Patricio Escalante, M.D., M.S.
Critical Care Specialist
Pulmonologist
Sleep Medicine Specialist
Marty PK, Pathakumari B, Cox TM, Van Keulen VP, Erskine CL, Shah M, Vadiyala M, Arias-Sanchez P, Karnakoti S, Pennington KM, Theel ES, Lindestam Arlehamn CS, Peikert T,
Escalante P
. Multiparameter immunoprofiling for the diagnosis and differentiation of progressive versus nonprogressive nontuberculous mycobacterial lung disease-A pilot study. PLoS One. 2024; 19 (4):e0301659 Epub 2024 Apr 19
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Pathakumari B, Marty PK, Shah M, Van Keulen VP, Erskine CL, Block MS, Arias-Sanchez P,
Escalante P
, Peikert T. Convalescent Adaptive Immunity Is Highly Heterogenous after SARS-CoV-2 Infection. J Clin Med. 2023 Nov 16; 12 (22)
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Escalante P
, Vadiyala MR, Pathakumari B, Marty PK, Van Keulen VP, Hilgart HR, Meserve K, Theel ES, Peikert T, Bailey RC, Laniado-Laborin R. New diagnostics for the spectrum of asymptomatic TB: from infection to subclinical disease. Int J Tuberc Lung Dis. 2023 Jul 1; 27 (7):499-505
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Marty PK, Yetmar ZA, Gerberi DJ,
Escalante P
, Pennington KM, Mahmood M. Risk factors and outcomes of non-tuberculous mycobacteria infection in lung transplant recipients: A systematic review and meta-analysis. J Heart Lung Transplant. 2023 Feb; 42(2):264-274. Epub 2022 Oct 12.
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Weathered C, Pennington K,
Escalante P
, Pienaar E. Agent-based model indicates chemoattractant signaling caused by Mycobacterium avium biofilms in the lung airway increases bacterial loads by spatially diverting macrophages. Tuberculosis (Edinb) 2023 Jan; 138:102300 Epub 2022 Dec 25
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Palacios-Gutierrez JJ, Rodriguez-Guardado A, Arias-Guillen M, Alonso-Arias R, Palacios-Penedo S, Garcia-Garcia JM, Balbin M, Perez-Hernandez D, Sandoval-Torrientes M, Torreblanca-Gil A, Melon S, Asensi-Alvarez V, Clain JM,
Escalante P
. Clinical and Epidemiological Correlates of Low IFN-Gamma Responses in Mitogen Tube of QuantiFERON Assay in Tuberculosis Infection Screening During the COVID-19 Pandemic: A Population-Based Marker of COVID-19 Mortality? Arch Bronconeumol. 2022 Sep; 58 (9):649-659 Epub 2022 Feb 13
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Nesbitt N, Martin MJ,
Escalante P
. 65-Year-Old Man With Weight Loss and Dyspnea on Exertion. Mayo Clin Proc. 2022 Jul; 97 (7):1363-1368
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Pennington KM, Katta R, Weathered C, Pienaar E,
Escalante P
. Characteristics and outcomes of anti-mycobacterial therapy compared to no anti-mycobacterial therapy for NTM pulmonary disease. Respir Med. 2022 Jun; 197:106829 Epub 2022 Mar 24
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Cullen GD, Tabaja H, Ogbonna CP, Menze AK,
Escalante P
, Wilson JW. Disseminated Tuberculosis in an Immunocompetent Patient Associated With the Use of Contaminated Bone Matrix Graft in Spine Surgery Infectious Diseases in Clinical Practice. 2022; 30(2):e1125.
Weathered C, Pennington K,
Escalante P
, Pienaar E. The Role of Biofilms, Bacterial Phenotypes, and Innate Immune Response in Mycobacterium avium Colonization to Infection. J Theor Biol. 2022 Feb 7; 534:110949 Epub 2021 Oct 27
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Marty PK, Van Keulen VP, Erskine CL, Shah M, Hummel A, Stachowitz M, Fatis S, Granger D, Block MS, Duarte-Garcia A, Warrington KJ, Theel ES, Zhou X, Zeng H, Specks U,
Escalante P
, Peikert T. Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting Therapy. Front Immunol. 2022; 13:834981 Epub 2022 Jan 28
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Stroh GR, Peikert T,
Escalante P
. Active and latent tuberculosis infections in patients treated with immune checkpoint inhibitors in a non-endemic tuberculosis area. Cancer Immunol Immunother. 2021 Nov; 70 (11):3105-3111 Epub 2021 Mar 26
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Robison HM, Chapman CA, Zhou H, Erskine CL, Theel E, Peikert T, Lindestam Arlehamn CS, Sette A, Bushell C, Welge M, Zhu R, Bailey RC,
Escalante P
. Risk assessment of latent tuberculosis infection through a multiplexed cytokine biosensor assay and machine learning feature selection. Sci Rep. 2021 Oct 15; 11 (1):20544
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McGarvey L, Rubin BK, Ebihara S, Hegland K, Rivet A, Irwin RS, Bolser DC, Chang AB, Gibson PG, Mazzone SB, CHEST Expert Cough Panel. Global Physiology and Pathophysiology of Cough: Part 2. Demographic and Clinical Considerations: CHEST Expert Panel Report. Chest. 2021 Oct; 160 (4):1413-1423 Epub 2021 Apr 24
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Herberts MB, Johnson TF,
Escalante P
. A 70-Year-Old Man With Cough and Recurrent Respiratory Infections. Chest. 2021 Oct; 160(4):e347-e350.
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Lee KK, Davenport PW, Smith JA, Irwin RS, McGarvey L, Mazzone SB, Birring SS, CHEST Expert Cough Panel. Global Physiology and Pathophysiology of Cough: Part 1: Cough Phenomenology - CHEST Guideline and Expert Panel Report. Chest. 2021 Jan; 159 (1):282-293 Epub 2020 Sept 02
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Malesker MA, Callahan-Lyon P, Madison JM, Ireland B, Irwin RS, CHEST Expert Cough Panel. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report. Chest. 2020 Aug; 158(2):705-718. Epub 2020 Feb 24.
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Escalante P
, Theel ES. Progress Towards Developing a Rapid Triage/Referral Test for Tuberculosis. Clin Chem 2020 Aug 1; 66 (8):995-997
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Cote A, Russell RJ, Boulet LP, Gibson PG, Lai K, Irwin RS, Brightling CE, CHEST Expert Cough Panel. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Guideline and Expert Panel Report. Chest. 2020 Jul; 158 (1):68-96 Epub 2020 Jan 20
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Chang AB, Oppenheimer JJ, Irwin RS, CHEST Expert Cough Panel. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2020 Jul; 158 (1):303-329 Epub 2020 Mar 14
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Irwin RS, Dudiki N, French CL, CHEST Expert Cough Panel, Abd Moain Abu Dabrh , Jay H Ryu. Life-Threatening and Non-Life-Threatening Complications Associated With Coughing: A Scoping Review. Chest. 2020 Jun 19 Epub 2020 June 19
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Smith MP, Lown M, Singh S, Ireland B, Hill AT, Linder JA, Irwin RS, CHEST Expert Cough Panel. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report. Chest. 2020 May; 157 (5):1256-1265 Epub 2020 Feb 21
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Arias-Guillen M,
Escalante P
, Palacios Gutierrez JJ. New Perspectives in Latent Tuberculosis Infection. Arch Bronconeumol (Engl Ed) 2020 Feb; 56 (2):74-75 Epub 2019 Aug 09
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Robison HM,
Escalante P
, Valera E, Erskine CL, Auvil L, Sasieta HC, Bushell C, Welge M, Bailey RC. Multiplexed cytokine detection for immunodiagnostics using silicon photonic microring resonator arrays 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. 2020; 3-4. Epub 1900 Jan 01.
Zhang Z, Kern RM, Joshi AY, Iyer VN,
Escalante P
. Cavitary lung lesions caused by Pneumocystis jirovecii in setting of common variable immune deficiency. Respir Med Case Rep. 2020; 31:101277. Epub 2020 Nov 06.
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Herberts MB, Bourne M,
Escalante P
. 51-Year-Old Man With Fever and Productive Cough. Mayo Clin Proc. 2019 Nov; 94 (11):2308-2313
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Shulha JA,
Escalante P
, Wilson JW. Pharmacotherapy Approaches in Nontuberculous Mycobacteria Infections. Mayo Clin Proc. 2019 Aug; 94 (8):1567-1581 Epub 2019 June 01
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Pennington KM, Yost KJ,
Escalante P
, Razonable RR, Kennedy CC. Antifungal prophylaxis in lung transplant: A survey of United States' transplant centers. Clin Transplant. 2019 Jul; 33 (7):e13630 Epub 2019 June 23
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Chang AB, Oppenheimer JJ, Kahrilas PJ, Kantar A, Rubin BK, Weinberger M, Irwin RS, CHEST Expert Cough Panel. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report. Chest. 2019 Jul; 156 (1):131-140 Epub 2019 Apr 16
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Rahimian A, Siltanen C, Feyzizarnagh H,
Escalante P
, Revzin A. Microencapsulated Immunoassays for Detection of Cytokines in Human Blood. ACS Sens. 2019 Mar 22; 4 (3):578-585 Epub 2019 Feb 18
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Robison HM,
Escalante P
, Valera E, Erskine CL, Auvil L, Sasieta HC, Bushell C, Welge M, Bailey RC. Precision immunoprofiling to reveal diagnostic signatures for latent tuberculosis infection and reactivation risk stratification. Integr Biol (Camb). 2019 Jan 1; 11 (1):16-25
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Moore A, Harnden A, Grant CC, Patel S, Irwin RS, CHEST Expert Cough Panel. Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report. Chest. 2019 Jan; 155 (1):147-154 Epub 2018 Oct 12
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Hill AT, Gold PM, El Solh AA, Metlay JP, Ireland B, Irwin RS, CHEST Expert Cough Panel. Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza: CHEST Guideline and Expert Panel Report. Chest. 2019 Jan; 155 (1):155-167 Epub 2018 Oct 06
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Arias-Guillen M, Sanchez Menendez MM, Alperi M, Riestra S, Gonzalez Budino MT, Garcia-Clemente MM, Martinez-Gonzalez S, Enriquez AI, Alonso-Arias R, Palacios Gutierrez JJ, Santibanez M, Coto-Segura P, Camblor PM, Garcia-Alfonso L, Morante I,
Escalante P
. High rates of tuberculin skin test positivity due to methotrexate therapy: False positive results? Semin Arthritis Rheum. 2018 Dec; 48 (3):538-546 Epub 2018 Mar 29
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Birring SS, Kavanagh JE, Irwin RS, Keogh KA, Lim KG, Ryu JH, Collaborators. Treatment of Interstitial Lung Disease Associated Cough: CHEST Guideline and Expert Panel Report. Chest. 2018 Oct; 154 (4):904-917 Epub 2018 July 20
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Ramos GP, Stroh G, Al-Bawardy B, Faubion WA, Papadakis KA,
Escalante P
. Outcomes of Treatment for Latent Tuberculosis Infection in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy. Inflamm Bowel Dis. 2018 Sep 15; 24 (10):2272-2277
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Chang AB, Oppenheimer JJ, Rubin BK, Weinberger M, Irwin RS, CHEST Expert Cough Panel. Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report. Chest. 2018 Aug; 154 (2):378-382 Epub 2018 Apr 26
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Theel ES, Hilgart H, Breen-Lyles M, McCoy K, Flury R, Breeher LE, Wilson J, Sia IG, Whitaker JA, Clain J, Aksamit TR,
Escalante P
. Comparison of the QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In-Tube Interferon Gamma Release Assays in Patients at Risk for Tuberculosis and in Health Care Workers. J Clin Microbiol. 2018 Jul; 56 (7) Epub 2018 June 25
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Pennington KM, Kennedy CC, Chandra S, Lauzardo M, Brito MO, Griffith DE, Seaworth BJ,
Escalante P
. Management and diagnosis of tuberculosis in solid organ transplant candidates and recipients: Expert survey and updated review(). J Clin Tuberc Other Mycobact Dis. 2018 May; 11:37-46 Epub 2018 Apr 10
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Fregonese F, Ahuja SD, Akkerman OW, Arakaki-Sanchez D, Ayakaka I, Baghaei P, Bang D, Bastos M, Benedetti A, Bonnet M, Cattamanchi A, Cegielski P, Chien JY, Cox H, Dedicoat M, Erkens C,
Escalante P
, Falzon D, Garcia-Prats AJ, Gegia M, Gillespie SH, Glynn JR, Goldberg S, Griffith D, Jacobson KR, Johnston JC, Jones-Lopez EC, Khan A, Koh WJ, Kritski A, Lan ZY, Lee JH, Li PZ, Maciel EL, Galliez RM, Merle CSC, Munang M, Narendran G, Nguyen VN, Nunn A, Ohkado A, Park JS, Phillips PPJ, Ponnuraja C, Reves R, Romanowski K, Seung K, Schaaf HS, Skrahina A, Soolingen DV, Tabarsi P, Trajman A, Trieu L, Banurekha VV, Viiklepp P, Wang JY, Yoshiyama T, Menzies D. Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2018 Apr; 6 (4):265-275
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Field SK,
Escalante P
, Fisher DA, Ireland B, Irwin RS, CHEST Expert Cough Panel. Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report. Chest. 2018 Feb; 153 (2):467-497 Epub 2017 Nov 28
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Irwin RS, French CL, Chang AB, Altman KW, CHEST Expert Cough Panel*. Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2018 Jan; 153 (1):196-209 Epub 2017 Nov 10
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Pennington K, Wilson J, Limper AH,
Escalante P
. Positive Pneumocystis jirovecii Sputum PCR Results with Negative Bronchoscopic PCR Results in Suspected Pneumocystis Pneumonia. Can Respir J. 2018; 2018:6283935 Epub 2018 Apr 03
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Egan AM, Clain JM,
Escalante P
. Non-antimicrobial airway management of non-cystic fibrosis bronchiectasis. J Clin Tuberc Other Mycobact Dis. 2018 Jan; 10:24-28 Epub 2017 Dec 12
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Chandrashekaran S,
Escalante P
, Kennedy CC. Mycobacterium abscessus disease in lung transplant recipients: Diagnosis and management. J Clin Tuberc Other Mycobact Dis. 2017 Dec; 9:10-18
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Malesker MA, Callahan-Lyon P, Ireland B, Irwin RS, CHEST Expert Cough Panel. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report. Chest. 2017 Nov; 152 (5):1021-1037 Epub 2017 Aug 22
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Rosen MJ, Ireland B, Narasimhan M, French C, Irwin RS, CHEST Expert Cough Panel. Cough in Ambulatory Immunocompromised Adults: CHEST Expert Panel Report. Chest. 2017 Nov; 152 (5):1038-1042 Epub 2017 Aug 19
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Boulet LP, Turmel J, Irwin RS, CHEST Expert Cough Panel. Cough in the Athlete: CHEST Guideline and Expert Panel Report. Chest. 2017 Feb; 151 (2):441-454 Epub 2016 Nov 16
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Meier E, Pennington K, Gallo de Moraes A,
Escalante P
. Characteristics of Mycobacterium avium complex (MAC) pulmonary disease in previously treated lung cancer patients. Respir Med Case Rep. 2017; 22:70-73 Epub 2017 June 23
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Pennington K, Sasieta HC, Ramos GP, Erskine CL, Van Keulen VP, Peikert T,
Escalante P
. Flow Cytometric Immune Profiling in Infliximab-Associated Tuberculosis. Clin Med Insights Case Rep. 2017; 10:1179547617724776 Epub 2017 Aug 24
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Kahrilas PJ, Altman KW, Chang AB, Field SK, Harding SM, Lane AP, Lim K, McGarvey L, Smith J, Irwin RS, CHEST Expert Cough Panel. Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report. Chest. 2016 Dec; 150 (6):1341-1360 Epub 2016 Sept 07
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Tarlo SM, Altman KW, Oppenheimer J, Lim K, Vertigan A, Prezant D, Irwin RS, CHEST Expert Cough Panel. Occupational and Environmental Contributions to Chronic Cough in Adults: Chest Expert Panel Report. Chest. 2016 Oct; 150 (4):894-907 Epub 2016 Aug 10
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Wilson JW, Ramos JG, Castillo F, F Castellanos E,
Escalante P
. Tuberculosis patient and family education through videography in El Salvador. J Clin Tuberc Other Mycobact Dis. 2016 Aug; 4:14-20 Epub 2016 May 10
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Clain JM,
Escalante P
. Novel treatments for drug-resistant tuberculosis Clinical Medicine Insights: Therapeutics. 2016; 8:21-8. Epub 1900 Jan 01.
Pennington K, Van Zyl M,
Escalante P
. Citrobacter koseri Pneumonia As Initial Presentation of Underlying Pulmonary Adenocarcinoma. Clin Med Insights Case Rep. 2016; 9:87-89 Epub 2016 Oct 06
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Gibson P, Wang G, McGarvey L, Vertigan AE, Altman KW, Birring SS, CHEST Expert Cough Panel. Treatment of Unexplained Chronic Cough: CHEST Guideline and Expert Panel Report. Chest. 2016 Jan; 149 (1):27-44 Epub 2016 Jan 06
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Escalante P
, Peikert T, Van Keulen VP, Erskine CL, Bornhorst CL, Andrist BR, McCoy K, Pease LR, Abraham RS, Knutson KL, Kita H, Schrum AG, Limper AH. Combinatorial Immunoprofiling in Latent Tuberculosis Infection. Toward Better Risk Stratification. Am J Respir Crit Care Med. 2015 Sep 1; 192 (5):605-17
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Vertigan AE, Murad MH, Pringsheim T, Feinstein A, Chang AB, Newcombe PA, Rubin BK, McGarvey LP, Weir K, Altman KW, Weinberger M, Irwin RS, CHEST Expert Cough Panel. Somatic Cough Syndrome (Previously Referred to as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children: CHEST Guideline and Expert Panel Report. Chest. 2015 Jul; 148: (1)24-31.
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French CT, Diekemper RL, Irwin RS, CHEST Expert Cough Panel. Assessment of Intervention Fidelity and Recommendations for Researchers Conducting Studies on the Diagnosis and Treatment of Chronic Cough in the Adult: CHEST Guideline and Expert Panel Report. Chest. 2015 Jul; 148: (1)32-54.
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Villarino ME, Scott NA, Weis SE, Weiner M, Conde MB, Jones B, Nachman S, Oliveira R, Moro RN, Shang N, Goldberg SV, Sterling TR, International Maternal Pediatric and Adolescents AIDS Clinical Trials Group//Tuberculosis Trials Consortium. Treatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid. JAMA Pediatr. 2015 Mar; 169: (3)247-55.
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Boulet LP, Coeytaux RR, McCrory DC, French CT, Chang AB, Birring SS, Smith J, Diekemper RL, Rubin B, Irwin RS, CHEST Expert Cough Panel. Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report. Chest. 2015 Mar; 147: (3)804-14.
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Escalante P
, Kooda KJ, Khan R, Aye SS, Christianakis S, Arkfeld DG, Ehresmann GR, Kort JJ, Jones BE. Diagnosis of latent tuberculosis infection with T-SPOT((R)).TB in a predominantly immigrant population with rheumatologic disorders. Lung. 2015 Feb; 193 (1):3-11 Epub 2014 Oct 16
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Canning BJ, Chang AB, Bolser DC, Smith JA, Mazzone SB, McGarvey L, CHEST Expert Cough Panel. Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report. Chest. 2014 Dec; 146: (6)1633-48.
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Lewis SZ, Diekemper RL, French CT, Gold PM, Irwin RS, CHEST Expert Cough Panel. Methodologies for the development of the management of cough: CHEST guideline and expert panel report. Chest. 2014 Nov; 146: (5)1395-402.
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Irwin RS, French CT, Lewis SZ, Diekemper RL, Gold PM, CHEST Expert Cough Panel. Overview of the management of cough: CHEST Guideline and Expert Panel Report. Chest. 2014 Oct; 146: (4)885-9.
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Birkenkamp KE, Lauzardo M, Mangura BT, Brito MO, Griffith DT, Seaworth BJ,
Escalante P
. Diagnosis and Management of Latent Tuberculosis and Tuberculosis in Candidates for TNF-alpha Antagonist Therapy: An Expert Survey J of Mycobac Dis.2014, Oct;4(5):171.
Arias-Guillen M, Riestra S, de Francisco R, Palacios JJ, Belda J,
Escalante P
, Perez-Martinez I, Molinos LM, Garcia-Clemente M, Pando-Sandoval A, Rodrigo L, Prieto A, Martinez-Camblor P, Losada A, Casan P. T-cell profiling and the immunodiagnosis of latent tuberculosis infection in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2014 Feb; 20 (2):329-38
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Escalante P
, McKean-Cowdin R, Ramaswamy SV, Williams-Bouyer N, Teeter LD, Jones BE, Graviss EA. Can mycobacterial katG genetic changes in isoniazid-resistant tuberculosis influence human disease features? Int J Tuberc Lung Dis. 2013 May; 17 (5):644-51 Epub 2013 Mar 01
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Haydour Q, Wells MA, McCoy SS, Nelsen E,
Escalante P
, Matteson EL. Anti-synthetase syndrome presenting as cryptogenic organizing pneumonia. Respir Med Case Rep. 2012; 6:13-5 Epub 2012 Oct 06
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Escalante P
. In the clinic. Tuberculosis. Ann Intern Med. 2009 Jun 2; 150(11):ITC61-614; quiz ITV616.
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Escalante P
. Mycobacterial infections in solid organ transplantation. Curr Opin Organ Transplant. 2007; 12:585-90.
El Sahly HM, Wright JA, Soini H, Bui TT, Williams-Bouyer N,
Escalante P
, Musser JM, Graviss EA. Recurrent tuberculosis in Houston, Texas: a population-based study. Int J Tuberc Lung Dis. 2004 Mar; 8(3):333-40.
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Slotar D,
Escalante P
, Jones BE. Pulmonary manifestations of HIV/AIDS in the tropics. Clin Chest Med. 2002 Jun; 23(2):355-67.
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Escalante P
, Graviss EA, Griffith DE, Musser JM, Awe RJ. Treatment of isoniazid-resistant tuberculosis in southeastern Texas. Chest. 2001 Jun; 119(6):1730-6.
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Escalante P
, Ramaswamy S, Sanabria H, Soini H, Pan X, Valiente-Castillo O, Musser JM. Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru. Tuber Lung Dis. 1998; 79(2):111-8.
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Sreevatsan S,
Escalante P
, Pan X, Gillies DA 2nd, Siddiqui S, Khalaf CN, Kreiswirth BN, Bifani P, Adams LG, Ficht T, Perumaalla VS, Cave MD, van Embden JD, Musser JM. Identification of a polymorphic nucleotide in oxyR specific for Mycobacterium bovis. J Clin Microbiol. 1996 Aug; 34(8):2007-10.
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