Sarosh R. Irani, B.M.B.Ch., D.Phil.

  1. Neurologist
  1. Huong NHT, Toan ND, Khanh TH, Thinh LQ, Nhan LNT, Minh NNQ, Thoa NTK, Hung NT, Quy DT, Thwaites CL, Irani SR, Tan LV, Turner HC. A Cost of Illness Analysis of Children with Encephalitis Presenting to a Major Hospital in Vietnam. Am J Trop Med Hyg. 2024 Nov 19 [Epub ahead of print]
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  2. Binks SNM, Elliott KS, Muniz-Castrillo S, Gilbert E, Kawasaki de Araujo T, Harper AR, Brown AC, Chong AY, Band G, Peris Sempere V, Pinto AL, Costantino F, Rayner NW, Mentzer AJ, Delanty N, Rogemond V, Picard G, Handel AE, Melzer N, Titulaer MJ, Lee ST, Leypoldt F, Kuhlenbaeumer G, Honnorat J, Mignot E, Cavelleri GL, Knight JC, Irani SR. Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts. Brain. 2024 Oct 26 [Epub ahead of print]
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  3. Al-Diwani A, Provine NM, Murchison A, Laban R, Swann OJ, Koychev I, Sheerin F, Da Mesquita S, Heslegrave A, Zetterberg H, Klenerman P, Irani SR. Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes. Brain. 2024 Oct 21 [Epub ahead of print]
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  4. das Neves SP, Delivanoglou N, Ren Y, Cucuzza CS, Makuch M, Almeida F, Sanchez G, Barber MJ, Rego S, Schrader R, Faroqi AH, Thomas JL, McLean PJ, Oliveira TG, Irani SR, Piehl F, Da Mesquita S. Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination. Immunity. 2024 Oct 8; 57 (10):2328-2343.e8 Epub 2024 Aug 31
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  5. Bennett JL, Pittock SJ, Paul F, Kim HJ, Irani SR, O'Connor KC, Patterson KR, Smith MA, Gunsior M, Mittereder N, Rees WA, Cimbora D, Cree BAC. B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity. Ann Clin Transl Neurol. 2024 Oct; 11 (10):2792-2798 Epub 2024 Sept 02
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  6. Handel A, Irani SR, Oswal A. Oculomotor Nerve Neuromyotonia: An Inflammatory Syndrome. Neurology. 2024 Sep 10; 103 (5):e209769 Epub 2024 Aug 12
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  7. Ritzau-Jost A, Gsell F, Sell J, Sachs S, Montanaro J, Kirmann T, Maass S, Irani SR, Werner C, Geis C, Sauer M, Shigemoto R, Hallermann S. LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K(v)1 Loss and Increased Action Potential Broadening. Neurol Neuroimmunol Neuroinflamm. 2024 Sep; 11 (5):e200284 Epub 2024 Aug 14
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  8. Upadhya M, Kirmann T, Wilson MA, Simon CM, Dhangar D, Geis C, Williams R, Woodhall G, Hallermann S, Irani SR, Wright SK. Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo. Brain. 2024 Aug 1; 147 (8):2636-2642
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  9. Cleaver J, Dale R, Irani SR. Hunting the origin and source of NR1-directed IgGs in patients with encephalitis. Brain Behav Immun 2024 Aug; 120:554-556 Epub 2024 July 08
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  10. Yogeshwar SM, Muniz-Castrillo S, Sabater L, Peris-Sempere V, Mallajosyula V, Luo G, Yan H, Yu E, Zhang J, Lin L, Fagundes Bueno F, Ji X, Picard G, Rogemond V, Pinto AL, Heidbreder A, Hoftberger R, Graus F, Dalmau J, Santamaria J, Iranzo A, Schreiner B, Giannoccaro MP, Liguori R, Shimohata T, Kimura A, Ono Y, Binks S, Mariotto S, Dinoto A, Bonello M, Hartmann CJ, Tambasco N, Nigro P, Pruss H, McKeon A, Davis MM, Irani SR, Honnorat J, Gaig C, Finke C, Mignot E. HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease. Brain. 2024 Jul 5; 147 (7):2579-2592
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  11. Rada A, Hagemann A, Aaberg Poulsen C, Baumgartner T, Berki T, Blaabjerg M, Brenner J, Britton JW, Christiana A, Ciano-Petersen NL, Crijnen Y, Elisak M, Farina A, Friedman AR, Hayden Z, Hebert J, Holtkamp M, Hong Z, Honnorat J, Ilyas-Feldmann M, Irani SR, Kovac S, Marusic P, Muniz-Castrillo S, Ramanathan S, Smith KM, Steriade C, Strippel C, Surges R, Titulaer MJ, Uy CE, de Vries JM, Bien CG, Specht U. Risk of Seizure Recurrence Due to Autoimmune Encephalitis With NMDAR, LGI1, CASPR2, and GABA(B)R Antibodies: Implications for Return to Driving. Neurol Neuroimmunol Neuroinflamm. 2024 Jul; 11 (4):e200225 Epub 2024 June 04
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  12. Xiong W, Yeo T, May JTM, Demmers T, Ceronie B, Ramesh A, McGinty RN, Michael S, Torzillo E, Sen A, Anthony DC, Irani SR, Probert F. Distinct plasma metabolomic signatures differentiate autoimmune encephalitis from drug-resistant epilepsy. Ann Clin Transl Neurol. 2024 Jul; 11 (7):1897-1908 Epub 2024 June 21
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  13. Kelly MJ, Grant E, Murchison AG, Binks S, Ramanathan S, Michael S, Handel AE, Handunnetthi L, Uy CE, Soltys JN, Dubey D, Day GS, Lopez-Chiriboga AS, Flanagan EP, Sheerin F, Irani SR. Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis. JAMA Neurol. 2024 May 1; 81 (5):525-533
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  14. Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG, Taams LS, Menon DK, ISARIC4C Investigators//COVID-CNS Consortium. Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nat Commun. 2024 Apr 4; 15 (1):2918 Epub 2024 Apr 04
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  15. Michael S, Varley J, Williams R, Bajorek T, Easton A, Irani SR. Criminality in patients with autoimmune encephalitis: A case series. Eur J Neurol. 2024 Apr; 31 (4):e16197 Epub 2024 Jan 08
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  16. Binks SNM, Veldsman M, Handel AE, Jacob S, Maddison P, Coebergh J, Michael S, Ramanathan S, Easton A, Nissen MS, Leite MI, Okai D, Blaabjerg M, Husain M, Irani SR. Fatigue predicts quality of life after leucine-rich glioma-inactivated 1-antibody encephalitis. Ann Clin Transl Neurol. 2024 Apr; 11 (4):1053-1058 Epub 2024 Feb 01
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  17. Budhram A, Irani SR, Flanagan EP. Looking Beyond Syndrome-Based Criteria for Autoimmune Encephalitis-The Need for Complementary Neural Antibody-Based Diagnostic Criteria. JAMA Neurol. 2024 Mar 1; 81 (3):227-228
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  18. Handel AE, Irani SR, Leite MI. MOG-IgA as a Potential Marker of Germinal Center Activity. JAMA Neurol. 2024 Mar 1; 81 (3):297
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  19. Theorell J, Harrison R, Williams R, Raybould MIJ, Zhao M, Fox H, Fower A, Miller G, Wu Z, Browne E, Mgbachi V, Sun B, Mopuri R, Li Y, Waters P, Deane CM, Handel A, Makuch M, Irani SR. Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis. Proc Natl Acad Sci U S A. 2024 Feb 13; 121 (7):e2311049121 Epub 2024 Feb 06
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  20. Peris Sempere V, Luo G, Muniz-Castrillo S, Pinto AL, Picard G, Rogemond V, Titulaer MJ, Finke C, Leypoldt F, Kuhlenbaumer G, Jones HF, Dale RC, Binks S, Irani SR, Bastiaansen AE, de Vries JM, de Bruijn MAAM, Roelen DL, Kim TJ, Chu K, Lee ST, Kanbayashi T, Pollock NR, Kichula KM, Mumme-Monheit A, Honnorat J, Norman PJ, Mignot E, GENERATE study group. HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis. Front Immunol. 2024; 15:1423149 Epub 2024 July 10
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  21. Lee ST, Abboud H, Irani SR, Nakajima H, Piquet AL, Pittock SJ, Yeh EA, Wang J, Rajan S, Overell J, Smith J, St Lambert J, El-Khairi M, Gafarova M, Gelfand JM. Innovation and optimization in autoimmune encephalitis trials: the design and rationale for the Phase 3, randomized study of satralizumab in patients with NMDAR-IgG-antibody-positive or LGI1-IgG-antibody-positive autoimmune encephalitis (CIELO). Front Neurol. 2024; 15:1437913 Epub 2024 Aug 13
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  22. Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG, Taams LS, Menon DK, ISARIC4C Investigators//COVID-CNS Consortium. Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nat Commun. 2023 Dec 22; 14 (1):8487
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  23. Zivelonghi C, Dinoto A, Irani SR, McKeon A, Pilotto A, Padovani A, Masciocchi S, Magni E, Mancinelli CR, Capra R, Maniscalco GT, Volonghi I, Easton A, Alberti D, Zanusso G, Monaco S, Salvagno GL, Lippi G, Ferrari S, Mariotto S. SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study. Immunol Res. 2023 Oct; 71 (5):717-724 Epub 2023 May 12
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  24. Sell J, Rahmati V, Kempfer M, Irani SR, Ritzau-Jost A, Hallermann S, Geis C. Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability. Neurol Neuroimmunol Neuroinflamm. 2023 May; 10 (3) Epub 2023 Apr 07
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  25. Handel AE, Palace J, Bateman E, Waters P, Irani SR. Changes in the Rate of Leucine-Rich Glioma-Inactivated 1 Seropositivity During the COVID-19 Lockdown. JAMA Neurol. 2023 Apr 1; 80 (4):419-420
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  26. Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, Binks S, Zitser J, Gelfand JM, Day GS, Dunham SR, Rodenbeck SJ, Clardy SL, Solomon AJ, Pittock SJ, McKeon A, Dubey D, Zekeridou A, Toledano M, Turner LE, Vernino S, Irani SR. Autoimmune Encephalitis Misdiagnosis in Adults. JAMA Neurol. 2023 Jan 1; 80(1):30-39. Epub 1900 Jan 01.
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  27. Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, Binks S, Zitser J, Gelfand JM, Day GS, Dunham SR, Rodenbeck SJ, Clardy SL, Solomon AJ, Pittock SJ, McKeon A, Dubey D, Zekeridou A, Toledano M, Turner LE, Vernino S, Irani SR. Autoimmune Encephalitis Misdiagnosis in Adults. JAMA Neurol. 2023 Jan 1; 80 (1):30-39
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  28. Al-Diwani A, Theorell J, Damato V, Bull J, McGlashan N, Green E, Kienzler AK, Harrison R, Hassanali T, Campo L, Browne M, Easton A, Soleymani Majd H, Tenaka K, Iorio R, Dale RC, Harrison P, Geddes J, Quested D, Sharp D, Lee ST, Nauen DW, Makuch M, Lennox B, Fowler D, Sheerin F, Waters P, Leite MI, Handel AE, Irani SR. Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis. Brain. 2022 Aug 27; 145 (8):2742-2754
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  29. Damato V, Theorell J, Al-Diwani A, Kienzler AK, Makuch M, Sun B, Handel A, Akdeniz D, Berretta A, Ramanathan S, Fower A, Whittam D, Gibbons E, McGlashan N, Green E, Huda S, Woodhall M, Palace J, Sheerin F, Waters P, Leite MI, Jacob A, Irani SR. Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders. Proc Natl Acad Sci U S A. 2022 Jun 14; 119 (24):e2121804119 Epub 2022 June 06
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  30. Goebel A, Andersson D, Barker C, Basu N, Bullock C, Bevan S, Bashford-Rogers RJM, Choy E, Clauw D, Dulake D, Dulake R, Flor H, Glanvill M, Helyes Z, Irani S, Kosek E, Laird J, MacFarlane G, McCullough H, Marshall A, Moots R, Perrot S, Shenker N, Sher E, Sommer C, Svensson CI, Williams A, Wood G, Dorris ER. Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome. Pain Med. 2022 May 30; 23 (6):1084-1094
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  31. Peris Sempere V, Muniz-Castrillo S, Ambati A, Binks S, Pinto AL, Rogemond V, Pittock SJ, Dubey D, Geschwind MD, Gelfand JM, Dilwali S, Lee ST, Knight J, Elliott KS, Irani S, Honnorat J, Mignot E. Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2022 Mar; 9 (2) Epub 2022 Feb 03
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  32. Klar VS, Ang YS, Lockwood P, Attaallah B, Dickson S, Drew D, Kienast A, Maio MR, Plant O, Slavkova E, Toniolo S, Zambellas R, Irani SR, Husain M. Assessment of apathy in neurological patients using the Apathy Motivation Index caregiver version. J Neuropsychol. 2022 Mar; 16 (1):236-258 Epub 2021 Sept 16
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  33. Binks S, Uy C, Honnorat J, Irani SR. Paraneoplastic neurological syndromes: a practical approach to diagnosis and management. Pract Neurol. 2022 Feb; 22 (1):19-31 Epub 2021 Sept 11
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  34. Jacob S, Mazibrada G, Irani SR, Jacob A, Yudina A. The Role of Plasma Exchange in the Treatment of Refractory Autoimmune Neurological Diseases: a Narrative Review. J Neuroimmune Pharmacol. 2021 Dec; 16 (4):806-817 Epub 2021 Oct 02
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  35. Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M, Anlar B, Armangue T, Benseler S, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostasy K, Sakuma H, Sartori S, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK, International NMDAR Antibody Encephalitis Consensus Group. Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis. JAMA Neurol. 2021 Nov 1; 78 (11):1333-1344
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  36. Ramanathan S, Tseng M, Davies AJ, Uy CE, Paneva S, Mgbachi VC, Michael S, Varley JA, Binks S, Themistocleous AC, Fehmi J, Anziska Y, Soni A, Hofer M, Waters P, Brilot F, Dale RC, Dawes J, Rinaldi S, Bennett DL, Irani SR. Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons. Ann Neurol. 2021 Oct; 90(4):683-690. Epub 2021 Aug 30.
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  37. Uy CE, Binks S, Irani SR. Autoimmune encephalitis: clinical spectrum and management. Pract Neurol. 2021 Oct; 21 (5):412-423 Epub 2021 June 09
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  38. Handunnetthi L, Knezevic B, Kasela S, Burnham KL, Milani L, Irani SR, Fang H, Knight JC. Genomic Insights into Myasthenia Gravis Identify Distinct Immunological Mechanisms in Early and Late Onset Disease. Ann Neurol. 2021 Sep; 90 (3):455-463 Epub 2021 Aug 04
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  39. Irani SR, Nath A, Zipp F. The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain. Brain. 2021 Aug 17; 144 (7):e59
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  40. Graus F, Vogrig A, Muñiz-Castrillo S, Antoine JG, Desestret V, Dubey D, Giometto B, Irani SR, Joubert B, Leypoldt F, McKeon A, Prüss H, Psimaras D, Thomas L, Titulaer MJ, Vedeler CA, Verschuuren JJ, Dalmau J, Honnorat J. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 Jul; 8(4). Epub 2021 May 18.
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  41. Nosadini M, Thomas T, Eyre M, Anlar B, Armangue T, Benseler SM, Cellucci T, Deiva K, Gallentine W, Gombolay G, Gorman MP, Hacohen Y, Jiang Y, Lim BC, Muscal E, Ndondo A, Neuteboom R, Rostasy K, Sakuma H, Sharma S, Tenembaum SN, Van Mater HA, Wells E, Wickstrom R, Yeshokumar AK, Irani SR, Dalmau J, Lim M, Dale RC. International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2021 Jul; 8 (5) Epub 2021 July 22
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  42. Schanda K, Peschl P, Lerch M, Seebacher B, Mindorf S, Ritter N, Probst M, Hegen H, Di Pauli F, Wendel EM, Lechner C, Baumann M, Mariotto S, Ferrari S, Saiz A, Farrell M, Leite MIS, Irani SR, Palace J, Lutterotti A, Kumpfel T, Vukusic S, Marignier R, Waters P, Rostasy K, Berger T, Probst C, Hoftberger R, Reindl M. Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases. Neurol Neuroimmunol Neuroinflamm. 2021 Jul; 8 (5) Epub 2021 June 15
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  43. Binks SNM, Veldsman M, Easton A, Leite MI, Okai D, Husain M, Irani SR. Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis. JAMA Neurol. 2021 May 1; 78 (5):617-619
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  44. Ramanathan S, Al-Diwani A, Waters P, Irani SR. The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis. J Neurol. 2021 May; 268 (5):1689-1707 Epub 2019 Oct 26
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  45. Abboud H, Probasco J, Irani SR, Ances B, Benavides DR, Bradshaw M, Christo PP, Dale RC, Fernandez-Fournier M, Flanagan EP, Gadoth A, George P, Grebenciucova E, Jammoul A, Lee ST, Li Y, Matiello M, Morse AM, Rae-Grant A, Rojas G, Rossman I, Schmitt S, Venkatesan A, Vernino S, Pittock SJ, Titulaer M, Autoimmune Encephalitis Alliance Clinicians Network. Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management. J Neurol Neurosurg Psychiatry. 2021 Mar 1; 92 (8):897-907 Epub 2021 Mar 01
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  46. McGinty RN, Handel A, Moloney T, Ramesh A, Fower A, Torzillo E, Kramer H, Howell S, Waters P, Adcock J, Sen A, Lang B, Irani SR. Clinical features which predict neuronal surface autoantibodies in new-onset focal epilepsy: implications for immunotherapies. J Neurol Neurosurg Psychiatry. 2021 Mar; 92 (3):291-294 Epub 2020 Nov 20
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  47. MacKenzie G, Subramaniam S, Caldwell LJ, Fitzgerald D, Harrison NA, Hong S, Irani SR, Khandaker GM, Liston A, Miron VE, Mondelli V, Morgan BP, Pariante C, Shah DK, Taams LS, Teeling JL, Upthegrove R. Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030. Wellcome Open Res. 2021; 6:194 Epub 2021 July 29
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  48. Nishimura S, Kobayashi Y, Ohnishi H, Moriya K, Tsumura M, Sakata S, Mizoguchi Y, Takada H, Kato Z, Sancho-Shimizu V, Picard C, Irani SR, Ohara O, Casanova JL, Puel A, Ishikawa N, Okada S, Kobayashi M. IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation. J Clin Immunol. 2021 Jan; 41 (1):125-135 Epub 2020 Oct 20
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  49. Varley JA, Andersson M, Grant E, Berretta A, Zandi MS, Bondet V, Duffy D, Hunt D, Piehl F, Waters P, Irani SR. Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus. Ann Neurol. 2020 Dec; 88 (6):1244-1250 Epub 2020 Oct 06
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  50. Michael S, Waters P, Irani SR. Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2. Pract Neurol. 2020 Oct; 20 (5):377-384 Epub 2020 June 28
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  51. Sun B, Ramberger M, O'Connor KC, Bashford-Rogers RJM, Irani SR. The B cell immunobiology that underlies CNS autoantibody-mediated diseases. Nat Rev Neurol. 2020 Sep; 16 (9):481-492 Epub 2020 July 28
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  52. Uribe-San-Martin R, Ciampi E, Santibanez R, Irani SR, Marquez A, Cruz JP, Soler B, Miranda MC, Henriquez M, Carcamo C. LGI1-antibody associated epilepsy successfully treated in the outpatient setting. J Neuroimmunol. 2020 Aug 15; 345:577268 Epub 2020 May 23
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  53. Steriade C, Britton J, Dale RC, Gadoth A, Irani SR, Linnoila J, McKeon A, Shao XQ, Venegas V, Bien CG. Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune-associated epilepsy: Conceptual definitions. Epilepsia. 2020 Jul; 61 (7):1341-1351 Epub 2020 June 16
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  54. Ramberger M, Berretta A, Tan JMM, Sun B, Michael S, Yeo T, Theorell J, Bashford-Rogers R, Paneva S, O'Dowd V, Dedi N, Topia S, Griffin R, Ramirez-Franco J, El Far O, Baulac S, Leite MI, Sen A, Jeans A, McMillan D, Marshall D, Anthony D, Lightwood D, Waters P, Irani SR. Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms. Brain. 2020 Jun 1; 143 (6):1731-1745
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  55. Kim Y, Hyun JW, Woodhall MR, Oh YM, Lee JE, Jung JY, Kim SY, Lee MY, Kim SH, Kim W, Irani SR, Waters P, Choi K, Kim HJ. Refining cell-based assay to detect MOG-IgG in patients with central nervous system inflammatory diseases. Mult Scler Relat Disord. 2020 May; 40:101939 Epub 2020 Jan 09
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  56. Argyropoulos GPD, Moore L, Loane C, Roca-Fernandez A, Lage-Martinez C, Gurau O, Irani SR, Zeman A, Butler CR. Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis. Neurology. 2020 Mar 24; 94 (12):e1320-e1335 Epub 2020 Jan 24
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  57. Reindl M, Schanda K, Woodhall M, Tea F, Ramanathan S, Sagen J, Fryer JP, Mills J, Teegen B, Mindorf S, Ritter N, Krummrei U, Stocker W, Eggert J, Flanagan EP, Ramberger M, Hegen H, Rostasy K, Berger T, Leite MI, Palace J, Irani SR, Dale RC, Probst C, Probst M, Brilot F, Pittock SJ, Waters P. International multicenter examination of MOG antibody assays. Neurol Neuroimmunol Neuroinflamm. 2020 Mar 5; 7 (2) Epub 2020 Feb 05
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  58. Lehmann-Horn K, Irani SR, Wang S, Palanichamy A, Jahn S, Greenfield AL, Dandekar R, Lepennetier G, Michael S, Gelfand JM, Geschwind MD, Wilson MR, Zamvil SS, von Budingen HC. Intrathecal B-cell activation in LGI1 antibody encephalitis. Neurol Neuroimmunol Neuroinflamm. 2020 Mar; 7 (2) Epub 2020 Feb 06
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  59. Xu M, Bennett DLH, Querol LA, Wu LJ, Irani SR, Watson JC, Pittock SJ, Klein CJ. Pain and the immune system: emerging concepts of IgG-mediated autoimmune pain and immunotherapies. J Neurol Neurosurg Psychiatry. 2020 Feb; 91(2):177-188. Epub 2018 Sep 17.
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  60. Dubey D, Britton J, McKeon A, Gadoth A, Zekeridou A, Lopez Chiriboga SA, Devine M, Cerhan JH, Dunlay K, Sagen J, Ramberger M, Waters P, Irani SR, Pittock SJ. Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy. Ann Neurol. 2020 Feb; 87 (2):313-323 Epub 2019 Dec 14
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  61. Miller TD, Chong TT, Aimola Davies AM, Johnson MR, Irani SR, Husain M, Ng TW, Jacob S, Maddison P, Kennard C, Gowland PA, Rosenthal CR. Human hippocampal CA3 damage disrupts both recent and remote episodic memories. Elife. 2020 Jan 24; 9
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  62. Williams D, McGlasson S, Irani SR, Duffy D, Crow Y, Hunt D; Scottish NMOSD study group. Neuromyelitis optica in patients with increased interferon alpha concentrations Lancet Neurology. 2020; 19(1).
  63. Chen H, Wu J, Irani SR. Distinctive Magnetic Resonance Imaging Findings in IgLON5 Antibody Disease. JAMA Neurol. 2020 Jan 1; 77 (1):125-126
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  64. Waters P, Fadda G, Woodhall M, O'Mahony J, Brown RA, Castro DA, Longoni G, Irani SR, Sun B, Yeh EA, Marrie RA, Arnold DL, Banwell B, Bar-Or A, Canadian Pediatric Demyelinating Disease Network. Serial Anti-Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes. JAMA Neurol. 2020 Jan 1; 77 (1):82-93
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  65. Romoli M, Krashia P, Sen A, Franciotta D, Gastaldi M, Nobili A, Mancini A, Nardi Cesarini E, Nigro P, Tambasco N, Mercuri NB, Parnetti L, Di Filippo M, D'Amelio M, Irani SR, Costa C, Calabresi P. Hippocampal epileptogenesis in autoimmune encephalitis. Ann Clin Transl Neurol. 2019 Nov; 6 (11):2261-2269 Epub 2019 Oct 15
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  66. Crisp SJ, Dixon CL, Jacobson L, Chabrol E, Irani SR, Leite MI, Leschziner G, Slaght SJ, Vincent A, Kullmann DM. Glycine receptor autoantibodies disrupt inhibitory neurotransmission. Brain. 2019 Nov 1; 142 (11):3398-3410
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  67. Loane C, Argyropoulos GPD, Roca-Fernandez A, Lage C, Sheerin F, Ahmed S, Zamboni G, Mackay C, Irani SR, Butler CR. Hippocampal network abnormalities explain amnesia after VGKCC-Ab related autoimmune limbic encephalitis. J Neurol Neurosurg Psychiatry. 2019 Sep; 90 (9):965-974 Epub 2019 May 09
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  68. Argyropoulos GP, Loane C, Roca-Fernandez A, Lage-Martinez C, Gurau O, Irani SR, Butler CR. Network-wide abnormalities explain memory variability in hippocampal amnesia. Elife. 2019 Jul 8; 8 Epub 2019 July 08
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  71. Hyun JW, Huh SY, Shin HJ, Woodhall M, Kim SH, Irani SR, Lee SH, Waters P, Kim HJ. Evaluation of brain lesion distribution criteria at disease onset in differentiating MS from NMOSD and MOG-IgG-associated encephalomyelitis. Mult Scler. 2019 Apr; 25 (4):585-590 Epub 2018 Mar 07
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  78. Jang Y, Lee ST, Bae JY, Kim TJ, Jun JS, Moon J, Jung KH, Park KI, Irani SR, Chu K, Lee SK. LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis. J Neuroinflammation. 2018 Sep 25; 15 (1):279 Epub 2018 Sept 25
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  81. Berridge G, Menassa DA, Moloney T, Waters PJ, Welding I, Thomsen S, Zuberi S, Fischer R, Aricescu AR, Pike M, Dale RC, Kessler B, Vincent A, Lim M, Irani SR, Lang B. Glutamate receptor delta2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome. Neurology. 2018 Aug 21; 91 (8):e714-e723 Epub 2018 July 25
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  82. Binks S, Varley J, Lee W, Makuch M, Elliott K, Gelfand JM, Jacob S, Leite MI, Maddison P, Chen M, Geschwind MD, Grant E, Sen A, Waters P, McCormack M, Cavalleri GL, Barnardo M, Knight JC, Irani SR. Distinct HLA associations of LGI1 and CASPR2-antibody diseases. Brain. 2018 Aug 1; 141 (8):2263-2271
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  85. Wilson R, Menassa DA, Davies AJ, Michael S, Hester J, Kuker W, Collins GP, Cossins J, Beeson D, Steven N, Maddison P, Rinaldi S, Jacob S, Irani SR. Seronegative antibody-mediated neurology after immune checkpoint inhibitors. Ann Clin Transl Neurol. 2018 May; 5 (5):640-645 Epub 2018 Mar 25
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  86. Wilson R, Makuch M, Kienzler AK, Varley J, Taylor J, Woodhall M, Palace J, Leite MI, Waters P, Irani SR. Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica. Brain. 2018 Apr 1; 141 (4):1063-1074
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  90. Nantes JC, Thomas AG, Voets NL, Best JG, Rosenthal CR, Al-Diwani A, Irani SR, Stagg CJ. Hippocampal Functional Dynamics Are Clinically Implicated in Autoimmune Encephalitis With Faciobrachial Dystonic Seizures. Front Neurol. 2018; 9:736 Epub 2018 Sept 04
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  92. Al-Diwani AAJ, Pollak TA, Irani SR, Lennox BR. Psychosis: an autoimmune disease? Immunology. 2017 Nov; 152 (3):388-401 Epub 2017 Aug 03
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  93. Hyun JW, Woodhall MR, Kim SH, Jeong IH, Kong B, Kim G, Kim Y, Park MS, Irani SR, Waters P, Kim HJ. Longitudinal analysis of myelin oligodendrocyte glycoprotein antibodies in CNS inflammatory diseases. J Neurol Neurosurg Psychiatry. 2017 Oct; 88 (10):811-817 Epub 2017 July 06
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  94. Nibber A, Mann EO, Pettingill P, Waters P, Irani SR, Kullmann DM, Vincent A, Lang B. Pathogenic potential of antibodies to the GABA(B) receptor. Epilepsia Open. 2017 Sep; 2 (3):355-359 Epub 2017 July 19
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  96. Miller TD, Chong TT, Aimola Davies AM, Ng TWC, Johnson MR, Irani SR, Vincent A, Husain M, Jacob S, Maddison P, Kennard C, Gowland PA, Rosenthal CR. Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis. Brain. 2017 May 1; 140 (5):1212-1219
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  115. Morales-Briceno H, Rodriguez-Violante M, Cervantes-Arriaga A, Irani SR, Lees AJ, Silveira-Moriyama L. Opsoclonus myoclonus syndrome associated with GQ1b antibodies. Mov Disord. 2012 Nov; 27 (13):1615-6
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  127. Vincent A, Irani SR. Caspr2 antibodies in patients with thymomas. J Thorac Oncol. 2010 Oct; 5 (10 Suppl 4):S277-80
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  128. Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain. 2010 Sep; 133 (9):2734-48 Epub 2010 July 27
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  129. Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, Zandi MS, Friese MA, Galea I, Kullmann DM, Beeson D, Lang B, Bien CG, Vincent A. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain. 2010 Jun; 133 (Pt 6):1655-67
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  130. Vincent A, Irani SR, Lang B. The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins. Curr Opin Neurol. 2010 Apr; 23 (2):144-50
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  131. Davies G, Irani SR, Coltart C, Ingle G, Amin Y, Taylor C, Radcliffe J, Hirsch NP, Howard RS, Vincent A, Kullmann DM. Anti-N-methyl-D-aspartate receptor antibodies: a potentially treatable cause of encephalitis in the intensive care unit. Crit Care Med. 2010 Feb; 38 (2):679-82
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  134. Soni A, Irani SR, Lang B, Taghipour K, Mann R, Vincent A, Collins D. Immunotherapy: responsive autoimmune encephalopathy associated with bullous pemphigoid. J Neurol Neurosurg Psychiatry 2009 Dec; 80 (12):1412-3
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  135. Dale RC, Irani SR, Brilot F, Pillai S, Webster R, Gill D, Lang B, Vincent A. N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica. Ann Neurol. 2009 Nov; 66 (5):704-9
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  142. Hogervorst E, Bandelow S, Combrinck M, Irani SR, Smith AD. The validity and reliability of 6 sets of clinical criteria to classify Alzheimer's disease and vascular dementia in cases confirmed post-mortem: added value of a decision tree approach. Dement Geriatr Cogn Disord. 2003; 16 (3):170-80
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