-CoV-2 RNA shedding and its temporal association to IgG seropositivity. Cell Death Discov. 2020 Dec 2; 6 (1):138 Epub 2020 Dec 02 View PubMed Challener DW, Shah A, O'Horo JC, Berbari E, Binnicker MJ, Tande AJ. Low Utility of Repeat Real-Time PCR Testing for SARS-CoV-2 in Clinical Specimens. Mayo Clin Proc. 2020 Sep; 95 (9):1942-1945 Epub 2020 July 04 View PubMed Shah AS, Tande AJ, Challener DW, O'Horo JC, Binnicker MJ, Berbari EF. Diagnostic Stewardship: An Essential Element in a Rapidly Evolving COVID-19 Pandemic. Mayo Clin Proc. 2020 Sep; 95 (9S):S17-S19 Epub 2020 June 23 View PubMed Challener DW, Dowdy SC, O'Horo JC. Analytics and Prediction Modeling During the COVID-19 Pandemic. Mayo Clin Proc. 2020 Sep; 95 (9S):S8-S10 Epub 2020 June 22 View PubMed Tande AJ, Challener DW, Shah AS, O'Horo JC, Beam E. Community-Based Drive-Through and Walk-Through Testing Centers. Mayo Clin Proc. 2020 Sep; 95 (9S):S20-S22 Epub 2020 June 30 View PubMed Challener DW, Challener GJ, Gow-Lee VJ, Fida M, Shah AS, O'Horo JC. Screening for COVID-19: Patient factors predicting positive PCR test. Infect Control Hosp Epidemiol. 2020 Aug; 41 (8):968-969 Epub 2020 May 19 View PubMed Wagner T, Shweta F, Murugadoss K, Awasthi S, Venkatakrishnan AJ, Bade S, Puranik A, Kang M, Pickering BW, O'Horo JC, Bauer PR, Razonable RR, Vergidis P, Temesgen Z, Rizza S, Mahmood M, Wilson WR, Challener D, Anand P, Liebers M, Doctor Z, Silvert E, Solomon H, Anand A, Barve R, Gores G, Williams AW, Morice WG 2nd, Halamka J, Badley A, Soundararajan V. Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis. Elife. 2020 Jul 7; 9 Epub 2020 July 07 View PubMed Shah A, Challener D, Tande AJ, Mahmood M, O'Horo JC, Berbari E, Crane SJ. Drive-Through Testing: A Unique, Efficient Method of Collecting Large Volume of Specimens During the SARS-CoV-2 (COVID-19) Pandemic. Mayo Clin Proc. 2020 Jul; 95 (7):1420-1425 Epub 2020 May 01 View PubMed Khalil S, Challener DW, Abu-Saleh O, Sohail MR. Laryngeal histoplasmosis in a kidney transplant recipient. Transpl Infect Dis. 2019 Aug; 21 (4):e13102 Epub 2019 May 22 View PubMed Fida M, Challener D, Hamdi A, O'horo J, Abu Saleh O. Babesiosis: A Retrospective Review of 38 Cases in the Upper Midwest. Open Forum Infect Dis. 2019 Jul 1; 6 (7) View PubMed Challener DW, Prokop LJ, Abu-Saleh O. The Proliferation of Reports on Clinical Scoring Systems: Issues About Uptake and Clinical Utility. JAMA. 2019 Jun 25; 321 (24):2405-2406 View PubMed Challener D, Abu Saleh O. A Traveler's Unwanted Souvenir. Am J Med. 2018 Apr; 131 (4):e137-e138 Epub 2017 Oct 12 View PubMed Challener D, Abu Saleh O. Disseminated blastomycosis in a transplant patient. Transpl Infect Dis. 2018 Apr; 20 (2):e12870 Epub 2018 Mar 25 View PubMed Challener D, Marcelin J, Visscher S, Baddour L. Hospital costs for patients with lower extremity cellulitis: a retrospective population-based study. Hosp Pract (1995). 2017 Dec; 45 (5):196-200 Epub 2017 Sept 27 View PubMed Challener DW, Saleh OA, Whitaker JA. 58-Year-Old Woman With Diarrhea, Weakness, and Memory Loss. Mayo Clin Proc. 2017 Nov; 92 (11):1706-1710 Epub 2017 Sept 13 View PubMed Marcelin JR, Challener DW, Tan EM, Lahr BD, Baddour LM. Incidence and Effects of Seasonality on Nonpurulent Lower Extremity Cellulitis After the Emergence of Community-Acquired Methicillin-Resistant Staphylococcus aureus. Mayo Clin Proc. 2017 Aug; 92 (8):1227-1233 Epub 2017 July 08 View PubMed DeSimone DC, El Rafei A, Challener DW, Carr AB, Kelly JA, Rocca WA, St Sauver JL, Bock-Goodner CM, Lahr BD, Steckelberg JM, Wilson WR, Baddour LM. Effect of the American Heart Association 2007 Guidelines on the Practice of Dental Prophylaxis for the Prevention of Infective Endocarditis in Olmsted County, Minnesota. Mayo Clin Proc. 2017 May 10 [Epub ahead of print] View PubMed PST-20517074 Home Publications