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Pablo R. Castillo, M.D.

  1. Internist
  2. Sleep Medicine Specialist
  3. Neurologist
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Publications

  1. Castillo PR, Patel V, Mera RM, Rumbea DA, Del Brutto OH. The association between slow-wave sleep and choroid plexus calcifications in older adults. Results from the sleep disorders substudy of the Atahualpa Project cohort. Clin Neurol Neurosurg. 2024 Nov; 246:108541 Epub 2024 Sept 10
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  2. Labarca G, Henriquez-Beltran M, Sanhueza R, Burgos M, Nova-Lamperti E, Fernandez-Bussy I, Castillo PR. Impact on health outcomes associated with changing the clock 1 hour during fall and spring transitions in the Southern Hemisphere. J Clin Sleep Med. 2024 Jun 1; 20 (6):887-893
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  3. Castillo PR, Patel V, Mera RM, Rumbea DA, Del Brutto OH. Choroid plexus calcifications are not associated with putative markers of glymphatic dysfunction: A population study in middle-aged and older adults. Neuroradiol J. 2024 Jun; 37 (3):342-350 Epub 2024 Mar 15
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  4. Del Brutto OH, Mera RM, Rumbea DA, Sedler MJ, Castillo PR. Poor sleep quality increases mortality risk: A population-based longitudinal prospective study in community-dwelling middle-aged and older adults. Sleep Health. 2024 Feb; 10 (1):144-148 Epub 2023 Nov 25
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  5. Mansur A, Castillo PR, Rocha Cabrero F, Bokhari SRA. Restless Legs Syndrome. StatPearls Treasure Island (FL) StatPearls Publishing 2024 Jan
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  6. Dredla BK, Castillo PR. Periodic limb movements in sleep: evolving role of autonomic nervous system. Neurol Neurochir Pol. 2024; 58 (2):145-146 Epub 2023 Nov 27
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  7. Punj M, Desai A, Hashash JG, Farraye FA, Castillo PR. COVID-19 breakthrough infections and sleep disorders: A population-based propensity matched analysis. Sleep Med X. 2023 Dec 15; 6:100089 Epub 2023 Oct 12
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  8. Dredla BK, Del Brutto OH, Castillo PR. Sleep and Perivascular Spaces. Curr Neurol Neurosci Rep. 2023 Oct; 23 (10):607-615 Epub 2023 Aug 12
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  9. Del Brutto OH, Mera RM, Rumbea DA, Castillo PR. Periodic limb movements in sleep are associated with hippocampal atrophy in stroke-free community-dwelling older adults. Sleep 2023 Jun 13; 46 (6)
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  10. Dredla BK, Castillo PR. Out of the Laboratory and into the Home: Home Testing for Sleep Apnea and Other Sleep Disorders. J Clin Neurophysiol. 2023 Mar 1; 40 (3):198-202 Epub 2020 Sept 17
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  11. Del Brutto OH, Mera RM, Costa AF, Rumbea DA, Recalde BY, Castillo PR. Long coronavirus disease-related persistent poor sleep quality and progression of enlarged perivascular spaces. A longitudinal study. Sleep. 2022 Sep 8; 45 (9)
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  12. Arosemena MA, Ramos AR, Marcus EN, Slota KA, Cheung J, Castillo PR. Primary hypothyroidism and chronotypes in adult women. BMC Res Notes. 2022 Feb 14; 15 (1):52
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  13. Mehra R, Heinzer R, Castillo P. Current Management of Residual Excessive Daytime Sleepiness Due to Obstructive Sleep Apnea: Insights for Optimizing Patient Outcomes. Neurol Ther. 2021 Dec; 10 (2):651-672 Epub 2021 Oct 18
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  14. Del Brutto OH, Mera RM, Costa AF, Recalde BY, Castillo PR. Sleep quality deterioration in middle-aged and older adults living in a rural Ecuadorian village severely struck by the SARS-CoV-2 pandemic. A population-based longitudinal prospective study. Sleep. 2021 Aug 13; 44 (8)
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  15. Tipton PW, Dredla BK, Castillo PR, Mauricio EA, Lemos J, Eggenberger ER. Eyelid Closure Downbeat Nystagmus: A Rare Cause of Insomnia. J Neuroophthalmol. 2021 Jun 1; 41 (2):e194-e196
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  16. Del Brutto OH, Mera RM, Castillo PR, Recalde BY, Costa AF. Previously diagnosed obstructive sleep apnea is not associated with increased risk of SARS-CoV-2 infection in community-dwelling older adults living in a highly endemic setting. Clin Neurol Neurosurg. 2021 Apr 12; 205:106639 [Epub ahead of print]
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  17. Castillo PR, Del Brutto OH, Mautong H, Garcia M, Tovar M, Middlebrooks EH, Bolona E. Hemorrhagic stroke in hispanics with severe SARS-CoV2 infection. J Neurol Sci 2020 Sep 15; 416:117046 Epub 2020 July 16
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  18. Castillo PR, Benarroch EE. How could the basal ganglia control sleep? Neurology. 2020 Aug 18; 95 (7):302-304
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  19. Del Brutto OH, Mera RM, Del Brutto VJ, Recalde BY, Castillo PR. The association between physical activity and sleep quality in stroke-free adults living in rural settings. The Three Villages Study. Sleep Med. 2020 Jun; 70:2-5 Epub 2020 Feb 17
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  20. Del Brutto OH, Matcha G, Mera RM, Del Brutto VJ, Costa AF, Castillo PR. On the association between abdominal aorta and basilar artery diameters: a population-based study in community-dwelling older adults. J Ultrasound. 2020 Mar; 23 (1):31-35 Epub 2018 Nov 09
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  21. Del Brutto OH, Mera RM, Del Brutto VJ, Castillo PR. Lack of Association between Periodic Limb Movements during Sleep and Neuroimaging Signatures of Cerebral Small Vessel Disease in Stroke-Free Community-Dwelling Older Adults. The Atahualpa Project. J Stroke Cerebrovasc Dis. 2020 Feb; 29 (2):104497 Epub 2019 Dec 04
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  22. Castillo PR, Middlebrooks EH, Grewal SS, Okromelidze L, Meschia JF, Quinones-Hinojosa A, Uitti RJ, Wharen RE Jr. Globus Pallidus Externus Deep Brain Stimulation Treats Insomnia in a Patient With Parkinson Disease. Mayo Clin Proc 2020 Feb; 95 (2):419-422
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  23. Del Brutto OH, Mera RM, Recalde BY, Castillo PR. Assessment of Neck Grasp as a Screening Tool for Identifying Obstructive Sleep Apnea in Community-Dwelling Older Adults. J Prim Care Community Health. 2020 Jan-Dec; 11:2150132720984421
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  24. Dredla BK, Castillo PR. Cardiovascular Consequences of Obstructive Sleep Apnea. Curr Cardiol Rep. 2019 Nov 9; 21 (11):137 Epub 2019 Nov 09
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  25. Del Brutto OH, Mera RM, Costa AF, Castillo PR. Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease. Stroke. 2019 Sep; 50 (9):2486-2491 Epub 2019 July 26
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  26. Del Brutto OH, Mera RM, Penaherrera E, Costa AF, Penaherrera R, Castillo PR. On the Association Between Sleep Quality and Arterial Stiffness: A Population Study in Community-Dwelling Older Adults Living in Rural Ecuador (The Atahualpa Project). J Clin Sleep Med. 2019 Aug 15; 15 (8):1101-1106
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  27. Del Brutto OH, Mera RM, Del Brutto VJ, Castillo PR. Enlarged basal ganglia perivascular spaces and sleep parameters. A population-based study. Clin Neurol Neurosurg. 2019 Jul; 182:53-57 Epub 2019 May 06
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  28. Del Brutto OH, Mera RM, Costa AF, Castillo PR, Matcha G. On the association between earlobe crease and the carotid intima-media thickness: A population-based study. Heliyon. 2019 Apr; 5 (4):e01556 Epub 2019 Apr 23
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  29. Del Brutto OH, Mera RM, Zambrano M, Simon LV, Matcha GV, Castillo PR. Sleep quality correlates with the carotid intima-media thickness in stroke-free community-dwelling adults living in rural Ecuador. The Atahualpa Project. Sleep Med. 2019 Mar; 55:22-25 Epub 2018 Dec 15
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  30. Del Brutto OH, Mera RM, Costa AF, Matcha G, Castillo PR. No association between the abdominal aorta diameter and cervicocephalic atherosclerosis-Potential non-atherosclerotic origins of abdominal aorta aneurysms? Pathophysiology. 2019 Mar; 26 (1):49-52 Epub 2018 Nov 30
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  31. Del Brutto OH, Mera RM, Nader JA, Zambrano M, Castillo PR, Matcha G, Simon LV. The relationship between the neck circumference and the carotid intima-media thickness in Amerindians. Potential links to health risks? Pathophysiology. 2018 Dec; 25 (4):427-431 Epub 2018 Sept 01
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  32. Del Brutto OH, Mera RM, Espinosa V, Nader JA, Zambrano M, Simon LV, Parikh PR, Castillo PR, Matcha G. Distribution of Cervicocephalic Atherosclerotic Lesions and Their Correlation with Cardiovascular Risk Factors in a Population of Amerindians. The Atahualpa Project. J Stroke Cerebrovasc Dis. 2018 Nov; 27 (11):3356-3364 Epub 2018 Aug 25
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  33. Friday T, Castillo PR, Hashmi A, Khawaja IS. Restless Legs Syndrome Among Veterans With Spinal Cord Lesions. Fed Pract. 2018 Apr; 35 (Suppl 3):S17-S20
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  34. Festic N, Alejos D, Bansal V, Mooney L, Fredrickson PA, Castillo PR, Festic E. Sleep Apnea in Patients Hospitalized With Acute Ischemic Stroke: Underrecognition and Associated Clinical Outcomes. J Clin Sleep Med. 2018 Jan 15; 14 (1):75-80
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  35. Del Brutto OH, Castillo PR, Sedler MJ, Del Brutto VJ, Zambrano M, Mera RM, Wright CB, Rundek T. Reasons for Declining Consent in a Population-Based Cohort Study Conducted in a Rural South American Community. J Environ Public Health. 2018; 2018:8267948 Epub 2018 Nov 26
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  36. Del Brutto OH, Mera RM, Castillo PR, Del Brutto VJ. Key findings from the Atahualpa Project: what should we learn? Expert Rev Neurother 2018 Jan; 18 (1):5-8 Epub 2017 Nov 06
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  37. Del Brutto OH, Mera RM, de Amador AR, Zambrano M, Castillo PR. Symptoms of Neurotoxicity among Carpenters Living in Rural Ecuador: A Population-based Study (The Atahualpa Project). J Neurosci Rural Pract. 2017 Oct-Dec; 8 (4):649-652
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  38. Del Brutto OH, Mera RM, Zambrano M, Castillo PR. Relationship between obstructive sleep apnea and neuroimaging signatures of cerebral small vessel disease in community-dwelling older adults. The Atahualpa Project. Sleep Med. 2017 Sep; 37:10-12 Epub 2017 June 27
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  39. Arosemena Coronel M, Sanchez Armijos J, Tettamanti Miranda D, Vasquez Cedeno D, Mariani Carrera R, Navarro Chavez M, Castillo PR. Excessive daytime somnolence is associated with hypoglycemia in adult Latinos with type 2 diabetes mellitus. Sleep Med. 2017 Aug; 36:6-9 Epub 2017 May 15
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  40. Del Brutto OH, Mera RM, Ha JE, Del Brutto VJ, Castillo PR, Zambrano M, Gillman J. Oily fish consumption is inversely correlated with cerebral microbleeds in community-dwelling older adults: results from the Atahualpa Project. Aging Clin Exp Res. 2016 Aug; 28 (4):737-43 Epub 2015 Oct 26
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  41. Del Brutto OH, Mera RM, Zambrano M, Castillo PR. The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project. Sleep Sci. 2016 Jul-Sep; 9 (3):147-150 Epub 2016 Sept 09
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  42. Del Brutto OH, Mera RM, Gillman J, Castillo PR, Zambrano M, Ha JE. Dietary Oily Fish Intake and Blood Pressure Levels: A Population-Based Study. J Clin Hypertens (Greenwich). 2016 Apr; 18 (4):337-41 Epub 2015 Sept 23
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  43. Del Brutto OH, Mera RM, Sedler MJ, Zambrano M, Nieves JL, Cagino K, Fanning KD, Milla-Martinez MF, Castillo PR. The Effect of Age in the Association between Frailty and Poor Sleep Quality: A Population-Based Study in Community-Dwellers (The Atahualpa Project). J Am Med Dir Assoc. 2016 Mar 1; 17 (3):269-71 Epub 2016 Jan 28
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  44. Del Brutto OH, Mera RM, Gillman J, Zambrano M, Castillo PR. Dietary fish intake and sleep quality: a population-based study Sleep Medicine. 2016.
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  45. Del Brutto OH, Mera RM, Zambrano M, Castillo PR. Caffeine intake has no effect on sleep quality in community dwellers living in a rural Ecuadorian village (The Atahualpa Project). Sleep Sci. 2016 Jan-Mar; 9 (1):35-9 Epub 2016 Jan 04
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  46. Del Brutto OH, Mera RM, Ha JE, Gillman J, Zambrano M, Castillo PR. Dietary fish intake and sleep quality: a population-based study. Sleep Med. 2016 Jan; 17:126-8.
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  47. Del Brutto OH, Mera RM, de la Luz Andrade M, Espinosa V, Castillo PR, Zambrano M, Nader JA. Temporal bone thickness and texture are major determinants of the high rate of insonation failures of transcranial Doppler in Amerindians (the Atahualpa Project). J Clin Ultrasound. 2016 Jan; 44: (1)55-60.
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  48. Del Brutto OH, Mera RM, Zambrano M, Castillo PR. Caffeine intake has no effect on sleep quality in community dwellers living in a rural Ecuadorian village (The Atahualpa Project). Sleep Sci. 2016 Jan-Mar; 9: (1)35-9.
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  49. Dredla BK, Del Brutto OH, Lee AS, Castillo PR. Willis-Ekbom disease is not associated with poor cardiovascular health in adults. J Negat Results Biomed. 2015 Nov 6; 14:17 Epub 2015 Nov 06
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  50. Castillo PR, Del Brutto OH, Andrade L, Zambrano M, Nader JA. The association of sleep-disordered breathing with high cerebral pulsatility might not be related to diffuse small vessel disease. A pilot study. BMC Res Notes. 2015 Sep 29; 8:500 Epub 2015 Sept 29
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  51. Del Brutto OH, Mera RM, Andrade L, Castillo PR, Zambrano M, Nader JA. Disappointing reliability of pulsatility indices to identify candidates for magnetic resonance imaging screening in population-based studies assessing prevalence of cerebral small vessel disease. J Neurosci Rural Pract. 2015 Jul-Sep; 6 (3):336-8
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  52. Del Brutto OH, Mera RM, Zambrano M, Lama J, Del Brutto VJ, Castillo PR. Poor sleep quality and silent markers of cerebral small vessel disease: a population-based study in community-dwelling older adults (The Atahualpa Project). Sleep Med. 2015 Mar; 16 (3):428-31 Epub 2015 Jan 28
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  53. Castillo PR, Mera RM, Fredrickson PA, Zambrano M, Del Brutto VJ, Del Brutto OH. Psychological distress in patients with restless legs syndrome (Willis-Ekbom disease): a population-based door-to-door survey in rural Ecuador. BMC Res Notes. 2014 Dec 15; 7:911
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  54. Del Brutto OH, Mera RM, Zambrano M, Castillo PR. Excessive daytime somnolence and cardiovascular health: A population-based study in rural Ecuador. Sleep Sci. 2014 Dec; 7 (4):186-8 Epub 2014 Oct 16
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  55. Castillo PR, Mera RM, Zambrano M, Del Brutto OH. Population-based study of facial morphology and excessive daytime somnolence. Pathophysiology. 2014 Nov; 21 (4):289-92 Epub 2014 June 13
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  56. Del Brutto OH, Del Brutto VJ, Zambrano M, Castillo PR. Prevalence of Willis-Ekbom disease in rural coastal Ecuador. A two-phase, door-to-door, population-based survey. J Neurol Sci. 2014 Sep 15; 344(1-2):139-42. Epub 2014 Jun 28.
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  57. Del Brutto OH, Mera RM, Farfan R, Castillo PR, Atahualpa Project Investigators. Cerebrovascular correlates of sleep disorders-rational and protocol of a door-to-door survey in rural Coastal Ecuador. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):1030-9. Epub 2013 Oct 06.
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  58. Del Brutto OH, Sedler MJ, Mera RM, Castillo PR, Cusick EH, Gruen JA, Phelan KJ, Del Brutto VJ, Zambrano M, Brown DL. Prevalence, correlates, and prognosis of peripheral artery disease in rural ecuador-rationale, protocol, and phase I results of a population-based survey: an atahualpa project-ancillary study. Int J Vasc Med. 2014; 2014:643589 Epub 2014 Sept 21
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  59. Del Brutto OH, Mera RM, Zambrano M, Del Brutto VJ, Castillo PR. Association between sleep quality and cardiovascular health: A door-to-door survey in rural Ecuador. Environmental Health and Preventive Medicine. 2014; 19(3):234-7.
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  60. Arunthari V, Kaplan J, Fredrickson PA, Lin SC, Castillo PR, Heckman MG. Prevalence of restless legs syndrome in blood donors. Mov Disord. 2010 Jul 30; 25(10):1451-5.
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  61. Boeve BF, Silber MH, Saper CB, Ferman TJ, Dickson DW, Parisi JE, Benarroch EE, Ahlskog JE, Smith GE, Caselli RC, Tippman-Peikert M, Olson EJ, Lin SC, Young T, Wszolek Z, Schenck CH, Mahowald MW, Castillo PR, Del Tredici K, Braak H. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain. 2007 Nov; 130(Pt 11):2770-88. Epub 2007 Apr 05.
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  62. Castillo PR, Miller DA, Meschia JF. Choice of neuroimaging in perioperative acute stroke management. Neurol Clin. 2006 Nov; 24(4):807-20.
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  63. Castillo PR, Kaplan J, Lin SC, Fredrickson PA, Mahowald MW. Prevalence of restless legs syndrome among native South Americans residing in coastal and mountainous areas. Mayo Clin Proc. 2006 Oct; 81(10):1345-7.
  64. Dominguez R, Vila JF, Augustovski F, Irazola V, Castillo PR, Rotta Escalante R, Brott TG, Meschia JF. Spanish cross-cultural adaptation and validation of the National Institutes of Health Stroke Scale. Mayo Clin Proc. 2006 Apr; 81(4):476-80.
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  65. Castillo P, Woodruff B, Caselli R, Vernino S, Lucchinetti C, Swanson J, Noseworthy J, Aksamit A, Carter J, Sirven J, Hunder G, Fatourechi V, Mokri B, Drubach D, Pittock S, Lennon V, Boeve B. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch Neurol. 2006 Feb; 63 (2):197-202
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  66. Freeman WD, Brott TG, Barrett KM, Castillo PR, Deen HG Jr, Czervionke LF, Meschia JF. Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc. 2004 Dec; 79: (12)1495-500.
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  67. Castillo PR, Brott TG, Alvarez S, Meschia JF. Creation of a bilingual Spanish-English version of the Questionnaire for Verifying Stroke-free Status. Neuroepidemiology. 2004 Sep-Oct; 23(5):236-9.
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  68. Castillo PR, Mignot E, Woodruff BK, Boeve BF. Undetectable CSF hypocretin-1 in "Hashimoto's encephalopathy" associated with coma. Neurology. 2004 May 25; 62 (10):1909
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  69. Schauble B, Castillo PR, Boeve BF, Westmoreland BF. EEG findings in steroid-responsive encephalopathy associated with autoimmune thyroiditis. Clin Neurophysiol. 2003 Jan; 114 (1):32-7
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  70. Del Brutto, Dolezal M, Castillo P. Neurocysticercosis and Oncogenesis. Arch Med Research. 2000; 31:151-5.
  71. Morgenstern LB, Gonzales Hl, Castillo P, et al. Worst headache and Subaracnoid hemorrhage: prospective modern CT and Spinal fluid analysis. Annals Emerg Med. 1998; 32:297.
  72. Del Brutto, Castillo P, et al. Neurocysticercosis among patients with cerebral gliomas. Arch of Neurology.1997;Vol 54,:(9):1041-76.
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