Eye melanoma

Diagnosis

To diagnose eye melanoma, your doctor may recommend:

• Eye exam. Your doctor will examine the outside of your eye, looking for enlarged blood vessels that can indicate a tumor inside your eye. Then, with the help of instruments, your doctor will look inside your eye.

  One method, called binocular indirect ophthalmoscopy, uses lenses and a bright light mounted on your doctor's forehead — a bit like a miner's lamp. Another method, called slit-lamp biomicroscopy, uses lenses and a microscope that produces an intense beam of light to illuminate the interior of your eye.

• Eye ultrasound. An eye ultrasound uses high-frequency sound waves from a hand-held, wandlike apparatus called a transducer to produce images of your eye. The transducer is placed on your closed eyelid or on the front surface of your eye.

• Imaging of the blood vessels in and around the tumor (angiogram). During an angiogram of your eye, a colored dye is injected into a vein in your arm. The dye travels to the blood vessels in your eye.

  A camera with special filters to detect the dye takes flash pictures every few seconds for several minutes.

• Optical coherence tomography. The imaging test creates pictures of portions of the uveal tract and retina.

• Removing a sample of suspicious tissue for testing. In some cases, your doctor may recommend a procedure to remove a sample of tissue (biopsy) from your eye.

  To remove the sample, a thin needle is inserted into your eye and used to extract suspicious tissue. The tissue is tested in a laboratory to determine whether it contains eye melanoma cells.

  An eye biopsy isn't usually necessary to diagnose eye melanoma.

Determining whether cancer has spread

Your doctor may recommend additional tests and procedures to determine whether the melanoma has spread (metastasized) to other parts of your body. Tests may include:

• Blood tests to measure liver function
• Chest X-ray
• Computerized tomography (CT) scan
• Magnetic resonance imaging (MRI) scan
• Abdominal ultrasound
• Positron emission tomography (PET) scan

Treatment

Your eye melanoma treatment options will depend on the location and size of the eye melanoma, as well as your overall health and your preferences.

Waiting to treat small eye melanomas

A small eye melanoma may not require immediate treatment. If the melanoma is small and isn't growing, you and your doctor may choose to wait and watch for signs of growth.

If the melanoma grows or causes complications, you may choose to undergo treatment at that time.

Radiation therapy

Radiation therapy uses high-powered energy, such as protons or gamma rays, to kill cancer cells. Radiation therapy is typically used for small to medium-sized eye melanomas.

The radiation is usually delivered to the tumor by placing a radioactive plaque on your eye, directly over the tumor in a procedure called brachytherapy. The plaque is held in place with temporary stitches. The plaque looks similar to a bottle cap and contains several radioactive seeds. The plaque remains in place for four to five days before it's removed.

The radiation can also come from a machine that directs radiation, such as proton beams, to your eye (external beam radiation, or teletherapy). This type of radiation therapy is often administered over several days.

Laser treatment

Treatment that uses a laser to kill the melanoma cells may be an option in certain situations. One type of laser treatment, called thermotherapy, uses an infrared laser and is sometimes used in combination with radiation therapy.

Photodynamic therapy

Photodynamic therapy combines medications with a special wavelength of light. The medicine makes the cancer cells vulnerable to light. The treatment damages the vessels and the cells that make up the eye melanoma. Photodynamic therapy is used in smaller tumors, as it isn't effective for larger cancers.

Cold treatments

Extreme cold (cryotherapy) may be used to destroy melanoma cells in some small eye melanomas, but this treatment isn't commonly used.

Surgery

Operations used to treat eye melanoma include procedures to remove part of the eye or a procedure to remove the entire eye. What procedure you'll undergo depends on the size and location of your eye melanoma. Options may include:

• Surgery to remove the melanoma and a small area of healthy tissue. Surgery to remove the melanoma and a band of healthy tissue that surrounds it may be an option for treating small melanomas.

• Surgery to remove the entire eye (enucleation). Enucleation is often used for large eye tumors. It may also be used if the tumor is causing eye pain.

  After the eye with melanoma is removed, an implant is inserted into the same position, and the muscles controlling movement of the eye are attached to the implant, which allows the implant to move.

  After you've had some time to heal, an artificial eye (prosthesis) is made. The front surface of your new eye will be custom painted to match your existing eye.

Coping and support

Coping with vision changes

If your cancer treatment causes total loss of vision in one eye, such as happens when an eye is removed, it's still possible to do most things you were able to do with two working eyes. But it may take a few months to adjust to your new vision.

Having only one eye affects your ability to judge distance. And it may be more difficult to be aware of things around you, especially things occurring on the side without vision.

Ask your doctor for a referral to a support group or an occupational therapist, who can help devise strategies for coping with and adjusting to your altered vision.

Preparing for your appointment

Start by seeing your family doctor if you have any signs or symptoms that worry you. If your doctor suspects you have an eye problem, you may be referred to an eye specialist (ophthalmologist).

If you have eye melanoma, you may be referred to an eye surgeon who specializes in treating eye melanoma. This specialist can explain your treatment options and may refer you to other specialists depending on the treatments you choose.

Because appointments can be brief, and because there's often a lot of ground to cover, it's a good idea to be well-prepared. Here's some information to help you get ready, and what to expect from your doctor.

What you can do

• Be aware of any pre-appointment restrictions. At the time you make the appointment, be sure to ask if there's anything you need to do in advance, such as restrict your diet.
• Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
• Write down key personal information, including general health and any major stresses or recent life changes. Family medical history also will be helpful.
• Make a list of all medications, vitamins or supplements that you're taking.
• Consider taking a family member or friend along. Sometimes it can be difficult to remember all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
• Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For eye melanoma, some basic questions to ask your doctor include:

• Do I have eye melanoma?
• Where is my eye melanoma located?
• What is the size of my eye melanoma?
• Has my eye melanoma spread beyond my eye?
• Will I need additional tests?
• What are my treatment options?
• Can any treatments cure my eye melanoma?
• What are the potential side effects of each treatment?
• Do I have to have treatment?
• How long can I take to decide on a treatment?
• Is there one treatment you feel is best for me?
• How will treatment affect my daily life? Can I continue working?
• How will treatment affect my vision?
• I have these other health conditions. How can I best manage them during treatment?
• Should I be referred to additional specialists? What will that cost, and will my insurance cover it?
• Are there brochures or other printed material that I can take with me? What websites do you recommend?
• What will determine whether I should plan for a follow-up visit?

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask other questions that occur to you.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may allow time later to cover other points you want to address. Your doctor may ask:

• When did you first begin experiencing symptoms?
• Have your symptoms been continuous or occasional?