Diagnosis

Diagnosis involves finding out if calciphylaxis is the cause of your symptoms. Your healthcare professional reviews your health history, asks about your symptoms and gives you a physical exam.

You also may need tests such as:

  • Skin biopsy. During this procedure, your healthcare professional removes a small tissue sample from an area of affected skin. Then, a lab checks the sample.
  • Blood tests. A lab can measure various substances in your blood. These include creatinine, calcium, phosphorus, parathyroid hormone and vitamin D. The results help your healthcare team check how well your kidneys are working.
  • Imaging tests. These can be useful if biopsy results aren't clear or if a biopsy can't be done. X-rays may show calcium buildups in the blood vessels. These buildups are common in calciphylaxis and in other advanced kidney diseases.

Treatment

Often, more than one treatment is needed for calciphylaxis. Treatments can restore oxygen and blood flow to the skin and reduce calcium buildup.

Restoring oxygen and blood flow to the skin

Medicine that helps keep blood from clotting can restore blood flow to affected tissues. These blood-thinning medicines are called anticoagulants. If these don't help, an experimental treatment may be available that can dissolve blood clots in the tiny blood vessels of the skin. This treatment is a type of medicine called a low-dose tissue plasminogen activator.

Another backup treatment option involves breathing pure oxygen in a pressurized chamber. This is called hyperbaric oxygen therapy. It's not available everywhere. A small amount of research suggests that this therapy may help control infections and limit tissue loss while the main treatments take effect.

Wound care is a crucial part of calciphylaxis treatment. So it can be very helpful to have a team of wound care specialists.

Reducing calcium buildup

Reducing calcium buildup in arteries may be helped by:

  • Dialysis. If you get kidney dialysis treatment, your healthcare professional may change the medicines used and how long and often you get dialysis. It might be helpful to increase the number and length of dialysis sessions.
  • Changing medicines. Your healthcare professional reviews your current medicines and gets rid of possible triggers for calciphylaxis. These triggers include warfarin, corticosteroids and iron. If you take calcium or vitamin D supplements, your healthcare professional may change the amount you take or have you stop taking them.
  • Taking medicines. A medicine called sodium thiosulfate can lower calcium buildup in the small arteries. It's given through a needle in a vein three times a week, usually during dialysis. Your healthcare professional may recommend that you take a medicine called cinacalcet (Sensipar), which can help control parathyroid hormone (PTH). Other medicines may be used to improve the balance of calcium and phosphorus in your body.
  • Surgery. If an overactive parathyroid gland that makes too much PTH plays a role in your condition, surgery may be a treatment option. Surgery called a parathyroidectomy can remove all or part of the parathyroid glands.

Applying intensive wound treatment

For sores to heal, some of the tissue damaged by calciphylaxis may need to be removed with surgery. This is called debridement. Sometimes, tissue can be removed using other methods, such as wet dressings. Medicines called antibiotics can clear up infections caused by germs. Antibiotics can help treat and prevent ulcer infections.

Pain control

You'll likely be offered medicines to manage pain due to calciphylaxis or during wound care. A pain medicine specialist may need to be involved if you're prescribed opioid pain medicines.

Preparing for your appointment

You may start by seeing your healthcare professional. Or you may be referred to a skin doctor called a dermatologist or a kidney doctor called a nephrologist.

Some other healthcare professionals who may become part of your healthcare team include:

  • An internal medicine doctor, called an internist.
  • A surgeon.
  • A wound care specialist.
  • A pain management expert.

Here's some information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance. For example, you may be told not to eat for a certain number of hours before some tests. This is called fasting. It's also a good idea to bring a family member or friend with you. A person you trust can help you remember all of the information from your appointment.

It's also helpful to make a list of:

  • Your symptoms, including any that do not seem related to the reason for your appointment.
  • Key personal information, including major stresses, recent life changes and family medical history.
  • All medicines, vitamins or other supplements you take, including the amounts you take.
  • Questions to ask your healthcare team.

For calciphylaxis, some basic questions to ask your healthcare team include:

  • What's likely causing my symptoms? Are there other possible causes?
  • What tests do I need?
  • What treatment do you recommend?
  • I have other health conditions. How can I best manage these conditions together?
  • Do I need to change my diet?
  • What's the outlook for my health?
  • Are there brochures or other printed material I can have? What websites do you recommend?

What to expect from your doctor

Your healthcare professional is likely to ask you questions such as:

  • When did your symptoms begin?
  • Have your symptoms been ongoing or do they come and go?
  • How bad are your symptoms?
  • Does anything seem to make your symptoms better?
  • What, if anything, appears to make your symptoms worse?
By Mayo Clinic Staff