Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of tolbutamide in the pediatric population. Safety and efficacy have not been established.
Geriatric
No information is available on the relationship of age to the effects of tolbutamide in geriatric patients. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require an adjustment of dosage in patients receiving tolbutamide.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Abiraterone Acetate
-
Acarbose
-
Adagrasib
-
Alogliptin
-
Alpelisib
-
Asciminib
-
Aspirin
-
Bexagliflozin
-
Capecitabine
-
Carbamazepine
-
Ceritinib
-
Chloroquine
-
Chlorothiazide
-
Chlorthalidone
-
Ciprofloxacin
-
Dabrafenib
-
Delafloxacin
-
Desmopressin
-
Disopyramide
-
Dulaglutide
-
Enoxacin
-
Entacapone
-
Fluconazole
-
Furosemide
-
Gatifloxacin
-
Gemifloxacin
-
Grepafloxacin
-
Hydrochlorothiazide
-
Hydroflumethiazide
-
Hydroxychloroquine
-
Indapamide
-
Insulin
-
Insulin Aspart, Recombinant
-
Insulin Bovine
-
Insulin Degludec
-
Insulin Detemir
-
Insulin Glargine, Recombinant
-
Insulin Glulisine
-
Insulin Lispro, Recombinant
-
Lanreotide Acetate
-
Levofloxacin
-
Liraglutide
-
Lixisenatide
-
Lomefloxacin
-
Mavacamten
-
Metformin
-
Methotrexate
-
Metolazone
-
Mitapivat
-
Moxifloxacin
-
Nitisinone
-
Norfloxacin
-
Octreotide Acetate
-
Ofloxacin
-
Pasireotide Diaspartate
-
Phenobarbital
-
Pioglitazone
-
Polythiazide
-
Porfimer
-
Pramlintide
-
Primidone
-
Semaglutide
-
Sitagliptin
-
Somatrogon-ghla
-
Sotagliflozin
-
Sparfloxacin
-
Sparsentan
-
Thioctic Acid
-
Tocilizumab
-
Triamterene
-
Trovafloxacin
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
-
Acebutolol
-
Aminolevulinic Acid
-
Atenolol
-
Betaxolol
-
Bisoprolol
-
Bitter Melon
-
Carteolol
-
Carvedilol
-
Celiprolol
-
Chloramphenicol
-
Dicumarol
-
Esmolol
-
Fenugreek
-
Fosphenytoin
-
Ginkgo Biloba
-
Glecaprevir
-
Glucomannan
-
Guar Gum
-
Isocarboxazid
-
Ketoconazole
-
Labetalol
-
Levobunolol
-
Linezolid
-
Methylene Blue
-
Metipranolol
-
Metoprolol
-
Nadolol
-
Nebivolol
-
Oxprenolol
-
Ozanimod
-
Penbutolol
-
Phenelzine
-
Phenytoin
-
Pibrentasvir
-
Pindolol
-
Practolol
-
Procarbazine
-
Propranolol
-
Psyllium
-
Rasagiline
-
Rifapentine
-
Safinamide
-
Saxagliptin
-
Selegiline
-
Sotalol
-
Sulfaphenazole
-
Timolol
-
Tirzepatide
-
Tranylcypromine
-
Trimethoprim
-
Voriconazole
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
-
Alcohol intoxication or
-
Underactive adrenal glands or
-
Underactive pituitary glands or
-
Undernourished condition or
-
Weakened physical condition or
-
Any other condition that causes low blood sugar—Patients with these conditions may be more likely to develop low blood sugar while taking tolbutamide.
-
Diabetic ketoacidosis (ketones in the blood) or
-
Type I diabetes—Should not be used in patients with these conditions.
-
Fever or
-
Infection or
-
Surgery or
-
Trauma—These conditions may cause temporary problems with blood sugar control and your doctor may want to treat you temporarily with insulin.
-
Heart disease—Use with caution. May make this condition worse.
-
Kidney disorder or
-
Liver disorder—Higher blood levels of this medicine may occur, which may cause serious problems.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.