Print DiagnosisTo diagnose CGD, a healthcare professional will review a family and medical history and do a physical exam. There are several tests used to diagnose CGD, including: Neutrophil function tests. A healthcare professional may do a dihydrorhodamine 123 (DHR) test or other tests to see how well a type of white blood cell, called a neutrophil, is functioning. This test is commonly used to diagnose CGD. Genetic testing. A genetic test can confirm the presence of a specific genetic alteration that results in chronic granulomatous disease. Prenatal testing. A healthcare professional may do prenatal testing to diagnose CGD if one of your children already has been diagnosed with CGD. Care at Mayo Clinic Our caring team of Mayo Clinic experts can help you with your chronic granulomatous disease-related health concerns Start Here More InformationChronic granulomatous disease care at Mayo ClinicGenetic testing TreatmentTreatment for CGD is aimed at helping avoid infections and manage the condition. Treatments may include: Infection management. A healthcare professional will work to prevent bacterial and fungal infections before they start. Treatment may include a trimethoprim and sulfamethoxazole combination (Bactrim, Sulfatrim Pediatric) or itraconazole (Sporanox, Tolsura). Additional antibiotics or antifungal medicines may be necessary should infection happen. Interferon-gamma. Someone with CGD may occasionally have interferon-gamma injections, which may help boost cells in the immune system to fight infections. Stem cell transplantation. For some people, a stem cell transplant can provide a cure for CGD. Deciding to treat with stem cell transplantation depends on a number of factors, including prognosis, donor availability and personal preference. Potential future treatmentsGene therapy is currently being explored for CGD treatment, but further research is necessary. Researchers also are investigating repairing defective genes to treat CGD.More InformationChronic granulomatous disease care at Mayo ClinicBone marrow transplant Request an appointment Clinical trials Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. By Mayo Clinic Staff Chronic granulomatous disease care at Mayo Clinic Request an appointment Symptoms & causesDoctors & departments March 28, 2025 Print Living with chronic granulomatous disease? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions AML successful treatment 21 Replies Wed, Apr 02, 2025 chevron-right Anyone want to talk about Myelofibrosis? 160 Replies Wed, Apr 02, 2025 chevron-right What are most common side effects when starting HU (Hydroxyurea)? 143 Replies Wed, Apr 02, 2025 chevron-right See more discussions Show references Zerbe CS, et al. Chronic granulomatous disease: Pathogenesis, clinical manifestations, and diagnosis. https://www.uptodate.com/contents/search. Accessed Feb. 8, 2023. Chronic granulomatous disease. Medline Plus. https://ghr.nlm.nih.gov/condition/chronic-granulomatous-disease?_ga=1.168947753.905232672.1468720729. Accessed Feb. 14, 2023. Chronic granulomatous disease. National Organization for Rare Disorders. https://rarediseases.org/rare-diseases/chronic-granulomatous-disease/?filter=ovr-ds-resources. Accessed Feb. 9, 2023. Marciano BE, et al. Chronic granulomatous disease: Treatment and prognosis. https://www.uptodate.com/contents/search. Accessed Feb. 9, 2023. Chronic granulomatous disease (CGD). Merck Manual Professional Version. https://www.merckmanuals.com/professional/immunology-allergic-disorders/immunodeficiency-disorders/chronic-granulomatous-disease-cgd. Accessed Oct. 16, 2024. Ami TR. Allscripts EPSi. Mayo Clinic. Nov. 23, 2022. Keller MD, et al. Future of care for patients with chronic granulomatous disease: Gene therapy and targeted molecular medicine. Journal of the Pediatric Infectious Diseases Society. 2018; doi:10.1093/jpids/piy011. Jeffrey Modell Foundation. https://info4pi.org/. Accessed Feb. 9, 2023. Related Associated Procedures Bone marrow transplant Genetic testing Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Chronic granulomatous diseaseSymptoms&causesDiagnosis&treatmentDoctors&departmentsCare atMayoClinic Advertisement Mayo Clinic does not endorse companies or products. 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