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M. Regina Castro, M.D.

  1. Endocrinologist
  2. Lipidologist
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Publications

  1. Rachmasari KN, Schmitz JJ, Castro MR, Kurup AN, Lee RA, Stan MN. Exploring Radiofrequency Ablation for T1 Papillary Thyroid Cancer in the United States: Mayo Clinic Experience. Mayo Clin Proc. 2024 Nov; 99 (11):1702-1709 Epub 2024 Aug 02
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  2. Dhanasekaran M, Schmitz J, Castro MR, Rajwani A, Lee RA, Hamadi D, Morris JC 3rd, Callstrom MR, Stan MN. Outcomes of Radiofrequency Ablation for Autonomously Functioning Thyroid Adenomas-Mayo Clinic Experience. J Endocr Soc. 2024 Oct 29; 8 (12):bvae175 Epub 2024 Oct 17
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  3. Lund S, Schmitz JJ, Foster T, Dy B, McKenzie T, Castro MR, Lyden ML. Ethanol ablation of papillary thyroid carcinoma nodal metastases: Long-term outcomes. Surgery. 2024 Apr; 175 (4):1034-1039 Epub 2024 Jan 08
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  4. Castro MR. Personal Reflection on International Women's Day. Thyroid. 2024 Mar; 34 (3):288-289 Epub 2024 Feb 21
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  5. Singh Ospina N, Patel Chavez C, Godinez Leiva E, Bagautdinova D, Hidalgo J, Hartasanchez S, Algarin Perneth S, Barb D, Danan D, Dziegielewski P, Hughley B, Srihari A, Subbarayan S, Castro MR, Dean D, Morris J, Ryder M, Stan MN, Hargraves I, Bylund CL, Treise D, Montori VM, Brito JP. Clinician feedback using a shared decision-making tool for the evaluation of patients with thyroid nodules-an observational study. Endocrine. 2024 Feb; 83 (2):449-458 Epub 2023 Sept 11
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  6. Gorman BG, Campbell E, Mullen BL, Deo N, Ahn J, Carley S, Castro MR, Todd A, Vidal NY. Association between Hashimoto's thyroiditis and melanoma: a retrospective matched cohort study. Arch Dermatol Res. 2023 Nov; 315 (9):2721-2724 Epub 2023 July 21
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  7. Patel Chavez CP, Godinez Leiva E, Bagautdinova D, Hidalgo J, Hartasanchez S, Barb D, Danan D, Dziegielewski P, Edwards C, Hughley B, Srihari A, Subbarayan S, Castro MR, Dean D, Morris J, Ryder M, Stan MN, Hargraves I, Shepel K, Brito JP, Bylund CL, Treise D, Montori V, Singh Ospina N. Patient feedback receiving care using a shared decision making tool for thyroid nodule evaluation-an observational study. Endocrine. 2023 Apr; 80 (1):124-133 Epub 2022 Dec 19
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  8. Navin PJ, Thompson SM, Kurup AN, Lee RA, Callstrom MR, Castro MR, Stan MN, Welch BT, Schmitz JJ. Radiofrequency Ablation of Benign and Malignant Thyroid Nodules. Radiographics. 2022 Oct; 42 (6):1812-1828
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  9. Burgos N, Zhao J, Brito JP, Hoang JK, Pitoia F, Maraka S, Castro MR, Lee JH, Singh Ospina N. Clinician Agreement on the Classification of Thyroid Nodules Ultrasound Features: A Survey of 2 Endocrine Societies. J Clin Endocrinol Metab. 2022 Jul 14; 107 (8):e3288-e3294
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  10. Asamoah EO, Caraballo G, Castro MR. Identifying and Addressing Health Disparities in Thyroid Cancer Care. J Clin Endocrinol Metab 2022 Apr 19; 107 (5):e2190-e2191
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  11. Stan MN, Papaleontiou M, Schmitz JJ, Castro MR. Nonsurgical Management of Thyroid Nodules: The Role of Ablative Therapies. J Clin Endocrinol Metab. 2022 Apr 19; 107 (5):1417-1430
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  12. Shen X, Ma S, Vemuri P, Castro MR, Caraballo PJ, Simon PJ. A novel method for causal structure discovery from EHR data and its application to type-2 diabetes mellitus. Sci Rep. 2021 Oct 25; 11 (1):21025
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  13. Merten MM, Foster T, Lyden M, Henry M, Regina Castro M. Favorable Early Outcomes With Thyroid Lobectomy for Low-Risk Papillary Thyroid Cancer: The Mayo Clinic Experience. Am Surg. 2021 Sep; 87 (9):1374-1378 Epub 2021 Sept 01
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  14. Boonrod A, Akkus Z, Castro MR, Zeinodini A, Philbrick K, Stan M, Erickson D, Erickson B. Thyroid Nodule Size as a Predictor of Malignancy in Follicular and Hurthle Neoplasms. Asian Pac J Cancer Prev. 2021 Aug 1; 22 (8):2597-2602 Epub 2021 Aug 01
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  15. Oh W, Steinbach MS, Castro MR, Peterson KA, Kumar V, Caraballo PJ, Simon GJ. A Computational Method for Learning Disease Trajectories From Partially Observable EHR Data. IEEE J Biomed Health Inform. 2021 Jul; 25 (7):2476-2486 Epub 2021 July 27
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  16. Kohlenberg JD, Panda A, Johnson GB, Castro MR. Radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE PET activity. Nucl Med Commun. 2021 May 1; 42 (5):510-516
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  17. Kotwal A, Erickson D, Geske JR, Hay ID, Castro MR. Predicting Outcomes in Sporadic and Hereditary Medullary Thyroid Carcinoma over Two Decades. Thyroid. 2021 Apr; 31 (4):616-626 Epub 2020 Nov 25
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  18. Li J, Simon G, Castro MR, Kumar V, Steinbach MS, Caraballo PJ. Association of BMI, comorbidities and all-cause mortality by using a baseline mortality risk model. PLoS One. 2021; 16 (7):e0253696 Epub 2021 July 09
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  19. Rodriguez V, Gonzales KM, Iqbal AM, Arbelo-Ramos N, Wyatt KD, Lteif AN, Castro MR. PANCYTOPENIA SECONDARY TO AUTOIMMUNE VITAMIN B12 DEFICIENCY IN GRAVES DISEASE. AACE Clin Case Rep. 2020 Nov-Dec; 6 (6):e282-e285 Epub 2020 June 23
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  20. Hay ID, Lee RA, Kaggal S, Morris JC, Stan MN, Castro MR, Fatourechi V, Thompson GB, Charboneau JW, Reading CC. Long-Term Results of Treating With Ethanol Ablation 15 Adult Patients With cT1aN0 Papillary Thyroid Microcarcinoma. J Endocr Soc. 2020 Nov 1; 4 (11):bvaa135 Epub 2020 Sept 15
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  21. Stan MN, Castro MR. NONSURGICAL TREATMENT OF THYROID CYSTS - "SEAL THEM UP". Endocr Pract. 2020 May; 26 (5):573-575
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  22. Simon GJ, Peterson KA, Castro MR, Steinbach MS, Kumar V, Caraballo PJ. Predicting diabetes clinical outcomes using longitudinal risk factor trajectories. BMC Med Inform Decis Mak. 2020 Jan 8; 20 (1):6 Epub 2020 Jan 08
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  23. Singh Ospina N, Iniguez-Ariza NM, Castro MR. Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment. BMJ. 2020 Jan 7; 368:l6670 Epub 2020 Jan 07
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  24. Gonzales KM, Stan MN, Morris JC 3rd, Bernet V, Castro MR. The Levothyroxine Absorption Test: A Four-Year Experience (2015-2018) at The Mayo Clinic. Thyroid. 2019 Dec; 29 (12):1734-1742 Epub 2019 Dec 04
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  25. Yadav P, Caraballo PJ, Steinbach M, Kumar V, Castro MR, Simon G. Frequent Causal Pattern Mining: A Computationally Efficient Framework For Estimating Bias-Corrected Effects. Proc IEEE Int Conf Big Data. 2019 Dec; 2019:1981-1990 Epub 2020 Feb 24
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  26. Oh W, Steinbach MS, Castro MR, Peterson KA, Kumar V, Caraballo PJ, Simona GJ. Evaluating the Impact of Data Representation on EHR-Based Analytic Tasks. Stud Health Technol Inform. 2019 Aug 21; 264:288-292
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  27. Njeru JW, Castro MR, Carta KG, Simon G, Caraballo PJ. CLINICAL RECOGNITION AND MANAGEMENT OF PATIENTS WITH PREDIABETES. Endocr Pract. 2019 Jun; 25 (6):545-553 Epub 2019 Mar 13
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  28. Kim E, Caraballo PJ, Castro MR, Pieczkiewicz DS, Simon GJ. Towards more Accessible Precision Medicine: Building a more Transferable Machine Learning Model to Support Prognostic Decisions for Micro- and Macrovascular Complications of Type 2 Diabetes Mellitus. J Med Syst. 2019 May 17; 43 (7):185
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  29. Iniguez-Ariza NM, Lee RA, Singh-Ospina NM, Stan MN, Castro MR. Ethanol Ablation for the Treatment of Cystic and Predominantly Cystic Thyroid Nodules. Mayo Clin Proc. 2018 Aug; 93 (8):1009-1017 Epub 2018 July 04
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  30. Hamidi O, Callstrom MR, Lee RA, Dean D, Castro MR, Morris JC, Stan MN. Outcomes of Radiofrequency Ablation Therapy for Large Benign Thyroid Nodules: A Mayo Clinic Case Series. Mayo Clin Proc. 2018 Aug; 93 (8):1018-1025 Epub 2018 Mar 21
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  31. Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC. An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. Thyroid. 2018 Jun; 28 (6):707-721 Epub 2018 Apr 05
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  32. Kim E, Pieczkiewicz DS, Castro MR, Caraballo PJ, Simon GJ. Multi-Task Learning to Identify Outcome-Specific Risk Factors that Distinguish Individual Micro and Macrovascular Complications of Type 2 Diabetes. AMIA Jt Summits Transl Sci Proc. 2018; 2017:122-131 Epub 2018 May 18
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  33. Oh Wonsuk, Yadav Pranjul, Kumar Vipin, Castro M, Steinbach Michael, Simon Gyorgy. Estimating disease onset time by modeling lab results Mrs. Kearns 2017 IEEE International Conference on Healthcare Informatics (ICHI). 2017; 374-379.
  34. Oh W, Yadav P, Kumar V, Caraballo PJ, Castro MR, Steinbach MS, Simon GJ. Estimating Disease Onset Time by Modeling Lab Result Trajectories via Bayes Networks. IEEE Int Conf Healthc Inform. 2017 Aug; 2017:374-379 Epub 2017 Sept 14
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  35. Al-Hilli Z, Strajina V, McKenzie TJ, Thompson GB, Farley DR, Regina Castro M, Algeciras-Schimnich A, Richards ML. Thyroglobulin Measurement in Fine-Needle Aspiration Improves the Diagnosis of Cervical Lymph Node Metastases in Papillary Thyroid Carcinoma. Ann Surg Oncol. 2017 Mar; 24 (3):739-744 Epub 2016 Oct 13
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  36. Merten MM, Castro MR, Zhang J, Durski J, Ryder M. Examining the Role of Preoperative Positron Emission Tomography/Computerized Tomography in Combination with Ultrasonography in Discriminating Benign from Malignant Cytologically Indeterminate Thyroid Nodules. Thyroid. 2017 Jan; 27 (1):95-102 Epub 2016 Dec 05
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  37. Singh Ospina N, Maraka S, Espinosa De Ycaza AE, Ahn HS, Castro MR, Morris JC, Montori VM, Brito JP. Physical exam in asymptomatic people drivers the detection of thyroid nodules undergoing ultrasound guided fine needle aspiration biopsy. Endocrine. 2016 Nov; 54 (2):433-439 Epub 2016 Aug 10
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  38. Espinosa De Ycaza AE, Lowe KM, Dean DS, Castro MR, Fatourechi V, Ryder M, Morris JC, Stan MN. Risk of Malignancy in Thyroid Nodules with Non-Diagnostic Fine-Needle Aspiration: A Retrospective Cohort Study. Thyroid. 2016 Nov; 26 (11):1598-1604 Epub 2016 Oct 05
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  39. Singh Ospina N, Maraka S, Espinosa de Ycaza AE, Brito JP, Castro MR, Morris JC, Montori VM. Prognosis of patients with benign thyroid nodules: a population-based study. Endocrine. 2016 Oct; 54 (1):148-155 Epub 2016 May 03
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  40. Singh Ospina N, Brito JP, Maraka S, Espinosa de Ycaza AE, Rodriguez-Gutierrez R, Gionfriddo MR, Castaneda-Guarderas A, Benkhadra K, Al Nofal A, Erwin P, Morris JC, Castro MR, Montori VM. Diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy for thyroid malignancy: systematic review and meta-analysis. Endocrine. 2016 Sep; 53 (3):651-61 Epub 2016 Apr 12
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  41. Singh Ospina N, Maraka S, Espinosa DeYcaza A, O'Keeffe D, Brito JP, Gionfriddo MR, Castro MR, Morris JC, Erwin P, Montori VM. Diagnostic accuracy of thyroid nodule growth to predict malignancy in thyroid nodules with benign cytology: systematic review and meta-analysis. Clin Endocrinol (Oxf). 2016 Jul; 85 (1):122-31 Epub 2016 Jan 25
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  42. Castro MR, Simon G, Cha SS, Yawn BP, Melton LJ 3rd, Caraballo PJ. Statin Use, Diabetes Incidence and Overall Mortality in Normoglycemic and Impaired Fasting Glucose Patients. J Gen Intern Med. 2016 May; 31 (5):502-8 Epub 2016 Feb 05
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  43. Oh W, Kim E, Castro MR, Caraballo PJ, Kumar V, Steinbach MS, Simon GJ. Type 2 Diabetes Mellitus Trajectories and Associated Risks. Big Data. 2016 Mar 1; 4 (1):25-30
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  44. Brito JP, Castaneda-Guarderas A, Gionfriddo MR, Ospina NS, Maraka S, Dean DS, Castro MR, Fatourechi V, Gharib H, Stan MN, Branda ME, Bahn RS, Montori VM. Development and Pilot Testing of an Encounter Tool for Shared Decision Making About the Treatment of Graves' Disease. Thyroid. 2015 Nov; 25 (11):1191-8 Epub 2015 Oct 15
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  45. Singh Ospina N, Sebo TJ, Morris JC, Castro MR. The Value of Repeat Thyroid Fine-Needle Aspiration Biopsy in Patients with a Previously Benign Result: How Often Does It Alter Management? Thyroid. 2015 Oct; 25: (10)1121-6.
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  46. Brito JP, Castro MR, Dean DS, Fatourechi V, Stan M. Survey of current approaches to non-diagnostic fine-needle aspiration from solid thyroid nodules. Endocrine. 2015 Aug; 49 (3):745-51 Epub 2015 Feb 04
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  47. Netzel BC, Grebe SK, Carranza Leon BG, Castro MR, Clark PM, Hoofnagle AN, Spencer CA, Turcu AF, Algeciras-Schimnich A. Thyroglobulin (Tg) Testing Revisited: Tg Assays, TgAb Assays, and Correlation of Results With Clinical Outcomes. J Clin Endocrinol Metab. 2015 Aug; 100 (8):E1074-83 Epub 2015 June 16
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  48. Simon GJ, Caraballo PJ, Therneau TM, Cha SS, Castro MR, Li PW. Extending association rule summarization techniques to assess risk of diabetes mellitus. IEEE Transactions on Knowledge and Data Engineering. 2015; 27(1):130-41.
  49. McIver B, Castro MR, Morris JC, Bernet V, Smallridge R, Henry M, Kosok L, Reddi H. An independent study of a gene expression classifier (Afirma) in the evaluation of cytologically indeterminate thyroid nodules. J Clin Endocrinol Metab. 2014 Nov; 99 (11):4069-77 Epub 2014 Apr 29
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  50. Kim E, Oh W, Pieczkiewicz DS, Castro MR, Caraballo PJ, Simon GJ. Divisive Hierarchical Clustering towards Identifying Clinically Significant Pre-Diabetes Subpopulations. AMIA Annu Symp Proc. 2014; 2014:1815-24 Epub 2014 Nov 14
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  51. Castro MR, Thomas BC, Richards ML, Zhang J, Morris JC. Multiple endocrine neoplasia type 2A due to an exon 8 (G533C) mutation in a large North American kindred. Thyroid. 2013 Dec; 23 (12):1547-52 Epub 2013 July 25
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  52. Simon GJ, Schrom J, Castro MR, Li PW, Caraballo PJ. Survival association rule mining towards type 2 diabetes risk assessment. AMIA Annu Symp Proc. 2013; 2013:1293-302 Epub 2013 Nov 16
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  53. Schrom JR, Caraballo PJ, Castro MR, Simon GJ. Quantifying the effect of statin use in pre-diabetic phenotypes discovered through association rule mining. AMIA Annu Symp Proc. 2013; 2013:1249-57 Epub 2013 Nov 16
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  54. Castro MR, Espiritu RP, Bahn RS, Henry MR, Gharib H, Caraballo PJ, Morris JC. Predictors of malignancy in patients with cytologically suspicious thyroid nodules. Thyroid. 2011 Nov; 21 (11):1191-8 Epub 2011 Oct 18
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  55. Bahn RS, Castro MR. Approach to the patient with nontoxic multinodular goiter. J Clin Endocrinol Metab. 2011 May; 96 (5):1202-12
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  56. Clarke MJ, Erickson D, Castro MR, Atkinson JL. Thyroid-stimulating hormone pituitary adenomas. J Neurosurg. 2008 Jul; 109 (1):17-22
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  57. Castro MR. Multinodular goiter-diagnostic and treatment considerations. US Endocrinology. 2008; 4(2):107-10.
  58. Castro MR, Gharib H. Continuing controversies in the management of thyroid nodules. Ann Intern Med. 2005 Jun 7; 142 (11):926-31
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  59. Castro MR, Gharib H. Thyroid fine-needle aspiration biopsy: progress, practice, and pitfalls. Endocr Pract. 2003 Mar-Apr; 9(2):128-36.
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  60. Castro MR, Caraballo PJ, Morris JC. Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J Clin Endocrinol Metab. 2002 Sep; 87(9):4154-9.
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  61. Castro MR, Bergert ER, Goellner JR, Hay ID, Morris JC. Immunohistochemical analysis of sodium iodide symporter expression in metastatic differentiated thyroid cancer: correlation with radioiodine uptake. J Clin Endocrinol Metab. 2001 Nov; 86 (11):5627-32
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  62. Smallridge RC, Castro MR, Morris JC, Young PR, Reynolds JC, Merino MJ, Sarlis NJ. Renal metastases from thyroid papillary carcinoma: study of sodium iodide symporter expression. Thyroid. 2001 Aug; 11 (8):795-804
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  63. Spitzweg C, Dutton CM, Castro MR, Bergert ER, Goellner JR, Heufelder AE, Morris JC. Expression of the sodium iodide symporter in human kidney. Kidney Int. 2001 Mar; 59 (3):1013-23
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  64. Castro MR, Kocher D, Morris JC. An unusual case of inappropriate secretion of thyrotropin: neoplastic or nonneoplastic? Endocr Pract. 2000 Jan-Feb; 6 (1):29-33
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  65. Castro MR, Gharib H. Thyroid nodules and cancer. When to wait and watch, when to refer. Postgrad Med. 2000 Jan; 107: (1)113-6, 119-20, 123-4.
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  66. Castro MR, Bergert ER, Beito TG, Roche PC, Ziesmer SC, Jhiang SM, Goellner JR, Morris JC, Morris JC. Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer. J Endocrinol. 1999 Dec; 163 (3):495-504
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  67. Castro MR, Nguyen TT, O'Brien T. Clomiphene-induced severe hypertriglyceridemia and pancreatitis. Mayo Clin Proc. 1999 Nov; 74(11):1125-8.
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  68. Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O'Fallon WM, Castro MR, Melton LJ 3rd, Melton LJ 3rd. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med. 1999 Aug 9-23; 159 (15):1750-6
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  69. Castro MR, Bergert ER, Beito TG, McIver B, Goellner JR, Morris JC. Development of monoclonal antibodies against the human sodium iodide symporter: immunohistochemical characterization of this protein in thyroid cells. J Clin Endocrinol Metab. 1999 Aug; 84(8):2957-62.
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  70. Spitzweg C, Zhang S, Bergert ER, Castro MR, McIver B, Heufelder AE, Tindall DJ, Young CY, Morris JC. Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines. Cancer Res. 1999 May 1; 59 (9):2136-41
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  71. Caraballo PJ, Gabriel SE, Castro MR, Atkinson EJ, Melton LJ 3rd, Melton LJ 3rd. Changes in bone density after exposure to oral anticoagulants: a meta-analysis. Osteoporos Int. 1999; 9 (5):441-8
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PST-20223221