Barry A. Borlaug, M.D.

1. Cardiologist

1. Melenovsky V, Hoskova E, Velebova K, Veleba J, Borlaug BA, Benes J, Kuda O, Cajka T, Segetova M, Thieme L, Kopecky J Jr, Kopecky J Sr, Pelikanova T, Haluzik M, Hill M, Kahleova H. Metformin Improves Glycemic Control and Postprandial Metabolism and Enhances Postprandial Glucagon-Like Peptide 1 Secretion in Patients With Type 2 Diabetes and Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Diabetes. 2025 Winter; 43 (1):23-32 Epub 2024 Sept 09
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2. Doi S, Reddy YNV, Jensen MD, Smith JR, Borlaug BA. Dapagliflozin and ventilatory control during exercise in heart failure with preserved ejection fraction: the CAMEO-DAPA trial. Eur Heart J. 2025 Apr 22; 46 (16):1554-1556
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3. Reddy YNV, Tada A, Obokata M, Carter RE, Kaye DM, Handoko ML, Andersen MJ, Sharma K, Tedford RJ, Redfield MM, Borlaug BA. Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting. Circulation. 2025 Apr 8; 151 (14):976-989 Epub 2025 Jan 22
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4. Naser JA, Rahme SJ, Ibrahim H, Scott CG, Michelena HI, Borlaug BA, Kennedy AM, Eleid MF, Nkomo VT, Pellikka PA, Enriquez-Sarano M, Pislaru SV. Role of Quantitative Assessment of Atrial Functional Mitral Regurgitation. J Am Soc Echocardiogr. 2025 Apr; 38 (4):353-355 Epub 2024 Dec 15
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5. Sorimachi H, Obokata M, Omote K, Reddy YNV, Burkhoff D, Shah SJ, Borlaug BA. Racial Differences of Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction. J Card Fail. 2025 Apr; 31 (4):624-634 Epub 2024 Aug 23
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6. Younis A, Reddy YNV, Miranda WR, Abdelhalim AT, Borlaug BA, Connolly HM, Egbe AC. Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta. Int J Cardiol Heart Vasc. 2025 Apr; 57:101626 Epub 2025 Feb 07
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7. Egbe AC, Reddy YNV, Miranda WR, Jain CC, Connolly HM, Borlaug BA. Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta. Circ Heart Fail. 2025 Apr; 18 (4):e012459 Epub 2025 Mar 05
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8. Naser JA, Ibrahim H, Andi K, Scott CG, Pellikka PA, Kennedy AM, Connolly HM, Nkomo VT, Enriquez-Sarano M, Pislaru SV, Warnes CA, Jain CC, Borlaug BA, Egbe AC. Prevalence, aetiology, and outcomes of native pulmonary regurgitation in the general adult population. Eur Heart J Cardiovasc Imaging. 2025 Mar 27; 26 (4):695-702
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9. Packer M, Zile MR, Kramer CM, Murakami M, Ou Y, Borlaug BA, SUMMIT Trial Study Group. Interplay of Chronic Kidney Disease and the Effects of Tirzepatide in Patients With Heart Failure, Preserved Ejection Fraction, and Obesity: The SUMMIT Trial. J Am Coll Cardiol. 2025 Mar 24 [Epub ahead of print]
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10. Pandey A, Lewis GD, Borlaug BA, Shah SJ, Sauer AJ, Litwin S, Sharma K, Jorkasky DK, Tarka EA, Khan SM, Kitzman DW. Novel Controlled Metabolic Accelerator for Obesity-Related HFpEF: The HuMAIN-HFpEF Randomized Clinical Trial. JAMA Cardiol. 2025 Mar 12 [Epub ahead of print]
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11. Fazzini L, Padkins MR, Berg-Hansen K, Gori M, Kane GC, Hillerson DB, Tavazzi G, Reddy YNV, Jae OK, Borlaug B, Jentzer JC. Left ventricular-arterial coupling and mortality in the cardiac intensive care unit. Eur Heart J Acute Cardiovasc Care. 2025 Mar 12 [Epub ahead of print]
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12. Zile MR, Borlaug BA, Kramer CM, Baum SJ, Litwin SE, Menon V, Ou Y, Weerakkody GJ, Hurt KC, Kanu C, Murakami M, Packer M, SUMMIT Trial Study Group. Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity. Circulation. 2025 Mar 11; 151 (10):656-668 Epub 2024 Nov 18
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13. Farha S, Asosingh K, Hassoun PM, Barnard J, Comhair S, Reichard A, Wanner N, Radeva M, Aldred MA, Beck GJ, Berman-Rosenzweig E, Borlaug BA, Finet JE, Frantz RP, Grunig G, Hemnes AR, Hill N, Horn EM, Jellis C, Leopold JA, Mehra R, Park MM, Rischard FP, Tang WHW, Erzurum SC, PVDOMICS Study Group. Alterations in Mitochondrial Function in Pulmonary Vascular Diseases. Antioxid Redox Signal. 2025 Mar; 42 (7-9):361-377 Epub 2024 Dec 10
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14. Davies MJ, van der Meer P, Verma S, Patel S, Chinnakondepalli KM, Borlaug BA, Butler J, Kitzman DW, Shah SJ, Harring S, Salsali A, Rasmussen S, von Lewinski D, Abhayaratna W, Petrie MC, Kosiborod MN, STEP-HFpEF Trials Committees and Investigators. Semaglutide in obesity-related heart failure with preserved ejection fraction and type 2 diabetes across baseline HbA(1c) levels (STEP-HFpEF DM): a prespecified analysis of heart failure and metabolic outcomes from a randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2025 Mar; 13 (3):196-209 Epub 2025 Jan 20
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15. Cao JJL, Miranda WR, Borlaug BA, Reddy YNV. Pseudo-Severe Mitral Stenosis From Obesity-Related HFpEF and Atrial Myopathy. Circ Heart Fail. 2025 Mar; 18 (3):e012703 Epub 2025 Jan 28
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16. Shah SJ, Bonderman D, Borlaug BA, Cleland JGF, Lack G, Lu W, Voors AA, Zannad F, Gladwin MT. Macitentan for Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Pulmonary Vascular Disease: Results of the SERENADE Randomized Clinical Trial and Open-Label Extension Study. Circ Heart Fail. 2025 Mar; 18 (3):e011381 Epub 2025 Mar 11
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17. Davies MJ, van der Meer P, Verma S, Patel S, Chinnakondepalli KM, Borlaug BA, Butler J, Kitzman DW, Shah SJ, Harring S, Salsali A, Rasmussen S, von Lewinski D, Abhayaratna W, Petrie MC, Kosiborod MN. Semaglutide in obesity-related heart failure with preserved ejection fraction and type 2 diabetes across baseline hba levels (step-hfpef dm): a prespecified analysis of heart failure and metabolic outcomes from a randomised, placebo-controlled trial 1c. Lancet Diabetes & Endocrinology. 2025 Mar; 13 (3):196-209
    
18. Kramer CM, Borlaug BA, Zile MR, Ruff D, DiMaria JM, Menon V, Ou Y, Zarante AM, Hurt KC, Murakami M, Packer M, SUMMIT Trial Study Group. Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy. J Am Coll Cardiol. 2025 Feb 25; 85 (7):699-706 Epub 2024 Nov 18
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19. Opp DN, Jain CC, Egbe AC, Borlaug BA, Reddy YV, Connolly HM, Lara-Breitinger KM, Cordina R, Miranda WR. Fontan haemodynamics in adults with obesity compared with overweight and normal body mass index: a retrospective invasive exercise study. Eur J Prev Cardiol. 2025 Feb 18; 32 (3):221-230
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20. Salah HM, Fudim M, Borlaug BA, Litwin SE, Stark M, Shah SJ, Burkhoff D. Changes in Stressed Blood Volume With Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: The REBALANCE-HF Trial. J Card Fail. 2025 Feb 13 [Epub ahead of print]
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21. Fioretti F, Nair AP, Anker SD, Borlaug BA, Kereiakes DJ, Lindenfeld J, Stone GW, Butler J. Therapeutic left-to-right shunting in heart failure. Eur Heart J. 2025 Feb 13 [Epub ahead of print]
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22. Zalawadiya SK, Kiernan M, Borlaug BA, Stevenson LW, Desai AS, Bennett M, Mullens W, Hiivala NJ, Owens MM, Klein L. Changes in Seated Pulmonary Artery Pressure in Response to Titration of Heart Failure Medications During Ambulatory Monitoring. J Card Fail. 2025 Feb 11 [Epub ahead of print]
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23. Molinsky RL, Shah A, Yuzefpolskaya M, Yu B, Misialek JR, Bohn B, Vock D, MacLehose R, Borlaug BA, Colombo PC, Ndumele CE, Ishigami J, Matsushita K, Lutsey PL, Demmer RT. Infection-Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study. J Am Heart Assoc. 2025 Feb 4; 14 (3):e033877 Epub 2025 Jan 30
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24. Borlaug BA, Zile MR, Kramer CM, Baum SJ, Hurt K, Litwin SE, Murakami M, Ou Y, Upadhyay N, Packer M. Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial. Nat Med. 2025 Feb; 31 (2):544-551 Epub 2024 Nov 17
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25. Egbe AC, Ali AE, Miranda WR, Connolly HM, Borlaug BA. Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes. Circ Heart Fail. 2025 Feb; 18 (2):e011981 Epub 2024 Dec 09
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26. Naser JA, Harada T, Reddy YN, Pislaru SV, Michelena HI, Scott CG, Kennedy AM, Pellikka PA, Nkomo VT, Eleid MF, Borlaug BA. Prevalence of HFpEF in Isolated Severe Secondary Tricuspid Regurgitation. JAMA Cardiol 2025 Feb 1; 10 (2):182-187
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27. Monzo L, Jarolim P, Borlaug BA, Benes J, Jurcova I, Jenca D, Kroupova K, Wohlfahrt P, Kotrc M, Melenovsky V. Growth Differentiation Factor-15 Is Associated With Congestion-Related Anorexia and Weight Loss in Advanced Heart Failure. JACC Heart Fail. 2025 Feb; 13 (2):315-329 Epub 2025 Jan 08
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28. Fayyaz AU, Eltony M, Prokop LJ, Koepp KE, Borlaug BA, Dasari S, Bois MC, Margulies KB, Maleszewski JJ, Wang Y, Redfield MM. Pathophysiological insights into HFpEF from studies of human cardiac tissue. Nat Rev Cardiol. 2025 Feb; 22 (2):90-104 Epub 2024 Aug 28
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29. Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, Ge J, Weerakkody GJ, Ou Y, Bunck MC, Hurt KC, Murakami M, Borlaug BA, SUMMIT Trial Study Group. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2025 Jan 30; 392 (5):427-437 Epub 2024 Nov 16
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30. Hortegal RA, Jain CC, Reddy YNV, Borlaug BA, Egbe AC, Miranda WR. Single-leg supine cycling: An alternative for patients requiring exercise catheterization and femoral access. Eur J Heart Fail. 2025 Jan 17 [Epub ahead of print]
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31. Egbe AC, Reddy YNV, Miranda WR, Jain CC, Anderson JH, Connolly HM, Borlaug BA. Clinical features, hemodynamics, and outcomes of pulmonary hypertension in adults with coarctation of aorta. Int J Cardiol. 2025 Jan 1; 418:132634 Epub 2024 Oct 11
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32. Doi S, Borlaug BA. Pericardiotomy as a novel treatment for heart failure with preserved ejection fraction. Heart Fail Rev. 2025 Jan; 30 (1):137-142 Epub 2024 Oct 08
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33. Ambrosy AP, Sauer AJ, Patel S, Windsor SL, Borlaug BA, Husain M, Inzucchi SE, Kitzman DW, McGuire DK, Shah SJ, Sharma K, Umpierrez G, Kosiborod MN. Baseline kidney function and the effects of dapagliflozin on health status in heart failure in DEFINE-HF and PRESERVED-HF. ESC Heart Fail. 2024 Dec 24 [Epub ahead of print]
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34. Naser JA, Harada T, Tada A, Doi S, Tsaban G, Pislaru SV, Nkomo VT, Scott CG, Kennedy AM, Eleid MF, Reddy YNV, Lin G, Pellikka PA, Borlaug BA. Prevalence, Incidence, and Outcomes of Diastolic Dysfunction in Isolated Tricuspid Regurgitation: Perhaps Not Really "Isolated"? JACC Cardiovasc Imaging. 2024 Dec; 17 (12):1411-1424 Epub 2024 July 24
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35. Hammer SM, Bruhn EJ, Bissen TG, Cifci G, Borlaug BA, Olson TP, Smith JR. Impaired Vastus Lateralis Blood Flow During Cycling Exercise in Heart Failure With Preserved Ejection Fraction. J Card Fail. 2024 Dec; 30 (12):1637-1640 Epub 2024 May 20
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36. Akhiyat N, Anand V, Kumar V, Ryu A, Gibbons R, Borlaug BA, Chandrasekaran K, Abou Ezzeddine O, Anavekar N. The myocardial function index (MFI): An integrated measure of cardiac function in AL-cardiomyopathy. Int J Cardiol Heart Vasc. 2024 Dec; 55:101525 Epub 2024 Oct 15
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37. Egbe AC, Reddy YNV, Ali AE, Younis A, Borlaug BA. Clinical features, haemodynamics, and outcomes of heart failure with preserved ejection fraction in coarctation of aorta. Eur J Heart Fail. 2024 Dec; 26 (12):2595-2603 Epub 2024 July 16
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38. Fudim M, Borlaug BA, Mohan RC, Price MJ, Fail P, Goyal P, Hummel SL, Zirakashvili T, Shaburishvili T, Patel RB, Reddy VY, Nielsen CD, Chetcuti SJ, Sukul D, Gulati R, Kim L, Benzuly K, Mitter SS, Klein L, Uriel N, Augostini RS, Blair JE, Rocha-Singh K, Burkhoff D, Patel MR, Somo SI, Litwin SE, Shah SJ. Endovascular Ablation of the Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: The REBALANCE-HF Randomized Clinical Trial. JAMA Cardiol. 2024 Dec 1; 9 (12):1143-1153
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39. Litwin SE, Komtebedde J, Borlaug BA, Kaye DM, Hasenfubeta G, Kawash R, Hoendermis E, Hummel SL, Cikes M, Gustafsson F, Chung ES, Mohan RC, Sverdlov AL, Swarup V, Winkler S, Hayward CS, Bergmann MW, Bugger H, McKenzie S, Nair A, Rieth A, Burkhoff D, Cutlip DE, Solomon SD, van Veldhuisen DJ, Leon MB, Shah SJ. Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials. Am Heart J. 2024 Dec; 278:106-116 Epub 2024 Sept 03
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40. Jain CC, Egbe AC, Allison TG, van de Bruaene A, Borlaug BA, Connolly HM, Burchill LJ, Miranda WR. Functional Capacity Assessment in Adults After Fontan Palliation: A Cardiopulmonary Exercise Test-Invasive Exercise Hemodynamics Correlation Study. Am J Cardiol. 2024 Dec 1; 232:82-88 Epub 2024 Sept 06
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41. Reddy YNV, Frantz RP, Hassoun PM, Hemnes AR, Horn E, Leopold JA, Rischard F, Rosenzweig EB, Hill NS, Erzurum SC, Beck GJ, Finet JE, Jellis CL, Mathai SC, Tang WHW, Borlaug BA. Clinical Implications of Pretest Probability of HFpEF on Outcomes in Precapillary Pulmonary Hypertension. J Am Coll Cardiol. 2024 Nov 26; 84 (22):2196-2210 Epub 2024 Oct 23
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42. Sharif SM, Smith JR, Borlaug BA, Olson TP. Association between locomotor muscle quality and cardiac function during exercise in heart failure with preserved ejection fraction. Eur J Heart Fail. 2024 Nov 19 [Epub ahead of print]
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43. Gopalasingam N, Berg-Hansen K, Christensen KH, Ladefoged BT, Poulsen SH, Andersen MJ, Borlaug BA, Nielsen R, Moller N, Wiggers H. Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction. Circulation. 2024 Nov 12; 150 (20):1570-1583 Epub 2024 Aug 20
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44. Reddy YNV, Miranda WR, Jain CC, Borlaug BA, Egbe AC. Haemodynamic contributors to pulmonary hypertension across the spectrum of adult congenital heart disease. Eur J Heart Fail. 2024 Nov; 26 (11):2356-2366 Epub 2024 July 02
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45. Reddy YNV, Dubrock H, Hassoun PM, Hemnes A, Horn E, Leopold JA, Rischard F, Rosenzweig EB, Hill NS, Erzurum SC, Beck GJ, Mathai SC, Mukherjee M, Tang WHW, Borlaug BA, Frantz RP, and the PVDOMICS Study Group. Non-invasive prediction of pulmonary vascular disease-related exercise intolerance and survival in non-group 1 pulmonary hypertension. Eur J Heart Fail. 2024 Nov; 26 (11):2323-2336 Epub 2024 July 26
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46. Egbe AC, Borlaug BA, Miranda WR, Karnakoti S, Ali AE, Younis A, Connolly HM. Sex Differences in Outcomes of Adults with Repaired Coarctation of Aorta and Concomitant Aortic Valve Disease. CJC Open. 2024 Nov; 6 (11):1386-1394 Epub 2024 Aug 22
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47. Selvaraj S, Patel S, Sauer AJ, McGarrah RW, Jones P, Kwee LC, Windsor SL, Ilkayeva O, Muehlbauer MJ, Newgard CB, Borlaug BA, Kitzman DW, Shah SJ, Margulies KB, Husain M, Inzucchi SE, McGuire DK, Lanfear DE, Javaheri A, Umpierrez G, Mentz RJ, Sharma K, Kosiborod MN, Shah SH. Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction. Circ Heart Fail. 2024 Nov; 17 (11):e011980 Epub 2024 Oct 18
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48. Harada T, Tada A, Borlaug BA. Imaging and mechanisms of heart failure with preserved ejection fraction: a state-of-the-art review. Eur Heart J Cardiovasc Imaging. 2024 Oct 30; 25 (11):1475-1490
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49. Solomon SD, Ostrominski JW, Wang X, Shah SJ, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Verma S, Abildstrom SZ, Nygaard Einfeldt M, Rasmussen S, Abhayaratna WP, Ahmed FZ, Ben-Gal T, Chopra V, Ito H, Merkely B, Nunez J, Senni M, van der Meer P, Wolf D, Petrie MC, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Effect of Semaglutide on Cardiac Structure and Function in Patients With Obesity-Related Heart Failure. J Am Coll Cardiol. 2024 Oct 22; 84 (17):1587-1602 Epub 2024 Aug 30
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50. Verma S, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Ronnback C, Abildstrom SZ, Liisberg K, Wolf D, von Lewinski D, Lelonek M, Melenovsky V, Senni M, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Inflammation in Obesity-Related HFpEF: The STEP-HFpEF Program. J Am Coll Cardiol. 2024 Oct 22; 84 (17):1646-1662 Epub 2024 Aug 30
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51. Verma S, Butler J, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Jensen TJ, Rasmussen S, Ronnback C, Merkely B, O'Keefe E, Kosiborod MN, STEP-HFpEF and STEP-HFpEF DM Investigators. Atrial Fibrillation and Semaglutide Effects in Obesity-Related Heart Failure With Preserved Ejection Fraction: STEP-HFpEF Program. J Am Coll Cardiol. 2024 Oct 22; 84 (17):1603-1614 Epub 2024 Aug 30
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52. Reddy YNV, Melenovsky V, Asokan AK, Haluzik M, Carter RE, Nair S, Jensen MD, Borlaug BA. Dapagliflozin, peptide YY, and weight loss in heart failure with preserved ejection fraction. Eur Heart J. 2024 Oct 05; 45(37):3889-3891.
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53. Tada A, Burkhoff D, Naser JA, Harada T, Pourmussa B, Reddy YNV, Jensen MD, Carter RE, Demmer RT, Testani JM, Chirinos JA, Borlaug BA. Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial. Circulation. 2024 Sep 24; 150 (13):997-1009 Epub 2024 Aug 05
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54. Tada A, Burkhoff D, Naser JA, Harada T, Pourmussa B, Reddy YNV, Jensen MD, Carter RE, Demmer RT, Testani JM, Chirinos JA, Borlaug BA. Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction: insights from the cameo-dapa trial. Circulation. 2024 Sep 24; 150 (13):997-1009
    
55. Ng ACT, Dong X, Koepp KE, Obokata M, Sorimachi H, Galloway G, Araoz P, Delgado V, Bax JJ, Borlaug BA. Sexual dimorphism in the relationships between intramyocardial fat, myocardial fibrosis, and exercise intolerance in heart failure with preserved ejection fraction. Eur J Heart Fail. 2024 Sep 24 Epub 2024 Sept 24
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56. Shah SJ, Sharma K, Borlaug BA, Butler J, Davies M, Kitzman DW, Petrie MC, Verma S, Patel S, Chinnakondepalli KM, Einfeldt MN, Jensen TJ, Rasmussen S, Asleh R, Ben-Gal T, Kosiborod MN. Semaglutide and diuretic use in obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF-DM trials. Eur Heart J. 2024 Sep 14; 45 (35):3254-3269
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57. Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, Emerson SS, Kahn SE, Kitzman DW, Lingvay I, Mahaffey KW, Petrie MC, Plutzky J, Rasmussen S, Ronnback C, Shah SJ, Verma S, Weeke PE, Lincoff AM, SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM Trial Committees and Investigators. Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials. Lancet. 2024 Sep 7; 404 (10456):949-961 Epub 2024 Aug 30
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58. Reddy YNV, Carter RE, Sorimachi H, Omar M, Popovic D, Alogna A, Jensen MD, Borlaug BA. Dapagliflozin and Right Ventricular-Pulmonary Vascular Interaction in Heart Failure With Preserved Ejection Fraction: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol 2024 Sep 1; 9 (9):843-851
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59. Cassianni C, Huntley GD, Castrichini M, Akerman AP, Porumb M, Scott CG, Davison HN, Hawkes W, Woodward G, Borlaug B, Upton R, Pellikka PA. Automated Echocardiographic Detection of Heart Failure With Preserved Ejection Fraction Using Artificial Intelligence Is Associated With Cardiac Mortality and Heart Failure Hospitalization. J Am Soc Echocardiogr 2024 Sep; 37 (9):914-916 Epub 2024 July 02
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60. Kitzman DW, Lewis GD, Pandey A, Borlaug BA, Sauer AJ, Litwin SE, Sharma K, Jorkasky DK, Khan S, Shah SJ. A novel controlled metabolic accelerator for the treatment of obesity-related heart failure with preserved ejection fraction: Rationale and design of the Phase 2a HuMAIN trial. Eur J Heart Fail. 2024 Sep; 26 (9):2013-2024 Epub 2024 June 26
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61. Monzo L, Kovar J, Borlaug BA, Benes J, Kotrc M, Kroupova K, Jabor A, Franekova J, Melenovsky V. Circulating beta-hydroxybutyrate levels in advanced heart failure with reduced ejection fraction: Determinants and prognostic impact. Eur J Heart Fail. 2024 Sep; 26 (9):1931-1940 Epub 2024 June 10
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62. Verma S, Butler J, Borlaug BA, Davies M, Kitzman DW, Shah SJ, Petrie MC, Barros E, Ronnback C, Vestergaard LS, Schou M, Ezekowitz JA, Sharma K, Patel S, Chinnakondepalli KM, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Efficacy of Semaglutide by Sex in Obesity-Related Heart Failure With Preserved Ejection Fraction: STEP-HFpEF Trials. J Am Coll Cardiol. 2024 Aug 27; 84 (9):773-785 Epub 2024 June 23
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63. Borlaug BA, Kindel TL. Obesity and Heart Failure: A New Era Begins. J Card Fail 2024 Aug; 30 (8):1063-1064 Epub 2024 Mar 04
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64. Reddy YNV, Carter RE, Sundaram V, Kaye DM, Handoko ML, Tedford RJ, Andersen MJ, Sharma K, Obokata M, Verbrugge FH, Borlaug BA. An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score. Nat Med. 2024 Aug; 30 (8):2258-2264 Epub 2024 July 12
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65. Khan MS, Talha KM, Maqsood MH, Rymer JA, Borlaug BA, Docherty KF, Pandey A, Kahles F, Cikes M, Lam CSP, Ducharme A, Voors AA, Hernandez AF, Lincoff AM, Petrie MC, Ridker PM, Fudim M. Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA. JACC Adv. 2024 Aug; 3 (8):101063 Epub 2024 July 09
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66. Gustafsson F, Petrie MC, Komtebedde J, Swarup V, Winkler S, Hasenfuss G, Borlaug BA, Mohan RC, Flaherty JD, Sverdlov AL, Fail PS, Chung ES, Lurz P, Lilly S, Kaye DM, Cleland JGF, Cikes M, Leon MB, Cutlip DE, van Veldhuisen DJ, Solomon SD, Shah SJ. 2-Year Outcomes of an Atrial Shunt Device in HFpEF/HFmrEF: Results From REDUCE LAP-HF II. JACC Heart Fail. 2024 Aug; 12 (8):1425-1438 Epub 2024 June 26
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67. Schou M, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Verma S, Patel S, Chinnakondepalli KM, Harring S, Abildstrom SZ, Liisberg K, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Semaglutide and NYHA Functional Class in Obesity-Related Heart Failure With Preserved Ejection Fraction: The STEP-HFpEF Program. J Am Coll Cardiol. 2024 Jul 16; 84 (3):247-257 Epub 2024 June 23
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68. Hahn RT, Lindenfeld J, Bohm M, Edelmann F, Lund LH, Lurz P, Metra M, Tedford RJ, Butler J, Borlaug BA. Tricuspid Regurgitation in Patients With Heart Failure and Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2024 Jul 9; 84 (2):195-212
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69. Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Verma S, Jensen TJ, Einfeldt MN, Liisberg K, Perna E, Sharma K, Ezekowitz JA, Fu M, Melenovsky V, Ito H, Lelonek M, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Semaglutide and NT-proBNP in Obesity-Related HFpEF: Insights From the STEP-HFpEF Program. J Am Coll Cardiol. 2024 Jul 2; 84 (1):27-40 Epub 2024 May 13
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70. Fudim M, Litwin SE, Borlaug BA, Mohan RC, Price MJ, Fail P, Zirakashvili T, Shaburishvili T, Goyal P, Hummel SL, Patel RB, Reddy VY, Burkhoff D, Patel MR, Somo SI, Shah SJ. Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: Rationale, Design and Lead-in Phase Results of the REBALANCE-HF Trial. J Card Fail. 2024 Jul; 30 (7):877-889 Epub 2024 Jan 09
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71. Rajagopalan N, Borlaug BA, Bailey AL, Eckman PM, Guglin M, Hall S, Montgomery M, Ramani G, Khazanie P. Practical Guidance for Hemodynamic Assessment by Right Heart Catheterization in Management of Heart Failure. JACC Heart Fail. 2024 Jul; 12 (7):1141-1156
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72. Tada A, Doi S, Harada T, Ibe T, Naser JA, Amdahl M, Reddy YNV, Borlaug BA. Autoimmune Disorders in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2024 Jul; 12 (7):1257-1269 Epub 2024 May 29
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130. Fayyaz AU, Sabbah MS, Dasari S, Griffiths LG, DuBrock HM, Wang Y, Charlesworth MC, Borlaug BA, Jenkins SM, Edwards WD, Redfield MM. Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension. Cardiovasc Res. 2023 Mar 17; 119 (1):268-282
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137. Dong X, Strudwick M, Wang WY, Borlaug BA, van der Geest RJ, Ng AC, Delgado V, Bax JJ, Ng AC. Impact of body mass index and diabetes on myocardial fat content, interstitial fibrosis and function. Int J Cardiovasc Imaging. 2023 Feb; 39 (2):379-390 Epub 2022 Oct 28
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222. Ryu AJ, Kumar V, Borlaug BA, Manduca A, Rao CK, Gibbons RJ, Asirvatham SJ, Gersh BJ, Chandrasekaran K, Araoz PA, Oh JK, Egbe AC, Behfar A, Anavekar NS. Systolic-to-diastolic myocardial volume ratio as a novel imaging marker of cardiomyopathy. Int J Cardiol. 2021 Jan 1; 322:272-277 Epub 2020 Aug 12
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223. Omar M, Jensen J, Frederiksen PH, Kistorp C, Videbaek L, Poulsen MK, Moller S, Ali M, Gustafsson F, Kober L, Borlaug BA, Schou M, Moller JE. Effect of Empagliflozin on Hemodynamics in Patients With Heart Failure and Reduced Ejection Fraction. J Am Coll Cardiol. 2020 Dec 8; 76 (23):2740-2751
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225. Smith JR, Joyner MJ, Curry TB, Borlaug BA, Keller-Ross ML, Van Iterson EH, Olson TP. Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure. J Physiol. 2020 Dec; 598 (23):5379-5390 Epub 2020 Sept 23
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226. Jain CC, Borlaug BA. Performance and Interpretation of Invasive Hemodynamic Exercise Testing. Chest. 2020 Nov; 158 (5):2119-2129 Epub 2020 May 28
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227. Jentzer JC, Anavekar NS, Burstein BJ, Borlaug BA, Oh JK. Noninvasive Echocardiographic Left Ventricular Stroke Work Index Predicts Mortality in Cardiac Intensive Care Unit Patients. Circ Cardiovasc Imaging. 2020 Nov; 13 (11):e011642 Epub 2020 Nov 16
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228. Fermoyle CC, Stewart GM, Borlaug BA, Johnson BD. Effects of exercise on thoracic blood volumes, lung fluid accumulation, and pulmonary diffusing capacity in heart failure with preserved ejection fraction. Am J Physiol Regul Integr Comp Physiol. 2020 Nov 1; 319 (5):R602-R609 Epub 2020 Sept 16
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229. Reddy YNV, Obokata M, Jones AD, Lewis GD, Shah SJ, Abouezzedine OF, Fudim M, Alhanti B, Stevenson LW, Redfield MM, Borlaug BA. Characterization of the Progression From Ambulatory to Hospitalized Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 Nov; 26 (11):919-928 Epub 2020 Aug 19
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231. Egbe AC, Connolly HM, Miranda WR, Scott CG, Borlaug BA. Prognostic implications of inferior vena cava haemodynamics in ambulatory patients with tetralogy of Fallot. ESC Heart Fail. 2020 Oct; 7 (5):2589-2596 Epub 2020 June 26
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232. Jain CC, Egbe AC, Borlaug BA. Every Now and Then I Fall Apart: Total Eclipse of the Mitral Valve. Circ Heart Fail 2020 Oct; 13 (10):e007145 Epub 2020 Sept 08
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233. Taher R, Sara JD, Toya T, Borlaug BA, Lerman LO, Lerman A. Peripheral endothelial dysfunction is a novel risk factor for systolic dysfunction and heart failure progression. Int J Cardiol Heart Vasc. 2020 Oct; 30:100584 Epub 2020 July 23
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234. Borlaug BA, Maleszewski JJ. The heavy heart of HFpEF. Eur Heart J. 2020 Sep 21; 41 (36):3447
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235. Verbrugge FH, Guazzi M, Testani JM, Borlaug BA. Altered Hemodynamics and End-Organ Damage in Heart Failure: Impact on the Lung and Kidney. Circulation. 2020 Sep 8; 142 (10):998-1012 Epub 2020 Sept 08
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236. Packer M, Lam CSP, Lund LH, Maurer MS, Borlaug BA. Characterization of the inflammatory-metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution and potential treatment of the disease. Eur J Heart Fail. 2020 Sep; 22 (9):1551-1567 Epub 2020 June 26
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237. Borlaug BA. Evaluation and management of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2020 Sep; 17 (9):559-573 Epub 2020 Mar 30
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238. Del Buono MG, Iannaccone G, Scacciavillani R, Carbone S, Camilli M, Niccoli G, Borlaug BA, Lavie CJ, Arena R, Crea F, Abbate A. Heart failure with preserved ejection fraction diagnosis and treatment: An updated review of the evidence. Prog Cardiovasc Dis. 2020 Sep - Oct; 63 (5):570-584 Epub 2020 May 05
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239. Stewart GM, Johnson BD, Sprecher DL, Reddy YNV, Obokata M, Goldsmith S, Bart B, Oughton A, Fillmore C, Behm DJ, Borlaug BA. Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial. Eur J Heart Fail. 2020 Sep; 22 (9):1641-1645 Epub 2020 Mar 30
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240. Griffin JM, Borlaug BA, Komtebedde J, Litwin SE, Shah SJ, Kaye DM, Hoendermis E, Hasenfuss G, Gustafsson F, Wolsk E, Uriel N, Burkhoff D. Impact of Interatrial Shunts on Invasive Hemodynamics and Exercise Tolerance in Patients With Heart Failure. J Am Heart Assoc. 2020 Sep; 9 (17):e016760 Epub 2020 Aug 15
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241. Reddy YNV, Obokata M, Verbrugge FH, Lin G, Borlaug BA. Atrial Dysfunction in Patients With Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation. J Am Coll Cardiol. 2020 Sep 1; 76 (9):1051-1064
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242. Selvaraj S, Myhre PL, Vaduganathan M, Claggett BL, Matsushita K, Kitzman DW, Borlaug BA, Shah AM, Solomon SD. Application of Diagnostic Algorithms for Heart Failure With Preserved Ejection Fraction to the Community. JACC Heart Fail. 2020 Aug; 8 (8):640-653 Epub 2020 June 10
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243. Koepp KE, Obokata M, Reddy YNV, Olson TP, Borlaug BA. Hemodynamic and Functional Impact of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2020 Aug; 8 (8):657-666 Epub 2020 July 08
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244. Ezzeddine FM, Mulpuru SK, Borlaug BA. A Tough Time Running Around the Block. Circ Heart Fail. 2020 Aug; 13 (8):e007182 Epub 2020 July 15
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245. Sabbah MS, Fayyaz AU, de Denus S, Felker GM, Borlaug BA, Dasari S, Carter RE, Redfield MM. Obese-Inflammatory Phenotypes in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2020 Aug; 13 (8):e006414 Epub 2020 July 29
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246. Guazzi M, Generati G, Borlaug B, Alfonzetti E, Sugimoto T, Castelvecchio S, Menicanti L, Bandera F. Redistribution of cardiac output during exercise by functional mitral regurgitation in heart failure: compensatory O2 peripheral uptake to delivery failure. Am J Physiol Heart Circ Physiol. 2020 Jul 1; 319 (1):H100-H108 Epub 2020 May 22
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247. Reddy YNV, Rikhi A, Obokata M, Shah SJ, Lewis GD, AbouEzzedine OF, Dunlay S, McNulty S, Chakraborty H, Stevenson LW, Redfield MM, Borlaug BA. Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity. Eur J Heart Fail. 2020 Jun; 22 (6):1009-1018 Epub 2020 Mar 09
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248. Reddy YNV, Borlaug BA, O'Connor CM, Gersh BJ. Novel approaches to the management of chronic systolic heart failure: future directions and unanswered questions. Eur Heart J. 2020 May 7; 41 (18):1764-1774
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249. Egbe AC, Pellikka PA, Miranda WR, Bonnichsen C, Reddy YNV, Borlaug BA, Connolly HM. Echocardiographic predictors of severe right ventricular diastolic dysfunction in tetralogy of Fallot: Relations to patient outcomes. Int J Cardiol. 2020 May 1; 306:49-55 Epub 2020 Feb 27
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250. Redouane B, Greene SJ, Fudim M, Vaduganathan M, Ambrosy AP, Sun JL, DeVore AD, McNulty SE, Mentz RJ, Hernandez AF, Felker GM, Cooper LB, Borlaug BA, Velazquez EJ, Margulies KB, Sharma A. Effects of Liraglutide on Worsening Renal Function Among Patients With Heart Failure With Reduced Ejection Fraction: Insights From the FIGHT Trial. Circ Heart Fail. 2020 May; 13 (5):e006758 Epub 2020 May 04
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251. Guglin M, Zucker MJ, Borlaug BA, Breen E, Cleveland J, Johnson MR, Panjrath GS, Patel JK, Starling RC, Bozkurt B, ACC Heart Failure and Transplant Member Section and Leadership Council. Evaluation for Heart Transplantation and LVAD Implantation: JACC Council Perspectives. J Am Coll Cardiol. 2020 Mar 31; 75 (12):1471-1487
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252. Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB. Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. Circulation. 2020 Mar 24; 141 (12):1001-1026 Epub 2020 Mar 23
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253. Miranda WR, Hagler DJ, Taggart NW, Borlaug BA, Connolly HM, Egbe AC. Elevated ventricular filling pressures and long-term survival in adults post-Fontan. Catheter Cardiovasc Interv. 2020 Mar 1; 95 (4):803-809 Epub 2019 May 30
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254. Tamargo M, Obokata M, Reddy YNV, Pislaru SV, Lin G, Egbe AC, Nishimura RA, Borlaug BA. Functional mitral regurgitation and left atrial myopathy in heart failure with preserved ejection fraction. Eur J Heart Fail. 2020 Mar; 22 (3):489-498 Epub 2020 Jan 07
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255. Patel RB, Mehta R, Redfield MM, Borlaug BA, Hernandez AF, Shah SJ, Dubin RF. Renal Dysfunction in Heart Failure With Preserved Ejection Fraction: Insights From the RELAX Trial. J Card Fail. 2020 Mar; 26 (3):233-242 Epub 2020 Jan 11
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256. Yang JH, Obokata M, Reddy YNV, Redfield MM, Lerman A, Borlaug BA. Endothelium-dependent and independent coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction. Eur J Heart Fail. 2020 Mar; 22 (3):432-441 Epub 2019 Dec 15
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257. Tang WHW, Wilcox JD, Jacob MS, Rosenzweig EB, Borlaug BA, Frantz RP, Hassoun PM, Hemnes AR, Hill NS, Horn EM, Singh HS, Systrom DM, Tedford RJ, Vanderpool RR, Waxman AB, Xiao L, Leopold JA, Rischard FP. Comprehensive Diagnostic Evaluation of Cardiovascular Physiology in Patients With Pulmonary Vascular Disease: Insights From the PVDOMICS Program. Circ Heart Fail. 2020 Mar; 13 (3):e006363 Epub 2020 Feb 24
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258. Jain CC, Borlaug BA. Hemodynamic assessment in heart failure. Catheter Cardiovasc Interv. 2020 Feb 15; 95 (3):420-428 Epub 2019 Sept 10
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259. Miller WL, Borlaug BA. Impact of Obesity on Volume Status in Patients With Ambulatory Chronic Heart Failure. J Card Fail. 2020 Feb; 26 (2):112-117 Epub 2019 Sept 27
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260. Obokata M, Kane GC, Sorimachi H, Reddy YNV, Olson TP, Egbe AC, Melenovsky V, Borlaug BA. Noninvasive evaluation of pulmonary artery pressure during exercise: the importance of right atrial hypertension. Eur Respir J. 2020 Feb; 55 (2) Epub 2020 Feb 12
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261. Egbe AC, Reddy YNV, Obokata M, Borlaug BA. Doppler-Derived Arterial Load Indices Better Reflect Left Ventricular Afterload Than Systolic Blood Pressure in Coarctation of Aorta. Circ Cardiovasc Imaging. 2020 Feb; 13 (2):e009672 Epub 2020 Feb 13
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264. Sara JDS, Maor E, Borlaug B, Lewis BR, Orbelo D, Lerman LO, Lerman A. Non-invasive vocal biomarker is associated with pulmonary hypertension. PLoS One. 2020; 15 (4):e0231441 Epub 2020 Apr 16
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265. Hanff TC, Kaye DM, Hayward CS, Post MC, Malek F, Hasenfubeta G, Gustafsson F, Burkhoff D, Shah SJ, Litwin SE, Kahwash R, Hummel SL, Borlaug BA, Solomon SD, Lam CSP, Komtebedde J, Silvestry FE, REDUCE LAP-HF study investigators, and research staff. Assessment of Predictors of Left Atrial Volume Response to a Transcatheter InterAtrial Shunt Device (from the REDUCE LAP-HF Trial). Am J Cardiol. 2019 Dec 15; 124 (12):1912-1917 Epub 2019 Sept 26
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267. Egbe AC, Taggart NW, Reddy YNV, Sufian M, Banala K, Vojjini R, Najam M, Osman K, Obokata M, Borlaug BA. Assessment and Implications of Right Ventricular Afterload in Tetralogy of Fallot. Am J Cardiol. 2019 Dec 1; 124 (11):1780-1784 Epub 2019 Sept 09
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268. Reddy YNV, Obokata M, Wiley B, Koepp KE, Jorgenson CC, Egbe A, Melenovsky V, Carter RE, Borlaug BA. The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction. Eur Heart J. 2019 Dec 1; 40 (45):3721-3730
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270. Egbe AC, Bonnichsen C, Reddy YNV, Anderson JH, Borlaug BA. Pathophysiologic and Prognostic Implications of Right Atrial Hypertension in Adults With Tetralogy of Fallot. J Am Heart Assoc. 2019 Nov 19; 8 (22):e014148 Epub 2019 Nov 08
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273. AbouEzzeddine OF, Kemp BJ, Borlaug BA, Mullan BP, Behfar A, Pislaru SV, Fudim M, Redfield MM, Chareonthaitawee P. Myocardial Energetics in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2019 Oct; 12 (10):e006240 Epub 2019 Oct 15
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276. Yang JH, Miranda WR, Borlaug BA, Nishimura RA, Schaff HV, Greason KL, Maleszewski JJ, Oh JK. Right Atrial/Pulmonary Arterial Wedge Pressure Ratio in Primary and Mixed Constrictive Pericarditis. J Am Coll Cardiol. 2019 Jul 2; 73 (25):3312-3321
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280. Egbe AC, Kothapalli S, Miranda WR, Pislaru S, Ammash NM, Borlaug BA, Pellikka PA, Najam M, Connolly HM. Assessment of Right Ventricular-Pulmonary Arterial Coupling in Chronic Pulmonary Regurgitation. Can J Cardiol. 2019 Jul; 35 (7):914-922 Epub 2019 Mar 18
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283. Nishimura RA, Borlaug BA. Diastology for the clinician. J Cardiol. 2019 Jun; 73 (6):445-452 Epub 2019 Mar 25
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284. Pfeffer MA, Shah AM, Borlaug BA. Heart Failure With Preserved Ejection Fraction In Perspective. Circ Res. 2019 May 24; 124 (11):1598-1617
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285. Del Buono MG, Arena R, Borlaug BA, Carbone S, Canada JM, Kirkman DL, Garten R, Rodriguez-Miguelez P, Guazzi M, Lavie CJ, Abbate A. Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 May 7; 73 (17):2209-2225
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286. Smith JR, Borlaug BA, Olson TP. Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction. J Card Fail. 2019 Apr; 25 (4):278-285 Epub 2019 Feb 27
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288. Wolsk E, Kaye D, Komtebedde J, Shah SJ, Borlaug BA, Burkhoff D, Kitzman DW, Lam CSP, van Veldhuisen DJ, Ponikowski P, Petrie MC, Hassager C, Moller JE, Gustafsson F. Central and Peripheral Determinants of Exercise Capacity in Heart Failure Patients With Preserved Ejection Fraction. JACC Heart Fail. 2019 Apr; 7 (4):321-332 Epub 2019 Mar 06
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289. El Sabbagh A, Reddy YNV, Barros-Gomes S, Borlaug BA, Miranda WR, Pislaru SV, Nishimura RA, Pellikka PA. Low-Gradient Severe Mitral Stenosis: Hemodynamic Profiles, Clinical Characteristics, and Outcomes. J Am Heart Assoc. 2019 Mar 5; 8 (5):e010736
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291. Reddy YNV, Obokata M, Koepp KE, Egbe AC, Wiley B, Borlaug BA. The beta-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure With Preserved Ejection Fraction. Circ Res. 2019 Jan 18; 124 (2):306-314
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292. Smith JR, Van Iterson EH, Johnson BD, Borlaug BA, Olson TP. Exercise ventilatory inefficiency in heart failure and chronic obstructive pulmonary disease. Int J Cardiol. 2019 Jan 1; 274:232-236 Epub 2018 Sept 05
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293. Chignalia AZ, Isbatan A, Patel M, Ripper R, Sharlin J, Shosfy J, Borlaug BA, Dull RO. Pressure-dependent NOS activation contributes to endothelial hyperpermeability in a model of acute heart failure. Biosci Rep. 2018 Dec 21; 38 (6) Epub 2018 Nov 23
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294. Fudim M, Ambrosy AP, Sun JL, Anstrom KJ, Bart BA, Butler J, AbouEzzeddine O, Greene SJ, Mentz RJ, Redfield MM, Reddy YNV, Vaduganathan M, Braunwald E, Hernandez AF, Borlaug BA, Felker GM. High-Sensitivity Troponin I in Hospitalized and Ambulatory Patients With Heart Failure With Preserved Ejection Fraction: Insights From the Heart Failure Clinical Research Network. J Am Heart Assoc. 2018 Dec 18; 7 (24):e010364
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295. Egbe AC, Miranda WR, Said SM, Pislaru SV, Pellikka PA, Borlaug BA, Kothapalli S, Connolly HM. Risk stratification and clinical outcomes after surgical pulmonary valve replacement. Am Heart J. 2018 Dec; 206:105-112 Epub 2018 Sept 29
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296. Sharma A, Ambrosy AP, DeVore AD, Margulies KB, McNulty SE, Mentz RJ, Hernandez AF, Michael Felker G, Cooper LB, Lala A, Vader J, Groake JD, Borlaug BA, Velazquez EJ. Liraglutide and weight loss among patients with advanced heart failure and a reduced ejection fraction: insights from the FIGHT trial. ESC Heart Fail. 2018 Dec; 5 (6):1035-1043 Epub 2018 Aug 17
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297. Egbe AC, Reddy YNV, Khan AR, Al-Otaibi M, Akintoye E, Obokata M, Borlaug BA. Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment. Int J Cardiol. 2018 Nov 15; 271:312-316
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298. Borlaug BA, Schaff HV, Pochettino A, Pedrotty DM, Asirvatham SJ, Abel MD, Carter RE, Mauermann WJ. Pericardiotomy Enhances Left Ventricular Diastolic Reserve With Volume Loading in Humans. Circulation 2018 Nov 13; 138 (20):2295-2297
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299. Borlaug BA, Anstrom KJ, Lewis GD, Shah SJ, Levine JA, Koepp GA, Givertz MM, Felker GM, LeWinter MM, Mann DL, Margulies KB, Smith AL, Tang WHW, Whellan DJ, Chen HH, Davila-Roman VG, McNulty S, Desvigne-Nickens P, Hernandez AF, Braunwald E, Redfield MM, National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network. Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. JAMA. 2018 Nov 6; 320 (17):1764-1773
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300. Melenovsky V, Hlavata K, Sedivy P, Dezortova M, Borlaug BA, Petrak J, Kautzner J, Hajek M. Skeletal Muscle Abnormalities and Iron Deficiency in Chronic Heart FailureAn Exercise (31)P Magnetic Resonance Spectroscopy Study of Calf Muscle. Circ Heart Fail. 2018 Sep; 11 (9):e004800
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308. Fernandes-Silva MM, Shah AM, Claggett B, Cheng S, Tanaka H, Silvestre OM, Nadruz W, Borlaug BA, Solomon SD. Adiposity, body composition and ventricular-arterial stiffness in the elderly: the Atherosclerosis Risk in Communities Study. Eur J Heart Fail. 2018 Aug; 20 (8):1191-1201 Epub 2018 Apr 16
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309. Obokata M, Reddy YNV, Melenovsky V, Kane GC, Olson TP, Jarolim P, Borlaug BA. Myocardial Injury and Cardiac Reserve in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2018 Jul 3; 72 (1):29-40
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310. Asleh R, Hasin T, Briasoulis A, Schettle SD, Borlaug BA, Behfar A, Pereira NL, Edwards BS, Clavell AL, Joyce LD, Maltais S, Stulak JM, Kushwaha SS. Hemodynamic Assessment of Patients With and Without Heart Failure Symptoms Supported by a Continuous-Flow Left Ventricular Assist Device. Mayo Clin Proc. 2018 Jul; 93 (7):895-903 Epub 2018 June 19
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311. Joyce DL, Redfield MM, Kushwaha SS, Behfar A, Borlaug BA, Daly RC, Sandhu GS, Joyce LD. Pulmonary Pressure Assessment with the Total Artificial Heart. ASAIO J. 2018 May/Jun; 64 (3):e34-e36
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312. Fayyaz AU, Edwards WD, Maleszewski JJ, Konik EA, DuBrock HM, Borlaug BA, Frantz RP, Jenkins SM, Redfield MM. Global Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated With Heart Failure and Preserved or Reduced Ejection Fraction. Circulation. 2018 Apr 24; 137 (17):1796-1810 Epub 2017 Dec 15
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314. Wolsk E, Kaye D, Borlaug BA, Burkhoff D, Kitzman DW, Komtebedde J, Lam CSP, Ponikowski P, Shah SJ, Gustafsson F. Resting and exercise haemodynamics in relation to six-minute walk test in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2018 Apr; 20 (4):715-722 Epub 2017 Sept 26
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316. Egbe AC, Connolly HM, Taggart NW, Al-Otaibi M, Borlaug BA. Invasive and noninvasive hemodynamic assessment in adults with Fontan palliation. Int J Cardiol. 2018 Mar 1; 254:96-100 Epub 2017 Dec 05
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317. Bakkestrom R, Banke A, Christensen NL, Pecini R, Irmukhamedov A, Andersen M, Borlaug BA, Moller JE. Hemodynamic Characteristics in Significant Symptomatic and Asymptomatic Primary Mitral Valve Regurgitation at Rest and During Exercise. Circ Cardiovasc Imaging. 2018 Feb; 11 (2):e007171
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318. Pandey A, Khera R, Park B, Haykowsky M, Borlaug BA, Lewis GD, Kitzman DW, Butler J, Berry JD. Relative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure With Preserved Ejection Fraction: A Study-Level Pooled Analysis. JACC Heart Fail. 2018 Feb; 6 (2):117-126
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319. Bakkestrom R, Banke A, Pecini R, Irmukhamedov A, Nielsen SK, Andersen MJ, Borlaug BA, Moller JE. Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation. Open Heart. 2018; 5 (2):e000919 Epub 2018 Dec 16
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320. Reddy YNV, Obokata M, Haykowsky MJ, Borlaug BA. Skeletal Muscle Compensation for Cardiac Muscle Insufficiency in Heart Failure and Reduced Ejection Fraction. Circ Heart Fail. 2018 Jan; 11 (1):e004714
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321. Gorter TM, van Veldhuisen DJ, Bauersachs J, Borlaug BA, Celutkiene J, Coats AJS, Crespo-Leiro MG, Guazzi M, Harjola VP, Heymans S, Hill L, Lainscak M, Lam CSP, Lund LH, Lyon AR, Mebazaa A, Mueller C, Paulus WJ, Pieske B, Piepoli MF, Ruschitzka F, Rutten FH, Seferovic PM, Solomon SD, Shah SJ, Triposkiadis F, Wachter R, Tschope C, de Boer RA. Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018 Jan; 20 (1):16-37 Epub 2017 Oct 16
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322. Van Iterson EH, Johnson BD, Borlaug BA, Olson TP. Physiological dead space and arterial carbon dioxide contributions to exercise ventilatory inefficiency in patients with reduced or preserved ejection fraction heart failure. Eur J Heart Fail. 2017 Dec; 19 (12):1675-1685 Epub 2017 Oct 08
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323. Egbe AC, Connolly HM, Miranda WR, Ammash NM, Hagler DJ, Veldtman GR, Borlaug BA. Hemodynamics of Fontan Failure: The Role of Pulmonary Vascular Disease. Circ Heart Fail. 2017 Dec; 10 (12)
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324. Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA, PVDOMICS Study Group. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ Res. 2017 Oct 27; 121 (10):1136-1139
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325. Borlaug BA, Obokata M. Is it time to recognize a new phenotype? Heart failure with preserved ejection fraction with pulmonary vascular disease. Eur Heart J 2017 Oct 7; 38 (38):2874-2878
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326. Lloyd JW, Nishimura RA, Borlaug BA, Eleid MF. Hemodynamic Response to Nitroprusside in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Ejection Fraction. J Am Coll Cardiol. 2017 Sep 12; 70 (11):1339-1348
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327. Van Iterson EH, Olson TP, Borlaug BA, Johnson BD, Snyder EM. Comparisons of Noninvasive Methods Used to Assess Exercise Stroke Volume in Heart Failure with Preserved Ejection Fraction. Med Sci Sports Exerc. 2017 Sep; 49 (9):1758-1768
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328. Melenovsky V, Benes J, Franekova J, Kovar J, Borlaug BA, Segetova M, Tura A, Pelikanova T. Glucose Homeostasis, Pancreatic Endocrine Function, and Outcomes in Advanced Heart Failure. J Am Heart Assoc. 2017 Aug 7; 6 (8) Epub 2017 Aug 07
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329. Reddy YNV, Andersen MJ, Obokata M, Koepp KE, Kane GC, Melenovsky V, Olson TP, Borlaug BA. Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2017 Jul 11; 70 (2):136-148
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330. Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA. Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction. Circulation. 2017 Jul 4; 136 (1):6-19 Epub 2017 Apr 05
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331. Chandrashekar P, Park JY, Al-Hijji MA, Reddy YNV, Zack CJ, Reeder GS, Rea RF, Borlaug BA. Atrial Septostomy to Treat Stiff Left Atrium Syndrome. Circ Heart Fail. 2017 Jul; 10 (7)
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332. Reddy YNV, Obokata M, Dean PG, Melenovsky V, Nath KA, Borlaug BA. Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease. Eur Heart J. 2017 Jun 21; 38 (24):1913-1923
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333. Givertz MM, Fang JC, Sorajja P, Dimas V, Forfia PR, Kapur NK, Kern MJ, Naidu SS, Borlaug BA. Executive Summary of the SCAI/HFSA Clinical Expert Consensus Document on the Use of Invasive Hemodynamics for the Diagnosis and Management of Cardiovascular Disease. J Card Fail. 2017 Jun; 23 (6):487-491 Epub 2017 Apr 25
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334. Sorajja P, Borlaug BA, Dimas V, Fang JC, Forfia PR, Givertz MM, Kapur NK, Kern MJ, Naidu SS. Executive summary of the SCAI/HFSA clinical expert consensus document on the use of invasive hemodynamics for the diagnosis and management of cardiovascular disease. Catheter Cardiovasc Interv. 2017 Jun 1; 89 (7):1294-1299 Epub 2017 May 10
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335. Reddy YNV, Lewis GD, Shah SJ, LeWinter M, Semigran M, Davila-Roman VG, Anstrom K, Hernandez A, Braunwald E, Redfield MM, Borlaug BA. INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design. Circ Heart Fail. 2017 May; 10 (5)
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336. Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H, Pluhacek T, Spatenka J, Kovalcikova J, Drahota Z, Kautzner J, Pirk J, Houstek J. Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail. 2017 Apr; 19 (4):522-530 Epub 2016 Sept 19
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337. Wohlfahrt P, Rokosny S, Melenovsky V, Borlaug BA, Pecenkova V, Balaz P. Reply to 'Cardiac remodeling after reduction of high-flow arteriovenous fistulas in end-stage renal disease: methodological issues'. Hypertens Res 2017 Apr; 40 (4):411 Epub 2016 Dec 01
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338. Borlaug BA, Carter RE, Melenovsky V, DeSimone CV, Gaba P, Killu A, Naksuk N, Lerman L, Asirvatham SJ. Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2017 Apr; 10 (4):e003612
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339. Killu AM, Naksuk N, Desimone CV, Gaba P, Suddendorf S, Powers J, Ladewig DJ, Lerman LO, Borlaug BA, Asirvatham SJ. Beating Heart Validation of Safety and Efficacy of a Percutaneous Pericardiotomy Tool. J Cardiovasc Electrophysiol. 2017 Mar; 28 (3):357-361 Epub 2016 Nov 17
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340. Fernandes-Silva MM, Shah AM, Hegde S, Goncalves A, Claggett B, Cheng S, Nadruz W, Kitzman DW, Konety SH, Matsushita K, Mosley T, Lam CS, Borlaug BA, Solomon SD. Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study. JACC Heart Fail. 2017 Mar; 5 (3):157-165 Epub 2016 Dec 21
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341. Obokata M, Kane GC, Reddy YN, Olson TP, Melenovsky V, Borlaug BA. Role of Diastolic Stress Testing in the Evaluation for Heart Failure With Preserved Ejection Fraction: A Simultaneous Invasive-Echocardiographic Study. Circulation. 2017 Feb 28; 135 (9):825-838 Epub 2016 Dec 30
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342. AbouEzzeddine OF, McKie PM, Dunlay SM, Stevens SR, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM. Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2017 Feb 18; 6 (2)
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343. Wohlfahrt P, Melenovsky V, Redfield MM, Olson TP, Lin G, Abdelmoneim SS, Hametner B, Wassertheurer S, Borlaug BA. Aortic Waveform Analysis to Individualize Treatment in Heart Failure. Circ Heart Fail. 2017 Feb; 10 (2)
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344. Ghimire A, Andersen MJ, Burrowes LM, Bouwmeester JC, Grant AD, Belenkie I, Fine NM, Borlaug BA, Tyberg JV. The reservoir-wave approach to characterize pulmonary vascular-right ventricular interactions in humans. J Appl Physiol (1985). 2016 Dec 1; 121 (6):1348-1353 Epub 2016 Oct 20
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346. Borlaug BA, Melenovsky V, Koepp KE. Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction. Circ Res. 2016 Sep 16; 119 (7):880-6 Epub 2016 July 25
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347. Wohlfahrt P, Rokosny S, Melenovsky V, Borlaug BA, Pecenkova V, Balaz P. Cardiac remodeling after reduction of high-flow arteriovenous fistulas in end-stage renal disease. Hypertens Res. 2016 Sep; 39 (9):654-9 Epub 2016 May 26
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348. Reddy YNV, Melenovsky V, Redfield MM, Nishimura RA, Borlaug BA. High-Output Heart Failure: A 15-Year Experience. J Am Coll Cardiol. 2016 Aug 2; 68 (5):473-482
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349. Wan SH, Stevens SR, Borlaug BA, Anstrom KJ, Deswal A, Felker GM, Givertz MM, Bart BA, Tang WH, Redfield MM, Chen HH. Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure). Circ Heart Fail. 2016 Aug; 9 (8)
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350. Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ. Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap. Circulation. 2016 Jul 5; 134 (1):73-90
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351. Olson TP, Johnson BD, Borlaug BA. Impaired Pulmonary Diffusion in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2016 Jun; 4 (6):490-8
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352. Hussain I, Mohammed SF, Forfia PR, Lewis GD, Borlaug BA, Gallup DS, Redfield MM. Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. Circ Heart Fail. 2016 Apr; 9 (4):e002729
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353. Reddy YN, Borlaug BA. Heart Failure With Preserved Ejection Fraction. Curr Probl Cardiol. 2016 Apr; 41: (4)145-88.
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354. Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E, NHLBI Heart Failure Clinical Research Network. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10; 373 (24):2314-24 Epub 2015 Nov 08
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355. Melenovsky V, Andersen MJ, Andress K, Reddy YN, Borlaug BA. Lung congestion in chronic heart failure: haemodynamic, clinical, and prognostic implications. Eur J Heart Fail. 2015 Nov; 17: (11)1161-71.
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356. Ye Z, Coutinho T, Pellikka PA, Villarraga HR, Borlaug BA, Kullo IJ. Associations of Alterations in Pulsatile Arterial Load With Left Ventricular Longitudinal Strain. Am J Hypertens. 2015 Nov; 28(11):1325-31. Epub 2015 Apr 03.
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357. Borlaug BA, Koepp KE, Melenovsky V. Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. 2015 Oct 13; 66: (15)1672-82.
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358. St John Sutton M, Cerkvenik J, Borlaug BA, Daubert C, Gold MR, Ghio S, Chirinos JA, Linde C, Ky B. Effects of Cardiac Resynchronization Therapy on Cardiac Remodeling and Contractile Function: Results From Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE). J Am Heart Assoc. 2015 Sep 11; 4 (9):e002054 Epub 2015 Sept 11
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359. Tsang MY, Choi JO, Borlaug BA, Greason KL, Cha SS, Nishimura RA, Oh JK. Low-Flow, Low-Gradient Severe Aortic Stenosis in the Setting of Constrictive Pericarditis: Clinical Characteristics, Echocardiographic Features, and Outcomes. Circ Cardiovasc Imaging. 2015 Jul; 8: (7)e002812.
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360. Borlaug BA, Lewis GD, McNulty SE, Semigran MJ, LeWinter M, Chen H, Lin G, Deswal A, Margulies KB, Redfield MM. Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circ Heart Fail. 2015 May; 8 (3):533-41 Epub 2015 Mar 17
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361. Andersen MJ, Hwang SJ, Kane GC, Melenovsky V, Olson TP, Fetterly K, Borlaug BA. Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction. Circ Heart Fail. 2015 May; 8(3):542-50. Epub 2015 Apr 09.
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362. AbouEzzeddine OF, Haines P, Stevens S, Nativi-Nicolau J, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM. Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). JACC Heart Fail. 2015 Mar; 3 (3):245-52
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363. Melenovsky V, Hwang SJ, Redfield MM, Zakeri R, Lin G, Borlaug BA. Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction. Circ Heart Fail. 2015 Mar; 8(2):295-303. Epub 2015 Jan 15.
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364. Fleg JL, Cooper LS, Borlaug BA, Haykowsky MJ, Kraus WE, Levine BD, Pfeffer MA, Pina IL, Poole DC, Reeves GR, Whellan DJ, Kitzman DW, National Heart, Lung, and Blood Institute Working Group. Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail. 2015 Jan; 8 (1):209-20
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365. Zakeri R, Levine JA, Koepp GA, Borlaug BA, Chirinos JA, LeWinter M, VanBuren P, Davila-Roman VG, de las Fuentes L, Khazanie P, Hernandez A, Anstrom K, Redfield MM. Nitrate's effect on activity tolerance in heart failure with preserved ejection fraction trial: rationale and design. Circ Heart Fail. 2015 Jan; 8 (1):221-8
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366. Wohlfahrt P, Redfield MM, Melenovsky V, Lopez-Jimenez F, Rodeheffer RJ, Borlaug BA. Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans. Eur J Heart Fail. 2015 Jan; 17 (1):27-34 Epub 2014 Oct 31
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368. Melenovsky V, Hwang SJ, Lin G, Redfield MM, Borlaug BA. Right heart dysfunction in heart failure with preserved ejection fraction. Eur Heart J. 2014 Dec 21; 35 (48):3452-62 Epub 2014 May 29
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369. van Empel VP, Mariani J, Borlaug BA, Kaye DM. Impaired myocardial oxygen availability contributes to abnormal exercise hemodynamics in heart failure with preserved ejection fraction. J Am Heart Assoc. 2014 Dec 2; 3 (6):e001293 Epub 2014 Dec 02
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370. Andersen MJ, Ersboll M, Bro-Jeppesen J, Moller JE, Hassager C, Kober L, Borlaug BA, Goetze JP, Gustafsson F. Relationships between biomarkers and left ventricular filling pressures at rest and during exercise in patients after myocardial infarction. J Card Fail. 2014 Dec; 20 (12):959-67 Epub 2014 Oct 05
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371. Konecny T, Khanna AD, Novak J, Jama AA, Zawadowski GM, Orban M, Pressman G, Bukartyk J, Kara T, Cetta F Jr, Borlaug BA, Somers VK, Reeder GS. Interatrial pressure gradients during simulated obstructive sleep apnea: a catheter-based study. Catheter Cardiovasc Interv. 2014 Dec 1; 84 (7):1138-45 Epub 2014 Mar 11
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372. Borlaug BA. MY APPROACH to heart failure with preserved ejection fraction. Trends Cardiovasc Med. 2014 Nov; 24: (8)369-70.
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373. Andersen MJ, Nishimura RA, Borlaug BA. The hemodynamic basis of exercise intolerance in tricuspid regurgitation. Circ Heart Fail. 2014 Nov; 7(6):911-7. Epub 2014 Sep 04.
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374. Wohlfahrt P, Redfield MM, Lopez-Jimenez F, Melenovsky V, Kane GC, Rodeheffer RJ, Borlaug BA. Impact of general and central adiposity on ventricular-arterial aging in women and men. JACC Heart Fail. 2014 Oct; 2 (5):489-99 Epub 2014 Sept 03
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375. Borlaug BA. The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2014 Sep; 11 (9):507-15 Epub 2014 June 24
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376. van Empel VP, Kaye DM, Borlaug BA. Effects of healthy aging on the cardiopulmonary hemodynamic response to exercise. Am J Cardiol. 2014 Jul 1; 114 (1):131-5 Epub 2014 Apr 18
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377. Andersen MJ, Borlaug BA. Heart failure with preserved ejection fraction: current understandings and challenges. Curr Cardiol Rep. 2014 Jul; 16 (7):501
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378. Andersen MJ, Borlaug BA. Invasive hemodynamic characterization of heart failure with preserved ejection fraction. Heart Fail Clin. 2014 Jul; 10(3):435-44.
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379. Mohammed SF, Borlaug BA, McNulty S, Lewis GD, Lin G, Zakeri R, Semigran MJ, LeWinter M, Hernandez AF, Braunwald E, Redfield MM. Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail. 2014 Jul; 7 (4):580-9 Epub 2014 May 15
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380. Hwang SJ, Melenovsky V, Borlaug BA. Implications of coronary artery disease in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2014 Jul 1; 63 (25 Pt A):2817-27 Epub 2014 Apr 23
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381. Miles JM, Rule AD, Borlaug BA. Use of metformin in diseases of aging. Curr Diab Rep. 2014 Jun; 14 (6):490
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382. Borlaug BA, Olson TP, Abdelmoneim SS, Melenovsky V, Sorrell VL, Noonan K, Lin G, Redfield MM. A randomized pilot study of aortic waveform guided therapy in chronic heart failure. J Am Heart Assoc. 2014 Mar 20; 3 (2):e000745
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383. Kaye D, Shah SJ, Borlaug BA, Gustafsson F, Komtebedde J, Kubo S, Magnin C, Maurer MS, Feldman T, Burkhoff D. Effects of an interatrial shunt on rest and exercise hemodynamics: results of a computer simulation in heart failure. J Card Fail. 2014 Mar; 20(3):212-21. Epub 2014 Jan 30.
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384. Borlaug BA. Mechanisms of exercise intolerance in heart failure with preserved ejection fraction. Circ J. 2014; 78 (1):20-32 Epub 2013 Dec 03
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385. Zakeri R, Borlaug BA, McNulty SE, Mohammed SF, Lewis GD, Semigran MJ, Deswal A, LeWinter M, Hernandez AF, Braunwald E, Redfield MM. Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail. 2014 Jan; 7 (1):123-30 Epub 2013 Oct 25
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386. Zhang KW, French B, Khan AM, Plappert T, Fang JC, Sweitzer NK, Borlaug BA, Chirinos JA, John Sutton MS, Cappola TP, Ky B. Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure. Journal of the American Heart Association. 2014; 3(1):e000550.
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387. Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Davila-Roman VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM, NHLBI Heart Failure Clinical Research Network. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA. 2013 Dec 18; 310 (23):2533-43
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388. Greene SJ, Gheorghiade M, Borlaug BA, Pieske B, Vaduganathan M, Burnett JC Jr, Roessig L, Stasch JP, Solomon SD, Paulus WJ, Butler J. The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction. J Am Heart Assoc. 2013 Dec; 2(6):e000536. Epub 2013 Dec 11.
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389. Dong YX, Madhavan M, Wu JH, Oh JK, Mitsuru M, Powell BD, Dong K, Yang YZ, Hodge DO, Nishimura RA, Packer DL, Borlaug BA, Cha YM. Acute effects of atrial fibrillation on atrial and ventricular function: a simultaneous invasive-echocardiographic hemodynamic study. Int J Cardiol 2013 Nov 30; 169 (6):e114-9 Epub 2013 Oct 12
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390. Melenovsky V, Kotrc M, Borlaug BA, Marek T, Kovar J, Malek I, Kautzner J. Relationships between right ventricular function, body composition, and prognosis in advanced heart failure. J Am Coll Cardiol. 2013 Oct 29; 62 (18):1660-1670 Epub 2013 July 31
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391. Ky B, French B, May Khan A, Plappert T, Wang A, Chirinos JA, Fang JC, Sweitzer NK, Borlaug BA, Kass DA, St John Sutton M, Cappola TP. Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. J Am Coll Cardiol. 2013 Sep 24; 62(13):1165-72. Epub 2013 Jun 13.
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392. Eleid MF, Nishimura RA, Sorajja P, Borlaug BA. Systemic hypertension in low-gradient severe aortic stenosis with preserved ejection fraction. Circulation. 2013 Sep 17; 128(12):1349-53. Epub 2013 Aug 16.
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393. Borlaug BA, Redfield MM, Melenovsky V, Kane GC, Karon BL, Jacobsen SJ, Rodeheffer RJ. Longitudinal changes in left ventricular stiffness: a community-based study. Circ Heart Fail. 2013 Sep 1; 6 (5):944-52 Epub 2013 June 28
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394. Miller WL, Grill DE, Borlaug BA. Clinical features, hemodynamics, and outcomes of pulmonary hypertension due to chronic heart failure with reduced ejection fraction: pulmonary hypertension and heart failure. JACC Heart Fail. 2013 Aug; 1 (4):290-299 Epub 2013 Aug 05
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395. Abudiab MM, Redfield MM, Melenovsky V, Olson TP, Kass DA, Johnson BD, Borlaug BA. Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction. Eur J Heart Fail. 2013 Jul; 15 (7):776-85 Epub 2013 Feb 20
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396. Eleid MF, Nishimura RA, Borlaug BA, Sorajja P. Invasive measures of afterload in low gradient severe aortic stenosis with preserved ejection fraction. Circ Heart Fail. 2013 Jul; 6(4):703-10. Epub 2013 May 24.
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397. Benes J, Kotrc M, Borlaug BA, Lefflerova K, Jarolim P, Bendlova B, Jabor A, Kautzner J, Melenovsky V. Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact: a prospective pilot study. JACC Heart Fail. 2013 Jun; 1(3):259-66. Epub 2013 Jun 03.
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398. Kalogeropoulos AP, Georgiopoulou VV, Borlaug BA, Gheorghiade M, Butler J. Left ventricular dysfunction with pulmonary hypertension: part 2: prognosis, noninvasive evaluation, treatment, and future research. Circ Heart Fail. 2013 May; 6(3):584-93.
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399. Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, LeWinter MM, Rouleau JL, Bull DA, Mann DL, Deswal A, Stevenson LW, Givertz MM, Ofili EO, O'Connor CM, Felker GM, Goldsmith SR, Bart BA, McNulty SE, Ibarra JC, Lin G, Oh JK, Patel MR, Kim RJ, Tracy RP, Velazquez EJ, Anstrom KJ, Hernandez AF, Mascette AM, Braunwald E, RELAX Trial. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2013 Mar 27; 309 (12):1268-77
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400. Andersen MJ, Ersboll M, Axelsson A, Gustafsson F, Hassager C, Kober L, Borlaug BA, Boesgaard S, Skovgaard LT, Moller JE. Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction: the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial. Circulation. 2013 Mar 19; 127(11):1200-8. Epub 2013 Feb 13.
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401. Georgiopoulou VV, Kalogeropoulos AP, Borlaug BA, Gheorghiade M, Butler J. Left ventricular dysfunction with pulmonary hypertension: Part 1: epidemiology, pathophysiology, and definitions. Circ Heart Fail. 2013 Mar; 6(2):344-54.
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402. Lam CS, Shah AM, Borlaug BA, Cheng S, Verma A, Izzo J, Oparil S, Aurigemma GP, Thomas JD, Pitt B, Zile MR, Solomon SD. Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. Eur Heart J. 2013 Mar; 34(9):676-83. Epub 2012 Sep 10.
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403. Coutinho T, Borlaug BA, Pellikka PA, Turner ST, Kullo IJ. Sex differences in arterial stiffness and ventricular-arterial interactions. J Am Coll Cardiol. 2013 Jan 08; 61(1):96-103. Epub 2012 Nov 01.
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404. Miller WL, Grill DE, Borlaug BA. Clinical Features, Hemodynamics and Natural History of Pulmonary Hypertension due to Heart Failure with reduced Ejection Fraction. JACC: Heart Failure. 2013 (in press).
     
405. Fujimoto N, Borlaug BA, Lewis GD, Hastings JL, Shafer KM, Bhella PS, Carrick-Ranson G, Levine BD. Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure. Circulation. 2013 Jan 1; 127(1):55-62. Epub 2012 Nov 21.
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406. Borlaug BA. Invasive hemodynamic characterization of Heart Failure with preserved Ejection Fraction. Heart Failure Clinics. 2013 in press.
     
407. Borlaug BA. Heart Failure with preserved EF: curret understandings and challenges. Curr Cardiol Rep. 2013 in press.
     
408. Mohammed SF, Borlaug BA, Roger VL, Mirzoyev SA, Rodeheffer RJ, Chirinos JA, Redfield MM. Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study. Circ Heart Fail. 2012 Nov; 5 (6):710-9 Epub 2012 Oct 17
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409. Bishu K, Deswal A, Chen HH, LeWinter MM, Lewis GD, Semigran MJ, Borlaug BA, McNulty S, Hernandez AF, Braunwald E, Redfield MM. Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J. 2012 Nov; 164 (5):763-770.e3 Epub 2012 Oct 16
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410. Redfield MM, Borlaug BA, Lewis GD, Mohammed SF, Semigran MJ, Lewinter MM, Deswal A, Hernandez AF, Lee KL, Braunwald E, Heart Failure Clinical Research Network. PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design. Circ Heart Fail. 2012 Sep 1; 5(5):653-9.
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411. Fang JC, DeMarco T, Givertz MM, Borlaug BA, Lewis GD, Rame JE, Gomberg-Maitland M, Murali S, Frantz RP, McGlothlin D, Horn EM, Benza RL. World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult--a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2012 Sep; 31(9):913-33.
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412. Munger TM, Dong YX, Masaki M, Oh JK, Mankad SV, Borlaug BA, Asirvatham SJ, Shen WK, Lee HC, Bielinski SJ, Hodge DO, Herges RM, Buescher TL, Wu JH, Ma C, Zhang Y, Chen PS, Packer DL, Cha YM. Electrophysiological and hemodynamic characteristics associated with obesity in patients with atrial fibrillation. J Am Coll Cardiol. 2012 Aug 28; 60(9):851-60. Epub 2012 Jun 20.
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413. Guazzi M, Borlaug BA. Pulmonary hypertension due to left heart disease. Circulation. 2012 Aug 21; 126(8):975-90.
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414. Andersen MJ, Ersboll M, Bro-Jeppesen J, Gustafsson F, Hassager C, Kober L, Borlaug BA, Boesgaard S, Kjaergaard J, Moller JE. Exercise hemodynamics in patients with and without diastolic dysfunction and preserved ejection fraction after myocardial infarction. Circ Heart Fail. 2012 Jul 1; 5(4):444-51. Epub 2012 Jun 15.
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415. Schwartzenberg S, Redfield MM, From AM, Sorajja P, Nishimura RA, Borlaug BA. Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. J Am Coll Cardiol. 2012 Jan 31; 59 (5):442-51
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416. Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA. Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation. 2012 Jan 17; 125(2):289-97. Epub 2011 Nov 30.
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417. Gharacholou SM, Scott CG, Borlaug BA, Kane GC, McCully RB, Oh JK, Pellikka PA. Relationship between diastolic function and heart rate recovery after symptom-limited exercise. J Card Fail. 2012 Jan; 18 (1):34-40 Epub 2011 Nov 09
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418. From AM, Lam CS, Pitta SR, Kumar PV, Balbissi KA, Booker JD, Singh IM, Sorajja P, Reeder GS, Borlaug BA. Bedside assessment of cardiac hemodynamics: the impact of noninvasive testing and examiner experience. Am J Med. 2011 Nov; 124(11):1051-7. Epub 2011 Sep 22.
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419. Scantlebury DC, Borlaug BA. Why are women more likely than men to develop heart failure with preserved ejection fraction? Curr Opin Cardiol. 2011 Nov; 26 (6):562-8
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420. From AM, Borlaug BA. Heart failure with preserved ejection fraction: pathophysiology and emerging therapies. Cardiovasc Ther. 2011 Aug; 29(4):e6-21. Epub 2010 Mar 29.
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421. Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Cardiol Clin. 2011 Aug; 29(3):447-59.
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422. Borlaug BA, Jaber WA, Ommen SR, Lam CS, Redfield MM, Nishimura RA. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart. 2011 Jun; 97 (12):964-9 Epub 2011 Apr 08
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423. Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation. 2011 May 10; 123 (18):2006-13; discussion 2014
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424. Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Cardiol Clin. 2011 May; 29 (2):269-80
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425. Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011 Mar; 32 (6):670-9 Epub 2010 Dec 07
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426. Gharacholou SM, Maleszewski JJ, Borlaug BA, Cosio FG, Dearani JA, Kushwaha SS, Ammash NM. "Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. Echocardiography. 2011 Mar; 28: (3)E46-9.
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427. Sobieszczyk P, Borlaug BA, Gornik HL, Knauft WD, Beckman JA. Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans. Clin Sci (Lond). 2010 Nov; 119(10):437-42. Epub 2010 Aug 05.
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428. Park SJ, Nishimura RA, Borlaug BA, Sorajja P, Oh JK. The effect of loading alterations on left ventricular torsion: a simultaneous catheterization and two-dimensional speckle tracking echocardiographic study. Eur J Echocardiogr. 2010 Oct; 11(9):770-7. Epub 2010 May 18.
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429. Borlaug BA, Olson TP, Lam CS, Flood KS, Lerman A, Johnson BD, Redfield MM. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2010 Sep 7; 56 (11):845-54
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430. Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010 Sep; 3 (5):588-95 Epub 2010 June 11
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431. Borlaug BA, Redfield MM. Heart Failure with Reduced the Preserved Ejection Fraction Represent Distinct Phenotypes in the Heart Failure Syndrome. Circulation. 2010 Jun 14 (in press).
     
432. Lam CS, Grewal J, Borlaug BA, Ommen SR, Kane GC, McCully RB, Pellikka PA. Size, shape, and stamina: the impact of left ventricular geometry on exercise capacity. Hypertension. 2010 May; 55 (5):1143-9 Epub 2010 Mar 09
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433. Boilson BA, Schirger JA, Borlaug BA. Caveat medicus! Pulmonary hypertension in the elderly: a word of caution. Eur J Heart Fail. 2010 Jan; 12(1):89-93.
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434. Borlaug BA. Sex, load and relaxation: Are women more susceptible to afterload-dependent diastolic dysfunciton? J Am Coll Cardiol. 2010 (n press).
     
435. Madhavan M, Borlaug BA, Lerman A, Rihal CS, Prasad A. Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart. 2009 Sep; 95: (17)1436-41.
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436. Jaber WA, Sorajja P, Borlaug BA, Nishimura RA. Differentiation of tricuspid regurgitation from constrictive pericarditis: novel criteria for diagnosis in the cardiac catheterisation laboratory. Heart. 2009 Sep; 95(17):1449-54. Epub 2009 May 17.
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437. Borlaug BA, Lam CS, Roger VL, Rodeheffer RJ, Redfield MM. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009 Jul 28; 54 (5):410-8
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438. Lam CS, Borlaug BA, Kane GC, Enders FT, Rodeheffer RJ, Redfield MM. Age-associated increases in pulmonary artery systolic pressure in the general population. Circulation. 2009 May 26; 119 (20):2663-70 Epub 2009 May 11
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439. Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Heart Fail Clin. 2009 Apr; 5 (2):217-28
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440. Lam CS, Roger VL, Rodeheffer RJ, Borlaug BA, Enders FT, Redfield MM. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009 Mar 31; 53 (13):1119-26
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441. Borlaug BA. Treatment of heart failure with preserved ejection fraction. Curr Treat Options Cardiovasc Med. 2009 Feb; 11 (1):79-87
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442. Sorajja P, Borlaug BA. Severe heart failure in the setting of relatively mild mitral stenosis: the role of invasive hemodynamic assessment. Catheter Cardiovasc Interv. 2008 Nov 1; 72(5):739-48.
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443. Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Heart Fail Clin. 2008 Jan; 4 (1):23-36
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444. Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, Kwiterovich PO Jr. Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease. J Am Coll Cardiol. 2007 Oct 30; 50(18):1735-41 Epub 2007 Oct 15.
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445. Borlaug BA, Melenovsky V, Redfield MM, Kessler K, Chang HJ, Abraham TP, Kass DA. Impact of arterial load and loading sequence on left ventricular tissue velocities in humans. J Am Coll Cardiol. 2007 Oct 16; 50: (16)1570-7.
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446. Melenovsky V, Borlaug BA, Fetics B, Kessler K, Shively L, Kass DA. Estimation of central pressure augmentation using automated radial artery tonometry.[see comment]. J Hypertens. 2007 Jul; 25(7):1403-9.
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447. Lam CS, Roger VL, Rodeheffer RJ, Bursi F, Borlaug BA, Ommen SR, Kass DA, Redfield MM. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation. 2007 Apr 17; 115 (15):1982-90 Epub 2007 Apr 02
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448. Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction. J Am Coll Cardiol. 2007 Jan 16; 49(2):198-207.
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449. Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006 Nov 14; 114(20):2138-47. Epub 2006 Nov 06.
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450. Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion HC, Abraham TP, Girgis RE, Hassoun PM. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 2006 Nov 1; 174(9):1034-41. Epub 2006 Aug 03.
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451. Borlaug BA, Kass DA. Mechanisms of diastolic dysfunction in heart failure. Trends Cardiovasc Med. 2006 Nov; 16(8):273-9.
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452. Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA. Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans. Circulation. 2005 Oct 25; 112(17):2642-9.
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453. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005 Oct 11; 112 (15):2254-62 Epub 2005 Oct 03
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454. Melenovsky V, Hay I, Fetics BJ, Borlaug BA, Kramer A, Pastore JM, Berger R, Kass DA. Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy. Eur Heart J. 2005 Apr; 26(7):705-11.
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