Michael W. Ruff, M.D.

  1. Neurologist
  2. Oncologist
  1. Vora S, Pafundi D, Voss M, Buras M, Ashman J, Bendok B, Breen W, Hu L, Kizilbash S, Laack N, Liu W, Mahajan A, Mrugala M, Porter A, Ruff M, Sio T, Uhm J, Yang M, Brinkmann D, Brown P. Short-course hypofractionated proton beam therapy, incorporating (18)F-DOPA PET and contrast-enhanced MRI targeting, for patients aged 65 years and older with newly diagnosed glioblastoma: a single-arm phase 2 trial. Lancet Oncol. 2024 Dec; 25 (12):1625-1634 Epub 2024 Nov 18
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  2. Vora SA, Pafundi DH, Voss MM, Buras MR, Ashman JB, Bendok BR, Breen W, Hu LS, Kizilbash SH, Laack NN, Liu W, Mahajan A, Mrugala MM, Porter Umphrey AB, Ruff MW, Sio TT, Uhm J, Yang M, Brinkmann DH, Brown PD. Phase 2 Study of Short-Course, Hypofractionated Proton Beam Therapy Incorporating 18F-DOPA PET–MRI for Older Patients With Newly Diagnosed Glioblastoma (In review with Editor, Manuscript Number: D-24-00665R1) The Lancet. 2024.
  3. Khurana A, Rosenthal AC, Mohty R, Gaddam M, Bansal R, Hathcock MA, Nedved AN, Durani U, Iqbal M, Wang Y, Paludo J, Villasboas JC, Dingli D, Kourelis T, Leung N, Alkhateeb H, Ruff MW, Gallo de Moraes A, Vergidis P, Herrmann J, Kenderian SS, Bennani NN, Johnston PB, Ansell SM, Lin Y. Chimeric antigen receptor T-cell therapy associated hemophagocytic lymphohistiocytosis syndrome: clinical presentation, outcomes, and management. Blood Cancer J 2024 Aug 12; 14 (1):136
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  4. Webb LM, Webb MJ, Campian JL, Caron SJ, Ruff MW, Uhm JH, Sener U. A case series of osseous metastases in patients with glioblastoma. Medicine (Baltimore). 2024 Jul 5; 103 (27):e38794
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  5. Webb LM, Neth BJ, Raghunathan A, Greipp PT, Ida CM, Carabenciov ID, Ruff MW. A Case of Long-Term Survival After Glioblastoma, IDH-Wild Type. Neurologist. 2024 Jul 01; 29(4):254-258.
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  6. Hooshmand SJ, Chohan KL, Raghunathan A, Renaud DL, Ruff MW. BRAT1-Associated Leukodystrophy Exacerbated by Classic Hodgkin Lymphoma-Directed Therapy. Neurologist. 2024 May 1; 29 (3):170-172 Epub 2024 May 01
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  7. Chohan KL, Bansal R, Hathcock MA, Paludo J, Bennani NN, Johnston PB, Khurana A, Durani U, Wang Y, Ruff MW, Villasboas Bisneto JC, Ansell SM, Lin Y, Kenderian SS. Real-world associations of cytokine release syndrome and neurotoxicity with efficacy in patients receiving anti-CD-19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: the Mayo Clinic experience. Leuk Lymphoma. 2024 Mar; 65 (3):389-393 Epub 2023 Nov 30
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  8. Sakemura RL, Manriquez Roman C, Horvei P, Siegler EL, Girsch JH, Sirpilla OL, Stewart CM, Yun K, Can I, Ogbodo EJ, Adada MM, Bezerra ED, Kankeu Fonkoua LA, Hefazi M, Ruff MW, Kimball BL, Mai LK, Huynh TN, Nevala WK, Ilieva K, Augsberger C, Patra-Kneuer M, Schanzer J, Endell J, Heitmuller C, Steidl S, Parikh SA, Ding W, Kay NE, Nowakowski GS, Kenderian SS. CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS. Blood. 2024 Jan 18; 143 (3):258-271
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  9. Breen WG, Geno CS, Waddle MR, Qian J, Harmsen WS, Burns TC, Sener UT, Ruff MW, Neth BJ, Uhm JH, Routman DM, Yan E, Kruse JJ, Laack NN, Brown PD, Mahajan A. Proton versus photon craniospinal irradiation for adult medulloblastoma: A dosimetric, toxicity, and exploratory cost analysis. Neurooncol Adv. 2024 Jan-Dec; 6 (1):vdae034 Epub 2024 Mar 08
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  10. Neth BJ, Winters JL, Sairaj RT, Gharibi Loron A, Rahman M, Hirte R, Riviere-Cazaux C, Ruff MW, Burns TC. Plasma exchange as a tool for removal of bevacizumab: Highlighting application for urgent surgery. Neurooncol Pract. 2023 Dec; 10(6):592-595. Epub 2023 Aug 30.
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  11. Neth BJ, Raghunathan A, Kizilbash SH, Uhm JH, Breen WG, Johnson DR, Daniels DJ, Sener U, Carabenciov ID, Campian JL, Khatua S, Mahajan A, Ruff MW. Management and Long-term Outcomes of Adults With Medulloblastoma: A Single-Center Experience. Neurology. 2023 Sep 19; 101 (12):e1256-e1271 Epub 2023 July 31
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  12. Rael S, Webb M, Brown RD Jr, Ruff MW, Keser Z, Sener U. Safety of intravenous thrombolysis for ischemic stroke in patients with hematologic malignancies: A single institution experience. J Stroke Cerebrovasc Dis. 2023 Sep; 32 (9):107294 Epub 2023 Aug 08
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  13. Sakemura RL, Hefazi M, Cox MJ, Siegler EL, Sinha S, Hansen MJ, Stewart CM, Feigin JM, Manriquez Roman C, Schick KJ, Can I, Tapper EE, Horvei P, Adada MM, Bezerra ED, Kankeu Fonkoua LA, Ruff MW, Forsman CL, Nevala WK, Boysen JC, Tschumper RC, Grand CL, Kuchimanchi KR, Mouritsen L, Foulks JM, Warner SL, Call TG, Parikh SA, Ding W, Kay NE, Kenderian SS. AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells. Cancer Immunol Res. 2023 Sep 01; 11(9):1222-1236.
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  14. Brastianos PK, Twohy E, Geyer S, Gerstner ER, Kaufmann TJ, Tabrizi S, Kabat B, Thierauf J, Ruff MW, Bota DA, Reardon DA, Cohen AL, De La Fuente MI, Lesser GJ, Campian J, Agarwalla PK, Kumthekar P, Mann B, Vora S, Knopp M, Iafrate AJ, Curry WT Jr, Cahill DP, Shih HA, Brown PD, Santagata S, Barker FG 2nd, Galanis E. BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. N Engl J Med. 2023 Jul 13; 389 (2):118-126
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  15. Neth BJ, Lachance DH, Uhm JH, Ruff MW. Management and Long-Term Outcomes of Patients With Recurrent Stroke-Like Episodes After Cranial Radiotherapy. Neurologist. 2023 Jul 1; 28 (4):218-225 Epub 2023 July 01
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  16. Webb MJ, Neth BJ, Webb LM, Van Gompel JJ, Link MJ, Neff BA, Carlson ML, Driscoll CL, Dornhoffer J, Ruff MW, Anderson KA, Kizilbash SH, Campian JL, Uhm JH, Lane JI, Benson JC, Blezek DJ, Mehta PM, Bathla G, Sener UT. Withdrawal of bevacizumab is associated with rebound growth of vestibular schwannomas in neurofibromatosis type 2-related schwannomatosis patients. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad123. Epub 2023 Sep 22.
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  17. Fortin Ensign SP, Gaulin C, Hrachova M, Ruff M, Harahsheh E, Vicenti K, Castro J, Munoz J, Rosenthal A, Mrugala MM. Evaluating the Patient with Neurotoxicity after Chimeric Antigen Receptor T-cell Therapy. Curr Treat Options Oncol. 2022 Dec; 23 (12):1845-1860 Epub 2022 Dec 16
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  18. Breen WG, Youland RS, Giri S, Jacobson SB, Pafundi DH, Brown PD, Hunt CH, Mahajan A, Ruff MW, Kizilbash SH, Uhm JH, Routman DM, Jones JE, Brinkmann DH, Laack NN. Initial results of a phase II trial of (18)F-DOPA PET-guided re-irradiation for recurrent high-grade glioma. J Neurooncol. 2022 Jul; 158 (3):323-330 Epub 2022 May 18
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  19. Sakemura R, Hefazi M, Siegler EL, Cox MJ, Larson DP, Hansen MJ, Manriquez Roman C, Schick KJ, Can I, Tapper EE, Horvei P, Adada MM, Bezerra ED, Kankeu Fonkoua LA, Ruff MW, Nevala WK, Walters DK, Parikh SA, Lin Y, Jelinek DF, Kay NE, Bergsagel PL, Kenderian SS. Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma. Blood. 2022 Jun 30; 139 (26):3708-3721
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  20. Sener U, Ruff MW, Campian JL. Immunotherapy in Glioblastoma: Current Approaches and Future Perspectives. Int J Mol Sci. 2022 Jun 24; 23 (13) Epub 2022 June 24
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  21. Cox MJ, Manriquez Roman C, Tapper EE, Siegler EL, Chappell D, Durrant C, Ahmed O, Sinha S, Mwangi R, Scott NS, Hefazi M, Schick KJ, Horvei P, Ruff MW, Can I, Adada M, Bezerra E, Kankeu Fonkoua LA, Parikh SA, Kay NE, Sakemura R, Kenderian SS. GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity. Leukemia. 2022 Jun; 36(6):1635-1645. Epub 2022 Apr 19.
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  22. Neth BJ, Carabenciov ID, Ruff MW, Johnson DR. Temporal Trends in Glioblastoma Survival: Progress then Plateau. Neurologist. 2022 May 1; 27 (3):119-124 Epub 2022 May 01
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  23. Neth BJ, Balakrishnan SN, Carabenciov ID, Uhm JH, Daniels DJ, Kizilbash SH, Ruff MW. Panobinostat in adults with H3 K27M-mutant diffuse midline glioma: a single-center experience. J Neurooncol. 2022 Mar; 157 (1):91-100 Epub 2022 Jan 25
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  24. Chompoopong P, Zekeridou A, Shelly S, Ruff M, Dyck PJ, Klein CJ, Pittock SJ, Mauermann M, Dubey D. Comparison of immune checkpoint inhibitor-related neuropathies among patients with neuroendocrine and non-neuroendocrine tumours. J Neurol Neurosurg Psychiatry 2022 Jan; 93 (1):112-114 Epub 2021 May 26
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  25. Kerezoudis P, Yolcu YU, Laack NN, Ruff MW, Khatua S, Daniels DJ, Burns TC, Kizilbash SH. Survival and associated predictors for patients with pineoblastoma or pineal parenchymal tumors of intermediate differentiation older than 3 years: Insights from the National Cancer Database. Neurooncol Adv. 2022 Jan-Dec; 4 (1):vdac057 Epub 2022 Apr 17
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  26. Sakemura R, Bansal A, Siegler EL, Hefazi M, Yang N, Khadka RH, Newsom AN, Hansen MJ, Cox MJ, Manriquez Roman C, Schick KJ, Can I, Tapper EE, Nevala WK, Adada MM, Bezerra ED, Kankeu Fonkoua LA, Horvei P, Ruff MW, Parikh SA, Pandey MK, DeGrado TR, Suksanpaisan L, Kay NE, Peng KW, Russell SJ, Kenderian SS. Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity. Cancer Immunol Res. 2021 Sep; 9(9):1035-1046. Epub 2021 Jul 08.
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  27. Eschbacher KL, Ida CM, Johnson DR, Alvi MA, Jenkins SM, Ruff MW, Kerezoudis P, Neth BJ, Pasion RM, Daniels DJ, Kizilbash SH, Raghunathan A. Diffuse Gliomas of the Brainstem and Cerebellum in Adults Show Molecular Heterogeneity. Am J Surg Pathol. 2021 Aug 1; 45 (8):1082-1090
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  28. Laack NN, Pafundi D, Anderson SK, Kaufmann T, Lowe V, Hunt C, Vogen D, Yan E, Sarkaria J, Brown P, Kizilbash S, Uhm J, Ruff M, Zakhary M, Zhang Y, Seaberg M, Wan Chan Tseung HS, Kabat B, Kemp B, Brinkmann D. Initial Results of a Phase 2 Trial of (18)F-DOPA PET-Guided Dose-Escalated Radiation Therapy for Glioblastoma. Int J Radiat Oncol Biol Phys. 2021 Aug 1; 110 (5):1383-1395 Epub 2021 Mar 23
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  29. DeFino CE, Barreto JN, Pawlenty AG, Ruff MW, Carabenciov ID, Mara KC, Thompson CA. Lack of drug interaction between levetiracetam and high-dose methotrexate in patients with lymphoma. Pharmacotherapy. 2021 May; 41 (5):430-439 Epub 2021 Mar 16
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  30. Cox MJ, Lucien F, Sakemura R, Boysen JC, Kim Y, Horvei P, Manriquez Roman C, Hansen MJ, Tapper EE, Siegler EL, Forsman C, Crotts SB, Schick KJ, Hefazi M, Ruff MW, Can I, Adada M, Bezerra E, Kankeu Fonkoua LA, Nevala WK, Braggio E, Ding W, Parikh SA, Kay NE, Kenderian SS. Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia. Mol Ther. 2021 Apr 7; 29 (4):1529-1540 Epub 2021 Jan 01
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  31. Cohen-Cohen S, Brown DA, Himes BT, Wheeler LP, Ruff MW, Major BT, Singh Ospina NM, Atkinson JLD, Meyer FB, Bancos I, Young WF, Van Gompel JJ. Pituitary adenomas in the setting of multiple endocrine neoplasia type 1: a single-institution experience. J Neurosurg. 2021 Mar 1; 134 (3):1132-1138 Epub 2020 Apr 03
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  32. Ruff MW, Siegler EL, Kenderian SS. A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy. Neurol Clin. 2020 Nov; 38(4):953-963. Epub 2020 Sep 12.
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  33. Neth BJ, Ruff MW, Uhm JH, Johnson DR, Divekar RD, Maddox DE. Temozolomide desensitization followed by metronomic dosing in patients with hypersensitivity. Cancer Chemother Pharmacol. 2020 Sep; 86 (3):375-382 Epub 2020 Aug 10
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  34. Mark IT, Carr CM, Ruff MW, Flanagan EP, Johnson DR. Enlarging Perivascular Spaces Following Radiation Therapy in the Brain: A Report of 2 Cases and Literature Review. World Neurosurg. 2020 Jun; 138:436-439 Epub 2020 Apr 03
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  35. Ruff M, Kizilbash S, Buckner J. Further understanding of glioma mechanisms of pathogenesis: implications for therapeutic development. Expert Rev Anticancer Ther. 2020 May; 20 (5):355-363 Epub 2020 May 12
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  36. Hawkes MA, Blaginykh E, Ruff MW, Burrus T, Wijdicks EFM, Rabinstein AA. Long-term mortality, disability and stroke recurrence in patients with basilar artery occlusion. Eur J Neurol. 2020 Mar; 27 (3):579-585 Epub 2019 Dec 08
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  37. Carabenciov ID, Bhargav AG, Uhm JH, Ruff MW. Bevacizumab Use in Refractory Adult Pilocytic Astrocytoma: A Single-Center Case Series. Neurologist. 2019 May; 24 (3):87-89
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  38. Himes BT, Ruff MW, Van Gompel JJ, Park SS, Galanis E, Kaufmann TJ, Uhm JH. Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib: case report. J Neurosurg. 2019 Apr 1; 130 (4):1299-1303 Epub 2018 Apr 27
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  39. Ruff MW, Uhm JH, Benarroch EE. Neuro-oncology: Implications of the molecular era. Neurology. 2019 Mar 19; 92 (12):568-574 Epub 2019 Feb 13
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  40. Ruff MW, Kizilbash SH. Glioblastoma with bilateral extraocular muscle infiltration preceded by evidence of vascular tropism. J Clin Neurosci. 2019 Mar; 61:277-278 Epub 2018 Nov 22
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  41. Johnson DR, Guerin JB, Ruff MW, Fang S, Hunt CH, Morris JM, Morris PP, Pearse Morris P, Kaufmann TJ. Glioma response assessment: Classic pitfalls, novel confounders, and emerging imaging tools. Br J Radiol. 2019 Feb; 92 (1094):20180730 Epub 2018 Nov 14
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  42. Ruff MW, Buckner JC, Johnson DR, van den Bent MJ, Geurts M. Neuro-Oncology Clinical Debate: PCV or temozolomide in combination with radiation for newly diagnosed high-grade oligodendroglioma. Neurooncol Pract. 2019 Jan; 6 (1):17-21 Epub 2018 Nov 03
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  43. Zalewski NL, Rabinstein AA, Brinjikji W, Kaufmann TJ, Nasr D, Ruff MW, Flanagan EP. Unique Gadolinium Enhancement Pattern in Spinal Dural Arteriovenous Fistulas. JAMA Neurol. 2018 Dec 1; 75 (12):1542-1545
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  44. Ruff MW, Uhm J. Anaplastic Glioma: Treatment Approaches in the Era of Molecular Diagnostics. Curr Treat Options Oncol. 2018 Oct 25; 19 (12):61
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  45. Ruff MW, Fine A, Mandrekar J, Sweeney C, Jones LK Jr, Klaas JP. Activity Aprons for Inpatients Requiring Individual Nursing Assignment Care: A Prospective Randomized Controlled Pilot Study. Neurohospitalist. 2018 Oct; 8 (4):183-187 Epub 2018 May 06
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  46. Ruff MW, Carabenciov ID, Johnson DR, Pollock BE, Parisi JE, Klaas JP. A cavernous sinus lesion clinically responsive to steroids. J Clin Neurosci. 2018 Jul; 53:239-240 Epub 2018 Apr 21
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  47. Ruff MW, Bhargav AG, Raghunathan A. A case of epidural glioblastoma metastasis presenting with a cervical myelopathy, torticollis, and L'hermitte's phenomenon. Brain Tumor Pathol. 2018 Jul; 35 (3):181-185 Epub 2018 May 09
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  48. Ruff MW, Mauermann ML. The Mayo Clinic Experience With the Neurological Complications of the CTLA-4 Inhibitor Ipilimumab. Neurologist. 2018 May; 23 (3):98-99
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  49. Ruff MW, Bhargav AG, English SW, Klaas JP. Hyperkinetic transient ischemic attacks preceding deep ganglionic infarction in a patient with a treated parasellar chondrosarcoma. J Clin Neurosci. 2018 Feb; 48:104-105 Epub 2017 Nov 04
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  50. Huntley GD, Ruff MW, Hicks SB, Yost MD, Fulgham JR. Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage. J Stroke Cerebrovasc Dis. 2017 Apr; 26(4):e72-e73. Epub 2017 Feb 22.
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  51. Ruff MW, Nasr DM, Klaas JP, Renaud DL. Internal Carotid Artery Pseudoaneurysm and Ischemic Stroke Secondary to Retropharyngeal and Parapharyngeal Abscess. J Child Neurol. 2017 Feb; 32 (2):230-236 Epub 2016 Nov 25
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  52. Ruff MW, Fugate JE. Teaching Video NeuroImages: Slow upward ocular bobbing. Neurology. 2016 Apr 19; 86 (16):e179
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  53. Hoffman EM, Ruff MW, Patterson MC. Acute Encephalopathy With Biphasic Seizures and Late Restricted Diffusion. Pediatr Neurol. 2016 Feb; 55:74-5.
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  54. Palazzo P, Ruff M, Lyerly MJ, Alexandrov AV. Basilar artery thrombus vs. fenestration: a differential diagnostic challenge in acute ischemic stroke. J Neuroimaging. 2014 Nov-Dec; 24 (6):607-609 Epub 2013 Nov 19
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  55. Delong RK, Risor A, Kanomata M, Laymon A, Jones B, Zimmerman SD, Williams J, Witkowski C, Warner M, Ruff M, Garrad R, Fallon JK, Hickey AJ, Sedaghat-Herati R. Characterization of biomolecular nanoconjugates by high-throughput delivery and spectroscopic difference. Nanomedicine (Lond). 2012 Dec; 7 (12):1851-62 Epub 2012 Sept 03
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