Description and Brand Names
Drug information provided by: Merative, Micromedex®
US Brand Name
- Desoxyn
Descriptions
Methamphetamine is used to treat attention-deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous system (CNS) stimulants.
Methamphetamine works in the treatment of ADHD by increasing attention and decreasing restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. This medicine is used as part of a total treatment program that also includes social, educational, and psychological treatment.
This medicine is available only with a doctor's prescription.
This product is available in the following dosage forms:
Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of methamphetamine in children younger than 6 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methamphetamine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving methamphetamine.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
-
Furazolidone
-
Iproniazid
-
Isocarboxazid
-
Linezolid
-
Methylene Blue
-
Moclobemide
-
Nialamide
-
Ozanimod
-
Phenelzine
-
Procarbazine
-
Rasagiline
-
Safinamide
-
Selegiline
-
Sibutramine
-
Tranylcypromine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Abiraterone Acetate
-
Acetazolamide
-
Alfentanil
-
Almotriptan
-
Aluminum
-
Amifampridine
-
Amineptine
-
Amitriptyline
-
Amitriptylinoxide
-
Amoxapine
-
Amphetamine
-
Anileridine
-
Benzhydrocodone
-
Benzthiazide
-
Brompheniramine
-
Buprenorphine
-
Bupropion
-
Buspirone
-
Butorphanol
-
Calcium Carbonate
-
Carbamazepine
-
Chlorothiazide
-
Chlorpheniramine
-
Cimetidine
-
Cinacalcet
-
Citalopram
-
Clobazam
-
Clomipramine
-
Cobicistat
-
Cocaine
-
Codeine
-
Cyclobenzaprine
-
Desipramine
-
Desvenlafaxine
-
Dexlansoprazole
-
Dextroamphetamine
-
Dextromethorphan
-
Diazoxide
-
Dibenzepin
-
Difenoxin
-
Dihydrocodeine
-
Dihydroxyaluminum Aminoacetate
-
Diphenoxylate
-
Dolasetron
-
Donepezil
-
Doxepin
-
Duloxetine
-
Eletriptan
-
Escitalopram
-
Esomeprazole
-
Ethylmorphine
-
Fenfluramine
-
Fentanyl
-
Fluoxetine
-
Fluvoxamine
-
Frovatriptan
-
Gepirone
-
Granisetron
-
Hydrochlorothiazide
-
Hydrocodone
-
Hydroflumethiazide
-
Hydromorphone
-
Hydroxytryptophan
-
Imipramine
-
Iobenguane I 131
-
Ketobemidone
-
Lansoprazole
-
Lasmiditan
-
Levomilnacipran
-
Levorphanol
-
Lisdexamfetamine
-
Lithium
-
Lofepramine
-
Lorcaserin
-
Magaldrate
-
Magnesium Carbonate
-
Melitracen
-
Meperidine
-
Metaxalone
-
Methadone
-
Milnacipran
-
Mirabegron
-
Mirtazapine
-
Morphine
-
Morphine Sulfate Liposome
-
Nalbuphine
-
Naratriptan
-
Nefazodone
-
Nicomorphine
-
Nortriptyline
-
Oliceridine
-
Omeprazole
-
Ondansetron
-
Opipramol
-
Opium
-
Opium Alkaloids
-
Oxycodone
-
Oxymorphone
-
Palonosetron
-
Pantoprazole
-
Papaveretum
-
Paregoric
-
Paroxetine
-
Pentazocine
-
Piritramide
-
Polythiazide
-
Protriptyline
-
Quinidine
-
Quinine
-
Rabeprazole
-
Remifentanil
-
Ritonavir
-
Rizatriptan
-
Rolapitant
-
Sertraline
-
Sodium Bicarbonate
-
St John's Wort
-
Sufentanil
-
Sumatriptan
-
Tapentadol
-
Terbinafine
-
Tianeptine
-
Tilidine
-
Tramadol
-
Trazodone
-
Trichlormethiazide
-
Trimipramine
-
Tryptophan
-
Venlafaxine
-
Vilazodone
-
Vortioxetine
-
Xipamide
-
Ziprasidone
-
Zolmitriptan
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
-
Agitation, severe or
-
Arteriosclerosis (hardening of the arteries), severe or
-
Drug abuse, history of or
-
Glaucoma or
-
Heart attack, recent or
-
Heart failure or
-
Hypertension (high blood pressure), severe or
-
Hyperthyroidism (overactive thyroid) or
-
Stroke, history of—Should not be used in patients with these conditions.
-
Alcohol abuse, history of—Use with caution. Dependence may be more likely to develop.
-
Bipolar disorder (manic-depressive illness), history of or
-
Depression, or a family history of or
-
Heart or blood vessel disease (eg, cardiomyopathy, coronary artery disease) or
-
Heart rhythm problem (eg, ventricular arrhythmia), or family history of or
-
Hypertension (high blood pressure), mild or
-
Psychosis (mental illness), history of or
-
Raynaud's phenomenon (blood vessel disease) or
-
Seizures, history of or
-
Tachycardia (rapid heart rate) or
-
Tourette syndrome, or family history of—Use with caution. May make these conditions worse.
Proper Use
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If you take too much, the medicine may become habit-forming (causing mental or physical dependence).
This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.
Do not take this medicine late in the evening. It may prevent you from falling asleep.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
-
For oral dosage form (tablets):
-
For ADHD:
-
Adults and children 6 years of age and older—At first, 5 milligrams (mg) 1 or 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 25 mg per day.
-
Children younger than 6 years of age—Use and dose must be determined by your doctor.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions
It is very important that your doctor check your or your child's progress at regular visits to make sure the medicine is working properly. Blood tests may be needed to check for unwanted effects.
Do not use this medicine if you are using or have used an MAO inhibitor (MAOI), including isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]), within the past 14 days.
You or your child will also need to have your blood pressure and heart rate measured before starting this medicine and while you are using it. If you notice any change in your blood pressure, call your doctor right away. If you have questions about this, talk to your doctor.
This medicine may cause serious heart or blood vessel problems. This may be more likely to occur in patients who have a family history of heart disease. Check with your doctor right away if you have chest pain, trouble breathing, or fainting while taking this medicine.
Tell your doctor right away if you or your family notice any unusual changes in behavior, such as an increase in aggression, hostility, agitation, irritability, or suicidal thinking or behavior. Also tell your doctor if you or your child see, hear, or feel things that are not there, or have any unusual thoughts, especially if they are new or getting worse quickly.
If you have been using this medicine for a long time and you think you may have become mentally or physically dependent on it, check with your doctor. Some signs of dependence may be:
-
A strong desire or need to continue taking the medicine.
-
A need to increase the dose to receive the same effects.
-
Withdrawal effects after stopping the medicine such as mental depression, nausea or vomiting, stomach cramps or pain, trembling, or unusual tiredness or weakness.
Symptoms of an overdose include: agitation, aggressive, blurred vision, change in consciousness, chest pain or discomfort, confusion, dark urine, diarrhea, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, fever, headache, inability to speak, loss of consciousness, muscle pains, stiffness, cramps, or spasms, nausea, nervousness, pain or discomfort in the arms, jaw, back, or neck, pale, clammy skin, palpitations, panic state, pounding in the ears, restlessness, seeing, hearing, or feeling things that are not there, seizures, shakiness in legs, arms, hands, feet, shivering, slow or fast heartbeat, slurred speech, sweating, talking or acting with excitement you cannot control, temporary blindness, thirst, trembling or shaking of hands or feet, overactive reflexes, rapid breathing, unusual tiredness or weakness, vomiting, or weakness in the arm or leg on one side of the body, sudden and severe. Call your doctor right away if you notice these symptoms.
This medicine may cause some people to feel a false sense of wellbeing or to become dizzy, lightheaded, or less alert than they are normally. It may also cause blurred vision or other vision problems. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.
This medicine may cause slow growth. If your child is using this medicine, the doctor will need to keep track of your child's height and weight.
This medicine may cause Raynaud's phenomenon, which is a problem with blood circulation in the fingers or toes. Tell your doctor if you have tingling or pain, a cold feeling, paleness, or skin color changes in the fingers or toes, especially when exposed to cold. Call your doctor right away if you have unexplained sores or ulcers on your fingers or toes.
Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines, herbal or vitamin supplements, and medicine for appetite control, asthma, colds, cough, hayfever, or sinus problems.
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
-
Agitation
-
false beliefs that cannot be changed by facts
-
seeing, hearing, or feeling things that are not there
Incidence not known
-
Blurred vision
-
chest discomfort or pain
-
dark-colored urine
-
difficulty breathing
-
dizziness
-
faintness
-
false or unusual sense of wellbeing
-
fast, pounding, or irregular heartbeat or pulse
-
fever
-
headache
-
muscle cramps, spasms, pain, or stiffness
-
pounding in the ears
-
restlessness
-
shakiness in the legs, arms, hands, or feet
-
swelling of the feet or lower legs
-
trembling or shaking of the hands or feet
-
trouble sleeping
-
twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
-
uncontrolled vocal outbursts and tics
-
unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
-
Aggressive
-
agitation
-
angry
-
blurred vision
-
change in consciousness
-
chest pain or discomfort
-
confusion
-
dark urine
-
diarrhea
-
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
-
fainting
-
fast breathing
-
fast, slow, or irregular heartbeat
-
fever
-
headache
-
inability to speak
-
loss of consciousness
-
muscle cramps, spasms, pain, or stiffness
-
nausea
-
nervousness
-
overactive reflexes
-
pain or discomfort in the arms, jaw, back, or neck
-
pale, clammy skin
-
palpitations
-
pounding in the ears
-
restlessness
-
seeing, hearing, or feeling things that are not there
-
seizures
-
shivering
-
slow or fast heartbeat
-
slurred speech
-
stomach cramps
-
sweating
-
talking or acting with excitement you cannot control
-
temporary blindness
-
thirst
-
tremor
-
trouble breathing
-
unusual tiredness or weakness
-
vomiting
-
weakness in the arm or leg on one side of the body, sudden and severe
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
-
Bad, unusual, or unpleasant (after) taste
-
change in taste
-
constipation
-
decreased interest in sexual intercourse
-
dry mouth
-
hives or welts, itching, or skin rash
-
inability to have or keep an erection
-
indigestion
-
loss in sexual ability, desire, drive, or performance
-
passing of gas
-
redness of the skin
-
weight loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Portions of this document last updated: Aug. 01, 2024
Original article: https://www.mayoclinic.org/zh-hans/drugs-supplements/methamphetamine-oral-route/side-effects/drg-20071824