Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of saxagliptin and metformin combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of saxagliptin and metformin combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution for patients receiving this medicine. This medicine is not recommended in patients 80 years of age and older who have kidney problems.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abametapir
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Abiraterone Acetate
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Acarbose
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Acetazolamide
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Alogliptin
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Aspirin
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Avacopan
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Bexagliflozin
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Bictegravir
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Brinzolamide
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Bupropion
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Capmatinib
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Carbamazepine
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Ceritinib
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Chloroquine
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Chlorothiazide
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Chlorpropamide
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Chlorthalidone
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Cimetidine
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Ciprofloxacin
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Dasabuvir
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Delafloxacin
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Diatrizoate
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Dichlorphenamide
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Dofetilide
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Dolutegravir
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Dorzolamide
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Enoxacin
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Ethiodized Oil
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Fedratinib
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Fexinidazole
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Fosnetupitant
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Furosemide
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Gatifloxacin
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Gemifloxacin
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Glimepiride
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Glipizide
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Glyburide
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Grepafloxacin
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Hydrochlorothiazide
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Hydroflumethiazide
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Hydroxychloroquine
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Indapamide
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Insulin
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Insulin Aspart, Recombinant
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Insulin Bovine
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Insulin Degludec
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Insulin Detemir
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Insulin Glargine, Recombinant
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Insulin Glulisine
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Insulin Lispro, Recombinant
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Iodipamide
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Iodixanol
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Iohexol
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Iopamidol
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Iopanoic Acid
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Iopromide
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Iothalamate
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Iotrolan
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Ioversol
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Ioxaglate
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Ipodate
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Isavuconazole
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Lanreotide Acetate
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Levofloxacin
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Levoketoconazole
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Liraglutide
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Lomefloxacin
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Mavacamten
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Mavorixafor
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Methazolamide
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Metolazone
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Metrizamide
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Moxifloxacin
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Nateglinide
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Netupitant
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Norfloxacin
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Octreotide Acetate
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Ofloxacin
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Omaveloxolone
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Ombitasvir
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Paritaprevir
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Pasireotide Diaspartate
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Phenobarbital
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Pioglitazone
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Polythiazide
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Pramlintide
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Primidone
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Ranolazine
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Repaglinide
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Semaglutide
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Simeprevir
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Sitagliptin
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Somatrogon-ghla
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Sotagliflozin
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Sparfloxacin
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Tafenoquine
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Thioctic Acid
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Tolazamide
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Tolbutamide
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Topiramate
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Triamterene
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Trimethoprim
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Trovafloxacin
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Vandetanib
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Zonisamide
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Acebutolol
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Acetohexamide
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Atenolol
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Betaxolol
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Bisoprolol
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Bitter Melon
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Carteolol
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Carvedilol
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Celiprolol
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Chlorpropamide
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Colesevelam
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Esmolol
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Fenugreek
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Glecaprevir
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Gliclazide
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Glimepiride
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Glipizide
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Gliquidone
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Glucomannan
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Glyburide
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Goldenseal
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Guar Gum
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Hydrastis
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Insulin
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Insulin Aspart, Recombinant
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Insulin Bovine
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Insulin Degludec
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Insulin Detemir
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Insulin Glulisine
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Insulin Lispro, Recombinant
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Isocarboxazid
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Labetalol
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Levobunolol
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Linezolid
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Methylene Blue
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Metipranolol
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Metoprolol
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Nadolol
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Nebivolol
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Oxprenolol
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Ozanimod
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Patiromer
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Penbutolol
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Phenelzine
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Pibrentasvir
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Pindolol
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Practolol
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Procarbazine
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Propranolol
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Psyllium
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Rasagiline
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Rifampin
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Safinamide
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Selegiline
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Sotalol
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Timolol
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Tirzepatide
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Tolazamide
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Tolbutamide
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Tranylcypromine
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Verapamil
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Alcohol, excessive use or
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Congestive heart failure or
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Dehydration or
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Gallstones, history of or
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Hypertriglyceridemia (high triglycerides or fats in the blood) or
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Kidney disease or
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Liver disease or
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Pancreas problems, history of or
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Sepsis (severe infection) or
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Weakened physical condition—Use with caution. May cause side effects to become worse.
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Anemia or
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Vitamin B12 deficiency—Use with caution. May make these conditions worse.
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Angioedema (swelling of the face, lips, tongue, throat, arms, or legs), history with other dipeptidyl peptidase-4 (DPP-4) inhibitors—Use with caution. May increase the risk of this condition occurring again.
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Heart failure, history of or
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Kidney disease—May increase risk for heart failure.
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Kidney disease, severe or
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Metabolic acidosis (including diabetic ketoacidosis)—Should not be used in patients with these conditions.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.