Sahar Saddoughi, M.D., Ph.D.

  1. Transplant Surgeon
  1. Shariff M, Kumar A, Stulak J, Naumann KE, Blackmon SH, Saddoughi SA. Gender gap in cardiothoracic surgery randomized controlled trial and post-hoc analysis of randomized controlled trial authorship from 2014 to 2020. Eur J Cardiothorac Surg. 2024 Oct 1; 66 (4)
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  2. Treffalls JA, Bilgili A, Brennan Z, Sharaf OM, Griffeth EM, Chen Q, Pennington K, Spencer PJ, Villavicencio MA, Daly RC, Saddoughi SA. Procurement Trends, Indications, and Outcomes of Heart-Lung Transplantation in the Contemporary Era. Clin Transplant. 2024 Sep; 38 (9):e15447
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  3. Gillaspie EA, Enofe N, Tompkins A, Cooke DT, Freeman K, DiMaio JM, Merrill W, Erkmen CP, Society of Thoracic Surgeons Workforces on Diversity, Equity, and Inclusion, Cardiothoracic Surgery Practice Models, and Career Development. A Report of Salaries of Academic Cardiothoracic Surgeons Based on Race and Ethnicity. Ann Thorac Surg. 2024 Sep; 118 (3):569-578 Epub 2024 May 08
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  4. Sawal N, Pennington KM, Petrossian R, Reisenauer J, Mullon J, Midthun D, Nelson D, Anderson D, Edell E, Saddoughi SA, Spencer PJ, Villavicencio MA, Kennedy CC, Scott JP, Peters SG, Wylam ME, Kern RM. Custom silicone Y-stents for the management of anastomotic stenosis in lung transplant recipients. Respir Med. 2024 Sep; 231:107737 Epub 2024 July 08
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  5. Choi K, Altarabsheh SE, Saddoughi SA, Spencer PJ, Lahr B, Ergi DG, Schumer E, Villavicencio MA. Impact of Time of Day on Surgical Outcomes After Lung Transplantation (Night-Time Lung Transplant). Ann Thorac Surg. 2024 Aug 30 [Epub ahead of print]
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  6. Pennington KM, Martin MJ, Murad MH, Sanborn D, Saddoughi SA, Gerberi D, Peters SG, Razonable RR, Kennedy CC. Risk Factors for Early Fungal Disease in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis. Transplantation. 2024 Apr 1; 108 (4):970-984 Epub 2023 Nov 13
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  7. Saddoughi SA, Powell C, Stroh GR, Rajagopalan S, Bartholmai BJ, Boland JM, Aubry MC, Harmsen WS, Blackmon SH, Cassivi SD, Nichols FC, Reisenauer JS, Shen KR, Mansfield AS, Maldonado F, Peikert T, Wigle DA. Long-Term Survival and CANARY-Based Artificial Intelligence for Multifocal Lung Adenocarcinoma Mayo Clin Proc: Digital Health. 2024; 2(1):44-52.
  8. Spencer PJ, Saddoughi SA, Choi K, Dickinson TA, Richman A, Reynolds FA, Villavicencio MA. Heart-Lung Transplantation From Donation After Circulatory Death Using Mobile Normothermic Regional Perfusion. ASAIO J. 2024 Jan 1; 70 (1):e13-e15 Epub 2023 Dec 23
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  9. Choi K, Spadaccio C, Ribeiro RVP, Langlais BT, Villavicencio MA, Pennington K, Spencer PJ, Daly RC, Mallea J, Keshavjee S, Cypel M, Saddoughi SA. Early national trends of lung allograft use during donation after circulatory death heart procurement in the United States. JTCVS Open. 2023 Dec; 16:1020-1028. Epub 2023 Sep 04.
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  10. Abou Chaar , M.K., Saddoughi , S. A., Harmsen , W. M., Lee , M. K., Yost , K. J., Blackmon , S. H.. Patients Struggle With Severe Symptoms Even After Surviving Esophagectomy for Esophageal Cancer Annals of Thoracic Surgery Short Reports. 2023; 2(1):98-102.
  11. Abou Chaar MK, Godin A, Harmsen WS, Wzientek C, Saddoughi SA, Hallemeier CL, Cassivi SD, Nichols FC, Reisenauer JS, Shen KR, Tapias LF, Wigle DA, Blackmon SH. Determinants of Long-term Survival Decades After Esophagectomy for Esophageal Cancer. Ann Thorac Surg. 2023 Nov; 116(5):1036-1044. Epub 2023 Jun 22.
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  12. Wahab A, Hanson AC, Peters S, Villavicencio MA, Saddoughi SA, Shah SZ, Spencer PJ, Kennedy CC, Pennington KM. Expanded extracorporeal membrane oxygenation bridge to heart and lung transplant candidate selection does not impact outcomes compared to traditional candidate selection criteria. J Thorac Dis. 2023 Jun 30; 15 (6):3421-3430 Epub 2023 May 24
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  13. Choi K, Spadaccio C, Altarabsheh SE, Knop G, Spencer PJ, Saddoughi SA, Tabar KR, Hassler KR, Villavicencio MA. Bilateral lung transplantation from a left ventricular assist device supported donor. JTCVS Tech. 2023 Jun; 19:164-165. Epub 2023 Apr 20.
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  14. Saddoughi SA, Cypel M. Expanding the Lung Donor Pool: Donation After Circulatory Death, Ex-Vivo Lung Perfusion and Hepatitis C Donors. Clin Chest Med. 2023 Mar; 44 (1):77-83
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  15. Powell CL, Saddoughi SA, Wigle DA. Progress in genome-inspired treatment decisions for multifocal lung adenocarcinoma. Expert Rev Respir Med. 2023 Jul-Dec; 17(11):1009-1021. Epub 2023 Dec 26.
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  16. Saddoughi SA, Garijo JM, Yeung JC. Reply: There is no substitution for a surgeon's eyes, but sometimes she might need glasses. JTCVS Tech. 2022 Oct; 15:210-211 Epub 2021 Aug 14
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  17. Schumer EM, Saddoughi SA, Spencer PJ, Pochettino A, Daly RC, Villavicencio MA. Lung transplantation long-term survival is worse in patients who have undergone previous cardiac surgery. Eur J Cardiothorac Surg. 2022 Sep 2; 62 (4)
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  18. Krishnan P, Saddoughi SS. Procurement of lungs from brain-dead donors. Indian J Thorac Cardiovasc Surg. 2021 Sep; 37 (Suppl 3):416-424 Epub 2021 Mar 19
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  19. Saddoughi S, Taswell J, Spears G, Harmsen W, Allen M, Blackmon S, Cassivi S, Nichols F, Wigle D, Shen K. Patients younger than 45 years of age have superior 5-year survival in advanced esophageal cancer Shanghai Chest. 2019.
  20. Saddoughi SA, Abdelsattar ZM, Blackmon SH. National Trends in the Epidemiology of Malignant Pleural Mesothelioma: A National Cancer Data Base Study. Ann Thorac Surg. 2018 Feb; 105 (2):432-437 Epub 2017 Dec 07
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  21. Saddoughi SA, Abel MD, Maleszewski JJ, Schaff HV. Acute aortitis of the ascending aorta. Interact Cardiovasc Thorac Surg. 2017 Jul 1; 25 (1):142-144
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  22. Saddoughi SA, Reinersman JM, Zhukov YO, Taswell J, Mara K, Harmsen SW, Blackmon SH, Cassivi SD, Nichols F 3rd, Shen KR, Wigle DA, Allen MS. Survival After Surgical Resection of Stage IV Esophageal Cancer. Ann Thorac Surg. 2017 Jan; 103 (1):261-266 Epub 2016 Sept 09
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  23. Saddoughi SA, Maleszewski JJ, Schaff HV. Cardiac myxoma: Simplifying a "complex" case. J Thorac Cardiovasc Surg. 2016 Nov; 152 (5):1439-1440 Epub 2016 Aug 04
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  24. Saddoughi SA, Taswell J, Harmsen WS, Inra ML, Blackmon SH, Nichols FC 3rd, Cassivi SD, Wigle DA, Shen KR, Allen MS. Surgical Resection of Rare Esophageal Cancers. Ann Thorac Surg. 2016 Jan; 101: (1)311-5.
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  25. Saddoughi SA, Steinberg DH, Ikonomidis JS. Functioning Cooley-Cutter aortic valve prosthesis 40 years after implantation. J Thorac Cardiovasc Surg. 2014 Mar; 147 (3):e21-2 Epub 2013 Nov 27
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  26. Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013 Oct; 123 (10):4144-57 Epub 2013 Sept 03
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  27. Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, Quintas-Cardama A, Goldman JM, Apperley J, Reid A, Milojkovic D, Ziolo MT, Marcucci G, Ogretmen B, Neviani P, Perrotti D. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 2013 Sep 12; 122 (11):1923-34 Epub 2013 Aug 07
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  28. Saddoughi SA, Ogretmen B. Diverse functions of ceramide in cancer cell death and proliferation. Adv Cancer Res. 2013; 117:37-58
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  29. Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 2013 Jan; 5 (1):105-21 Epub 2012 Nov 25
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  30. Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11 (5):1092-102 Epub 2012 Mar 27
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  31. Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. J Biol Chem. 2011 Dec 9; 286 (49):42446-58 Epub 2011 Oct 19
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  32. Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C(1)(8)-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15; 17 (18):6097-105 Epub 2011 July 26
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  33. Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 2011 Jun 2; 117 (22):5941-52 Epub 2011 Apr 28
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  34. Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol. 2010 Oct; 6 (10):1603-24
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  35. Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23 (3):751-63 Epub 2008 Nov 21
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  36. Saddoughi SA, Song P, Ogretmen B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem. 2008; 49:413-40
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  37. Buzzeo MC, Iqbal AH, Long CM, Millar D, Patel S, Pellow MA, Saddoughi SA, Smenton AL, Turner JF, Wadhawan JD, Compton RG, Golen JA, Rheingold AL, Doerrer LH. Homoleptic cobalt and copper phenolate A2[M(OAr)4] compounds: the effect of phenoxide fluorination. Inorg Chem. 2004 Nov 29; 43 (24):7709-25
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