Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride, and potassium chloride combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride, and potassium chloride combination in the elderly. However, elderly patients are more likely to have unwanted effects and age-related liver, kidney, or heart problems, which may require caution for patients receiving this medicine.

Breastfeeding

Ascorbic Acid

Potassium

Ascorbic Acid

Polyethylene Glycol

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Sodium Chloride

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Eplerenone
  • Fesoterodine
  • Glycopyrrolate
  • Trospium

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alacepril
  • Amiloride
  • Amygdalin
  • Benazepril
  • Bisacodyl
  • Canrenoate
  • Captopril
  • Cilazapril
  • Deferoxamine
  • Delapril
  • Fosinopril
  • Imidapril
  • Indomethacin
  • Licorice
  • Lisinopril
  • Moexipril
  • Pentopril
  • Perindopril
  • Quinapril
  • Ramipril
  • Senna
  • Sodium Picosulfate
  • Sparsentan
  • Spirapril
  • Spironolactone
  • Temocapril
  • Trandolapril
  • Triamterene
  • Zofenopril

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Indinavir
  • Licorice

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (chest pain), unstable or
  • Heart attack, recent or
  • Heart disease (eg, cardiomyopathy) or
  • Heart rhythm problems (eg, prolonged QT interval, uncontrolled arrhythmia), history of or
  • Hypocalcemia (low calcium in the blood) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hyponatremia (low sodium level in the blood) or
  • Withdrawal from alcohol or benzodiazepines (eg, alprazolam, clonazepam, diazepam, lorazepam, Xanax®)—May increase risk for seizures, arrhythmia, or kidney problems.
  • Congestive heart failure or
  • Dehydration or
  • Inflammatory bowel disease or
  • Kidney disease or
  • Seizures, history of or
  • Trouble swallowing or
  • Ulcerative colitis, active and severe—Use with caution. May make these conditions worse.
  • Fluid and electrolyte imbalance—Must be corrected first before starting treatment with this medicine.
  • Gastric retention (problems with emptying of food or fluid from the stomach) or
  • Stomach or bowel problems (eg, blockage, ileus, perforation) or
  • Toxic megacolon (a very dilated intestine)—Should not be used in patients with these conditions.
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency with an infection, or a history of hemolysis—Use with caution. This medicine contains sodium ascorbate and ascorbic acid which may cause serious unwanted effects in patients with this condition.
  • Phenylketonuria—Use with caution. This medicine contains phenylalanine which may cause serious unwanted effects in patients with this condition.

Portions of this document last updated: March 01, 2024

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