Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of paliperidone in children with schizophrenia younger than 12 years of age and in children with schizoaffective disorder. Safety and efficacy have not been established in these age groups.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of paliperidone in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving paliperidone.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Bepridil
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Bromopride
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Cisapride
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Dronedarone
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Levoketoconazole
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Mesoridazine
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Metoclopramide
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Pimozide
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Piperaquine
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Saquinavir
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Sparfloxacin
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Terfenadine
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Thioridazine
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Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Acecainide
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Adagrasib
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Ajmaline
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Alfuzosin
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Amiodarone
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Amisulpride
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Amitriptyline
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Amoxapine
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Anagrelide
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Apomorphine
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Aripiprazole
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Aripiprazole Lauroxil
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Arsenic Trioxide
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Artemether
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Asenapine
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Atazanavir
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Azimilide
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Azithromycin
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Bedaquiline
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Bretylium
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Buprenorphine
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Buserelin
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Carbamazepine
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Ceritinib
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Chloroquine
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Chlorpromazine
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Ciprofloxacin
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Citalopram
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Clarithromycin
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Clofazimine
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Clomipramine
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Clothiapine
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Clozapine
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Crizotinib
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Cyclobenzaprine
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Dabrafenib
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Dasatinib
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Degarelix
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Delamanid
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Desipramine
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Deslorelin
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Deutetrabenazine
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Dexmedetomidine
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Disopyramide
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Dofetilide
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Dolasetron
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Domperidone
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Donepezil
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Droperidol
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Efavirenz
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Encorafenib
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Entrectinib
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Enzalutamide
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Erythromycin
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Escitalopram
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Etrasimod
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Fexinidazole
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Fingolimod
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Flecainide
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Fluconazole
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Fluoxetine
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Formoterol
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Foscarnet
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Fosphenytoin
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Fostemsavir
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Gatifloxacin
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Gemifloxacin
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Gepirone
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Givinostat
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Glasdegib
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Gonadorelin
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Goserelin
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Granisetron
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Halofantrine
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Haloperidol
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Histrelin
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Hydroquinidine
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Hydroxychloroquine
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Hydroxyzine
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Ibutilide
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Iloperidone
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Imipramine
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Inotuzumab Ozogamicin
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Itraconazole
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Ivabradine
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Ivosidenib
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Ketoconazole
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Lapatinib
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Lefamulin
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Lenvatinib
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Leuprolide
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Levofloxacin
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Lofexidine
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Lonafarnib
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Lopinavir
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Lumacaftor
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Lumefantrine
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Macimorelin
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Mavorixafor
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Mefloquine
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Methadone
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Metronidazole
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Mifepristone
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Mirtazapine
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Mitotane
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Mobocertinib
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Moxifloxacin
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Nafarelin
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Nilotinib
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Norfloxacin
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Nortriptyline
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Octreotide
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Ofloxacin
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Olanzapine
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Ondansetron
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Osilodrostat
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Osimertinib
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Oxaliplatin
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Ozanimod
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Pacritinib
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Panobinostat
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Paroxetine
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Pasireotide
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Pazopanib
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Phenobarbital
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Phenytoin
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Pimavanserin
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Pitolisant
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Ponesimod
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Posaconazole
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Primidone
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Procainamide
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Prochlorperazine
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Promethazine
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Propafenone
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Protriptyline
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Quetiapine
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Quinidine
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Quinine
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Quizartinib
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Ranolazine
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Relugolix
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Ribociclib
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Rifampin
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Rilpivirine
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Selpercatinib
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Sematilide
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Sertraline
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Sevoflurane
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Simeprevir
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Siponimod
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Sodium Phosphate
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Sodium Phosphate, Dibasic
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Sodium Phosphate, Monobasic
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Solifenacin
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Sorafenib
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Sotalol
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St John's Wort
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Sulpiride
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Sunitinib
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Tacrolimus
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Tedisamil
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Telavancin
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Telithromycin
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Tetrabenazine
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Tipranavir
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Toremifene
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Trazodone
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Triclabendazole
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Trifluoperazine
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Trimipramine
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Triptorelin
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Vandetanib
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Vardenafil
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Vemurafenib
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Venlafaxine
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Vilanterol
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Vinflunine
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Voclosporin
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Voriconazole
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Zuclopenthixol
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Blood or bone marrow problems (eg, leukopenia, neutropenia) or
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Breast cancer, prolactin-dependent or
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Diabetes or
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Dyslipidemia (high cholesterol or fats in the blood) or
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Hyperglycemia (high blood sugar) or
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Hyperprolactinemia (high prolactin in the blood) or
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Neuroleptic malignant syndrome (NMS), history of or
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Priapism (painful or prolonged erection of the penis) or
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Seizures, history of or
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Stomach or bowel problems (eg, blockage)—Use with caution. May make these conditions worse.
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Bradycardia (slow heartbeat) or
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Heart rhythm problems (eg, arrhythmia, QT prolongation), or history of or
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Hypokalemia (low potassium in the blood) or
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Hypomagnesemia (low magnesium in the blood)—Use with caution. May increase risk for more serious side effects.
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Dehydration or
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Heart attack, recent or history of or
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Heart failure or
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Heart or blood vessel disease or
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Hypotension (low blood pressure) or
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Hypovolemia (low amount of blood) or
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Ischemic heart disease, history of or
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Stroke, history of or
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Trouble with swallowing—Use with caution. May cause side effects to become worse.
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Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
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Lewy body dementia or
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Parkinson's disease—Use with caution. Patients with these conditions may have increased sensitivity to the effects of this medicine.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.