Before Using

Drug information provided by: Merative, Micromedex®

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Benzocaine may be absorbed through the skin of young children and cause unwanted effects. There is no specific information comparing use of other topical anesthetics in children with use in other age groups, but it is possible that they may also cause unwanted effects in young children. Check with your doctor before using any product that contains a topical anesthetic for a child younger than 2 years of age.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of topical anesthetics in the elderly with use in other age groups.

Pregnancy

Although studies on effects in pregnancy have not been done in humans, topical anesthetics have not been reported to cause problems in humans. Lidocaine has not been shown to cause birth defects or other problems in animal studies. Other topical anesthetics have not been studied in animals.

Breastfeeding

Topical anesthetics have not been reported to cause problems in nursing babies.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

  • Dronedarone
  • Saquinavir
  • Vernakalant

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Alcuronium
  • Amifampridine
  • Amiodarone
  • Amprenavir
  • Arbutamine
  • Articaine
  • Atracurium
  • Benoxinate
  • Benzocaine
  • Benzyl Alcohol
  • Bretylium
  • Bupivacaine Liposome
  • Bupropion
  • Chloroprocaine
  • Cisatracurium
  • Cobicistat
  • Cocaine
  • Darunavir
  • Dasabuvir
  • Delavirdine
  • Dibucaine
  • Disopyramide
  • Dofetilide
  • Donepezil
  • Doxacurium
  • Dronedarone
  • Dyclonine
  • Encainide
  • Ethyl Chloride
  • Etidocaine
  • Etravirine
  • Fazadinium
  • Flecainide
  • Fosamprenavir
  • Fosphenytoin
  • Gallamine
  • Hexafluorenium
  • Hyaluronidase
  • Ibutilide
  • Levobupivacaine
  • Lidocaine
  • Lopinavir
  • Mepivacaine
  • Metocurine
  • Metoprolol
  • Mexiletine
  • Mivacurium
  • Moricizine
  • Nadolol
  • Opicapone
  • Pancuronium
  • Phenytoin
  • Pipecuronium
  • Pramoxine
  • Prilocaine
  • Procainamide
  • Procaine
  • Propafenone
  • Proparacaine
  • Quinidine
  • Rapacuronium
  • Rocuronium
  • Ropivacaine
  • Sotalol
  • St John's Wort
  • Succinylcholine
  • Telaprevir
  • Tetracaine
  • Tocainide
  • Tubocurarine
  • Varicella Virus Vaccine, Live
  • Vecuronium
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Infection at or near the place of application or
  • Large sores, broken skin, or severe injury at the area of application—The chance of side effects may be increased.

Portions of this document last updated: May 01, 2024

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