News April 26, 2024 AI helps map glioma heterogeneity Mayo Clinic researchers are using AI to create a system that predicts glioma biology based solely on imaging. The goal is to better personalize cancer treatment. April 26, 2024 Elucidating the role of microglia in emergence from anesthesia Mayo Clinic researchers have shown that microglia boost neuronal activity after anesthesia. The discovery may lead to new ways to manage post-anesthesia complications. April 09, 2024 Predicting biochemical remission after surgical management of GH-secreting adenomas Results from a retrospective analysis helped clinicians design a scoring system to predict biochemical remission after surgical management of GH-secreting adenomas. March 26, 2024 New options for imaging MRI-resistant Cushing tumors Mayo Clinic has cutting-edge imaging that can identify MRI-resistant corticotroph adenomas. Pinpointing these tumors enhances treatment for Cushing disease. March 26, 2024 'Seeing through the walls': Augmented reality facilitates tumor surgery Patient-specific simulations guide presurgical planning. The images are then superimposed on the surgical field, to optimize intraoperative navigation. Feb. 24, 2024 Plasma biomarkers of Alzheimer's disease in the continuum of DLB A Mayo Clinic study found that blood tests can detect Alzheimer's pathology in patients with DLB. The results can facilitate future clinical trials of potential DLB therapies. Feb. 24, 2024 Awake craniotomy can cut costs without compromising patient care Standardizing protocols for the surgery to treat complex brain tumors can lower costs — with no adverse effect on patient outcomes, according to Mayo Clinic research. Jan. 26, 2024 Cavernous malformations: 7T MRI enhances expertise Mayo Clinic uses advanced imaging to aid diagnosis and decisions about whether cavernous malformations should be surgically removed to prevent bleeding. Jan. 26, 2024 Promising developments in the search for glioblastoma therapies Mayo Clinic is advancing the search for new glioblastoma treatments. Laboratory studies combining small molecule inhibitors with approved drugs have yielded positive results. Jan. 16, 2024 Collaborative surgical innovation can reduce complications and hospital stay Meningiomas account for 15% to 20% of primary brain tumors. Mayo Clinic ophthalmologists collaborating across the clinical practice has allowed a new treatment option to emerge for anterior skull base meningioma resecti[...] Dec. 22, 2023 New aneurysm devices expand treatment options Mayo Clinic uses the latest aneurysm treatment devices, which can enhance the safety of aneurysm repair. Embracing innovation allows neurosurgeons to offer patients more treatment options. Dec. 22, 2023 Technical advances in epilepsy care Mayo Clinic uses a range of innovative techniques for the diagnosis and treatment of medication-refractory seizures. Subspecialized expertise can provide options for patients who aren't surgical candidates. Nov. 23, 2023 AVMs: Multimodal approach for individualized treatment Mayo Clinic neurosurgeons have experience with the range of treatment options for arteriovenous malformations. That expertise facilitates a patient-specific approach. Nov. 23, 2023 Autoimmune neurology: Enhanced expertise for treatable conditions Mayo Clinic is augmenting its team of autoimmune neurology clinician-researchers. The move epitomizes Mayo Clinic's commitment to excellence in the field. Oct. 27, 2023 Laboratory study sheds light on pathogenesis of MS progression Mayo Clinic research describes the role of neuroantigen-specific T cells in promoting neuron loss in mouse models of multiple sclerosis. Oct. 27, 2023 Beyond the status quo: Technical advances in managing brain tumors Mayo Clinic applies the latest technology to all aspects of neuro-oncological care. The goal is to optimize outcomes and improve quality of life for all patients. Oct. 27, 2023 Pituitary tumors: Team approach facilitates strong outcomes Mayo Clinic has a high-volume practice in pituitary tumors. Subspecialists work together to maximize resection and avoid morbidity. Oct. 27, 2023 Electrical impedance rhythms in the human limbic system The results of a Mayo Clinic study can potentially impact the forecasting of epileptic seizures. The study found that human brain impedance exhibits multiscale oscillations. Oct. 27, 2023 Specialized expertise for spinal deformity surgery The wide range of spinal deformity treated at Mayo Clinic encompasses scoliosis and kyphosis, high-grade spondylolisthesis, and cervical spine and post-laminectomy deformity, as well as revision surgeries. Sept. 22, 2023 Choosing optimal treatments for cerebrovascular pathologies Mayo Clinic's experience with multiple treatment modalities means that patients with cerebrovascular pathologies can be offered the approach that best meets their needs. Aug. 26, 2023 Robotic system facilitates complex stereotactic surgeries The new system can increase the accuracy of complex neurosurgeries and shorten operating times. It is available at all three main Mayo Clinic campuses. Aug. 26, 2023 Defining markers for future CASH clinical trials Mayo Clinic is part of a national effort to find endpoints for clinical trials of therapies for cavernous angioma with symptomatic hemorrhage (CASH) — a rare cerebrovascular malformation. Aug. 26, 2023 Groundbreaking studies of regenerative medicine treatment for intracerebral hemorrhage Mayo Clinic researchers are studying how mesenchymal stem cells might treat the effects of intracerebral hemorrhage. Preclinical work demonstrated the cells' capacity to rescue injured neurons. Aug. 26, 2023 Melding technology and expertise for optimal spinal surgery Spinal surgery at Mayo Clinic combines advanced technology with the personalized expertise of a multidisciplinary team to deliver optimal outcomes for patients with a range of conditions. July 21, 2023 Study links hyperinflammatory monocytes to FIRES Mayo Clinic researchers describe their successful treatment of a child with febrile infection-related epilepsy syndrome (FIRES). The case report offers guidance for clinicians seeking to manage this challenging syndrome[...] July 21, 2023 7-T MRI: Providing hope by seeing the previously unseen Mayo Clinic neuroradiologists are using clinical 7-T MRI to manage a growing list of neurological conditions. Imaging sequences developed by Mayo Clinic are directly impacting patients' lives. July 21, 2023 Chronic neurological pain: Managing an undertreated condition Mayo Clinic neurosurgeons use a variety of neurostimulation techniques to treat severe neuropathic pain syndromes. Lesioning procedures are an additional option for patients with cancer-related pain. June 16, 2023 Innovations spur post-stroke recovery Mayo Clinic uses vagus nerve stimulation paired with rehabilitation exercises to treat upper extremity deficits after ischemic stroke. Neurostimulation increases neuroplasticity to augment the effects of physical and oc[...] June 16, 2023 Personalized treatment for movement disorders Mayo Clinic neurologists have extensive experience with the treatment of complex movement disorders. Innovations in diagnosis and deep brain stimulation (DBS) can potentially improve outcomes. June 03, 2023 Mayo Clinic neuroscientists discover a new brain area Somatotopy of cells in the precentral gyrus extends throughout the volume of the pericentral brain. But somatotopy is interrupted by an area in the central sulcus. May 26, 2023 Applying technology to improve hydrocephalus care Sophisticated gait assessments and artificial intelligence are spurring Mayo Clinic's innovations in the diagnosis and treatment of idiopathic normal-pressure hydrocephalus. May 26, 2023 Brachial plexus injuries: Seamless pediatric and adult care Mayo Clinic's integrated approach facilitates rapid evaluation by multiple subspecialized surgeons. A "one-stop shop" provides individualized treatment for all ages. April 22, 2023 Spinal oncology surgery focuses on preserving quality of life Mayo Clinic increasingly uses a minimally invasive or a "mini open" approach for resecting spinal tumors. The procedure requires a multidisciplinary team and the latest technology. April 22, 2023 Seeking biomarkers for Alzheimer's disease in multiethnic populations Mayo Clinic is leading a multicenter program that aims to identify biomarkers and potential therapeutic targets for Alzheimer's disease. The federally funded effort involves multiethnic cohorts. April 22, 2023 Photon-counting CT: Next-generation technology for CSF-venous fistulas Mayo Clinic is one of the first centers in the United States to use photon-counting detector CT myelography to localize CSF-venous fistulas. The technology improves upon digital subtraction myelography. April 22, 2023 Endoscopic spinal surgery: The next level of minimally invasive care Mayo Clinic neurosurgeons have experience with this ultra-minimally invasive technique. The advantages include fewer permanent biomechanical changes after elective spinal surgery. March 24, 2023 Intracranial artery dissection: Managing a life-threatening condition Mayo Clinic specialists have experience with the diagnosis and treatment of this rare condition. State-of-the-art imaging of complex vascular pathology facilitates optimal outcomes. March 24, 2023 Deep learning fuels neurodegenerative disease research Mayo Clinic researchers developed a deep learning model that produces a biomarker of neurodegenerative disease states. The model helps assess differences between chronological age and "brain age." March 24, 2023 Pediatric brain tumor research: Enhancing treatment and quality of life Multidisciplinary teams are overcoming challenges and making discoveries in the laboratory and clinic. The efforts include finding new drugs and delivery methods and enhanced radiation protocols. March 24, 2023 State-of-the-art molecular diagnostics for brain tumor care Mayo Clinic uses comprehensive molecular and genetic testing to refine brain tumor diagnoses. A multidisciplinary team helps ensure individualized tumor treatment. Feb. 24, 2023 Reassessing 'clinically meaningful' in Alzheimer's disease therapies Slowing the progression of Alzheimer's disease has meaningful benefits for patients and their families. Expectations of outcomes from therapeutic interventions might need to be modified. Feb. 24, 2023 Carotid plaque imaging spurs innovative care Advanced technology allows Mayo Clinic neuroradiologists to assess specific plaque features as well as the degree of luminal stenosis, for improved management of carotid artery disease. Feb. 24, 2023 Overcoming the challenges of leptomeningeal inflammation diagnosis Mayo Clinic has a multispecialty group focused on managing leptomeningeal diseases. The goal is to improve diagnosis so that individuals receive appropriate and timely treatment. Jan. 28, 2023 Optimizing bone health before complex spinal surgery Strengthening bone before surgery can improve the outcomes of complex spinal surgeries. Mayo Clinic neurosurgeons and endocrinologists routinely collaborate to help patients avoid proximal junctional kyphosis and failur[...] Dec. 30, 2022 Avoiding misdiagnosis of autoimmune encephalitis Mistaken diagnosis of autoimmune encephalitis occurs frequently and can lead to inappropriate treatment. A study led by Mayo Clinic offers guidance for correct diagnosis. Nov. 04, 2022 Improving detection of respiratory insufficiency for patients with ALS Mayo Clinic researchers found that overnight pulse oximetry and maximum inspiratory pressure yield the earliest identification of individuals who would benefit from noninvasive ventilation. Oct. 29, 2022 Role for stereotactic radiosurgery in pituitary-dependent Cushing syndrome A retrospective study shows that stereotactic radiosurgery increases biochemical remission and controls tumor growth in patients with persistent or recurrent Cushing disease. Oct. 01, 2022 Sophisticated imaging and models guide pediatric brain tumor care Multidisciplinary teams are overcoming challenges and making discoveries in the laboratory and clinic. The efforts include finding new drugs and delivery methods, and enhanced radiation protocols. Oct. 01, 2022 Multispecialty team provides rapid, individualized care for pediatric brain tumors The Pediatric Brain Tumor Clinic focuses on children's needs while offering Mayo Clinic's deep expertise. Patients have access to the latest treatments and technology. Oct. 01, 2022 Fertility preservation for children with brain tumors Mayo Clinic's Pediatric Fertility Preservation Program provides unique services to children with brain tumors. Neuro-oncologists determine when this option is appropriate to offer. Oct. 01, 2022 New study assesses the risk of stroke before and after central retinal artery occlusion Mayo Clinic researchers analyzed population-based data to study the correlation between central retinal artery occlusion and incidence of ischemic stroke to evaluate the associated risk. Sept. 21, 2022 7-T MRI: Identifying lesions for optimal epilepsy care State-of-the-art MRI enhances Mayo Clinic's ability to localize seizure-origin sites. Pinpointing these sites is key to optimizing treatment for medication-refractory epilepsy. Sept. 21, 2022 Expertise in defining and treating neuromyelitis optica spectrum disease Mayo Clinic neurologists have published a review of neuromyelitis optica spectrum disorder in The New England Journal of Medicine. Treatment seeks to preserve neurological function. Sept. 21, 2022 Preventing recurrent ischemic stroke The Heart Brain Clinic brings together neurologists and cardiologists to determine stroke etiology. Patients see both types of specialists during the same half-day visit. Aug. 25, 2022 Single position spinal surgery: How patients benefit Mayo Clinic has experience and expertise with this advanced approach. Single position spinal reconstruction shortens operating times while generally providing equivalent outcomes compared with typical spinal surgeries. Aug. 25, 2022 DISCOVERY: Unraveling post-stroke cognitive impairment Mayo Clinic is a lead partner in a major study of post-stroke cognition in diverse populations. DISCOVERY draws on Mayo Clinic's expertise in multiple domains of neurology and imaging. Aug. 25, 2022 Study identifies causes of neurodevelopmental syndrome Mayo Clinic led an international team that found 15 additional genetic alterations associated with KCNK9 imprinting syndrome. Identifying the syndrome's root cause is key to finding a cure. July 23, 2022 Summer program trains high school researchers, fuels real advances Mayo Clinic scientists mentor talented students in world-class laboratories. One student's award-winning Alzheimer's disease work will help guide future research efforts. July 23, 2022 Expanding insights into autoimmune GI dysmotility Mayo Clinic has expertise and experience with this debilitating dysautonomia. Autoimmune neurologists work closely with GI specialists to provide care. July 23, 2022 Expert guidance for vestibular schwannomas' complex treatment decisions The treatment options for vestibular schwannomas are evolving. Mayo Clinic has deep experience and expertise with managing care for individuals with these benign tumors. June 24, 2022 Expert management of autoimmune dementia Mayo Clinic autoimmune neurologists have experience differentiating between dementias with autoimmune and neurodegenerative etiologies. Autoimmune dementia is potentially reversible with timely diagnosis and treatment. June 24, 2022 Leadership role in NCI effort to advance glioblastoma treatments Mayo Clinic is a key participant in a nationwide program that aims to bring new glioblastoma therapeutics into clinical trials. The effort represents a new approach to experimental therapies. June 24, 2022 Innovation can avoid complications of microvascular decompression Mayo Clinic has a novel approach for the surgical treatment of trigeminal neuralgia. The technique uses fibrin instead of Teflon, to minimize the risk of recurrent pain. May 25, 2022 Laser ablation: Expert minimally invasive treatment for epilepsy and brain tumors Mayo Clinic routinely performs laser interstitial thermal therapy (LITT) to treat epilepsy and brain tumors. LITT can be an option for individuals who wish to avoi[...] May 25, 2022 Preclinical study suggests strategy for re-myelination Altered NAD+ metabolism is linked to high-fat diets and multiple sclerosis. Mayo Clinic found that normalizing levels of that enzyme promotes re-myelination in laboratory models. April 23, 2022 Improving health equity in Alzheimer's disease diagnosis Mayo Clinic has created a predictive model for the diagnosis of Alzheimer's disease in African Americans. The model incorporates plasma mRNA measures. April 23, 2022 Routine screening for individuals with a family history of aneurysm Regular assessments of individuals with a family history of aneurysm can help prevent hemorrhagic stroke. A family history of aneurysm greatly increases an individual's risk of aneurysm. April 23, 2022 Novel global information processing model of neurodegenerative disease Mayo Clinic's model localizes mental functions relevant for Alzheimer's disease and related disorders. The model can potentially impact the diagnosis, treatment and understanding of neurodegenerative disease. April 23, 2022 New antibody test for MS diagnosis Mayo Clinic has identified an immunoglobulin kappa value comparable to the detection of oligoclonal bands for the diagnosis of MS. The antibody test is more automated and provides faster results. April 23, 2022 Awake spinal surgery: A paradigm shift in neurosurgery Mayo Clinic can perform lumbar fusion, as well as laminectomy and diskectomy, with spinal anesthesia. The awake procedures can lessen operating room time and postoperative pain. March 29, 2022 Emerging therapies for pediatric lysosomal disorders Mayo Clinic offers the latest treatments for children with lysosomal diseases. Early diagnosis and treatment are key to minimizing the effects of these rare inherited metabolic disorders. March 26, 2022 Proposed pathogenesis for stroke in patients with COVID-19 An interaction of vascular risk factors and immune responses to the SARS-CoV-2 virus may explain the increased risk of stroke for people with COVID-19. March 26, 2022 Radiogenomics: Exploring MRI's potential for predicting heterogeneous tumor biology Mayo Clinic applies machine learning to research aimed at connecting brain tumors' morphological and physiological appearance with the tumors' underlying genomic features. March 26, 2022 Pediatric epilepsy: Defining syndromes and applying innovative therapies Mayo Clinic uses the latest technology to learn the cause of childhood seizures and to provide treatment as soon as possible. A multidisciplinary team addresses quality-of-life issues. March 26, 2022 Diffuse midline glioma: Investigating new approaches Mayo Clinic is studying two techniques to improve the treatment of this pediatric brain tumor: fractionated radiation therapy and convection-enhanced delivery of medication. Feb. 25, 2022 New effort manages stroke care for younger adults Mayo Clinic's neurovascular care process addresses the needs of people age 55 and under who have strokes. A multidisciplinary team helps patients regain function and avoid future strokes. Feb. 25, 2022 Virtual reality for enhanced neurological exams Mayo Clinic plans to test novel software aimed at enhancing remote neurological evaluations. The pilot project highlights the potential of virtual reality to provide objective data that guide treatment decisions. Feb. 25, 2022 Using AI to improve brain stimulation devices Mayo Clinic researchers have developed an algorithm that reveals the complex results of stimulating brain networks. The goal is to develop more-sophisticated stimulation devices for treating brain disorders. Feb. 25, 2022 Combined neurosurgical and orthopedic training facilitates complex spinal surgery Mayo Clinic neurosurgeons apply skills acquired through combined neurosurgical and orthopedic fellowship training in spinal procedures. The complementary skill sets optimize patient care. Dec. 28, 2021 'Intelligently aggressive' approach to MRI for people with implanted devices Radiologists, MRI safety officers and physicists collaborate to provide vital imaging while ensuring patient safety. Altering MRI parameters can ensure safety with devices technically considered MRI nonconditional. Dec. 28, 2021 Study shows potential of wrist-worn devices to predict seizures Mayo Clinic researchers have documented the feasibility of forecasting seizures without directly measuring brain activity. The preliminary study indicates a possible future option for people with refractory epilepsy. Dec. 21, 2021 Research aims to develop an adjunct therapy for cervical spondylotic myelopathy Mayo Clinic researchers are testing a protein-based therapy in laboratory models. The goal is to help the spinal cord recover from injuries due to chronic compression. Nov. 25, 2021 COVID-19 upends neuro-oncology worldwide The first global study of how the pandemic affected neuro-oncology found both negative and positive aspects. Basic and clinical research declined, but telemedicine was popular among practitioners and patients. Nov. 25, 2021 Comprehensive data registry helps transform neurosurgical practice Mayo Clinic's registry provides hard data on quality, costs, volumes and outcomes. The registry helps to standardize neurosurgical outcomes across the enterprise while also tracking value. Nov. 25, 2021 New strategy controls pain after Chiari malformation surgery An intraoperative injection of liposomal bupivacaine can reduce opioid use in the first 24 hours after surgery. Following that period, Mayo Clinic uses nonopioid medications to aggressively treat pain. Nov. 25, 2021 Autoimmune encephalitis: Paving the way to better outcomes Mayo Clinic is exploring a new therapy for this disease, which can cause lingering complications. Mayo's specialists have extensive experience with the diagnosis and treatment of this rare disease. Oct. 26, 2021 Guiding young people toward managing their epilepsy care A Mayo Clinic program helps teenagers and young adults transition to adult care for their chronic illness. The program addresses the medical, emotional and psychosocial needs of young people and their families. Oct. 26, 2021 Gamma Knife milestone highlights expertise and outcomes Mayo Clinic uses Gamma Knife radiosurgery to treat challenging tumors, cerebrovascular conditions and functional disorders. More than 10,000 patients have had the procedure at Mayo Clinic. Oct. 26, 2021 Predicting the progression from sleep disorder to neurodegenerative disease Mayo Clinic is co-leading research to identify biomarkers for neurodegenerative diseases in people with rapid eye movement sleep behavior disorder. The ultimate goal is clinical trials of therapies to delay or prevent s[...] Oct. 26, 2021 Adolescent scoliosis surgery: A nuanced approach nationwide Mayo Clinic's neurosurgeons have strong expertise in spinal mechanics, which they apply to scoliosis surgery for individuals regardless of age. State-of-the-art imaging modalities help prevent surgical complications for[...] Sept. 21, 2021 Clues for defining the diagnosis and course of demyelinating diseases A Mayo Clinic study identified clear differences in the resolution of lesions in three demyelinating diseases. The findings shed light on the development of long-term disability in MS. Sept. 21, 2021 3D-printed models enhance pediatric cerebrovascular education and care Mayo Clinic's patient-specific, life-sized models help neurosurgeons to visualize the anatomy of rare pediatric cerebrovascular lesions. The goal is to better prepare surgeons to treat young patients with challenging co[...] Aug. 20, 2021 Combining PET scans and 7-tesla MRI to pinpoint subtle epileptogenic lesions Overlays of PET images and 7-tesla MRI can help identify candidates for surgery among the one-third of individuals with epilepsy who have medically refractory seizures. Aug. 20, 2021 Alzheimer's biomarker testing: Boosting diagnostic accuracy so that patients can plan for the future Cerebral spinal fluid (CSF) biomarkers can predict the results of PET scan findings in people with mild cognitive impairment or dementia. Test results are available quickly. Aug. 20, 2021 Pituitary tumors: Patient-centered care facilitates strong outcomes A Mayo Clinic study documented fewer surgical complications and shorter hospital stays for individuals having pituitary tumor surgery at Mayo compared with results from a multicenter study. Aug. 20, 2021 Genetic tumor testing for more-precise treatment of glioma Mayo Clinic's cerebral spinal fluid biomarker tests use next-generation sequencing to evaluate mutations and rearrangements in 187 genes, for optimal tumor management. July 21, 2021 Carotid plaque imaging: Updating the management of atherosclerotic disease Mayo Clinic's robust imaging protocol can detect intraplaque hemorrhage and other signs of instability — information key to guiding the diagnosis and prevention of strokes. July 21, 2021 Telestroke: World-class expertise 24/7 for patients in remote areas Mayo Clinic's expanding telestroke network has morbidity and mortality outcomes that don't differ statistically from outcomes for patients treated at a Mayo stroke center. July 21, 2021 Chemotherapy-induced cognitive impairment: A potential preventive strategy Mice pre-treated with nicotinamide mononucleotide before cisplatin therapy performed better on subsequent learning and memory tests than did mice that weren't pre-treated. July 21, 2021 Vestibular schwannoma: Meeting each patient's needs through shared decision-making Mayo Clinic diagnoses and treats nearly 800 people a year with vestibular schwannomas. The treatment team has extensive experience in microsurgery, radiosurgery and observation of these intracranial tumors. June 19, 2021 Focused ultrasound: Incisionless epilepsy treatment Mayo Clinic is participating in an invitation-only clinical trial of a new thermoablative treatment for medically refractory focal epilepsy. The new approach can treat seizure-origin sites in deep brain areas. June 19, 2021 Prenatal repair can improve hindbrain herniation About 90% of prenatal myelomeningocele repairs performed at Mayo Clinic reverse brain malformations before birth. The procedure requires multidisciplinary neurological, pediatric and radiologic expertise. June 19, 2021 Neuromyelitis optica: New therapies offer hope Mayo Clinic's experience and expertise with neuromyelitis optica spectrum disorder (NMOSD), a rare inflammatory disorder, facilitate decisions about optimal treatment choices for individual patients. June 19, 2021 New myelography protocol helps localize cerebrospinal fluid leaks Mayo Clinic's use of state-of-the-art digital subtraction myelography paves the way for definitive treatment of debilitating cerebrospinal fluid leaks. May 21, 2021 Comprehensive mapping of cognitive functions during awake surgery The innovative technology provides detailed and efficient information in real time to avoid damage to eloquent tissue in epilepsy and tumor surgeries. May 21, 2021 Moyamoya: New protocol for managing a complex disease Critical imaging tests can be performed in a single session and without ionizing radiation. Timely diagnosis facilitates optimal treatment. May 21, 2021 Building the knowledge for skull base surgery Mayo Clinic clinician-researchers are learning more about cranial anatomy. Their work paves the way for the development of new surgical techniques for skull base disease. May 21, 2021 Precise and personalized guidance for epilepsy's complex decisions Mayo Clinic specialists are committed to educating individuals about their many nonmedical treatment options. April 15, 2021 Innovative treatment eases hundreds of daily seizures The patient was the first at Mayo Clinic to have the noninvasive therapy as a treatment for seizures. April 15, 2021 Novel endovascular therapy for CSF-venous fistulas Mayo Clinic's new approach provides an alternative to invasive spinal surgery. April 15, 2021 Elucidating a rare pituitary cancer A Mayo Clinic study describes the challenges of diagnosing individuals with this cancer and outlines treatment options. March 27, 2021 Point-of-care additive manufacturing provides complex scoliosis models Mayo Clinic radiologists and neurosurgeons collaborate to rapidly create 3D-printed anatomic models. March 27, 2021 Spondylolisthesis: Individualized approach for optimal outcomes Mayo Clinic spinal surgeons use a wide range of approaches to treat patients with congenital and degenerative spondylolisthesis. March 20, 2021 New technology for the treatment of pediatric epilepsy Mayo Clinic Children's Center has a multispecialty team devoted to epilepsy care. New technology and clinical trials offer options even for rare syndromes. March 20, 2021 Retinoblastoma: Specialized neuroradiology for optimal care Mayo Clinic's experienced specialists work to preserve the child's life, eye and sight. March 13, 2021 NF2 Clinic: Proactive, coordinated multidisciplinary care Providers in 12 specialties collaborate to provide timely diagnosis and treatment for teenagers and adults with neurofibromatosis 2 (NF2). March 13, 2021 Robotic systems can perform simple ICU care tasks Automation can reduce health risks for nurses and free them to focus on more-critical aspects of care. Jan. 23, 2021 Burr hole approach offers minimally invasive option for resecting brain lesions Select brain lesions can be surgically removed through a 14-millimeter burr hole. Jan. 23, 2021 Telemedicine offers benefits in the COVID-19 era and beyond Mayo Clinic's expanded use of telemedicine is likely to continue after the current pandemic eases. Jan. 23, 2021 Longitudinal study maps the transition to Alzheimer's disease A Mayo Clinic study underway since 1994 is providing key insights, including behavioral changes before symptoms start. Jan. 23, 2021 Robot-assisted spinal surgery shows promising initial results None of the 402 screws implanted in Mayo Clinic's study of robot-assisted spinal surgery required postoperative revision. Dec. 31, 2020 McArdle sign can provide reliable clinical detection of MS McArdle sign — a clinical phenomenon in which neck flexion induces rapid, reversible weakness — is also moderately sensitive for a diagnosis of multiple sclerosis compared with other myelopathy conditions. Dec. 31, 2020 Leading NIH's Lewy body dementia initiative A National Institutes of Health (NIH) initiative studies the proteins involved in Lewy body dementia to better characterize disease progression and identify potential therapeutic targets. Dec. 31, 2020 Research highlights in Neurology and Neurosurgery — May 2020 Mayo Clinic Neurology and Neurosurgery studies address the risk of carotid artery injury, clinical diagnosis of progressive supranuclear palsy and characterization of amphiphysin-IgG autoimmunity. Nov. 02, 2020 3D Brain Model Advances Alzheimer's Research at Mayo Clinic The model system allows stem cells to grow in three dimensions, ensuring researchers can study amyloid-beta plaques and tau tangles associated with neurodegeneration together. Oct. 03, 2020 Favorable long-term outcomes in pediatric AVM interventions Intervention is critical in maximizing the outcomes of pediatric arteriovenous malformations (AVMs). Mayo Clinic researchers have found that favorable functional outlooks for pediatric patients with AVMs can persist for[...] Oct. 02, 2020 Ventricular volume: Clinical utility for assessing current and future cognition and gait Mayo Clinic researchers have found that ventricular volume measures are clinically more useful than the Evans index ratio in evaluating a patient's current and future cognition and gait. Oct. 02, 2020 Looking at burnout and attrition in neurology: Expanding the gender gap? Studies suggest burnout may be 20% to 60% higher among women than men. In an article published in Neurology, Mayo Clinic physicians and researchers focused on burnout, attrition and the expanding gender gap. Oct. 02, 2020 Post-traumatic headache: Clinical trial seeks predictors and therapies Nearly 40% of patients who develop acute post-traumatic headache experience persistent headaches. Researchers are conducting a major study to identify mechanisms and predictors of persistent post-traumatic headache caus[...] Oct. 02, 2020 Epilepsy: The next generation of neurostimulation therapies Translating neurostimulation research and innovations into patient care is the overarching goal of Kai J. Miller, M.D., Ph.D., and Dora Hermes, Ph.D., both Mayo Clinic physicians and researchers. Oct. 02, 2020 Spinal vascular malformations: Early interventions and importance of proper diagnosis Mayo Clinic's depth of expertise allows for detailed diagnosis of spinal vascular malformations and covers the complexity of these conditions, enabling timely, precise diagnosis that allows for optimal individualized tr[...] Oct. 02, 2020 Neurological simulations: The next generation Simulation of neurological disease is difficult. Mayo Clinic has advanced its simulation training capabilities and envisions a future where specific learning objectives are matched to simulation modality and are best ac[...] Oct. 02, 2020 Elucidating the structural diversity of tauopathies Using a new method, Mayo Clinic researchers identify post-translational modifications as playing an important role in mediating the distinct structures of tau fibrils in corticobasal degeneration and Alzheimer's disease[...] Aug. 14, 2020 Glioblastoma: Seeking personalized care through radiomics Mayo Clinic is using radiomics to learn more about individuals' responses to glioblastoma treatment. Tumor volume can affect an individual's response to chemotherapy. Differences in the molecular mechanisms of tumors in[...] Aug. 04, 2020 Pediatric brain tumors: Rapid and focused care Patients referred to Mayo Clinic for pediatric brain tumor can often be seen the next day. A team of specialists works together, drawing on Mayo's broad expertise in neuro-oncology. Aug. 04, 2020 Cervical myelopathy: Discoveries paving the way to better care Cervical myelopathy symptoms often recur after surgery, due to suboptimal positioning of the spinal cord during the procedure. Mayo Clinic is learning more about the stress placed on the spinal cord, to determine the be[...] June 27, 2020 Stem cell treatment after spinal cord injury: The next steps Mayo Clinic's CELLTOP trial involves intrathecal injections of autologous adipose-derived stem cells. Mayo's investigations focus on how stem cells can potentially reverse the microenvironmental changes that inhibit axo[...] June 27, 2020 Glioblastoma extracellular vesicles: Targeting the ill effects, using the good The mechanisms by which glioblastoma-derived extracellular vesicles promote tumor growth appear to be more complicated than previously thought. Mayo Clinic is working to exploit certain factors of extracellular vesicles[...] June 27, 2020 Moyamoya: Specialized care for a rare cerebrovascular disease Mayo Clinic's moyamoya clinic provides comprehensive care for this rare cerebrovascular disease. Within a single clinic visit, patients can see a multidisciplinary care team and receive a treatment plan. June 13, 2020 Robot-assisted brain surgery: Innovating to improve patient care Alfredo Quinones-Hinojosa, M.D., chair of Neurosurgery at Mayo Clinic in Jacksonville, Florida, discusses Mayo's efforts to develop robotic technology for performing brain surgery. June 13, 2020 New approaches to immunotherapy for glioblastoma Mayo Clinic is advancing new applications of immunotherapy for glioblastoma, with a focus on more-potent and combination therapies for optimal effectiveness. April 11, 2020 Research focus: Spina bifida surgery before birth restores brain structure Mayo Clinic researchers have discovered that the benefit from spina bifida repair performed on a fetus in the womb works beyond the spine to improve the brain structure. Feb. 28, 2020 Enterprisewide expertise for spinal oncology care Mayo's spinal oncology specialists may employ proton beam therapy, carbon fiber implants or surgical alternatives ― such as decompression, stabilization, ablation technologies or cement augmentation ― to meet each patie[...] Feb. 28, 2020 Autoimmune neurology: Evolving care for immune-inflammatory diseases of the CNS Alfonso (Sebastian) S. Lopez Chiriboga, M.D., and Iris (Vanessa) V. Marin Collazo, M.D., discuss autoimmune neurology, one of neurology's most rapidly evolving subspecialties. Jan. 31, 2020 Multiple options for the treatment of children with epilepsy At Mayo Clinic Children's Center, research and clinical teams function seamlessly to provide novel therapies to treat seizures and preserve brain function for pediatric patients with epilepsy. Dec. 21, 2019 Whole-patient epilepsy care: Uniting technology and psychosocial expertise Mayo Clinic's patient-centered care combines sophisticated imaging and surgical techniques with a multidisciplinary focus encompassing the psychosocial problems associated with epilepsy. Dec. 21, 2019 Nanotechnology: Potential options for glioblastoma treatment Mayo Clinic is developing ways to use nanoparticles to modify adipose-derived mesenchymal stem cells to secrete anti-tumor proteins. The therapy can then be delivered at the time of tumor resection. Dec. 10, 2019 Mayo Clinic calls out need for aggressive glioblastoma treatment Aggressive cellular therapy, new drugs, surgery & clinical trials needed for glioblastoma brain tumor survival: Mayo Clinic Forefront cancer magazine. Nov. 27, 2019 Mayo Clinic research is a step toward hope for spinal cord injuries In a study of mesenchymal stem cell treatment for spinal cord injury, stem cell intervention following surgery plus physical and occupational therapy restored some function in a patient. Nov. 15, 2019 Cellular “Cleaners” More Active in Quiet Brains Researchers found that in mice, microglia (immune cells of the central nervous system) are more active when the brain is quiet than when it is awake, due to norepinephrine signaling. Nov. 09, 2019 Fetoscopic repair of myelomeningocele: A minimally invasive option Fetoscopic repair of myelomeningocele can provide surgical outcomes for the fetus that are similar to those of open surgery while lessening the risk of preterm birth. Nov. 01, 2019 Refining CT perfusion imaging for optimal stroke care Mayo Clinic specialists fine-tune quantifiable CT perfusion imaging to widen the treatment window for acute ischemic stroke and optimize outcomes in carefully selected patients. Oct. 11, 2019 Glioma Forecast? Excellent Chance for Better Weather says Researcher Kristin R. Swanson, Ph.D., uses mathematical modeling to document glioblastoma texture, density, direction of growth and rate of invasion ― and predict the best treatment for each patient. Sept. 05, 2019 Robot-guided technology to enhance spinal surgery Mayo specialists employ robotic technology for surgery in the thoracic and lumbar spine. The system can be applied to small, minimally invasive procedures and more-complex open surgeries for oncologic or spinal deformit[...] Sept. 05, 2019 New clue for earlier diagnosis of spinal dural AVF Mayo Clinic has identified a unique radiographic finding that facilitates earlier diagnosis of spinal dural arteriovenous fistulas (dAVFs), paving the way to improved treatment outcomes. Aug. 30, 2019 Objective testing for sports-related concussion The Mayo Clinic Concussion Check Protocol can be used by parents or other adults on the sidelines to quickly assess whether a young athlete should be removed from play. Aug. 30, 2019 Preserving vision, easing headaches: Timely multidisciplinary care for idiopathic intracranial hypertension At Mayo Clinic's cerebral spinal fluid dynamics clinic, patients can see a neurologist and neuro-ophthalmologist, have diagnostic testing, and see a neurosurgeon, if needed, within a few days. Aug. 30, 2019 Quantifying neuroimaging: A revolution in patient care Mayo Clinic specialists apply innovative neuroimaging techniques and quantifiable machine learning methodology for individualized prognosis and treatment of brain tumors and epilepsy. Aug. 30, 2019 Idiopathic transverse myelopathy: Pinpointing the cause A review of idiopathic transverse myelitis cases referred to Mayo Clinic from 2010 to 2015 confirms that in nearly 70% of cases, Mayo specialists supplied an accurate diagnosis. Aug. 30, 2019 Innovative options for medically refractory epilepsy All three Mayo Clinic campuses offer intensive neurodiagnostic monitoring and extensive medical, neuropsychological and psychosocial treatment for medically refractory epilepsy. Neurologist Anthony L. Ritaccio, M.D., di[...] Aug. 30, 2019 Research highlights in Neurology and Neurosurgery ― September 2019 Studies address checkpoint inhibitors and neurological immune-related adverse events, a tissue biomarker for Parkinson's disease, glioma-related seizures and tumor molecular markers, and imaging factors related to cogni[...] Aug. 13, 2019 The BeST approach to functional movement disorders Mayo Clinic physiatrist Jeffrey M. Thompson, M.D., discusses the behavioral shaping therapy (BeST) approach to functional movement disorders in this episode of Simply PM&R Podcast. July 30, 2019 What's new in motor recovery research and helping patients stay active with spinal cord injuries Mayo Clinic physiatrist Kristin L. Garlanger, D.O., describes traumatic and nontraumatic spinal cord injuries and research advances and interventions in this Simply PM&R Podcast episode. July 16, 2019 Study identifies clinical phenotype, visual outcomes of MOG-IgG antibody optic neuritis Research supports that MOG-IgG positivity should be suspected if optic disk edema is moderate to severe at onset or if MRI shows optic nerve sheath involvement. July 13, 2019 BeST program treatment model focuses on motor retraining for functional movement disorders Mayo Clinic physiatrist Jeffrey M. Thompson, M.D., discusses the behavioral shaping therapy (BeST) approach to functional movement disorders in this episode of Simply PM&R Podcast. June 25, 2019 Onco-epilepsy: Simultaneous management of tumor and seizures Mayo's multidisciplinary, proactive approach facilitates the safe removal of noneloquent tissue that is potentially epileptogenic, to manage tumor and epilepsy at the same time. June 25, 2019 Headache disorders: Subspecialized, compassionate care Headache neurologist Jonathan H. Smith, M.D., answers questions about subspecialized management of headache disorders. June 25, 2019 Cavernous malformations: 7-tesla MRI enhances expertise Mayo specialists use 7-tesla MRI advanced imaging technology to aid diagnosis and decisions about whether cavernous malformations should be surgically removed to prevent bleeding. June 25, 2019 Halting the circle: Comprehensive neurogenetics test panels Mayo Clinic's use of comprehensive next-generation sequencing panels for the diagnosis of neurogenetic disorders covers the expanding genotype-phenotype complexity of these conditions, facilitating timely, accurate diag[...] June 25, 2019 Research highlights in Neurology and Neurosurgery ― May 2019 Studies address cerebral microbleeds and amyloid burden, treatment outcomes for spinal cord low-grade gliomas, and unplanned returns to the operating room following neurosurgery. April 26, 2019 Investigating autoinflammatory epileptic encephalopathies in children Mayo specialists answer questions about pediatric epileptic encephalopathies caused by neuroinflammation in the absence of antibodies, which can present with signs and symptoms similar to those of autoimmune epilepsy. April 26, 2019 Coordinated management of young-onset Parkinson's disease A new clinic addresses the needs of people who are diagnosed with Parkinson's disease while still working, raising children and living a more active lifestyle than people diagnosed in their late 60s. March 01, 2019 Research highlights in Neurology and Neurosurgery – March 2019 Studies address atypical presentations of central nervous system tumors, APOE e4 and Lewy bodies pathology, and obstructive sleep apnea related to unexpected death in people with epilepsy. March 01, 2019 Endoscopic skull base surgery: The advantages of Mayo's team approach Mayo Clinic specialists have extensive experience with endoscopic skull base surgery for the treatment of pituitary tumors, meningiomas, clival tumors, chordomas and craniopharyngiomas. March 01, 2019 Neurofibromatosis Clinic: A team for lifelong care At Mayo Clinic, multidisciplinary teams of specialists collaborate to manage neurofibromatosis types 1 and 2 (NF1 and NF2) in children and adults. March 01, 2019 Vascular pathologies and Alzheimer's disease: Probing genetic pathways With funding from the National Institutes of Health M2OVE-AD Consortium, Mayo researchers investigate genetic pathways that may contribute to both vascular pathologies and Alzheimer's disease. Jan. 21, 2019 Halting the Wheel of Misfortune: ‘A New Era’ in Migraine Care New understanding of the biology underlying migraine and the development of mechanism-based, disease-specific therapies developed specifically to treat and prevent the disorder are changing migraine care. Jan. 11, 2019 Neonatal brachial plexus injuries: An integrated approach Mayo Clinic's multidisciplinary team approach to neonatal brachial plexus surgery allows for surgical reconstruction tailored to the individual patient's needs — nerve surgery, tendon transfers and shoulder-to-han[...] Jan. 11, 2019 Pediatric care in Arizona and Florida Mayo Clinic collaborates with Phoenix Children's Hospital in Arizona and Wolfson Children's Hospital in Florida to provide certain pediatric neurological and neurosurgical services. The collaborations offer pediatric pa[...] Jan. 11, 2019 Team approach for optimal tumor care Mayo's pediatric brain tumor laboratory has screened thousands of promising drugs in numerous cancer cell lines, uncovering pathways such as signal transducer and activator of transcription 3 (STAT3) proteins and Aurora[...] Jan. 11, 2019 Advances in pediatric refractory epilepsy Quantitative morphometric MRI analysis provides voxel-by-voxel comparisons between patient MRIs and a normative pediatric sample to detect the subtle signs of focal cortical dysplasia in children and guide decisions abo[...] Dec. 11, 2018 Neurosurgery registry for continuous improvement of care and quality of life Mayo's neurosurgery registry improves patient safety and outcomes by detailing surgical and patient-reported outcomes for all neurosurgical procedures performed at Mayo Clinic. The registry augments efforts to collect s[...] Dec. 11, 2018 CREST-2 update: Enrolling patients for optimal care Mayo neurologist Kevin M. Barrett, M.D., answers questions about the Carotid Revascularization Endarterectomy Versus Stenting Trial 2 (CREST-2), a multicenter, randomized study that compares methods to identify an optim[...] Dec. 11, 2018 7-Tesla MRI: Pioneering use for patient care Clinical use of 7-Tesla MRI enhances Mayo Clinic's ability to manage epilepsy, certain brain and peripheral nerve tumors, and other neurological disorders. Nov. 12, 2018 Neuro-Oncology Testing [A Test in Focus] Mayo Clinic Laboratories offers a neuro-oncology expanded gene panel (NONCP) and chromosomal microarray testing (CMAPT) to provide a clear picture of the diagnosis, prognosis and treatment options for patients in neuro-[...] Oct. 30, 2018 New directions in the study of Alzheimer’s disease Researchers in Jacksonville, Florida, study immune system pathways that contribute to Alzheimer's disease, protein variants that lead to different types of Alzheimer's disease, and biological factors that protect people[...] Sept. 12, 2018 Minimally invasive surgery for craniosynostosis Minimally invasive surgery can be performed earlier than open surgery for infants with craniosynostosis — with the same outcomes. Babies with multiple suture or syndromic conditions may also benefit. May 22, 2018 Novel MOG assay aids diagnosis of demyelinating diseases Mayo Clinic has developed the first test available in the United States to identify the myelin oligodendrocyte glycoprotein (MOG) antibody in patients' blood. The MOG antibody can distinguish a spectrum of autoimmune de[...] May 22, 2018 Subspecialized neuro-ophthalmology care Mayo neuro-ophthalmologists work closely with neurologists and neurosurgeons to treat people with any problems involving sight or eye movement that arise from the nervous system, including migraine, stroke or multiple s[...] May 19, 2018 Minimally invasive brain surgery: Safer treatment of deep-seated lesions Minimally invasive surgery using a tubular retractor system can be an option for selected patients with subcortical high-grade glioma, metastatic brain tumors or vascular lesions. April 27, 2018 Advances in endoscopic skull base surgery Mayo specialists employ image guidance and intraoperative CT, 3-D endoscopy, simulations that integrate endoscopic surgery and proton beam therapy, and 3-D models and holography for pre-surgical planning to treat pituit[...] April 27, 2018 Clinical trial of stem cell therapy for traumatic spinal cord injury Mayo Clinic is enrolling patients in a clinical trial of adipose stem cell treatment for spinal cord injury caused by trauma. Participants will receive intrathecal injections of adipose-derived mesenchymal stem cells. N[...] Feb. 15, 2018 Minimally invasive options for medically refractory epilepsy The Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE) clinical trial tests the efficacy of MRI-guided laser ablation for mesial temporal sclerosis. The approach allows patients to avoid open temporal lobect[...] Jan. 30, 2018 Timely ALS care in Florida At Mayo Clinic's campus in Jacksonville, Florida, patients with amyotrophic lateral sclerosis (ALS) benefit from a holistic approach to care, including coordinated appointments that ensure prompt intervention, remote fo[...] June 28, 2016 Acoustic neuroma: Treatment and quality of life Although benign, acoustic neuromas can impact patients' quality of life significantly. Common symptoms include unilateral hearing loss and tinnitus. Mayo Clinic specialists offer a range of individualized treatment opti[...] Dec. 23, 2015 Autoimmune dementia: Defining a treatable disorder Patients whose symptoms mimic those of neurodegenerative dementias may have a treatable autoimmune cause for their conditions. Mayo's standardized approach to evaluation of suspected autoimmune neurological disorders in[...] June 19, 2015 Complexities of low CSF volume headache Spontaneous intracranial hypotension (SIH) is typically the result of spontaneous cerebral spinal fluid (CSF) leak at the spine level. It now appears that the core pathogenic factor in SIH is decreased CSF volume rather[...] March 14, 2015 Intraspinal stimulation shows promise for restoring function after spinal cord injury Mayo Clinic researchers are studying the use of electronic devices that can wirelessly transmit signals from the brain to the intact spinal cord circuitry below the injury. Medical Professionals Neurology & Neurosurgery News