Publications Print Anker CJ, Tchelebi L, Selfridge JE, Jabbour SK, Akselrod D, Cataldo P, Abood G, Berlin J, Hallemeier CL, Jethwa KR, Kim E, Kennedy T, Lee P, Sharma N, Small W Jr, Williams VM, Russo S. Executive Summary of the American Radium Society(R) (ARS) Appropriate Use Criteria (AUC) for Non-Operative Management (NOM) for Rectal Adenocarcinoma: Systematic Review and Guidelines. Int J Radiat Oncol Biol Phys. 2024 May 24 [Epub ahead of print] View PubMed Jethwa KR, Kim E, Berlin J, Anker CJ, Tchelebi L, Abood G, Hallemeier CL, Jabbour S, Kennedy T, Kumar R, Lee P, Sharma N, Small W Jr, Williams V, Russo S. Executive Summary of the American Radium Society Appropriate Use Criteria for Neoadjuvant Therapy for Nonmetastatic Pancreatic Adenocarcinoma: Systematic Review and Guidelines. Am J Clin Oncol. 2024 Apr 1; 47 (4):185-199 Epub 2023 Dec 22 View PubMed Jabbour SK, Kumar R, Anderson B, Chino JP, Jethwa KR, McDowell L, Lo AC, Owen D, Pollom EL, Tree AC, Tsang DS, Yom SS. Combinatorial Approaches for Chemotherapies and Targeted Therapies With Radiation: United Efforts to Innovate in Patient Care. Int J Radiat Oncol Biol Phys. 2024 Apr 1; 118 (5):1240-1261 Epub 2024 Jan 10 View PubMed Emiloju OE, Storandt M, Zemla T, Tran N, Jethwa K, Mahipal A, Mitchell J, Thiels C, Mathis K, McWilliams R, Hubbard J, Sinicrope F, Shi Q, Jin Z. Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer. JCO Precis Oncol. 2024 Jan; 8:e2300127 View PubMed Hallemeier CL, Sharma N, Anker C, Selfridge JE, Lee P, Jabbour S, Williams V, Liu D, Kennedy T, Jethwa KR, Kim E, Kumar R, Small W Jr, Tchelebi L, Russo S. American Radium Society Appropriate Use Criteria for the use of liver-directed therapies for nonsurgical management of liver metastases: Systematic review and guidelines. Cancer. 2023 Oct 15; 129 (20):3193-3212 Epub 2023 July 06 View PubMed Herndon J, Hallemeier C, Jethwa K, Shariff A, Bancos I. Radiation of bilateral adrenal metastases is associated with a high risk of primary adrenal insufficiency. Clin Endocrinol (Oxf). 2023 Jul; 99 (1):35-42 Epub 2023 Mar 16 View PubMed Peters GW, Talcott W, Peters NV, Dhanasopan A, Lacy J, Cecchini M, Kortmansky J, Stein S, Lattanzi S, Park HS, Boffa D, Johung KL, Jethwa KR. Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer. J Gastrointest Oncol. 2023 Jun 30; 14 (3):1181-1192 Epub 2023 June 26 View PubMed Jeans EB, Ebner DK, Takiyama H, Qualls K, Cunningham DA, Waddle MR, Jethwa KR, Harmsen WS, Hubbard JM, Dozois EJ, Mathis KL, Tsuji H, Merrell KW, Hallemeier CL, Mahajan A, Yamada S, Foote RL, Haddock MG. Comparing Oncologic Outcomes and Toxicity for Combined Modality Therapy vs. Carbon-Ion Radiotherapy for Previously Irradiated Locally Recurrent Rectal Cancer. Cancers (Basel). 2023 Jun 5; 15 (11) Epub 2023 June 05 View PubMed Peters Gabrielle, Talcott Wesley, Peters Nicholas, Dhanasopan Andrew, Lacey Jill, Cecchini Michael, Kortmansky Jeremy, Stein Stacey, Lattanzi Stephen, Park Henry, Boffa Daniel, Johung Kimberly, Jethwa Krishan. Pre-Operative Chemoradiotherapy With or Without Induction Chemotherapy for Operable Locally-Advanced Esophageal Cancer Journal of Gastrointestinal Oncology. 2023. Tchelebi LT, Jethwa KR, Levy AT, Anker CJ, Kennedy T, Grodstein E, Hallemeier CL, Jabbour SK, Kim E, Kumar R, Lee P, Small W Jr, Williams VM, Sharma N, Russo S. American Radium Society (ARS) Appropriate Use Criteria (AUC) for Extrahepatic Cholangiocarcinoma. Am J Clin Oncol. 2023 Feb 1; 46 (2):73-84 Epub 2022 Dec 19 View PubMed Grossberg AJ, Jethwa KR, Ellsworth SG. Neoadjuvant mFOLFIRINOX vs mFOLFIRINOX Plus Radiotherapy in Patients With Borderline Resectable Pancreatic Cancer-The A021501 Trial. JAMA Oncol 2023 Feb 1; 9 (2):275 View PubMed Kowalchuk RO, Spears GM, Morris LK, Owen D, Yoon HH, Jethwa K, Chuong MD, Ferris MJ, Haddock MG, Hallemeier CL, Wigle D, Lin SH, Merrell KW. Risk stratification of postoperative cardiopulmonary toxicity after trimodality therapy for esophageal cancer. Front Oncol. 2023; 13:1081024 Epub 2023 Feb 09 View PubMed Jethwa KR, Jin Z, Hallemeier CL. A Critical Review of the Role of Local Therapy for Oligometastatic Gastrointestinal Cancer. Int J Radiat Oncol Biol Phys. 2022 Nov 15; 114 (4):780-791 Epub 2022 July 04 View PubMed Jethwa KR, Neibart SS, Truty MJ, Jabbour SK, Hallemeier CL. Patterns of Recurrence After Primary Local Therapy for Pancreatic Ductal Adenocarcinoma - A Critical Review of Rationale and Target Delineation for (Neo)Adjuvant Radiation Therapy. Pract Radiat Oncol. 2022 Nov-Dec; 12 (6):e463-e473 Epub 2022 June 17 View PubMed Mokhtech M, Miccio JA, Johung K, Cecchini M, Stein S, Narang AK, Herman JM, Kunstman J, Haddock MG, Anker CJ, Jabbour S, Hallemeier CL, Jethwa KR. Multiagent Chemotherapy Followed by Stereotactic Body Radiotherapy Versus Conventional Radiotherapy for Resected Pancreas Cancer. Am J Clin Oncol. 2022 Nov 1; 45 (11):450-457 Epub 2022 Oct 21 View PubMed Routman DM, Kumar S, Chera BS, Jethwa KR, Van Abel KM, Frechette K, DeWees T, Golafshar M, Garcia JJ, Price DL, Kasperbauer JL, Patel SH, Neben-Wittich MA, Laack NL, Chintakuntlawar AV, Price KA, Liu MC, Foote RL, Moore EJ, Gupta GP, Ma DJ. Detectable Postoperative Circulating Tumor Human Papillomavirus DNA and Association with Recurrence in Patients With HPV-Associated Oropharyngeal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2022 Jul 1; 113 (3):530-538 Epub 2022 Feb 12 View PubMed Jairam V, Park HS, Yu JB, Bindra RS, Contessa JN, Jethwa KR. Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy. Adv Radiat Oncol. 2022 Jul-Aug; 7 (4):100949 Epub 2022 Mar 21 View PubMed Yolcu YU, Zreik J, Wahood W, Bhatti AUR, Bydon M, Houdek MT, Rose PS, Mahajan A, Petersen IA, Haddock MG, Ahmed SK, Laack NN, Jethwa K, Jeans EB, Imai R, Yamada S, Foote RL. Comparison of Oncologic Outcomes and Treatment-Related Toxicity of Carbon Ion Radiotherapy and En Bloc Resection for Sacral Chordoma. JAMA Netw Open. 2022 Jan 4; 5 (1):e2141927 Epub 2022 Jan 04 View PubMed Mohiuddin JJ, Jethwa KR, Grandhi N, Breen WG, Wang X, Anvari A, Lin H, Sandhyavenu H, Doucette A, Plastaras JP, Rule WG, Metz JM, Merrell KW, Sio TT, Ashman JB, Haddock MG, Ben-Josef E, Hallemeier CL, Wojcieszynski AP. Multi-institutional Comparison of Intensity Modulated Photon Versus Proton Radiation Therapy in the Management of Squamous Cell Carcinoma of the Anus. Adv Radiat Oncol. 2021 Sep-Oct; 6 (5):100744 Epub 2021 June 24 View PubMed Peters GW, Tao W, Wei W, Miccio JA, Jethwa KR, Cecchini M, Johung KL. Publication Bias in Gastrointestinal Oncology Trials Performed over the Past Decade. Oncologist. 2021 Aug; 26 (8):660-667 Epub 2021 Mar 31 View PubMed Jani KS, Lu SE, Murphy JD, Romesser PB, Jethwa KR, Li D, Chundury A, Wu AJ, Hathout L, Hallemeier CL, Jabbour SK. Malignancies diagnosed before and after anal squamous cell carcinomas: A SEER registry analysis. Cancer Med. 2021 Jun; 10 (11):3575-3583 Epub 2021 May 07 View PubMed Thomas J. Hayman, Aarti K. Bhatia, Krishan R. Jethwa, Melissa R. Young, Henry S. Park. Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review Translational Cancer Research. 2021; 10(5). Jethwa KR, Day CN, Sandhyavenu H, Gonuguntla K, Harmsen WS, Breen WG, Routman DM, Garda AE, Hubbard JM, Halfdanarson TR, Neben-Wittich MA, Merrell KW, Hallemeier CL, Haddock MG. Intensity modulated radiotherapy for anal canal squamous cell carcinoma: A 16-year single institution experience. Clin Transl Radiat Oncol. 2021 May; 28:17-23 Epub 2021 Feb 23 View PubMed Teyateeti A, Geno CS, Stafford SS, Mahajan A, Yan ES, Merrell KW, Laack NN, Parney IF, Brown PD, Jethwa KR. Does the dural resection bed need to be irradiated? Patterns of recurrence and implications for postoperative radiotherapy for temporal lobe gliomas. Neurooncol Pract. 2021 Apr; 8 (2):190-198 Epub 2020 Nov 04 View PubMed Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clin Transl Radiat Oncol. 2021 Mar; 27:15-23 Epub 2020 Dec 16 View PubMed Prabhu RS, Turner BE, Asher AL, Marcrom SR, Fiveash JB, Foreman PM, Press RH, Buchwald ZS, Curran WJ Jr, Patel KR, Breen WG, Brown PD, Jethwa KR, Grills IS, Arden JD, Foster LM, Manning MA, Vaslow ZK, Burri SH, Soltys SG. Leptomeningeal disease and neurologic death after surgical resection and radiosurgery for brain metastases: A multi-institutional analysis. Adv Radiat Oncol. 2021 Mar-Apr; 6 (2):100644 Epub 2021 Jan 08 View PubMed Breen WG, Jethwa KR, Yu NY, Spears GM, Harmsen WS, Miller RC, Ashman JB, Rule WG, Sio TT, Neben-Wittich MA, Haddock MG, Mahipal A, Truty MJ, Hallemeier CL, Merrell KW. Patient-Reported Quality of Life Before and After Chemoradiation for Intact Pancreas Cancer: A Prospective Registry Study. Pract Radiat Oncol. 2021 Jan-Feb; 11 (1):e63-e69 Epub 2020 July 23 View PubMed Jethwa KR, Sannapaneni S, Mullikin TC, Harmsen WS, Petersen MM, Antharam P, Laughlin B, Mahipal A, Halfdanarson TR, Merrell KW, Neben-Wittich M, Sio TT, Haddock MG, Hallemeier CL. Chemoradiotherapy for patients with locally advanced or unresectable extra-hepatic biliary cancer. J Gastrointest Oncol. 2020 Dec; 11 (6):1408-1420 View PubMed Gergelis KR, Jethwa KR, Tryggestad EJ, Ashman JB, Haddock MG, Hallemeier CL. Proton beam radiotherapy for esophagus cancer: state of the art. J Thorac Dis. 2020 Nov; 12 (11):7002-7010 View PubMed Krishan R.Jethwa, Michael G.Haddock, Christopher L.Hallemeier. The use of intraoperative radiation therapy in the management of locally recurrent rectal cancer Seminars in Colon and Rectal Surgery. 2020; 31(3). Jeans EB, Jethwa KR, Harmsen WS, Neben-Wittich M, Ashman JB, Merrell KW, Giffey B, Ito S, Kazemba B, Beltran C, Haddock MG, Hallemeier CL. Clinical Implementation of Preoperative Short-Course Pencil Beam Scanning Proton Therapy for Patients With Rectal Cancer. Adv Radiat Oncol. 2020 Sep-Oct; 5 (5):865-870 Epub 2020 May 22 View PubMed Deng W, Jethwa KR, Gonuguntla K, Liao Z, Yoon HH, Murphy MB, Haddock MG, Hallemeier CL, Lin SH. Multi-institutional Evaluation of Curative Intent Chemoradiotherapy for Patients With Clinical T1N0 Esophageal Adenocarcinoma. Adv Radiat Oncol. 2020 Sep-Oct; 5 (5):951-958 Epub 2020 Apr 27 View PubMed Jethwa KR, Jang S, Gonuguntla K, Garda AE, Evans JD, Whitaker TJ, Day CN, Haddock MG, Petersen IA. Lymph node-directed simultaneous integrated boost in patients with clinically lymph node-positive cervical cancer treated with definitive chemoradiotherapy: clinical outcomes and toxicity Journal of Radiation Oncology. 09 June 2020. Evans JD, Harper RH, Petersen M, Harmsen WS, Anand A, Hunzeker A, Deiter NC, Schultz H, Jethwa KR, Lester SC, Routman DM, Ma DJ, Garces YI, Neben-Wittich MA, Laack NN, Beltran CJ, Patel SH, McGee LA, Rwigema JM, Mundy DW, Foote RL. The Importance of Verification CT-QA Scans in Patients Treated with IMPT for Head and Neck Cancers. Int J Part Ther. 2020 Summer; 7 (1):41-53 Epub 2020 Aug 03 View PubMed Jethwa KR, Jang S, Mullikin TC, Harmsen WS, Petersen MM, Olivier KR, Park SS, Neben-Wittich MA, Hubbard JM, Sandhyavenu H, Whitaker TJ, Waltman LA, Kipp BR, Merrell KW, Haddock MG, Hallemeier CL. Association of tumor genomic factors and efficacy for metastasis-directed stereotactic body radiotherapy for oligometastatic colorectal cancer. Radiother Oncol. 2020 May; 146:29-36 Epub 2020 Feb 27 View PubMed Jethwa KR, Haddock MG, Tryggestad EJ, Hallemeier CL. The emerging role of proton therapy for esophagus cancer. J Gastrointest Oncol. 2020 Feb; 11 (1):144-156 View PubMed Mutter RW, Jethwa KR, Wan Chan Tseung HS, Wick SM, Kahila MMH, Viehman JK, Shumway DA, Corbin KS, Park SS, Remmes NB, Whitaker TJ, Beltran CJ. Incorporation of Biologic Response Variance Modeling Into the Clinic: Limiting Risk of Brachial Plexopathy and Other Late Effects of Breast Cancer Proton Beam Therapy. Pract Radiat Oncol. 2020 Mar-Apr; 10(2):e71-e81. Epub 2019 Sep 05. View PubMed Mutter RW, Jethwa KR, Gonuguntla K, Remmes NB, Whitaker TJ, Hieken TJ, Ruddy KJ, McGee LA, Corbin KS, Park SS. 3 fraction pencil-beam scanning proton accelerated partial breast irradiation: early provider and patient reported outcomes of a novel regimen. Radiat Oncol. 2019 Nov 21; 14 (1):211 View PubMed Smith NL, Jethwa KR, Viehman JK, Harmsen WS, Gonuguntla K, Elswick SM, Grauberger JN, Amundson AC, Whitaker TJ, Remmes NB, Harless CA, Boughey JC, Nguyen MT, Park SS, Corbin KS, Mutter RW. Post-mastectomy intensity modulated proton therapy after immediate breast reconstruction: Initial report of reconstruction outcomes and predictors of complications. Radiother Oncol. 2019 Nov; 140:76-83 Epub 2019 June 08 View PubMed Jethwa KR, Hellekson CD, Evans JD, Harmsen WS, Wilhite TJ, Whitaker TJ, Park SS, Choo CR, Stish BJ, Olivier KR, Haloi R, Lowe VJ, Welch BT, Quevedo JF, Mynderse LA, Karnes RJ, Kwon ED, Davis BJ. (11)C-Choline PET Guided Salvage Radiation Therapy for Isolated Pelvic and Paraortic Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: Rationale and Early Genitourinary or Gastrointestinal Toxicities. Adv Radiat Oncol. 2019 Oct-Dec; 4 (4):659-667 Epub 2019 July 04 View PubMed Prabhu RS, Turner BE, Asher AL, Marcrom SR, Fiveash JB, Foreman PM, Press RH, Patel KR, Curran WJ, Breen WG, Brown PD, Jethwa KR, Grills IS, Arden JD, Foster LM, Manning MA, Stern JD, Soltys SG, Burri SH. A multi-institutional analysis of presentation and outcomes for leptomeningeal disease recurrence after surgical resection and radiosurgery for brain metastases. Neuro Oncol. 2019 Aug 5; 21 (8):1049-1059 View PubMed Jethwa KR, Park SS, Gonuguntla K, Wick SM, Vallow LA, Deufel CL, Whitaker TJ, Furutani KM, Ruddy KJ, Corbin KS, Hieken TJ, Mutter RW. In Reply to Hannoun-Levi and Hannoun. Int J Radiat Oncol Biol Phys 2019 Aug 1; 104 (5):1177-1179 Epub 2019 Apr 27 View PubMed Jethwa KR, Park SS, Gonuguntla K, Wick SM, Vallow LA, Deufel CL, Whitaker TJ, Furutani KM, Ruddy KJ, Corbin KS, Hieken TJ, Mutter RW. Three-Fraction Intracavitary Accelerated Partial Breast Brachytherapy: Early Provider and Patient-Reported Outcomes of a Novel Regimen. Int J Radiat Oncol Biol Phys. 2019 May 1; 104 (1):75-82 Epub 2018 Dec 21 View PubMed Sperduto PW, Deegan BJ, Li J, Jethwa KR, Brown PD, Lockney N, Beal K, Rana NG, Attia A, Tseng CL, Sahgal A, Shanley R, Sperduto WA, Lou E, Zahra A, Buatti JM, Yu JB, Chiang V, Molitoris JK, Masucci L, Roberge D, Shi DD, Shih HA, Olson A, Kirkpatrick JP, Braunstein S, Sneed P, Mehta MP. Estimating survival for renal cell carcinoma patients with brain metastases: an update of the Renal Graded Prognostic Assessment tool. Neuro Oncol. 2018 Nov 12; 20(12):1652-1660. View PubMed Sperduto PW, Deegan BJ, Li J, Jethwa KR, Brown PD, Lockney N, Beal K, Rana NG, Attia A, Tseng CL, Sahgal A, Shanley R, Sperduto WA, Lou E, Zahra A, Buatti JM, Yu JB, Chiang V, Molitoris JK, Masucci L, Roberge D, Shi DD, Shih HA, Olson A, Kirkpatrick JP, Braunstein S, Sneed P, Mehta MP. Effect of Targeted Therapies on Prognostic Factors, Patterns of Care, and Survival in Patients With Renal Cell Carcinoma and Brain Metastases. Int J Radiat Oncol Biol Phys. 2018 Jul 15; 101 (4):845-853 Epub 2018 Apr 12 View PubMed Jethwa KR, Tryggestad EJ, Whitaker TJ, Giffey BT, Kazemba BD, Neben-Wittich MA, Merrell KW, Haddock MG, Hallemeier CL. Initial experience with intensity modulated proton therapy for intact, clinically localized pancreas cancer: Clinical implementation, dosimetric analysis, acute treatment-related adverse events, and patient-reported outcomes. Adv Radiat Oncol. 2018 Jul-Sep; 3 (3):314-321 Epub 2018 Apr 13 View PubMed Jethwa KR, Kahila MM, Mara KC, Harmsen WS, Routman DM, Pumper GM, Corbin KS, Sloan JA, Ruddy KJ, Hieken TJ, Park SS, Mutter RW. Patient-reported outcomes of catheter-based accelerated partial breast brachytherapy and whole breast irradiation, a single institution experience. Breast Cancer Res Treat. 2018 May; 169 (1):189-196 Epub 2018 Jan 18 View PubMed Evans JD, Jethwa KR, Ost P, Williams S, Kwon ED, Lowe VJ, Davis BJ. Prostate cancer-specific PET radiotracers: A review on the clinical utility in recurrent disease. Pract Radiat Oncol. 2018 Jan - Feb; 8 (1):28-39 Epub 2017 July 20 View PubMed Wilhite TJ, Routman D, Arnett AL, Glasgow AE, Habermann EB, Pisansky TM, Boorjian SA, Jethwa KR, Mynderse LA, Roberts KW, Frank I, Choo R, Davis BJ, Stish BJ. Increased utilization of external beam radiotherapy relative to cystectomy for localized, muscle-invasive bladder cancer: a SEER analysis. Bladder (San Franc). 2018; 5 (3):e34 Epub 2018 Aug 23 View PubMed Jethwa KR, Kahila MM, Whitaker TJ, Harmsen WS, Corbin KS, Park SS, Yan ES, Lemaine V, Boughey JC, Mutter RW. Immediate tissue expander or implant-based breast reconstruction does not compromise the oncologic delivery of post-mastectomy radiotherapy (PMRT). Breast Cancer Res Treat. 2017 Jul; 164 (1):237-244 Epub 2017 Apr 17 View PubMed Jethwa KR, Kahila MM, Hunt KN, Brown LC, Corbin KS, Park SS, Yan ES, Boughey JC, Mutter RW. Delineation of Internal Mammary Nodal Target Volumes in Breast Cancer Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017 Mar 15; 97 (4):762-769 Epub 2016 Nov 27 View PubMed Jethwa KR, Furutani KM, Mynderse LA, Wilson TM, Choo R, King BF, Bergstralh E, Davis BJ. Predictors of prostate volume reduction following neoadjuvant cytoreductive androgen suppression. J Contemp Brachytherapy. 2016 Oct; 8 (5):371-378 Epub 2016 Nov 04 View PubMed Brown PD, Blanchard M, Jethwa K, Flemming KD, Brown CA, Kline RW, Jacobson DJ, St Sauver J, Pollock BE, Garces YI, Stafford SL, Link MJ, Erickson D, Foote RL, Laack NN. The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study. Neurooncol Pract. 2014 Mar; 1 (1):22-28 View PubMed Wei J, Wang F, Kong LY, Xu S, Doucette T, Ferguson SD, Yang Y, McEnery K, Jethwa K, Gjyshi O, Qiao W, Levine NB, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res. 2013 Jul 1; 73 (13):3913-26 Epub 2013 May 01 View PubMed Jethwa K, Wei J, McEnery K, Heimberger AB. miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma. Clin Investig (Lond). 2011 Dec; 1 (12):1637-1650 View PubMed PST-20525729 Home Publications