Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of trandolapril and verapamil combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of trandolapril and verapamil combination in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
-
Aliskiren
-
Colchicine
-
Dofetilide
-
Eliglustat
-
Flibanserin
-
Lomitapide
-
Sacubitril
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Abametapir
-
Acalabrutinib
-
Acebutolol
-
Adenosine
-
Afatinib
-
Alfentanil
-
Alprazolam
-
Alteplase, Recombinant
-
Amiloride
-
Amiodarone
-
Apixaban
-
Aprepitant
-
Aspirin
-
Atazanavir
-
Atenolol
-
Atorvastatin
-
Avacopan
-
Avapritinib
-
Azathioprine
-
Azilsartan
-
Azilsartan Medoxomil
-
Bedaquiline
-
Benzhydrocodone
-
Betaxolol
-
Betrixaban
-
Bisoprolol
-
Bosutinib
-
Brexpiprazole
-
Brigatinib
-
Budesonide
-
Bupivacaine
-
Bupivacaine Liposome
-
Buprenorphine
-
Candesartan
-
Canrenoate
-
Capivasertib
-
Carbamazepine
-
Carteolol
-
Carvedilol
-
Celiprolol
-
Ceritinib
-
Cilostazol
-
Clarithromycin
-
Clonidine
-
Clopidogrel
-
Clozapine
-
Cobicistat
-
Cobimetinib
-
Codeine
-
Conivaptan
-
Crizotinib
-
Cyclobenzaprine
-
Cyclosporine
-
Dabigatran Etexilate
-
Dantrolene
-
Daridorexant
-
Darunavir
-
Deflazacort
-
Digoxin
-
Dihydrocodeine
-
Dihydroergotamine
-
Domperidone
-
Doxorubicin
-
Doxorubicin Hydrochloride Liposome
-
Dronedarone
-
Edoxaban
-
Elacestrant
-
Elexacaftor
-
Encorafenib
-
Entrectinib
-
Epirubicin
-
Eplerenone
-
Eprosartan
-
Erythromycin
-
Esmolol
-
Everolimus
-
Fedratinib
-
Fentanyl
-
Fexinidazole
-
Finerenone
-
Fingolimod
-
Fluconazole
-
Fosaprepitant
-
Fosnetupitant
-
Furosemide
-
Gepirone
-
Hydrocodone
-
Ibrutinib
-
Ifosfamide
-
Infigratinib
-
Irbesartan
-
Itraconazole
-
Ivabradine
-
Ivacaftor
-
Ivosidenib
-
Ketoconazole
-
Labetalol
-
Lacosamide
-
Larotrectinib
-
Lefamulin
-
Lemborexant
-
Levobunolol
-
Lithium
-
Lonafarnib
-
Losartan
-
Lovastatin
-
Lumateperone
-
Lurasidone
-
Lurbinectedin
-
Mavacamten
-
Mavorixafor
-
Melphalan
-
Meperidine
-
Mepivacaine
-
Mercaptopurine
-
Methadone
-
Metipranolol
-
Metoprolol
-
Mitapivat
-
Mobocertinib
-
Morphine
-
Morphine Sulfate Liposome
-
Nadolol
-
Naloxegol
-
Nebivolol
-
Neratinib
-
Netupitant
-
Nilotinib
-
Nirogacestat
-
Olaparib
-
Oliceridine
-
Olmesartan
-
Omaveloxolone
-
Oxprenolol
-
Oxycodone
-
Pacritinib
-
Palbociclib
-
Palovarotene
-
Pemigatinib
-
Penbutolol
-
Pentazocine
-
Pexidartinib
-
Phenobarbital
-
Pindolol
-
Piperaquine
-
Pixantrone
-
Ponesimod
-
Potassium
-
Potassium Citrate
-
Potassium Phosphate
-
Pralsetinib
-
Primidone
-
Propranolol
-
Ranolazine
-
Relugolix
-
Repotrectinib
-
Rimegepant
-
Rivaroxaban
-
Roflumilast
-
Selpercatinib
-
Selumetinib
-
Simeprevir
-
Simvastatin
-
Siponimod
-
Sirolimus
-
Sirolimus Protein-Bound
-
Sonidegib
-
Sotalol
-
Sparsentan
-
Spironolactone
-
Sufentanil
-
Suvorexant
-
Tacrolimus
-
Talazoparib
-
Tazemetostat
-
Telmisartan
-
Temsirolimus
-
Tenofovir Alafenamide
-
Tezacaftor
-
Timolol
-
Tizanidine
-
Tolvaptan
-
Topotecan
-
Tramadol
-
Triamterene
-
Trimethoprim
-
Ubrogepant
-
Valsartan
-
Venetoclax
-
Venlafaxine
-
Vincristine
-
Vincristine Sulfate Liposome
-
Voclosporin
-
Zanubrutinib
-
Zolpidem
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Aceclofenac
-
Acemetacin
-
Amlodipine
-
Amtolmetin Guacil
-
Bromfenac
-
Bufexamac
-
Bumetanide
-
Bupivacaine
-
Bupivacaine Liposome
-
Buspirone
-
Capsaicin
-
Celecoxib
-
Choline Salicylate
-
Clonixin
-
Dalfopristin
-
Dexibuprofen
-
Dexketoprofen
-
Diclofenac
-
Diflunisal
-
Digitoxin
-
Dipyrone
-
Droxicam
-
Dutasteride
-
Ethacrynic Acid
-
Etodolac
-
Etofenamate
-
Etoricoxib
-
Etozolin
-
Felbinac
-
Fenoprofen
-
Fepradinol
-
Feprazone
-
Flecainide
-
Floctafenine
-
Flufenamic Acid
-
Flurbiprofen
-
Fosphenytoin
-
Gold Sodium Thiomalate
-
Ibuprofen
-
Indinavir
-
Indomethacin
-
Ketoprofen
-
Ketorolac
-
Lithium
-
Lornoxicam
-
Loxoprofen
-
Lumiracoxib
-
Meclofenamate
-
Mefenamic Acid
-
Meloxicam
-
Metformin
-
Midazolam
-
Morniflumate
-
Nabumetone
-
Naproxen
-
Nepafenac
-
Nesiritide
-
Nevirapine
-
Niflumic Acid
-
Nimesulide
-
Nimesulide Beta Cyclodextrin
-
Oxaprozin
-
Oxcarbazepine
-
Oxyphenbutazone
-
Pancuronium
-
Parecoxib
-
Phenylbutazone
-
Phenytoin
-
Piketoprofen
-
Piretanide
-
Piroxicam
-
Pranoprofen
-
Proglumetacin
-
Propionic Acid
-
Propyphenazone
-
Proquazone
-
Quinidine
-
Quinupristin
-
Rifapentine
-
Rofecoxib
-
Salicylic Acid
-
Salsalate
-
Sodium Salicylate
-
St John's Wort
-
Sulindac
-
Tedisamil
-
Telithromycin
-
Tenoxicam
-
Tiaprofenic Acid
-
Tolfenamic Acid
-
Tolmetin
-
Torsemide
-
Tubocurarine
-
Valdecoxib
-
Vecuronium
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
-
Angioedema (swelling of the face, lips, tongue, throat, arms, or legs), history of—May increase the risk of this condition occurring again.
-
AV block, without a pacemaker or
-
Cardiogenic shock (shock caused by a heart attack) or
-
Diabetic patients who are also taking aliskiren (Tekturna®) or
-
Heart disease (eg, left ventricular dysfunction), severe or
-
Heart rhythm problems (eg, atrial flutter, atrial fibrillation, Wolff-Parkinson-White, Lown-Ganong-Levine syndromes) or
-
Hypotension (low blood pressure) or
-
Sick sinus syndrome (abnormal heart rhythm), without a pacemaker—Should not be used in patients with these conditions.
-
Collagen vascular disease (an autoimmune disease) together with kidney disease—Increased risk of blood problems.
-
Congestive heart failure—Use may lead to kidney problems.
-
Diabetes or
-
Kidney problems—Increased risk of potassium levels in the body becoming too high.
-
Duchenne's muscular dystrophy (muscle problem) or
-
Electrolyte imbalance (eg, low levels of potassium, salt or sodium in the body) or
-
Fluid imbalance (caused by dehydration, vomiting, diarrhea) or
-
Heart disease (eg, hypertrophic cardiomyopathy) or
-
Heart rhythm problems (eg, prolonged PR interval) or
-
Kidney disease or
-
Liver disease—Use with caution. May make these conditions worse.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.