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Chen Lin, Ph.D.

  1. Medical Physicist
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Publications

  1. Patel V, Tao S, Zhou X, Lin C, Westerhold E, Grewal S, Middlebrooks EH. Real-Time Optimal Synthetic Inversion Recovery Image Selection (RT-OSIRIS) for Deep Brain Stimulation Targeting. J Imaging Inform Med. 2024 Oct; 37 (5):2698-2705 Epub 2024 Apr 19
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  2. Lakhani DA, Zhou X, Tao S, Patel V, Wen S, Okromelidze L, Greco E, Lin C, Westerhold EM, Straub S, Wszolek ZK, Tipton PW, Uitti RJ, Grewal SS, Middlebrooks EH. Diagnostic utility of 7T neuromelanin imaging of the substantia nigra in Parkinson's disease. NPJ Parkinsons Dis. 2024 Jan 08; 10(1):13.
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  3. Tao S, Zhou X, Lin C, Patel V, Westerhold EM, Middlebrooks EH. Optimization of MP2RAGE T1 mapping with radial view-ordering for deep brain stimulation targeting at 7 T MRI. Magn Reson Imaging. 2023 Jul; 100:55-63. Epub 2023 Mar 15.
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  4. Lundstrom BN, Lin C, Starnes DK, Middlebrooks EH, Tatum W, Grewal SS, Crepeau AZ, Gregg NM, Miller KJ, Van Gompel JJ, Watson RE. Safety and Management of Implanted Epilepsy Devices for Imaging and Surgery. Mayo Clin Proc. 2022 Nov; 97 (11):2123-2138 Epub 2022 Oct 07
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  5. Tao S, Zhou X, Westerhold EM, Middlebrooks EH, Lin C. Optimization of fast gray matter acquisition T1 inversion recovery (FGATIR) on 7T MRI for deep brain stimulation targeting. Neuroimage. 2022 May 15; 252:119043 Epub 2022 Feb 27
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  6. Middlebrooks EH, Okromelidze L, Carter RE, Jain A, Lin C, Westerhold E, Pena AB, Quinones-Hinojosa A, Uitti RJ, Grewal SS. Directed stimulation of the dentato-rubro-thalamic tract for deep brain stimulation in essential tremor: a blinded clinical trial. Neuroradiol J. 2022 Apr; 35 (2):203-212 Epub 2021 Aug 02
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  7. Lu CQ, Gosden GP, Okromelidze L, Jain A, Gupta V, Grewal SS, Lin C, Tatum WO, Messina SA, Quinones-Hinojosa A, Ju S, Middlebrooks EH. Brain structural differences in temporal lobe and frontal lobe epilepsy patients: A voxel-based morphometry and vertex-based surface analysis. Neuroradiol J. 2022 Apr; 35 (2):193-202 Epub 2021 July 27
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  8. Middlebrooks EH, Okromelidze L, Lin C, Jain A, Westerhold E, Ritaccio A, Quinones-Hinojosa A, Gupta V, Grewal SS. Edge-enhancing gradient echo with multi-image co-registration and averaging (EDGE-MICRA) for targeting thalamic centromedian and parafascicular nuclei. Neuroradiol J. 2021 Dec; 34 (6):667-675 Epub 2021 June 13
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  9. Middlebrooks EH, Jain A, Okromelidze L, Lin C, Westerhold EM, O'Steen CA, Ritaccio AL, Quiñones-Hinojosa A, Tatum WO, Grewal SS. Acute Brain Activation Patterns of High- Versus Low-Frequency Stimulation of the Anterior Nucleus of the Thalamus During Deep Brain Stimulation for Epilepsy. Neurosurgery. 2021 Oct 13; 89(5):901-908.
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  10. Leon RL, Brown BP, Persohn SA, Norris CD, Steinhardt NP, Lin C, Territo PR. Intravoxel incoherent motion MR imaging analysis for diagnosis of placenta accrete spectrum disorders: A pilot feasibility study. Magn Reson Imaging. 2021 Jul; 80:26-32 Epub 2021 Mar 22
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  11. Monroe JC, Lin C, Perkins SM, Han Y, Wong BJ, Motaganahalli RL, Roseguini BT. Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease. J Appl Physiol (1985). 2020 Dec 1; 129 (6):1279-1289 Epub 2020 Oct 01
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  12. Middlebrooks EH, Lin C, Okromelidze L, Lu CQ, Tatum WO, Wharen RE Jr, Grewal SS. Functional Activation Patterns of Deep Brain Stimulation of the Anterior Nucleus of the Thalamus. World Neurosurg. 2020 Apr; 136:357-363.e2 Epub 2020 Jan 27
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  13. Alhulail AA, Patterson DA, Xia P, Zhou X, Lin C, Thomas MA, Dydak U, Emir UE. Fat-water separation by fast metabolite cycling magnetic resonance spectroscopic imaging at 3 T: A method to generate separate quantitative distribution maps of musculoskeletal lipid components. Magn Reson Med. 2020 Feb 26 [Epub ahead of print]
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  14. Ho CY, Supakul N, Patel PU, Seit V, Groswald M, Cardinal J, Lin C, Kralik SF. Differentiation of pilocytic and pilomyxoid astrocytomas using dynamic susceptibility contrast perfusion and diffusion weighted imaging. Neuroradiology. 2020 Jan; 62 (1):81-88 Epub 2019 Nov 01
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  15. Middlebrooks EH, Lin C, Westerhold E, Okromelidze L, Vibhute P, Grewal SS, Gupta V. Improved detection of focal cortical dysplasia using a novel 3D imaging sequence: Edge-Enhancing Gradient Echo (3D-EDGE) MRI. Neuroimage Clin. 2020; 28:102449 Epub 2020 Sept 28
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  16. Tirkes T, Zhao X, Lin C, Stuckey AJ, Li L, Giri S, Nickel D. Evaluation of variable flip angle, MOLLI, SASHA, and IR-SNAPSHOT pulse sequences for T1 relaxometry and extracellular volume imaging of the pancreas and liver. MAGMA. 2019 Oct; 32 (5):559-566 Epub 2019 June 04
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  17. Tirkes T, Mitchell JR, Li L, Zhao X, Lin C. Normal T1 relaxometry and extracellular volume of the pancreas in subjects with no pancreas disease: correlation with age and gender. Abdom Radiol (NY). 2019 Sep; 44 (9):3133-3138
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  18. Grewal SS, Middlebrooks EH, Kaufmann TJ, Stead M, Lundstrom BN, Worrell GA, Lin C, Baydin S, Van Gompel JJ. Fast gray matter acquisition T1 inversion recovery MRI to delineate the mammillothalamic tract for preoperative direct targeting of the anterior nucleus of the thalamus for deep brain stimulation in epilepsy. Neurosurg Focus. 2018 Aug; 45 (2):E6
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  19. Xu SW, Xi JH, Lin C, Wang XY, Fu LY, Kralik SF, Chen ZQ. Cognitive decline and white matter changes in mesial temporal lobe epilepsy. Medicine (Baltimore). 2018 Aug; 97 (33):e11803
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  20. Le Y, Nickel MD, Kannengiesser S, Kiefer B, Spottiswoode B, Dale B, Soon V, Lin C. A novel framework for evaluating the image accuracy of dynamic MRI and the application on accelerated breast DCE MRI. MAGMA. 2017 Sep 11 Epub 2017 Sept 11
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  21. Tirkes T, Lin C, Cui E, Deng Y, Territo PR, Sandrasegaran K, Akisik F. Quantitative MR Evaluation of Chronic Pancreatitis: Extracellular Volume Fraction and MR Relaxometry. AJR Am J Roentgenol. 2018 Mar; 210 (3):533-542 Epub 2018 Jan 16
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  22. Sandrasegaran K, Territo P, Elkady RM, Lin Y, Gasparis P, Borthakur G, Lin C. Does intravoxel incoherent motion reliably stage hepatic fibrosis, steatosis, and inflammation? Abdom Radiol (NY). 2018 Mar; 43 (3):600-606
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  23. Handa RK, Territo PR, Blomgren PM, Persohn SA, Lin C, Johnson CD, Jiang L, Connors BA, Hutchins GD. Development of a novel magnetic resonance imaging acquisition and analysis workflow for the quantification of shock wave lithotripsy-induced renal hemorrhagic injury. Urolithiasis. 2017 Jan 10 [Epub ahead of print]
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  24. Allen MR, McNerny E, Aref M, Organ JM, Newman CL, McGowan B, Jang T, Burr DB, Brown DM, Hammond M, Territo PR, Lin C, Persohn S, Jiang L, Riley AA, McCarthy BP, Hutchins GD, Wallace JM. Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model. PLoS One. 2017; 12 (8):e0181750 Epub 2017 Aug 09
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  25. Kralik SF, Yasrebi M, Supakul N, Lin C, Netter LG, Hicks RA, Hibbard RA, Ackerman LL, Harris ML, Ho CY. Diagnostic Performance of Ultrafast Brain MRI for Evaluation of Abusive Head Trauma. AJNR Am J Neuroradiol. 2017 Apr; 38 (4):807-813 Epub 2017 Feb 09
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  26. Tirkes T, Lin C, Fogel EL, Sherman SS, Wang Q, Sandrasegaran K. T1 mapping for diagnosis of mild chronic pancreatitis. J Magn Reson Imaging. 2017 Apr; 45 (4):1171-1176 Epub 2016 Aug 13
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  27. Tirkes T, Fogel EL, Sherman S, Lin C, Swensson J, Akisik F, Sandrasegaran K. Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis. Abdom Radiol (NY). 2017 Feb; 42 (2):544-551
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  28. Neff D, Kuhlenhoelter AM, Lin C, Wong BJ, Motaganahalli RL, Roseguini BT. Thermotherapy reduces blood pressure and circulating endothelin-1 concentration and enhances leg blood flow in patients with symptomatic peripheral artery disease. Am J Physiol Regul Integr Comp Physiol. 2016 Aug 01; 311 (2):R392-400 Epub 2016 June 22
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  29. Le Y, Kipfer HD, Nickel DM, Kroeker R, Dale BM, Holz SP, Weiland E, Lin C. Initial Experience of Applying TWIST-Dixon With Flexible View Sharing in Breast DCE-MRI. Clin Breast Cancer. 2016 Jun; 16 (3):202-6 Epub 2015 Nov 26
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  30. Le Y, Dale B, Akisik F, Koons K, Lin C. Improved T1, contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two-point Dixon for dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Med. 2016 Apr; 75 (4):1677-84 Epub 2015 May 19
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  31. Ho CY, Cardinal JS, Kamer AP, Lin C, Kralik SF. Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors. AJNR Am J Neuroradiol. 2016 Mar; 37 (3):544-51 Epub 2015 Nov 12
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  32. Ni P, Lin Y, Zhong Q, Chen Z, Sandrasegaran K, Lin C. Technical advancements and protocol optimization of diffusion-weighted imaging (DWI) in liver. Abdom Radiol (NY). 2016 Jan; 41 (1):189-202
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  33. Liu Y, Akisik F, Tirkes T, Tann M, Sandrasegaran K, Jennings SG, Lin C, Kakarala B, Fridell JA, Powelson JA, Liang C. Value of magnetic resonance imaging in evaluating the pancreatic allograft transplant complications. Abdom Imaging. 2015 Oct; 40 (7):2384-90
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  34. James JR, Panda A, Lin C, Dydak U, Dale BM, Bansal N. In vivo sodium MR imaging of the abdomen at 3T. Abdom Imaging. 2015 Oct; 40 (7):2272-80
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  35. Moorthi RN, Fadel W, Eckert GJ, Ponsler-Sipes K, Moe SM, Lin C. Bone marrow fat is increased in chronic kidney disease by magnetic resonance spectroscopy. Osteoporos Int. 2015 Jun; 26 (6):1801-7 Epub 2015 Feb 21
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  36. Le Y, Kipfer HD, Majidi SS, Holz S, Lin C. Comparison of the artifacts caused by metallic implants in breast MRI using dual-echo dixon versus conventional fat-suppression techniques. AJR Am J Roentgenol. 2014 Sep; 203 (3):W307-14
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  37. Lin C, Rogers DC, Majidi SS. Fat Suppression Techniques in Breast MRI: A Critical Comparison and State of the Art Reports in Medical Imaging. 2014.
  38. Le Y, Kipfer H, Majidi S, Holz S, Dale B, Geppert C, Kroeker R, Lin C. Application of time-resolved angiography with stochastic trajectories (TWIST)-Dixon in dynamic contrast-enhanced (DCE) breast MRI. J Magn Reson Imaging. 2013 Nov; 38 (5):1033-42 Epub 2013 Sept 05
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  39. Le Y, Kroeker R, Kipfer HD, Lin C. Development and evaluation of TWIST Dixon for dynamic contrast-enhanced (DCE) MRI with improved acquisition efficiency and fat suppression. J Magn Reson Imaging. 2012 Aug; 36 (2):483-91 Epub 2012 Apr 27
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  40. Karmazyn B, Lin C, Persohn SA, Buckwalter KA. Feasibility of mapping T2 relaxation time in the pediatric metacarpal head with a 3-T MRI system. AJR Am J Roentgenol. 2012 Jun; 198 (6):W602-4
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  41. Lin C, Lin C, Bernstein M. WE-G-217A-02: RF Heating of DBS Lead with T/R Head Coil versus T/R Body Coil. Med Phys. 2012 Jun; 39 (6Part28):3975
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  42. Buckwalter KA, Lin C, Ford JM. Managing postoperative artifacts on computed tomography and magnetic resonance imaging. Semin Musculoskelet Radiol. 2011 Sep; 15 (4):309-19 Epub 2011 Sept 16
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  43. Wang Y, Saykin AJ, Pfeuffer J, Lin C, Mosier KM, Shen L, Kim S, Hutchins GD. Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T. Neuroimage. 2011 Jan 15; 54 (2):1188-95 Epub 2010 Aug 25
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  44. Akisik MF, Sandrasegaran K, Bu G, Lin C, Hutchins GD, Chiorean EG. Pancreatic cancer: utility of dynamic contrast-enhanced MR imaging in assessment of antiangiogenic therapy. Radiology. 2010 Aug; 256 (2):441-9 Epub 2010 June 01
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  45. Sandrasegaran K, Lin C, Akisik FM, Tann M. State-of-the-art pancreatic MRI. AJR Am J Roentgenol. 2010 Jul; 195 (1):42-53
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  46. Sandrasegaran K, Sundaram CP, Ramaswamy R, Akisik FM, Rydberg MP, Lin C, Aisen AM. Usefulness of diffusion-weighted imaging in the evaluation of renal masses. AJR Am J Roentgenol. 2010 Feb; 194 (2):438-45
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  47. Sandrasegaran K, Akisik FM, Lin C, Tahir B, Rajan J, Saxena R, Aisen AM. Value of diffusion-weighted MRI for assessing liver fibrosis and cirrhosis. AJR Am J Roentgenol. 2009 Dec; 193 (6):1556-60
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  48. Sandrasegaran K, Akisik FM, Lin C, Tahir B, Rajan J, Aisen AM. The value of diffusion-weighted imaging in characterizing focal liver masses. Acad Radiol. 2009 Oct; 16 (10):1208-14 Epub 2009 July 15
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  49. Akisik MF, Sandrasegaran K, Jennings SG, Aisen AM, Lin C, Sherman S, Rydberg MP. Diagnosis of chronic pancreatitis by using apparent diffusion coefficient measurements at 3.0-T MR following secretin stimulation. Radiology. 2009 Aug; 252 (2):418-25 Epub 2009 June 09
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  50. Akisik MF, Aisen AM, Sandrasegaran K, Jennings SG, Lin C, Sherman S, Lin JA, Rydberg M. Assessment of chronic pancreatitis: utility of diffusion-weighted MR imaging with secretin enhancement. Radiology. 2009 Jan; 250 (1):103-9 Epub 2008 Nov 10
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  51. Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, Weiner MW. The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008 Apr; 27 (4):685-91
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  52. Lin C, Bernstein MA. 3D magnetization prepared elliptical centric fast gradient echo imaging. Magn Reson Med. 2008 Feb; 59 (2):434-9
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  53. Akisik FM, Sandrasegaran K, Aisen AM, Lin C, Lall C. Abdominal MR imaging at 3.0 T. Radiographics. 2007 Sep-Oct; 27 (5):1433-44; discussion 1462-4
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  54. Lin C, Bernstein MA, Gibbs GF, Huston J 3rd. Reduction of RF power for magnetization transfer with optimized application of RF pulses in k-space. Magn Reson Med. 2003 Jul; 50 (1):114-21
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  55. Kocharian A, Lane JI, Bernstein MA, Lin C, Witte RJ, Huston J 3rd, Felmlee JP. Hybrid phased array for improved internal auditory canal imaging at 3.0-T MR. J Magn Reson Imaging. 2002 Sep; 16 (3):300-4
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  56. Bernstein MA, Huston J 3rd, Lin C, Gibbs GF, Lin C, Felmlee JP. High-resolution intracranial and cervical MRA at 3.0T: technical considerations and initial experience. Magn Reson Med. 2001 Nov; 46 (5):955-62
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  57. Campeau NG, Huston J 3rd, Bernstein MA, Lin C, Gibbs GF, Lin C. Magnetic resonance angiography at 3.0 Tesla: initial clinical experience. Top Magn Reson Imaging. 2001 Jun; 12 (3):183-204
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  58. LeBlanc A, Lin C, Shackelford L, Sinitsyn V, Evans H, Belichenko O, Schenkman B, Kozlovskaya I, Oganov V, Bakulin A, Hedrick T, Feeback D. Muscle volume, MRI relaxation times (T2), and body composition after spaceflight. J Appl Physiol (1985). 2000 Dec; 89 (6):2158-64
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  59. LeBlanc A, Lin C, Evans H, Shackelford L, Martin C, Hedrick T. T2 vertebral bone marrow changes after space flight. Magn Reson Med. 1999 Mar; 41 (3):495-8
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  60. Lin C, Wendt RE 3rd, Evans HJ, Rowe RM, Hedrick TD, LeBlanc AD. Eddy current correction in volume-localized MR spectroscopy. J Magn Reson Imaging. 1994 Nov-Dec; 4 (6):823-7
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  61. Hazlewood CF, Rorschach HE, Lin C. Diffusion of water in tissues and MRI. Magn Reson Med. 1991 Jun; 19 (2):214-6
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PST-20384290