Chris Hartley, M.D.

  1. Pathologist
  1. Marya NB, Powers PD, Bois MC, Hartley C, Kerr SE, Thangaiah JJ, Norton D, Abu Dayyeh BK, Cantley R, Chandrasekhara V, Gores G, Gleeson FC, Law RJ, Maleki Z, Martin JA, Pantanowitz L, Petersen B, Storm AC, Levy MJ, Graham RP. Utilization of an artificial intelligence-enhanced, web-based application to review bile duct brushing cytologic specimens: A pilot study. Cancer Cytopathol. 2024 Aug 29 [Epub ahead of print]
    View PubMed
  2. Wu C, Pai RK, Kosiorek H, Banerjee I, Pfeiffer A, Hagen CE, Hartley CP, Graham RP, Sonbol MB, Bekaii-Saab T, Xie H, Sinicrope FA, Patel B, Westerling-Bui T, Shivji S, Conner J, Swallow C, Savage P, Cyr DP, Kirsch R, Pai RK. Improved Risk-Stratification Scheme for Mismatch-Repair Proficient Stage II Colorectal Cancers Using the Digital Pathology Biomarker QuantCRC. Clin Cancer Res. 2024 May 1; 30 (9):1811-1821
    View PubMed
  3. Yasir S, Chen ZE, Hartley C, Zhang L, Torbenson M. Morphological findings in different subtypes of hepatic amyloid. Hum Pathol. 2024 Apr; 146:35-42 Epub 2024 Mar 07
    View PubMed
  4. Righi FA, Vander Heide RS, Graham RP, Aubry MC, Trejo-Lopez JA, Bois MC, Roden AC, Reichard R, Maleszewski JJ, Alexander MP, Quinton RA, Jenkins SM, Hartley CP, Hagen CE. A case-control autopsy series of liver pathology associated with novel coronavirus disease (COVID-19). Ann Diagn Pathol. 2024 Feb; 68:152240 Epub 2023 Nov 20
    View PubMed
  5. Yu Lee-Mateus A, Sawal N, Hartley C, Edell E, Vierkant RA, Reisenauer J. Efficacy of Robotic Bronchoscopy for Molecular Marker Analysis in Primary Lung Cancer. Clin Lung Cancer. 2024 Jan; 25 (1):e11-e17 Epub 2023 Oct 12
    View PubMed
  6. Marya NB, Hartley C, Powers PD, Bois MC, Kerr SE, Graham RP, Levy MJ, UMass-Mayo Clinic AI Cytopathology Consortium, Gleeson F, Abu Dayyeh BK, Bofill-Garcia A, Chandrasekhara V, Gores G, Kipp B, Law RJ, Petersen B, Roberts LR, Storm AC, Vargas Valls EJ. Development of a Computer-aided Prediction Tool for Evaluating Brushing Samples of Biliary Strictures. Clin Gastroenterol Hepatol. 2024 Jan; 22 (1):185-187.e3 Epub 2023 Mar 24
    View PubMed
  7. Vu LH, Yu Lee-Mateus A, Edell ES, Hartley C, Vierkant RA, Fernandez-Bussy S, Reisenauer J. Accuracy of Preliminary Pathology for Robotic Bronchoscopic Biopsy. Ann Thorac Surg. 2023 Nov; 116(5):1028-1034. Epub 2022 Dec 05.
    View PubMed
  8. Burr SD, Chen Y, Hartley CP, Zhao X, Liu J. Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor. Sci Rep. 2023 Oct 6; 13 (1):16832 Epub 2023 Oct 06
    View PubMed
  9. Ricaurte Archila L, Smith L, Sihvo HK, Koponen V, Jenkins SM, O'Sullivan DM, Cardenas Fernandez MC, Wang Y, Sivasubramaniam P, Patil A, Hopson PE, Absah I, Ravi K, Mounajjed T, Dellon ES, Bredenoord AJ, Pai R, Hartley CP, Graham RP, Moreira RK. Performance of an Artificial Intelligence Model for Recognition and Quantitation of Histologic Features of Eosinophilic Esophagitis on Biopsy Samples. Mod Pathol. 2023 Oct; 36 (10):100285 Epub 2023 July 18
    View PubMed
  10. Patil A, Salvatori R, Smith L, Jenkins SM, Cannon A, Hartley CP, Graham RP, Moreira RK. Artificial intelligence-based reticulin proportionate area - a novel histological outcome predictor in hepatocellular carcinoma. Histopathology. 2023 Oct; 83 (4):512-525 Epub 2023 June 30
    View PubMed
  11. Sivasubramaniam P, Stokes N, Patil A, Smith L, Hartley CP, Graham RP, Moreira RK. Digital Hepatic Iron Content: An Artificial Intelligence Model for Spatially Resolved Histologic Iron Quantitative Analysis in Liver Samples. Lab Invest. 2023 Sep; 103 (9):100200 Epub 2023 June 16
    View PubMed
  12. Naso JR, Chan J, Reisenauer J, Edell ES, Stackhouse K, Bungum AO, Vierkant RA, Pierson K, Seidl A, Sturgis CD, Meroueh C, Huang Y, Hartley CP. Remotely operated robotic microscopy for rapid diagnosis of bronchoscopic cytology specimens. Diagn Cytopathol. 2023 Sep; 51 (9):554-562 Epub 2023 June 08
    View PubMed
  13. Duke JD, Sturgis CD, Hartley C, Bailey M, Reid M, Kern R, Bluestone A, Subramanian H, Reisenauer J. Evaluation of automated sample preparation system for lymph node sampling. J Thorac Dis. 2023 Aug 31; 15 (8):4229-4236 Epub 2023 July 21
    View PubMed
  14. Baban F, Koepplin JW, Ahmad M, Clarke-Brodber AL, Bois MC, Hartley CP, Sturgis CD. TRPS1 outperforms GATA3 in pleural effusions with metastatic breast carcinoma versus mesothelioma. Diagn Cytopathol. 2023 Aug; 51 (8):488-492 Epub 2023 Apr 25
    View PubMed
  15. Jawaid T, Swanson AA, Bois MC, Folpe AL, Rivera M, Hartley CP, Sturgis CD. Lymphangioleiomyomatosis in lymph node cytology: Another "Floating Island" to visit. Diagn Cytopathol. 2023 Jun; 51 (6):E204-E208 Epub 2023 Mar 28
    View PubMed
  16. Garcia Garcia de Paredes A, Hartley C, Hernandez-Lara AH, AbiMansour JP, Valls EJV, Pruthi RK, Graham RP, Storm AC, Gleeson FC, Levy MJ, Rajan E. Safety of endoscopic ultrasound-guided tissue acquisition with uninterrupted direct oral anticoagulation in a swine model. Endosc Int Open. 2023 Apr; 11(4):E413-E418. Epub 2023 Apr 28.
    View PubMed
  17. Baban F, Auen T, Eschbacher KL, Swanson AA, Hartley CP. Invasive urothelial carcinoma with squamous differentiation and associated high-risk human papilloma virus infection: Clinical, cytologic, and histologic features of a rare entity. Ann Diagn Pathol. 2023 Apr; 63:152103 Epub 2023 Jan 05
    View PubMed
  18. Rozenova KA, Roden AC, Hartley C, Peterson JF, Otteson GE, Al-Kali A, Fuentes Bayne HE, Shah MV, Patnaik MS, King RL, Larson DP. Dedifferentiation of B-lymphoblastic leukemia/lymphoma with t(9;22) BCR::ABL1 to an undifferentiated neoplasm with strong keratin expression in a patient receiving blinatumomab. Hum Pathol Rep. 2023; 31:1-5.
  19. Thangaiah JJ, Venable ER, Sivasubramaniam P, Tiegs-Heiden C, Rech KL, Hartley CP. Erdheim-Chester disease: Cytomorphologic clues for a rare histiocytic neoplasm including a distinct tigroid background pattern on smears. Ann Diagn Pathol. 2022 Oct; 60:151998. Epub 2022 Jun 21.
    View PubMed
  20. Clarke-Brodber AL, Hartley CP, Ahmed F, Thangaiah JJ, Tiegs-Heiden C, Hagen CE. Desmoid fibromatosis involving the pancreas: A retrospective case series with clinical, cytopathologic and radiologic correlation. Ann Diagn Pathol. 2022 Oct; 60:152015 Epub 2022 July 22
    View PubMed
  21. Farooq A, Gonzalez IA, Byrnes K, Jenkins SM, Hartley CP, Hagen CE. Multi-institutional development and validation of a novel histologic grading system for colonic graft-versus-host disease. Mod Pathol. 2022 Sep; 35 (9):1254-1261 Epub 2022 Apr 01
    View PubMed
  22. Firwana M, Clarke-Brodber AL, King RL, Dalland JC, Hartley CP, Boire NA, Sturgis CD. Cyto-histologic correlation of crystal-storing histiocytosis: Rare presentation in breast, predating diagnosis of B-cell lymphoma by two years. Ann Diagn Pathol. 2022 Aug; 59:151979 Epub 2022 May 18
    View PubMed
  23. Zhu M, Chen C, Foster NR, Hartley C, Mounajjed T, Salomao MA, Fruth BF, Beamer SE, Kim Y, Harrington SM, Pitot HC, Sanhueza CT, Feng Y, Herrmann J, McWilliams RR, Lucien F, Huang BQ, Ma WW, Bekaii-Saab TS, Dong H, Wigle D, Ahn DH, Hallemeier CL, Blackmon S, Yoon HH. Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction. Clin Cancer Res. 2022 Jul 15; 28 (14):3021-3031
    View PubMed
  24. McCarthy MR, Tiegs-Heiden CA, Sturgis CD, Swanson AA, Gupta S, Thangaiah JJ, Hartley CP. Biphasic squamoid alveolar renal cell carcinoma: Cytologic features of a rare entity. Ann Diagn Pathol. 2022 Jun; 58:151906 Epub 2022 Feb 03
    View PubMed
  25. Sivasubramaniam P, Tiegs-Heiden CA, Geiersbach KB, Hagen CE, Sturgis CD, Thangaiah JJ, Hartley CP. Mammary analogue secretory carcinoma: A challenging case arising in a young man with radiation exposure. Ann Diagn Pathol. 2022 Apr; 57:151862 Epub 2021 Nov 22
    View PubMed
  26. Jophlin LL, Hartley CP, Katzka DA. Ectopic Esophageal Sebaceous Glands. Clin Gastroenterol Hepatol. 2022 Apr; 20 (4):e647 Epub 2020 Dec 03
    View PubMed
  27. Lor K, Hartley CP, Pritt BS, Kemp AM, Swanson AA, Sturgis CD. Multiple Consecutive Cervicovaginal Cytology Specimens Confirm Persistent Colonization by Cokeromyces recurvatus: Case Report and Literature Review. Case Rep Pathol. 2022; 2022:2151926 Epub 2022 May 13
    View PubMed
  28. Archila LR, Smith L, Sihvo HK, Westerling-Bui T, Koponen V, O'Sullivan DM, Fernandez MCC, Alexander EE, Wang Y, Sivasubramaniam P, Patil A, Hopson PE, Absah I, Ravi K, Mounajjed T, Pai R, Hagen C, Hartley C, Graham RP, Moreira RK. Development and technical validation of an artificial intelligence model for quantitative analysis of histopathologic features of eosinophilic esophagitis. J Pathol Inform. 2022; 13:100144 Epub 2022 Sept 27
    View PubMed
  29. Sivasubramaniam P, Tiegs-Heiden CA, Sturgis CD, Hagen CE, Hartley CP, Thangaiah JJ. Malignant gastrointestinal neuroectodermal tumor: Cytologic, histologic, immunohistochemical, and molecular pitfalls. Ann Diagn Pathol. 2021 Dec; 55:151813 Epub 2021 Sept 06
    View PubMed
  30. Nisar US, Erickson LA, Folpe AL, Hartley CP, Littrell LA, Adamo DA, Sturgis CD. Eccrine angiomatous hamartoma: First case in the cytology literature. Ann Diagn Pathol. 2021 Oct; 54:151796 Epub 2021 July 17
    View PubMed
  31. Choi C, Osman K, Hartley CP, Maselli DB. Cholecystocolonic fistula as an uncommon cause of diarrhea: a case-report and review of the literature. Clin J Gastroenterol. 2021 Aug; 14 (4):1147-1151 Epub 2021 Apr 10
    View PubMed
  32. Swanson AA, Hartley C, Long ME, Chantigian PDM, Casey PM, Jenkins SM, Boerger AC, Binnicker MJ, Henry MR. Evaluation of high-risk human papillomavirus testing and anal cytology to detect high-grade anal intraepithelial neoplasia. J Am Soc Cytopathol. 2021 Jul-Aug; 10 (4):406-413 Epub 2021 Apr 06
    View PubMed
  33. Gonzalez IA, Hartley CP, Nalbantoglu I. Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft. Am J Clin Pathol. 2021 Feb 11; 155 (3):435-445
    View PubMed
  34. Lian X, Bond JS, Bharathy N, Boudko SP, Pokidysheva E, Shern JF, Lathara M, Sasaki T, Settelmeyer T, Cleary MM, Bajwa A, Srinivasa G, Hartley CP, Bachinger HP, Mansoor A, Gultekin SH, Berlow NE, Keller C. Defining the Extracellular Matrix of Rhabdomyosarcoma. Front Oncol. 2021; 11:601957 Epub 2021 Feb 23
    View PubMed
  35. Farooq A, Evans JJ, Hagen CE, Hartley CP. Lymphoepithelial cyst of the pancreas: A challenging diagnosis on fine needle aspiration. Ann Diagn Pathol. 2020 Dec; 49:151603 Epub 2020 Aug 21
    View PubMed
  36. Terra SBSP, Henry MR, Pritt BS, Hartley CP, Zanish JM, Chua HK, Sturgis CD. Incidental Giardia duodenalis cysts in exfoliative anal cytology: An immunocompetent adult female with prior squamous dysplasia. Diagn Cytopathol. 2020 Nov; 48 (11):1141-1143 Epub 2020 May 30
    View PubMed
  37. Kravtsov O, Hartley CP, Sheinin Y, Hunt BC, Felix JC, Giorgadze T. Utility of PD-L1 testing on non-small cell lung cancer cytology specimens: An institutional experience with interobserver variability analysis. Ann Diagn Pathol. 2020 Oct; 48:151602 Epub 2020 Aug 21
    View PubMed
  38. Hagen CE, Christians K, Hopp A, Giorgadze T, Hartley CP, Hunt B, Basturk O, Klimstra D. Intraductal papillary squamous neoplasm of the pancreas: Cyto-histologic correlation of a novel entity. Ann Diagn Pathol. 2020 Oct; 48:151583 Epub 2020 Aug 13
    View PubMed
  39. Hartley C, Rowan D, Chen X, Gomez-Arellano L, West AM, Oshima K, Mackinnon AC. Increased SPARC expression is associated with neoadjuvant therapy in resectable pancreatic ductal adenocarcinoma. Pract Lab Med. 2020 Aug; 21:e00171 Epub 2020 May 29
    View PubMed
  40. Rowan DJ, Hartley CP, Aldakkak M, Christians KK, Evans DB, Tsai S, Hagen CE. Gross tumor size using the AJCC 8th ed. T staging criteria does not provide prognostic stratification for neoadjuvant treated pancreatic ductal adenocarcinoma. Ann Diagn Pathol. 2020 Jun; 46:151485 Epub 2020 Mar 06
    View PubMed
  41. Mostafa M, Hartley CP, Hagen CE. Evaluation of the lower histologic threshold for gastric graft versus host disease. Mod Pathol. 2019 Dec 19 [Epub ahead of print]
    View PubMed
  42. Mostafa M, Abdelkader A, Evans JJ, Hagen CE, Hartley CP. Fatty Liver Disease: A Practical Approach. Arch Pathol Lab Med. 2020 Jan; 144 (1):62-70 Epub 2019 Oct 11
    View PubMed
  43. Mostafa M, Abdelkader A, Hagen C, Hartley C. Fatty Liver Disease: A Practical Approach Arch Pathol Lab Med. 2019. Epub 2019 Oct 11.
  44. Abdelkader A, Hunt B, Hartley C, Panarelli NC, Giorgadze T. Cystic lesions of the pancreas: Differential diagnosis and cytologic-histologic correlation Arch Pathol Lab Med. 2019.
  45. Holmen IC, Oakey Z, Raven M, Hartley C, Altaweel M. Minimally invasive 27-Gauge victrectomy for Coats' Disease detachment Journal of VitreoRetinal Diseases. 2019; 2(5):312 - 315.
  46. Farooq A, Goyal A, Giorgadze T, Scherr G, Evans JJ, Hartley C. Cytomorphological features of glomus tumors arising in the stomach: A series of two cases doagnosed on FNA Annals of Diagnostic Pathology. 2019.
  47. Kravtsov O, Hartley C, Comperat EM, Iczkowski KA. KIF3B protein expression loss correlates with metastatic ability of prostate cancer Am J Clin Exp Urol. 2019; 7(3):178 - 181.
  48. Hartley C, Carrillo-Polanco LF, Rowan DJ, Hagen CE. Colonic graft-vs.-host disease in autologus versis allogeneic transplant patients: Earlier onset, more apoptosis, and lack of regulatory T-cell attenuaiton Modern Pathology. 2018; 31(10):1619 -- 1626. Epub 2018 Jun 13.
  49. Hartley CP, Carrillo-Polanco LF, Rowan DJ, Hagen CE. Colonic graft-vs.-host disease in autologous versus allogeneic transplant patients: earlier onset, more apoptosis, and lack of regulatory T-cell attenuation. Mod Pathol. 2018 Oct; 31 (10):1619-1626 Epub 2018 June 13
    View PubMed
  50. Mostafa M, Flynn T, Hartley C, Ledeboer NA, Buchan BW. Effective utilization of C. difficile PCR and identification of clinicopathologic features associated with conversion to a positive result in symptomatic patients Diagn Microbiol Infect Dis. 2018; 90(4):307 - 310. Epub 2017 Dec 06.
  51. Hartley C, Vaughan JW, Jarzembowski J, Kroft SH, Hosking P, Harrington AM, Olteanu H. CD30 Expression in Monomorphic Posttransplant Lymphoproliferative Disorder, Diffuse Large B-Cell Lymphoma Correlates With Greater Regulatory T-Cell Infiltration. Am J Clin Pathol. 2017 Nov 20; 148 (6):485-493
    View PubMed
  52. Hartley C, Mahajan AM, Selvaggi SM, Rehrauer WM. RNA smears of pancreatic ductal adenocarcinoma are superior to formalin-fixed paraffin-embedded tissue as a source of DNA: Comparison of targeted KRAS amplificaiton and genotyping in matched preresection and postresection Cancer Cytopathology. 2017; 125(11):838 - 847.
  53. Hartley C, Kwiakowski DJ, Hamieh L, Lefferts JA, Smith KD, Lisovsky M. Pancreatic PEComa is a novel member of the family of tuberous sclerosis complex-associated tumors: Case reports and review fo the literature Virchows Archiv. 2016; 469(6):7407 - 710.
  54. Rowan DJ, Hartley CP, Carrillo-Polanco LF, Oshima K, Hagen CE. Diagnostic phrasing is independently correlated with the decision to treat for graft-versus-host disease: retrospective review of colon biopsies with rare apoptosis. Histopathology. 2016 Nov; 69 (5):802-811 Epub 2016 July 22
    View PubMed
  55. Hartley C, Regenmorter V, Rao N. Broncholithiasis: From the age of Aristotle to the Era of Surgical Pathology Curr Respir Med Rev. 2016; 12(2):152 - 156.
  56. Hembrough T, Liao WL, Hartley C, Ma PC, Velcheti V, Lanigan C, Thyparambil S, An E, Monga M, Krizman D, Burrows J, Tafe LJ. Quantification o fAmaplastic Lymphoma Kinases Protein expression in Non-small lung cancer tissues from patients treated with Crizotinib Clinical Chemistry. 2016; 62(1):252 - 261.
  57. Hartley C, Steinmetz HB, Memoli VA, Tafe LJ. Small cell neuroendocrine carcinomas o fthe lung do not harbor high-risk human papillomavirus (HR-HPV) Hum Pathol. 2015; 46(4):577 - 582.
  58. Fearing BV, Hartley C, Dayton OL, Sherwood G, AbouShwareb T, Van ME. Treatment of a spinal coard hemitransection injury with Keratin Biomaterial Hydrogel elecits recovery and tissue repair ISRN Biomaterials. 2014; 1 - 9.