Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of dextromethorphan and quinidine combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dextromethorphan and quinidine combination in the elderly.
Breastfeeding
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Atazanavir
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Aurothioglucose
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Bepridil
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Cisapride
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Clorgyline
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Colchicine
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Dronedarone
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Eliglustat
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Fingolimod
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Fluconazole
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Furazolidone
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Grepafloxacin
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Iproniazid
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Isocarboxazid
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Itraconazole
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Ketoconazole
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Lefamulin
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Levoketoconazole
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Levomethadyl
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Mavorixafor
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Mesoridazine
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Mifepristone
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Moclobemide
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Nelfinavir
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Nialamide
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Nirmatrelvir
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Ozanimod
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Pargyline
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Phenelzine
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Pimozide
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Piperaquine
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Posaconazole
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Procarbazine
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Rasagiline
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Ritonavir
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Safinamide
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Saquinavir
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Selegiline
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Sparfloxacin
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Terfenadine
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Thioridazine
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Tipranavir
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Toloxatone
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Tranylcypromine
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Vernakalant
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Voriconazole
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Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abametapir
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Acetazolamide
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Adagrasib
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Afatinib
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Ajmaline
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Alefacept
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Alfentanil
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Alfuzosin
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Almotriptan
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Amineptine
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Amiodarone
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Amisulpride
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Amitriptyline
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Amitriptylinoxide
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Amoxapine
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Amphetamine
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Amprenavir
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Anagrelide
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Apomorphine
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Aprindine
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Arbutamine
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Aripiprazole
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Aripiprazole Lauroxil
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Arsenic Trioxide
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Artemether
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Asciminib
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Asenapine
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Astemizole
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Atracurium
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Avacopan
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Azithromycin
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Bedaquiline
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Benzhydrocodone
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Benzphetamine
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Berotralstat
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Betrixaban
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Boceprevir
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Brexpiprazole
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Brompheniramine
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Buprenorphine
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Bupropion
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Buserelin
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Buspirone
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Butorphanol
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Carbamazepine
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Celecoxib
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Ceritinib
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Chloral Hydrate
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Chloroquine
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Chlorpheniramine
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Ciprofloxacin
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Citalopram
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Clarithromycin
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Clofazimine
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Clomipramine
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Clothiapine
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Clozapine
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Cobicistat
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Cocaine
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Codeine
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Conivaptan
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Crizotinib
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Cyclobenzaprine
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Cyclosporine
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Dabigatran Etexilate
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Dabrafenib
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Daridorexant
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Darunavir
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Dasabuvir
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Dasatinib
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Decamethonium
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Degarelix
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Delamanid
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Delavirdine
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Desipramine
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Deslorelin
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Desvenlafaxine
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Deutetrabenazine
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Dexmedetomidine
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Dextroamphetamine
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Dibenzepin
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Difenoxin
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Digitoxin
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Digoxin
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Dihydrocodeine
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Diphenoxylate
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Disopyramide
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Dofetilide
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Dolasetron
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Domperidone
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Donepezil
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Doxepin
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Doxorubicin
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Doxorubicin Hydrochloride Liposome
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Droperidol
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Duloxetine
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Edoxaban
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Efavirenz
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Eletriptan
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Enasidenib
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Encorafenib
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Enflurane
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Entrectinib
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Enzalutamide
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Erythromycin
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Escitalopram
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Ethylmorphine
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Etrasimod
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Etravirine
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Fedratinib
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Fenfluramine
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Fentanyl
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Fexinidazole
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Flecainide
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Fluoxetine
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Fluvoxamine
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Formoterol
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Fosamprenavir
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Foscarnet
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Fosnetupitant
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Fostemsavir
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Frovatriptan
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Gatifloxacin
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Gemifloxacin
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Gepirone
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Givinostat
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Givosiran
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Glasdegib
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Gonadorelin
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Goserelin
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Granisetron
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Halofantrine
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Haloperidol
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Halothane
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Histrelin
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Hydrocodone
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Hydromorphone
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Hydroquinidine
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Hydroxyamphetamine
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Hydroxychloroquine
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Hydroxytryptophan
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Hydroxyzine
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Ibutilide
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Iloperidone
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Imipramine
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Infliximab
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Inotuzumab Ozogamicin
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Isoflurane
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Isradipine
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Ivabradine
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Ivacaftor
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Ivosidenib
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Ketobemidone
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Lacosamide
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Lanreotide
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Lapatinib
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Lasmiditan
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Lenacapavir
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Lenvatinib
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Leuprolide
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Levofloxacin
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Levomilnacipran
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Levorphanol
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Lidocaine
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Lidoflazine
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Linezolid
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Lisdexamfetamine
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Lithium
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Lofepramine
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Lofexidine
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Lonafarnib
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Lopinavir
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Lorcainide
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Lorcaserin
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Lorlatinib
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Lumacaftor
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Lumefantrine
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Macimorelin
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Mavacamten
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Mavorixafor
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Mefloquine
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Melitracen
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Memantine
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Meperidine
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Metaxalone
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Methadone
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Methamphetamine
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Methylene Blue
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Metoclopramide
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Metronidazole
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Mexiletine
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Milnacipran
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Mirtazapine
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Mitotane
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Mobocertinib
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Morphine
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Morphine Sulfate Liposome
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Moxifloxacin
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Nafarelin
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Nalbuphine
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Nalidixic Acid
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Naratriptan
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Nebivolol
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Nefazodone
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Netupitant
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Nicomorphine
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Nifedipine
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Nilotinib
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Nirogacestat
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Norfloxacin
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Nortriptyline
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Octreotide
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Ofloxacin
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Olanzapine
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Oliceridine
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Omaveloxolone
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Ombitasvir
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Ondansetron
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Opipramol
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Opium
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Opium Alkaloids
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Osilodrostat
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Osimertinib
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Oxaliplatin
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Oxycodone
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Oxymorphone
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Ozanimod
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Pacritinib
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Palbociclib
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Paliperidone
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Palonosetron
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Pancuronium
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Panobinostat
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Papaveretum
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Paregoric
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Paritaprevir
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Paroxetine
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Pasireotide
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Pazopanib
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Pentamidine
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Pentazocine
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Phenobarbital
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Pimavanserin
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Piritramide
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Pirmenol
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Pirtobrutinib
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Pitolisant
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Pixantrone
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Ponesimod
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Pralsetinib
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Prilocaine
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Primidone
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Probucol
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Procainamide
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Prochlorperazine
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Promethazine
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Propafenone
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Protriptyline
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Quetiapine
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Quinine
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Quizartinib
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Ranolazine
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Relugolix
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Remifentanil
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Repotrectinib
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Ribociclib
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Rilpivirine
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Rimegepant
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Risperidone
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Ritlecitinib
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Rizatriptan
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Rolapitant
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Selpercatinib
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Sertraline
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Sevoflurane
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Sibutramine
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Simeprevir
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Siponimod
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Sirolimus Protein-Bound
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Sodium Phosphate
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Sodium Phosphate, Dibasic
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Sodium Phosphate, Monobasic
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Sofpironium
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Solifenacin
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Sorafenib
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Sotalol
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Sotorasib
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Spiramycin
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St John's Wort
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Succinylcholine
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Sufentanil
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Sulfamethoxazole
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Sulpiride
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Sumatriptan
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Sunitinib
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Tacrolimus
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Tapentadol
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Taurursodiol
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Telaprevir
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Telavancin
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Telithromycin
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Tenofovir Alafenamide
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Tetrabenazine
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Tianeptine
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Tilidine
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Tocilizumab
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Topotecan
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Toremifene
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Tovorafenib
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Tramadol
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Trazodone
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Triclabendazole
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Trifluoperazine
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Trimethoprim
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Trimipramine
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Triptorelin
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Trofinetide
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Tryptophan
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Tubocurarine
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Tucatinib
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Ubrogepant
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Ulipristal
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Valbenazine
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Vandetanib
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Vardenafil
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Vecuronium
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Vemurafenib
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Venetoclax
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Venlafaxine
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Vilanterol
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Vilazodone
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Vincristine
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Vincristine Sulfate Liposome
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Vinflunine
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Voclosporin
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Vonoprazan
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Vortioxetine
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Ziprasidone
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Zolmitriptan
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Zuclopenthixol
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abarelix
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Abiraterone Acetate
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Amiloride
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Atenolol
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Cimetidine
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Dalfopristin
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Dextromethorphan
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Dicumarol
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Fosphenytoin
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Galantamine
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Haloperidol
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Magaldrate
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Magnesium Carbonate
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Magnesium Hydroxide
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Magnesium Oxide
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Magnesium Trisilicate
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Metoprolol
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Nisoldipine
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Phenytoin
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Propranolol
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Quinidine
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Quinupristin
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Rifapentine
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Terbinafine
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Tolterodine
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Verapamil
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Bone marrow problems caused by quinidine, quinine, or mefloquine, history of or
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Heart block without a pacemaker or
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Heart failure or
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Heart rhythm problems (e.g., congenital long QT syndrome, prolonged QT interval, or a history of torsade de pointes) or
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Hepatitis caused by quinidine, quinine, or mefloquine, history of or
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Lupus-like syndrome caused by quinidine, quinine, or mefloquine, history of or
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Thrombocytopenia (low platelets in the blood) caused by quinidine, quinine, or mefloquine, history of—Should not be used in patients with these conditions.
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Drug abuse or dependence, or history of—Dependence may be more likely to develop.
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Heart or blood vessel disease or
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Hypokalemia (low potassium in the blood) or
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Hypomagnesemia (low magnesium in the blood) or
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Hypertension (high blood pressure) or
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Stroke, history of—May increase risk for more serious side effects.
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Kidney disease, severe or
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Liver disease, severe—Higher blood levels of this medicine can occur, which increases the risk of serious side effects.
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Myasthenia gravis (severe muscle weakness)—Use with caution. May make this condition worse.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.