Heparin (intravenous route, subcutaneous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of heparin injection in children. However, because heparin contains benzyl alcohol, use in newborn babies is not recommended.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of heparin injection in the elderly. However, elderly patients are more likely to develop bleeding problems, which may require an adjustment in the dose for patients receiving heparin injection.

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Defibrotide
• Oritavancin
• Telavancin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab
• Aceclofenac
• Acemetacin
• Alipogene Tiparvovec
• Alprostadil
• Alteplase, Recombinant
• Amtolmetin Guacil
• Anagrelide
• Anistreplase
• Antithrombin, Recombinant
• Apixaban
• Argatroban
• Aspirin
• Bemiparin
• Betrixaban
• Bivalirudin
• Bromfenac
• Bufexamac
• Cangrelor
• Caplacizumab-yhdp
• Cefamandole
• Cefoperazone
• Celecoxib
• Chamomile
• Choline Salicylate
• Cilostazol
• Citalopram
• Clonixin
• Clopidogrel
• Collagenase, Clostridium histolyticum
• Curcumin
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Desvenlafaxine
• Dexibuprofen
• Dexketoprofen
• Dextran
• Diclofenac
• Diflunisal

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Chondroitin
• Coenzyme Q10
• Dong Quai
• Ginger
• Palifermin
• Vitamin A

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Avocado

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bacterial endocarditis (heart infection) or
• Bleeding problems (eg, hemophilia) or
• Hypertension (high blood pressure), severe or
• Liver disease or
• Major surgery (eg, eye, brain, or spine) or
• Menstrual bleeding (periods), heavy or unusual or
• Spinal anesthesia (numbing medicine placed in the back) or
• Stomach or intestinal ulcer—Use with caution. The risk of bleeding may be increased.

• Bleeding, active or
• Thrombocytopenia (low platelets in the blood) caused by heparin, history of or
• Thrombocytopenia (low platelets in the blood), severe—Should not be used in patients with these conditions.

Less common

• Abdominal or stomach pain or swelling
• back pain or backaches
• bleeding from the gums when brushing teeth
• blood in the urine
• constipation
• coughing up blood
• dizziness
• headaches, severe or continuing
• heavy bleeding or oozing from cuts or wounds
• joint pain, stiffness, or swelling
• menstrual bleeding, unexpected or unusually heavy
• unexplained bruising or purplish areas on the skin
• unexplained nosebleeds
• vomiting of blood or material that looks like coffee grounds

Rare

• Blood under the skin (blood blister) at the place of injection
• chest pain
• chills or fever
• fast or irregular breathing
• irritation, pain, redness, or ulcers at the place of injection
• itching and burning feeling, especially on the bottom of the feet
• nausea or vomiting
• numbness or tingling in the hands or feet
• pain, coldness, or blue color of the skin on the arms or legs
• peeling of the skin
• puffiness or swelling of the eyelids or around the eyes
• shortness of breath
• skin color change, especially near the place of injection or in the fingers, toes, arms, or legs
• skin rash, hives, or itching
• tearing of the eyes
• tightness in the chest
• trouble with breathing
• wheezing