Overview

Aortic valve disease is a type of heart valve disease. In this condition, the valve between the lower left heart chamber and the body's main artery doesn't work properly.

The aortic valve helps keep blood flowing in the correct direction through the heart. A damaged or diseased aortic valve can affect blood flow to the rest of the heart and body.

Aortic valve disease includes:

  • Aortic valve stenosis. Each heart valve has flaps of tissue that open and close once per heartbeat. The flaps also are called cusps. Sometimes the aortic valve flaps become thick and stiff, or they connect together. These problems cause the valve opening to become narrow. The narrowed valve reduces or blocks blood flow from the heart to the rest of the body.
  • Aortic valve regurgitation. The aortic valve doesn't close properly, causing blood to flow backward into the left lower heart chamber.

A person may be born with aortic valve disease. This is called a congenital heart defect. Sometimes aortic valve disease occurs later in life due to other health conditions.

Treatment for aortic valve disease depends on the type and severity of disease. Some people may need surgery to repair or replace the aortic valve.

Symptoms

Some people with aortic valve disease may not notice symptoms for many years. Symptoms of aortic valve disease may include:

  • Chest pain or tightness.
  • Dizziness.
  • Fainting.
  • Fatigue after activity or having less ability to be active.
  • Irregular heartbeat.
  • Shortness of breath, particularly during vigorous activity or when lying down.
  • Not eating enough. This is mainly seen in children with aortic valve stenosis.
  • Not gaining enough weight. This is mainly seen in children with aortic valve stenosis.

When to see a doctor

If you're having sudden chest pain, call 911 or your local emergency number.

Make an appointment for a health checkup if you have symptoms of aortic valve disease, such as shortness of breath, fatigue after activity, or sensations of a pounding or an irregular heartbeat. Sometimes the first symptoms of aortic valve disease are related to heart failure. Get a health checkup if you have fatigue that doesn't get better with rest, shortness of breath, and swollen ankles and feet, which are common symptoms of heart failure.

Causes

Aortic valve disease may be caused by a heart problem present at birth, called a congenital heart defect. Other causes of aortic valve disease later in life include:

  • Age-related changes to the heart.
  • Infections.
  • High blood pressure.
  • Injury to the heart.

To better understand the causes of aortic valve disease, it may be helpful to know how the heart valves typically work.

The heart has four valves that keep blood flowing in the correct direction. These valves are:

  • Aortic valve.
  • Mitral valve.
  • Tricuspid valve.
  • Pulmonary valve.

Each valve has flaps, also called cusps or leaflets, that open and close once during each heartbeat.

In aortic valve disease, the valve between the lower left heart chamber and the body's main artery doesn't work properly. The lower left heart chamber is called the left ventricle. The body's main artery is called the aorta.

The valve may become thick and stiff or the valve may not close properly.

Risk factors

Many things can raise the risk of aortic valve disease, including:

  • Older age. Calcium can build up on the aortic valve as people age, causing the aortic valve to stiffen and become narrow.
  • Heart valve problems present at birth, called congenital heart defects. Some people are born with a missing, extra or fused valve flap. This increases the risk of aortic valve regurgitation.
  • Rheumatic fever. This complication of strep throat can cause aortic stenosis, a type of heart valve disease. If you have heart valve disease due to rheumatic fever, it's called rheumatic heart disease. If not, it's called nonrheumatic heart disease.
  • Inflammation of the lining of the heart's chambers and valves, called endocarditis. This life-threatening condition is usually caused by infection. It can damage the aortic valve.
  • History of radiation therapy to the chest. Some types of cancer are treated with radiation therapy. Symptoms of heart valve disease may not be noticed until many years after radiation therapy is received.
  • Other health conditions. Chronic kidney disease, lupus and Marfan syndrome, a connective tissue disease, can increase the risk of aortic stenosis or regurgitation.

Complications

Potential complications of aortic valve disease may include:

  • Blood clots.
  • Stroke.
  • Heart failure.
  • Heart rhythm problems, called arrhythmias.
  • Death due to sudden cardiac arrest.

Proper diagnosis and treatment can help reduce the risk of complications.

By Mayo Clinic Staff