Proper Use

Drug information provided by: Merative, Micromedex®

This medicine is given as a shot under your skin in the stomach, thigh, or upper arm. It may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use this medicine.

It is very important that you understand the requirements of the Zilbrysq® REMS program, and become familiar with the Zilbrysq® medication guide and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions. Ask your pharmacist for the medication guide if you do not have one.

Make sure you have received a vaccine to prevent meningococcus infections at least 2 weeks before you receive this medicine. You may also be given antibiotic medicines to prevent infections if you are to receive this medicine right away. If you have already received the meningococcal vaccine in the past, your doctor will decide if you need another dose.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into skin areas that are red, bruised, swollen, or hard, or areas with scars or stretch marks.

To use the prefilled syringe:

  • Allow 30 to 45 minutes for the medicine to warm up to room temperature. Do not warm it by using a heat source (eg, hot water, microwave, or direct sunlight) or in any other way.
  • Wash your hands with soap and water before and after using this medicine.
  • Check the liquid in the syringe. It should be clear and colorless. Do not use the medicine if it is cloudy, discolored, or has particles in it. Do not use the prefilled syringe if it has been cracked, leaking, or broken.
  • Remove the needle cap. Hold the syringe with one hand and pull the needle cap straight off with your other hand.
  • Do not touch or recap the needle. Do not remove any air bubbles.
  • Pinch the skin around the injection site with one hand. Insert the needle into the skin at a 45 to 90 degree angle.
  • Do not pull back on the plunger head. Do not touch the needle guard activation clips.
  • Push the plunger head all the way down while holding onto the finger grip to inject all the medicine.
  • Slowly release the plunger head by lifting your thumb. After injection, the needle guard will cover the needle and you may hear a click.
  • Use a new needle and prefilled syringe each time you inject your medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (prefilled syringe):
    • For myasthenia gravis:
      • Adults—Dose is based on body weight and must be determined by your doctor.
        • Weighing 77 kilograms (kg) or more—32.4 milligrams (mg) injected under the skin once a day.
        • Weighing 56 to less than 77 kg—23 mg injected under the skin once a day.
        • Weighing less than 56 kg—16.6 mg injected under the skin once a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

Call your doctor or pharmacist for instructions.

If you miss a dose, inject it as soon as possible. Then inject the next dose at your next scheduled time. Do not inject more than 1 dose each day.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may store the prefilled syringe at room temperature for up to 3 months. Do not put it back in the refrigerator. Throw the medicine away if not used within 3 months or if the expiration date has passed, whichever comes first.

Portions of this document last updated: March 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.