To get the most benefit from corticosteroid medicines with the least amount of risk:

Ask your health care provider about trying lower doses or intermittent dosing. Newer forms of corticosteroids come in various strengths and lengths of action. Ask your provider about using low-dose, short-term medications or taking oral corticosteroids every other day instead of daily.
Talk to your provider about switching to nonoral forms of corticosteroids. Inhaled corticosteroids for asthma, for example, reach lung surfaces directly. This reduces the rest of your body's exposure to them and may lead to fewer side effects.
Ask your provider if you should take calcium and vitamin D supplements. Long-term corticosteroid therapy may cause thinning bones, called osteoporosis. Talk with your provider about taking calcium and vitamin D supplements to help protect your bones.
Take care when discontinuing therapy. If you take oral corticosteroids for a long time, your adrenal glands may produce less of their natural steroid hormones. To give your adrenal glands time to recover this function, your provider may reduce your dose gradually. If the dosage is reduced too quickly, your adrenal glands may not have time to recover and you may experience fatigue, body aches and lightheadedness.
Wear a medical alert bracelet. This or similar identification is recommended if you've been using corticosteroids for a long time.
See your health care provider regularly. If you're taking long-term corticosteroid therapy, see your provider regularly to check for side effects.