Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of Synjardy® tablets in children younger than 10 years of age and Synjardy® XR extended-release tablets in children. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of empagliflozin and metformin combination in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving empagliflozin and metformin combination.
Breastfeeding
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Abiraterone Acetate
-
Acarbose
-
Acetazolamide
-
Alogliptin
-
Aspirin
-
Bexagliflozin
-
Bictegravir
-
Brinzolamide
-
Bupropion
-
Capmatinib
-
Chloroquine
-
Chlorothiazide
-
Chlorpropamide
-
Chlorthalidone
-
Cimetidine
-
Ciprofloxacin
-
Dasabuvir
-
Delafloxacin
-
Diatrizoate
-
Dichlorphenamide
-
Dofetilide
-
Dolutegravir
-
Dorzolamide
-
Enoxacin
-
Ethiodized Oil
-
Fedratinib
-
Fexinidazole
-
Furosemide
-
Gatifloxacin
-
Gemifloxacin
-
Glimepiride
-
Glipizide
-
Glyburide
-
Grepafloxacin
-
Hydrochlorothiazide
-
Hydroflumethiazide
-
Hydroxychloroquine
-
Indapamide
-
Insulin
-
Insulin Aspart, Recombinant
-
Insulin Bovine
-
Insulin Degludec
-
Insulin Detemir
-
Insulin Glargine, Recombinant
-
Insulin Glulisine
-
Insulin Lispro, Recombinant
-
Iodipamide
-
Iodixanol
-
Iohexol
-
Iopamidol
-
Iopanoic Acid
-
Iopromide
-
Iothalamate
-
Iotrolan
-
Ioversol
-
Ioxaglate
-
Ipodate
-
Isavuconazole
-
Lanreotide Acetate
-
Levofloxacin
-
Levoketoconazole
-
Liraglutide
-
Lithium
-
Lomefloxacin
-
Mavorixafor
-
Methazolamide
-
Metolazone
-
Metrizamide
-
Moxifloxacin
-
Nateglinide
-
Norfloxacin
-
Octreotide Acetate
-
Ofloxacin
-
Ombitasvir
-
Paritaprevir
-
Pasireotide Diaspartate
-
Pioglitazone
-
Polythiazide
-
Pramlintide
-
Ranolazine
-
Repaglinide
-
Semaglutide
-
Sitagliptin
-
Somatrogon-ghla
-
Sotagliflozin
-
Sparfloxacin
-
Tafenoquine
-
Thioctic Acid
-
Tolazamide
-
Tolbutamide
-
Topiramate
-
Triamterene
-
Trimethoprim
-
Trovafloxacin
-
Vandetanib
-
Zonisamide
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Acebutolol
-
Atenolol
-
Betaxolol
-
Bisoprolol
-
Bitter Melon
-
Carteolol
-
Carvedilol
-
Celiprolol
-
Colesevelam
-
Esmolol
-
Fenugreek
-
Glecaprevir
-
Glucomannan
-
Goldenseal
-
Guar Gum
-
Hydrastis
-
Isocarboxazid
-
Labetalol
-
Levobunolol
-
Linezolid
-
Methylene Blue
-
Metipranolol
-
Metoprolol
-
Nadolol
-
Nebivolol
-
Oxprenolol
-
Ozanimod
-
Patiromer
-
Penbutolol
-
Phenelzine
-
Pibrentasvir
-
Pindolol
-
Practolol
-
Procarbazine
-
Propranolol
-
Psyllium
-
Rasagiline
-
Rifampin
-
Safinamide
-
Selegiline
-
Sotalol
-
Timolol
-
Tirzepatide
-
Tranylcypromine
-
Verapamil
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
-
Alcohol abuse, history of or
-
Cardiovascular collapse (shock) or
-
Congestive heart failure or
-
Heart attack, acute or
-
Hypovolemia (low blood volume) or
-
Pancreatic insulin deficiency (eg, pancreatitis, pancreatic surgery), history of or
-
Poorly nourished condition or
-
Sepsis (severe infection) or
-
Weakened physical condition—Use with caution. May cause side effects to become worse.
-
Anemia (low red blood cells) or
-
Dehydration or
-
Genital yeast (fungus) infection (eg, balanitis, balanoposthitis, vulvovaginitis), history of or
-
Hypotension (low blood pressure) or
-
Kidney disease or
-
Urinary tract infections (eg, pyelonephritis, urosepsis), history of or
-
Vitamin B12 deficiency—Use with caution. May make these conditions worse.
-
Blood vessel disease (eg, peripheral artery disease) in the leg, history of or
-
Diabetic foot infection (eg, osteomyelitis), sores, or ulcers, history of—May increase the risk of leg amputations.
-
Diabetic ketoacidosis (high ketones and acid in the blood) or
-
Kidney disease, severe (eg, patients receiving dialysis) or
-
Liver disease or
-
Metabolic acidosis (acid in the blood) or
-
Type I diabetes—Should not be used in patients with these conditions.
-
Fever or
-
Infection or
-
Surgery or
-
Trauma—Use with caution. These conditions may cause problems with blood sugar control.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.