Proper Use
Drug information provided by: Merative, Micromedex®
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.
Take this medicine with food at about the same time each day.
Swallow the capsule whole. If you are not able to swallow the capsule whole, you may open it and mix it with 1 teaspoon (5 milliliters) of soft food (eg, apple sauce, low fat yogurt, or warm oatmeal) and take it within 1 hour of opening.
Do not eat grapefruit or pomelo, or drink grapefruit or pomelo juice while you are using this medicine.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
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For oral dosage form (capsules):
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For new heterotopic ossification (daily dose):
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Adults and children 14 years of age and older—5 milligrams (mg) once a day. Stop daily dosing when flare-up dosing begins.
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Female children 8 to 13 years of age and male children 10 to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 2.5 to 5 mg once a day. Stop daily dosing when flare-up dosing begins.
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Weighing 60 kilograms (kg) or more—5 mg once a day.
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Weighing 40 kg to 59.9 kg—4 mg once a day.
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Weighing 20 kg to 39.9 kg—3 mg once a day.
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Weighing 10 kg to 19.9 kg—2.5 mg once a day.
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Female children younger than 8 years of age and male children younger than 10 years of age—Use is not recommended.
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For new heterotopic ossification (flare-up dose):
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Adults and children 14 years of age and older—20 milligrams (mg) once a day on Weeks 1 to 4, followed by 10 mg once a day on Weeks 5 to 12. Your doctor may adjust your dose as needed and tolerated.
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Female children 8 to 13 years of age and male children 10 to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 to 20 mg once a day. Your doctor may adjust your dose as needed and tolerated.
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Weighing 60 kilograms (kg) or more—20 mg once a day on Weeks 1 to 4, followed by 10 mg once a day on Weeks 5 to 12.
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Weighing 40 kg to 59.9 kg—15 mg once a day on Weeks 1 to 4, followed by 7.5 mg once a day on Weeks 5 to 12.
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Weighing 20 kg to 39.9 kg—12.5 mg once a day on Weeks 1 to 4, followed by 6 mg once a day on Weeks 5 to 12.
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Weighing 10 kg to 19.9 kg—10 mg on once a day Weeks 1 to 4, followed by 5 mg once a day on Weeks 5 to 12.
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Female children younger than 8 years of age and male children younger than 10 years of age—Use is not recommended.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you miss a dose and it is more than 6 hours, skip the missed dose and go back to your regular schedule.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Portions of this document last updated: May 01, 2024
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