High blood protein is an increase in the concentration of protein in the bloodstream. The medical term for high blood protein is hyperproteinemia. High blood protein is not a specific disease or condition, but it might indicate that you have a disease.
High blood protein rarely causes symptoms on its own. But sometimes it is found when you have blood tests done for a separate issue or symptom.
If a healthcare professional discovers high blood protein during a test, more tests can help find if there is a condition that is causing it.
A total protein test may be done. Other, more-specific tests, including serum protein electrophoresis (SPEP), can help find the exact source, such as the liver or bone marrow. These tests also can identify the specific protein type involved in your high blood protein levels. Your healthcare professional may order an SPEP if a bone marrow disease is suspected.
Show References
- Testing.com. Total protein, albumin-globulin (A/G) ratio test. https://www.testing.com/tests/total-protein-albumin-globulin-ag-ratio/. Accessed Sept. 16, 2024.
- Amyloidosis and kidney disease. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis. Accessed Sept. 16, 2024.
- Monoclonal gammopathy of undetermined significance (MGUS). Merck Manual Professional Version. https://www.merckmanuals.com/professional/hematology-and-oncology/plasma-cell-disorders/monoclonal-gammopathy-of-undetermined-significance-mgus. Accessed Sept. 16, 2024.
- Laubach JP. Diagnosis of monoclonal gammopathy of undetermined significance. https://www.uptodate.com/contents/search. Accessed Sept. 16, 2024.
- Blood basics. American Society of Hematology. https://www.hematology.org/education/patients/blood-basics. Accessed Sept. 16, 2024.
Original article: https://www.mayoclinic.org/symptoms/high-blood-protein/basics/causes/sym-20050599