Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take this medicine on an empty stomach, at least 1 hour before or 2 hours after meals and at least 1 hour before or after any other medicine, food, or milk.

Trientine will not cure Wilson's disease, but it will help remove the excess copper from your body. Therefore, you must continue to take this medicine regularly, as directed. You may have to take trientine for the rest of your life. If Wilson's disease is not treated continually, it can cause severe liver damage and can cause death. Do not stop taking this medicine without first checking with your doctor.

It is very important for you to follow any special instructions from your doctor, such as following a low-copper diet. You may need to avoid foods known to be high in copper, such as chocolate, mushrooms, liver, molasses, broccoli, cereals enriched with copper, shellfish, organ meats, and nuts. If you have any questions about this, check with your doctor.

Swallow the tablet whole. Do not crush, chew, or dissolve it.

Take this medicine at least 2 hours before or 2 hours after taking iron supplements.

Take this medicine at least 1 hour before or 2 hours after taking calcium, magnesium, or zinc.

If you are unable to swallow the tablet, you may divide the it into half.

The starting dose of Curvior™ tablets will depend on the amount of penicillamine you are currently taking. You should stop taking penicillamine before starting treatment with Curvior™ tablets.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For Wilson's disease:
    • For oral dosage form (capsules):
      • Adults—The usual dose is 750 milligrams (mg) to 1.25 grams a day. The dose may be divided into two to four smaller doses.
      • Children—The usual dose is 500 to 750 mg a day. The dose may be divided into two to four smaller doses.
    • For oral dosage form (tablets):
      • Adults—At first, 300 to 3000 milligrams (mg), taken in divided doses (2 times a day). Your doctor may adjust your dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Remove the tablet from the blister pack only at the time of dosing. Do not store it for future use after opening the blister.

Portions of this document last updated: Feb. 01, 2024

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