Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more or less of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food.

Swallow the extended-release tablet whole with water. Do not cut, crush, break, or chew it.

To use the oral liquid:

  • Use this medicine with the provided press-in bottle adapter and oral dosing syringe.
  • Press down and twist the cap to remove it from the bottle. Do not throw away the cap. While holding the bottle firmly, use your thumb to push the adapter all the way down to the rim of the bottle. Do not remove the adapter after it is inserted.
  • Insert the tip of the syringe into the adapter. With the syringe attached to the bottle, turn the bottle upside down.
  • Slowly pull the plunger down. Check the syringe for large air bubbles. If you see air bubbles, flick the sides off the syringe to send large air bubbles to the tip. Move the plunger up and down to return air bubbles back into the bottle.
  • Move the plunger until it is even with the prescribed dose. Turn the bottle upright and remove the syringe. Hold the middle of the syringe and carefully remove it from the bottle.
  • Place the syringe against the inside of the child's cheek. Push the plunger to give the entire dose and give water.

Do not switch between extended-release tablet and oral liquid unless your doctor yells you to.

A part of the extended-release tablet may pass into your stools. This is normal and is nothing to worry about.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release tablets):
    • For atopic dermatitis:
      • Adults and children 12 years of age and older weighing at least 40 kilograms (kg)—At first, 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For Crohn's disease:
      • Adults—At first, 45 milligrams (mg) once a day for 12 weeks, then 15 mg once a day. Your doctor may adjust your dose as needed.
      • Children—Use and dose must be determined by your doctor.
    • For polyarticular juvenile idiopathic arthritis and psoriatic arthritis:
      • Adults and children 2 years of age and older weighing 30 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 15 milligrams (mg) once a day.
      • Children 2 years of age and older weighing less than 30 kg—Use of oral liquid is recommended.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For rheumatoid arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis:
      • Adults—15 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor.
    • For ulcerative colitis:
      • Adults—At first, 45 milligrams (mg) once a day for 8 weeks, then 15 mg once a day. Your doctor may adjust your dose as needed.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (solution):
    • For polyarticular juvenile idiopathic arthritis and psoriatic arthritis:
      • Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor.
        • Weighing 30 kilograms (kg) or more—6 milligrams (mg) or 6 milliliters (mL) 2 times a day.
        • Weighing 20 kg to less than 30 kg—4 mg or 4 mL 2 times a day.
        • Weighing 10 kg to less than 20 kg—3 mg or 3 mL 2 times a day.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away unused oral liquid 60 days after opening.

Portions of this document last updated: July 01, 2024

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