Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide combination in children weighing at least 40 kilograms (kg). Safety and efficacy have not been established in children weighing less than 40 kg.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide combination in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require caution in patients using this medicine.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Alfuzosin
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Alprazolam
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Astemizole
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Bromocriptine
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Carbamazepine
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Cisapride
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Colchicine
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Conivaptan
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Crizotinib
-
Dihydroergotamine
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Domperidone
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Doxorubicin
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Doxorubicin Hydrochloride Liposome
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Dronedarone
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Drospirenone
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Elbasvir
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Eletriptan
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Eliglustat
-
Eplerenone
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Ergoloid Mesylates
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Ergonovine
-
Ergotamine
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Finerenone
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Fosphenytoin
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Gepirone
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Grazoprevir
-
Isavuconazonium Sulfate
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Ivabradine
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Levoketoconazole
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Lisuride
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Lomitapide
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Lonafarnib
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Lovastatin
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Lurasidone
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Maraviroc
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Mavacamten
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Metergoline
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Methylergonovine
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Methysergide
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Midazolam
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Naloxegol
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Nicergoline
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Pacritinib
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Pazopanib
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Phenobarbital
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Phenytoin
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Pimozide
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Primidone
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Ranolazine
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Rifampin
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Riociguat
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Romidepsin
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Sildenafil
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Silodosin
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Simvastatin
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St John's Wort
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Terfenadine
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Tolvaptan
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Triazolam
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Ubrogepant
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Venetoclax
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Voclosporin
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abametapir
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Abrocitinib
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Acalabrutinib
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Acebutolol
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Acecainide
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Aceclofenac
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Acemetacin
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Acyclovir
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Adagrasib
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Adenosine
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Ado-Trastuzumab Emtansine
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Afatinib
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Ajmaline
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Alfentanil
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Alogliptin
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Alpelisib
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Alprazolam
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Amikacin
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Amikacin Liposome
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Amineptine
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Amiodarone
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Amitriptyline
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Amitriptylinoxide
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Amlodipine
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Amobarbital
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Amoxapine
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Amphetamine
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Amprenavir
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Amtolmetin Guacil
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Apalutamide
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Apixaban
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Aprepitant
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Aprindine
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Aprobarbital
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Aranidipine
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Aripiprazole
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Artemether
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Asciminib
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Aspirin
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Asunaprevir
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Atazanavir
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Atenolol
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Atidarsagene Autotemcel
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Atogepant
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Atorvastatin
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Avacopan
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Avanafil
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Avapritinib
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Azithromycin
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Bedaquiline
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Benzhydrocodone
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Benzphetamine
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Berotralstat
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Betamethasone
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Betaxolol
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Betrixaban
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Bictegravir
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Bisoprolol
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Boceprevir
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Bosentan
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Bosutinib
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Bretylium
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Brigatinib
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Bromfenac
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Budesonide
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Bufexamac
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Buprenorphine
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Buspirone
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Butabarbital
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Butalbital
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Cabazitaxel
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Cabotegravir
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Cabozantinib
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Calcifediol
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Canagliflozin
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Capivasertib
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Capmatinib
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Capreomycin
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Captopril
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Cariprazine
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Carteolol
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Carvedilol
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Celecoxib
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Celiprolol
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Ceritinib
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Choline Salicylate
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Ciclesonide
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Cidofovir
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Cilnidipine
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Cilostazol
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Cimetidine
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Citalopram
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Clarithromycin
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Clevidipine
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Clomipramine
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Clonazepam
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Clonixin
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Clopidogrel
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Clozapine
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Cobicistat
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Cobimetinib
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Codeine
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Conivaptan
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Copanlisib
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Crizotinib
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Cyclophosphamide
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Cyclosporine
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Dabigatran Etexilate
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Dabrafenib
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Daclatasvir
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Danicopan
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Daridorexant
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Darolutamide
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Dasabuvir
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Dasatinib
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Deflazacort
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Delamanid
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Delavirdine
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Desipramine
-
Desogestrel
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Dexamethasone
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Dexibuprofen
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Dexketoprofen
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Dextroamphetamine
-
Diazepam
-
Dibenzepin
-
Diclofenac
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Didanosine
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Dienogest
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Diflunisal
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Digoxin
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Dihydrocodeine
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Diltiazem
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Dipyrone
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Disopyramide
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Docetaxel
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Dofetilide
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Domperidone
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Donepezil
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Doxepin
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Doxorubicin
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Doxorubicin Hydrochloride Liposome
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Dronedarone
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Drospirenone
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Droxicam
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Duvelisib
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Edoxaban
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Efavirenz
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Elacestrant
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Elagolix
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Elbasvir
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Elexacaftor
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Eliglustat
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Eltrombopag
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Elvitegravir
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Enasidenib
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Encainide
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Encorafenib
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Entrectinib
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Enzalutamide
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Erdafitinib
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Erlotinib
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Erythromycin
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Escitalopram
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Eslicarbazepine Acetate
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Esmolol
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Estazolam
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Estetrol
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Estradiol
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Eszopiclone
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Ethinyl Estradiol
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Ethynodiol
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Etodolac
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Etofenamate
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Etonogestrel
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Etoricoxib
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Etravirine
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Everolimus
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Febuxostat
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Fedratinib
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Felbinac
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Felodipine
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Fenoprofen
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Fentanyl
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Fepradinol
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Feprazone
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Fesoterodine
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Fexinidazole
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Finerenone
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Flecainide
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Flibanserin
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Floctafenine
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Fluconazole
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Flufenamic Acid
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Fluoxetine
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Flurbiprofen
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Fluticasone
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Fluvastatin
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Fluvoxamine
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Fosamprenavir
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Fosaprepitant
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Fosnetupitant
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Fostamatinib
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Fostemsavir
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Futibatinib
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Ganciclovir
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Gentamicin
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Gepirone
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Gestodene
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Gilteritinib
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Glasdegib
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Glecaprevir
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Grazoprevir
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Haloperidol
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Horsetail
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Hydrocodone
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Hydrocortisone
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Hydroquinidine
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Hydroxyamphetamine
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Ibrexafungerp
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Ibrutinib
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Ibuprofen
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Ibutilide
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Idelalisib
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Ifosfamide
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Iloperidone
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Imipramine
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Indecainide
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Indinavir
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Indomethacin
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Infigratinib
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Irinotecan
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Irinotecan Liposome
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Isavuconazole
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Isradipine
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Istradefylline
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Itraconazole
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Ivacaftor
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Ivosidenib
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Ixabepilone
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Kanamycin
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Ketoconazole
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Ketoprofen
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Ketorolac
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Labetalol
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Lapatinib
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Larotrectinib
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Lefamulin
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Leflunomide
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Lemborexant
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Lenacapavir
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Leniolisib
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Lercanidipine
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Levobunolol
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Levoketoconazole
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Levomilnacipran
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Levonorgestrel
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Lidocaine
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Lisdexamfetamine
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Lofepramine
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Lonafarnib
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Lopinavir
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Lorlatinib
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Lornoxicam
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Lovotibeglogene Autotemcel
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Loxoprofen
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Lumacaftor
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Lumateperone
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Lumefantrine
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Lumiracoxib
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Lurbinectedin
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Macitentan
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Manidipine
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Maribavir
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Mavacamten
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Mavorixafor
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Meclofenamate
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Medroxyprogesterone
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Mefenamic Acid
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Melitracen
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Meloxicam
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Meperidine
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Mephobarbital
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Mestranol
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Methadone
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Methamphetamine
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Methohexital
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Methotrexate
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Methylprednisolone
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Metipranolol
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Metoprolol
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Mexiletine
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Mibefradil
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Midostaurin
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Mifepristone
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Mirabegron
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Mirtazapine
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Mirvetuximab Soravtansine-gynx
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Mitapivat
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Mobocertinib
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Modafinil
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Momelotinib
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Mometasone
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Moricizine
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Morniflumate
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Morphine
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Morphine Sulfate Liposome
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Nabumetone
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Nadolol
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Nafcillin
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Naproxen
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Nebivolol
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Nefazodone
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Nelfinavir
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Neomycin
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Nepafenac
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Neratinib
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Netilmicin
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Netupitant
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Nevirapine
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Nicardipine
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Nifedipine
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Niflumic Acid
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Nilotinib
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Nimesulide
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Nimesulide Beta Cyclodextrin
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Nimodipine
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Nirogacestat
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Nisoldipine
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Nitrendipine
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Nomegestrol
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Norelgestromin
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Norethindrone
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Norgestimate
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Norgestrel
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Nortriptyline
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Olanzapine
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Olaparib
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Oliceridine
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Olutasidenib
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Omaveloxolone
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Ombitasvir
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Omeprazole
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Ondansetron
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Opipramol
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Orlistat
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Osilodrostat
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Osimertinib
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Oxaprozin
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Oxcarbazepine
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Oxprenolol
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Oxycodone
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Oxyphenbutazone
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Ozanimod
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Pacritinib
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Palbociclib
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Palovarotene
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Panobinostat
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Pantoprazole
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Parecoxib
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Paritaprevir
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Paromomycin
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Paroxetine
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Pemigatinib
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Penbutolol
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Pentazocine
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Pentobarbital
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Perphenazine
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Pexidartinib
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Phenylbutazone
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Pibrentasvir
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Piketoprofen
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Pimavanserin
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Pindolol
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Piperaquine
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Piroxicam
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Pirtobrutinib
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Pitavastatin
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Pixantrone
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Plazomicin
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Ponatinib
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Prajmaline
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Pralsetinib
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Pranoprofen
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Pravastatin
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Prednisone
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Procainamide
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Proglumetacin
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Propafenone
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Propranolol
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Propyphenazone
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Proquazone
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Protriptyline
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Quetiapine
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Quinidine
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Quinine
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Quizartinib
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Ranolazine
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Reboxetine
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Regorafenib
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Relugolix
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Repotrectinib
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Retapamulin
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Ribociclib
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Rifabutin
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Rifapentine
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Rimegepant
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Risperidone
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Ritlecitinib
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Ritonavir
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Rivaroxaban
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Rofecoxib
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Roflumilast
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Rolapitant
-
Rosuvastatin
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Rucaparib
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Ruxolitinib
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Salicylic Acid
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Salmeterol
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Salsalate
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Saquinavir
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Sarecycline
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Secobarbital
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Segesterone
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Selpercatinib
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Selumetinib
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Sertraline
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Simeprevir
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Sirolimus
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Sirolimus Protein-Bound
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Sodium Salicylate
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Sofosbuvir
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Sonidegib
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Sotagliflozin
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Sotalol
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Sotorasib
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Sparsentan
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Sparteine
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Spectinomycin
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Spironolactone
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Streptomycin
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Sufentanil
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Sulindac
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Sunitinib
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Suvorexant
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Tacrolimus
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Tadalafil
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Tafamidis
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Talazoparib
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Tamoxifen
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Tamsulosin
-
Tazemetostat
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Tedisamil
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Telaprevir
-
Telithromycin
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Telmisartan
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Temsirolimus
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Tenofovir Alafenamide
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Tenoxicam
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Tepotinib
-
Teriflunomide
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Tezacaftor
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Thiopental
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Thioridazine
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Thiotepa
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Tianeptine
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Tiaprofenic Acid
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Ticagrelor
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Timolol
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Tipranavir
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Tobramycin
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Tocainide
-
Tolfenamic Acid
-
Tolmetin
-
Tolvaptan
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Topotecan
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Toremifene
-
Trabectedin
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Tramadol
-
Trazodone
-
Triamcinolone
-
Trimipramine
-
Trofinetide
-
Tucatinib
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Ulipristal
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Upadacitinib
-
Vadadustat
-
Valacyclovir
-
Valbenazine
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Valdecoxib
-
Valganciclovir
-
Vamorolone
-
Vandetanib
-
Vardenafil
-
Velpatasvir
-
Vemurafenib
-
Venetoclax
-
Venlafaxine
-
Verapamil
-
Vernakalant
-
Vibegron
-
Vilanterol
-
Vilazodone
-
Vinblastine
-
Vincristine
-
Vincristine Sulfate Liposome
-
Vinflunine
-
Voclosporin
-
Vorapaxar
-
Voriconazole
-
Vortioxetine
-
Voxilaprevir
-
Warfarin
-
Zaleplon
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Zanubrutinib
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Ziprasidone
-
Zolpidem
-
Zuranolone
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Amlodipine
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Aripiprazole Lauroxil
-
Atazanavir
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Cobicistat
-
Darunavir
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Indinavir
-
Nelfinavir
-
Tenofovir Disoproxil Fumarate
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Diabetes or
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Fanconi syndrome (kidney disease), history of or
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Hepatitis B infection, history of or
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Hemophilia (bleeding problem) or
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Kidney failure, history of or
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Sulfa allergy—Use with caution. May make these conditions worse.
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Kidney disease, severe or
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Liver disease, severe—Use is not recommended in patients with these conditions.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.