Proper Use

Drug information provided by: Merative, Micromedex®

Treprostinil inhalation should be taken when you wake up and also before any physical activity, but not more than every 4 hours. Do not change your dose without talking to your doctor.

This medicine is for use in your lungs. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away with water.

Tyvaso® oral inhalation solution is breathed into your lungs with Tyvaso® Inhalation System. This system consists of the Tyvaso® Inhalation System device and its accessories. Carefully follow your doctor's instructions for using the medicine and operating and cleaning the equipment. Do not put other medicines into this equipment.

Do not drink this medicine. Do not allow the inhalation solution to come into contact with your skin or eyes. If it does, rinse it off with water right away.

To avoid missing a dose or any possible problems with the drug delivery device you are using, you should have a back-up with Tyvaso® Inhalation System device.

Tyvaso DPI™ inhalation powder should only be inhaled using the Tyvaso DPI™ Inhaler. This medicine comes with patient instructions. Read these instructions carefully before using this medicine. If you do not understand the directions or you are not sure how to use the inhaler, ask your doctor to show you what to do. Also, ask your doctor to check regularly how you use the inhaler to make sure you are using it properly.

To use the Tyvaso DPI™ Inhaler:

  • Remove the mouthpiece cover and look at the mouthpiece to make sure it is clean.
  • Hold the inhaler away from your mouth, breathe out fully. Keep your head level, put the mouthpiece fully into your mouth and close your lips around it. Tilt the inhaler slightly downward to prevent your tongue from blocking the powder.
  • Breathe in through your mouth quickly and deeply as you can until you have taken a full deep breath. Hold your breath for as long as you can. Then breathe out and continue to breathe normally.
  • Put the mouthpiece cover back after each inhalation and lift up the mouthpiece in an upright position to open the inhaler.
  • Do not rinse the inhaler. Always keep it dry.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For pulmonary arterial hypertension and pulmonary hypertension with interstitial lung disease:
    • For inhalation dosage form (powder):
      • Adults—At first, 16 micrograms (mcg) per treatment session at least 4 hours apart, 4 times a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 64 mcg per treatment session, 4 times a day.
      • Children—Use and dose must be determined by your doctor.
    • For inhalation dosage form (solution):
      • Adults—At first, 18 micrograms (mcg) or three breaths, per treatment session at least 4 hours apart, 4 times a day. Each treatment session will take 2 to 3 minutes. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 12 breaths per treatment session, 4 times a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Protect the medicine from direct light. Keep your medicine in the unopened foil pouch until you are ready to use it. Once the foil pack is opened, the ampules should be used within 7 days.

Store the unopened blister strips in the refrigerator. You may also store at room temperature for 5 weeks.

Store the opened blister strips in the refrigerator. You may remove the medicine from the refrigerator and store at room temperature for 3 days. Do not return it in the refrigerator.

Store theTyvaso DPI™ Inhaler at room temperature. You may also store it in the refrigerator but should allow the medicine at room temperature for 10 minutes before use. Throw away used inhaler after 7 days.

Portions of this document last updated: Aug. 01, 2024

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