Research

Mayo Clinic researchers have a rich history in advancing precision medicine for breast cancer. Accomplishments in this area include:

  • Finding new treatments for breast cancer.
  • Identifying an enzyme that regulates DNA repair.
  • Identifying subsets of people with breast cancer who do not benefit from medicines called aromatase inhibitors.
  • Identifying variations in the enzyme CYP2D6, which helps explain why some people with breast cancer don't respond to tamoxifen.
  • Developing a new medicine to replace tamoxifen for people with low CYP2D6 enzyme activity.
  • Developing a new medicine for breast cancer that is resistant to aromatase inhibitors.
  • Identifying mechanisms for why some people do not respond to endocrine treatment, and then developing a new medicine for breast cancer.

Mayo Clinic Comprehensive Cancer Center is one of a handful of facilities that received a U.S. National Cancer Institute Specialized Programs of Research Excellence (SPORE) grant for breast cancer research. Learn more about the Mayo Clinic Breast Cancer SPORE.

Publications

See a list of publications about breast cancer by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

By Mayo Clinic Staff